	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 36181

FusionGeneSummary for SSR1_RBFOX2

Fusion gene summary

Fusion gene information	Fusion gene name: SSR1_RBFOX2
	Fusion gene ID: 36181
		Hgene	Tgene
	Gene symbol	SSR1	RBFOX2
	Gene ID	6745	23543
	Gene name	signal sequence receptor subunit 1	RNA binding fox-1 homolog 2
	Synonyms	TRAPA	FOX2\|Fox-2\|HNRBP2\|HRNBP2\|RBM9\|RTA\|dJ106I20.3\|fxh
	Cytomap	6p24.3	22q12.3
	Type of gene	protein-coding	protein-coding
	Description	translocon-associated protein subunit alphaSSR alpha subunitSSR-alphaTRAP alphasignal sequence receptor subunit alphasignal sequence receptor, alphatranslocon-associated protein alpha subunit	RNA binding protein fox-1 homolog 2RNA binding protein, fox-1 homolog 2RNA-binding motif protein 9fox-1 homolog Bfox-1 homologuehexaribonucleotide-binding protein 2repressor of tamoxifen transcriptional activity
	Modification date	20180523	20180523
	UniProtAcc	P43307	O43251
	Ensembl transtripts involved in fusion gene	ENST00000488834, ENST00000474597, ENST00000244763, ENST00000397511, ENST00000534851, ENST00000489567, ENST00000479365, ENST00000462112,	ENST00000405409, ENST00000414461, ENST00000449924, ENST00000262829, ENST00000397303, ENST00000359369, ENST00000416721, ENST00000438146,
Fusion gene scores	* DoF score	10 X 11 X 4=440	9 X 9 X 4=324
	# samples	11	10
	** MAII score	log2(11/440*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SSR1 [Title/Abstract] AND RBFOX2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RBFOX2	GO:0030520	intracellular estrogen receptor signaling pathway	11875103
Tgene	RBFOX2	GO:0045892	negative regulation of transcription, DNA-templated	11875103

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AI082662	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000488834	ENST00000405409	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000488834	ENST00000414461	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000488834	ENST00000449924	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000488834	ENST00000262829	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000488834	ENST00000397303	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000488834	ENST00000359369	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000488834	ENST00000416721	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000488834	ENST00000438146	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000474597	ENST00000405409	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000474597	ENST00000414461	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000474597	ENST00000449924	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000474597	ENST00000262829	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000474597	ENST00000397303	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000474597	ENST00000359369	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000474597	ENST00000416721	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000474597	ENST00000438146	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000244763	ENST00000405409	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000244763	ENST00000414461	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000244763	ENST00000449924	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000244763	ENST00000262829	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000244763	ENST00000397303	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000244763	ENST00000359369	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000244763	ENST00000416721	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000244763	ENST00000438146	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000397511	ENST00000405409	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000397511	ENST00000414461	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000397511	ENST00000449924	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000397511	ENST00000262829	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000397511	ENST00000397303	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000397511	ENST00000359369	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000397511	ENST00000416721	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000397511	ENST00000438146	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000534851	ENST00000405409	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000534851	ENST00000414461	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000534851	ENST00000449924	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000534851	ENST00000262829	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000534851	ENST00000397303	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000534851	ENST00000359369	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000534851	ENST00000416721	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000534851	ENST00000438146	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000489567	ENST00000405409	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000489567	ENST00000414461	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000489567	ENST00000449924	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000489567	ENST00000262829	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000489567	ENST00000397303	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000489567	ENST00000359369	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000489567	ENST00000416721	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000489567	ENST00000438146	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000479365	ENST00000405409	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000479365	ENST00000414461	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000479365	ENST00000449924	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000479365	ENST00000262829	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000479365	ENST00000397303	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000479365	ENST00000359369	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000479365	ENST00000416721	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000479365	ENST00000438146	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000462112	ENST00000405409	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000462112	ENST00000414461	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000462112	ENST00000449924	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000462112	ENST00000262829	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000462112	ENST00000397303	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000462112	ENST00000359369	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000462112	ENST00000416721	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+
intron-intron	ENST00000462112	ENST00000438146	SSR1	chr6	7300912	+	RBFOX2	chr22	36423124	+

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FusionProtFeatures for SSR1_RBFOX2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SSR1 P43307	RBFOX2 O43251

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for SSR1_RBFOX2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SSR1_RBFOX2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for SSR1_RBFOX2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SSR1_RBFOX2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	RBFOX2	C0010606	Adenoid Cystic Carcinoma	1	CTD_human
Tgene	RBFOX2	C0036095	Salivary Gland Neoplasms	1	CTD_human

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Fusion gene ID: 36181

FusionGeneSummary for SSR1_RBFOX2

FusionProtFeatures for SSR1_RBFOX2

FusionGeneSequence for SSR1_RBFOX2

FusionGenePPI for SSR1_RBFOX2

RelatedDrugs for SSR1_RBFOX2

RelatedDiseases for SSR1_RBFOX2