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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36182

FusionGeneSummary for SSR1_SRPK2

check button Fusion gene summary
Fusion gene informationFusion gene name: SSR1_SRPK2
Fusion gene ID: 36182
HgeneTgene
Gene symbol

SSR1

SRPK2

Gene ID

6745

6733

Gene namesignal sequence receptor subunit 1SRSF protein kinase 2
SynonymsTRAPASFRSK2
Cytomap

6p24.3

7q22.3

Type of geneprotein-codingprotein-coding
Descriptiontranslocon-associated protein subunit alphaSSR alpha subunitSSR-alphaTRAP alphasignal sequence receptor subunit alphasignal sequence receptor, alphatranslocon-associated protein alpha subunitSRSF protein kinase 2SFRS protein kinase 2SR protein kinase 2SR-protein-specific kinase 2serine kinase SRPK2serine/arginine-rich protein-specific kinase 2serine/arginine-rich splicing factor kinase 2serine/threonine-protein kinase SRPK2
Modification date2018052320180523
UniProtAcc

P43307

P78362

Ensembl transtripts involved in fusion geneENST00000488834, ENST00000474597, 
ENST00000244763, ENST00000397511, 
ENST00000534851, ENST00000489567, 
ENST00000479365, ENST00000462112, 
ENST00000393651, ENST00000357311, 
ENST00000489828, ENST00000493638, 
Fusion gene scores* DoF score10 X 11 X 4=4407 X 7 X 2=98
# samples 117
** MAII scorelog2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SSR1 [Title/Abstract] AND SRPK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSRPK2

GO:0000245

spliceosomal complex assembly

9472028

TgeneSRPK2

GO:0006468

protein phosphorylation

9472028

TgeneSRPK2

GO:0008284

positive regulation of cell proliferation

18559500

TgeneSRPK2

GO:0008380

RNA splicing

9472028

TgeneSRPK2

GO:0035556

intracellular signal transduction

9472028

TgeneSRPK2

GO:0045070

positive regulation of viral genome replication

20498328

TgeneSRPK2

GO:0045071

negative regulation of viral genome replication

12417631


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW392218SSR1chr6

7288657

+SRPK2chr7

104783707

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000488834ENST00000393651SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000488834ENST00000357311SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000488834ENST00000489828SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-intronENST00000488834ENST00000493638SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000474597ENST00000393651SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000474597ENST00000357311SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000474597ENST00000489828SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-intronENST00000474597ENST00000493638SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000244763ENST00000393651SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000244763ENST00000357311SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000244763ENST00000489828SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-intronENST00000244763ENST00000493638SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000397511ENST00000393651SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000397511ENST00000357311SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000397511ENST00000489828SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-intronENST00000397511ENST00000493638SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000534851ENST00000393651SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000534851ENST00000357311SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000534851ENST00000489828SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-intronENST00000534851ENST00000493638SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000489567ENST00000393651SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000489567ENST00000357311SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000489567ENST00000489828SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-intronENST00000489567ENST00000493638SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000479365ENST00000393651SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000479365ENST00000357311SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000479365ENST00000489828SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-intronENST00000479365ENST00000493638SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000462112ENST00000393651SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000462112ENST00000357311SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-3CDSENST00000462112ENST00000489828SSR1chr6

7288657

+SRPK2chr7

104783707

+
intron-intronENST00000462112ENST00000493638SSR1chr6

7288657

+SRPK2chr7

104783707

+

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FusionProtFeatures for SSR1_SRPK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SSR1

P43307

SRPK2

P78362

Serine/arginine-rich protein-specific kinase whichspecifically phosphorylates its substrates at serine residueslocated in regions rich in arginine/serine dipeptides, known as RSdomains and is involved in the phosphorylation of SR splicingfactors and the regulation of splicing. Promotes neuronalapoptosis by up-regulating cyclin-D1 (CCND1) expression. This isdone by the phosphorylation of SRSF2, leading to the suppressionof p53/TP53 phosphorylation thereby relieving the repressiveeffect of p53/TP53 on cyclin-D1 (CCND1) expression. PhosphorylatesACIN1, and redistributes it from the nuclear speckles to thenucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complexformation via the phosphorylation of DDX23/PRP28. Can mediatehepatitis B virus (HBV) core protein phosphorylation. Plays anegative role in the regulation of HBV replication through amechanism not involving the phosphorylation of the core proteinbut by reducing the packaging efficiency of the pregenomic RNA(pgRNA) without affecting the formation of the viral coreparticles. {ECO:0000269|PubMed:12134018,ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142,ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491,ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21157427,ECO:0000269|PubMed:9472028}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SSR1_SRPK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SSR1_SRPK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SSR1_SRPK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SSR1_SRPK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource