![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 36182 |
FusionGeneSummary for SSR1_SRPK2 |
![]() |
Fusion gene information | Fusion gene name: SSR1_SRPK2 | Fusion gene ID: 36182 | Hgene | Tgene | Gene symbol | SSR1 | SRPK2 | Gene ID | 6745 | 6733 |
Gene name | signal sequence receptor subunit 1 | SRSF protein kinase 2 | |
Synonyms | TRAPA | SFRSK2 | |
Cytomap | 6p24.3 | 7q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | translocon-associated protein subunit alphaSSR alpha subunitSSR-alphaTRAP alphasignal sequence receptor subunit alphasignal sequence receptor, alphatranslocon-associated protein alpha subunit | SRSF protein kinase 2SFRS protein kinase 2SR protein kinase 2SR-protein-specific kinase 2serine kinase SRPK2serine/arginine-rich protein-specific kinase 2serine/arginine-rich splicing factor kinase 2serine/threonine-protein kinase SRPK2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P43307 | P78362 | |
Ensembl transtripts involved in fusion gene | ENST00000488834, ENST00000474597, ENST00000244763, ENST00000397511, ENST00000534851, ENST00000489567, ENST00000479365, ENST00000462112, | ENST00000393651, ENST00000357311, ENST00000489828, ENST00000493638, | |
Fusion gene scores | * DoF score | 10 X 11 X 4=440 | 7 X 7 X 2=98 |
# samples | 11 | 7 | |
** MAII score | log2(11/440*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SSR1 [Title/Abstract] AND SRPK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SRPK2 | GO:0000245 | spliceosomal complex assembly | 9472028 |
Tgene | SRPK2 | GO:0006468 | protein phosphorylation | 9472028 |
Tgene | SRPK2 | GO:0008284 | positive regulation of cell proliferation | 18559500 |
Tgene | SRPK2 | GO:0008380 | RNA splicing | 9472028 |
Tgene | SRPK2 | GO:0035556 | intracellular signal transduction | 9472028 |
Tgene | SRPK2 | GO:0045070 | positive regulation of viral genome replication | 20498328 |
Tgene | SRPK2 | GO:0045071 | negative regulation of viral genome replication | 12417631 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW392218 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000488834 | ENST00000393651 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000488834 | ENST00000357311 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000488834 | ENST00000489828 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-intron | ENST00000488834 | ENST00000493638 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000474597 | ENST00000393651 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000474597 | ENST00000357311 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000474597 | ENST00000489828 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-intron | ENST00000474597 | ENST00000493638 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000244763 | ENST00000393651 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000244763 | ENST00000357311 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000244763 | ENST00000489828 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-intron | ENST00000244763 | ENST00000493638 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000397511 | ENST00000393651 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000397511 | ENST00000357311 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000397511 | ENST00000489828 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-intron | ENST00000397511 | ENST00000493638 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000534851 | ENST00000393651 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000534851 | ENST00000357311 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000534851 | ENST00000489828 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-intron | ENST00000534851 | ENST00000493638 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000489567 | ENST00000393651 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000489567 | ENST00000357311 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000489567 | ENST00000489828 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-intron | ENST00000489567 | ENST00000493638 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000479365 | ENST00000393651 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000479365 | ENST00000357311 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000479365 | ENST00000489828 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-intron | ENST00000479365 | ENST00000493638 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000462112 | ENST00000393651 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000462112 | ENST00000357311 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-3CDS | ENST00000462112 | ENST00000489828 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
intron-intron | ENST00000462112 | ENST00000493638 | SSR1 | chr6 | 7288657 | + | SRPK2 | chr7 | 104783707 | + |
Top |
FusionProtFeatures for SSR1_SRPK2 |
![]() |
Hgene | Tgene |
SSR1 | SRPK2 |
Serine/arginine-rich protein-specific kinase whichspecifically phosphorylates its substrates at serine residueslocated in regions rich in arginine/serine dipeptides, known as RSdomains and is involved in the phosphorylation of SR splicingfactors and the regulation of splicing. Promotes neuronalapoptosis by up-regulating cyclin-D1 (CCND1) expression. This isdone by the phosphorylation of SRSF2, leading to the suppressionof p53/TP53 phosphorylation thereby relieving the repressiveeffect of p53/TP53 on cyclin-D1 (CCND1) expression. PhosphorylatesACIN1, and redistributes it from the nuclear speckles to thenucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complexformation via the phosphorylation of DDX23/PRP28. Can mediatehepatitis B virus (HBV) core protein phosphorylation. Plays anegative role in the regulation of HBV replication through amechanism not involving the phosphorylation of the core proteinbut by reducing the packaging efficiency of the pregenomic RNA(pgRNA) without affecting the formation of the viral coreparticles. {ECO:0000269|PubMed:12134018,ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142,ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491,ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21157427,ECO:0000269|PubMed:9472028}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SSR1_SRPK2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SSR1_SRPK2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SSR1_SRPK2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SSR1_SRPK2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |