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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36179

FusionGeneSummary for SSR1_NTF3

check button Fusion gene summary
Fusion gene informationFusion gene name: SSR1_NTF3
Fusion gene ID: 36179
HgeneTgene
Gene symbol

SSR1

NTF3

Gene ID

6745

4908

Gene namesignal sequence receptor subunit 1neurotrophin 3
SynonymsTRAPAHDNF|NGF-2|NGF2|NT-3|NT3
Cytomap

6p24.3

12p13.31

Type of geneprotein-codingprotein-coding
Descriptiontranslocon-associated protein subunit alphaSSR alpha subunitSSR-alphaTRAP alphasignal sequence receptor subunit alphasignal sequence receptor, alphatranslocon-associated protein alpha subunitneurotrophin-3nerve growth factor 2neurotrophic factor
Modification date2018052320180523
UniProtAcc

P43307

P20783

Ensembl transtripts involved in fusion geneENST00000488834, ENST00000474597, 
ENST00000244763, ENST00000397511, 
ENST00000534851, ENST00000489567, 
ENST00000479365, ENST00000462112, 
ENST00000535299, ENST00000423158, 
ENST00000331010, 
Fusion gene scores* DoF score10 X 11 X 4=4401 X 1 X 1=1
# samples 111
** MAII scorelog2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: SSR1 [Title/Abstract] AND NTF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNTF3

GO:0000187

activation of MAPK activity

23027130

TgeneNTF3

GO:0002092

positive regulation of receptor internalization

23027130

TgeneNTF3

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

23027130

TgeneNTF3

GO:0008284

positive regulation of cell proliferation

23027130

TgeneNTF3

GO:0030335

positive regulation of cell migration

23027130

TgeneNTF3

GO:0032148

activation of protein kinase B activity

23027130

TgeneNTF3

GO:0033138

positive regulation of peptidyl-serine phosphorylation

23027130

TgeneNTF3

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

23027130

TgeneNTF3

GO:0050732

negative regulation of peptidyl-tyrosine phosphorylation

23027130

TgeneNTF3

GO:0050930

induction of positive chemotaxis

23027130

TgeneNTF3

GO:0090630

activation of GTPase activity

23027130

TgeneNTF3

GO:2000251

positive regulation of actin cytoskeleton reorganization

23027130


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-PC-A5DN-01ASSR1chr6

7290101

-NTF3chr12

5603360

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000488834ENST00000535299SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-intronENST00000488834ENST00000423158SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-5UTRENST00000488834ENST00000331010SSR1chr6

7290101

-NTF3chr12

5603360

+
5CDS-intronENST00000474597ENST00000535299SSR1chr6

7290101

-NTF3chr12

5603360

+
5CDS-intronENST00000474597ENST00000423158SSR1chr6

7290101

-NTF3chr12

5603360

+
5CDS-5UTRENST00000474597ENST00000331010SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-intronENST00000244763ENST00000535299SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-intronENST00000244763ENST00000423158SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-5UTRENST00000244763ENST00000331010SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-intronENST00000397511ENST00000535299SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-intronENST00000397511ENST00000423158SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-5UTRENST00000397511ENST00000331010SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-intronENST00000534851ENST00000535299SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-intronENST00000534851ENST00000423158SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-5UTRENST00000534851ENST00000331010SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-intronENST00000489567ENST00000535299SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-intronENST00000489567ENST00000423158SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-5UTRENST00000489567ENST00000331010SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-intronENST00000479365ENST00000535299SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-intronENST00000479365ENST00000423158SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-5UTRENST00000479365ENST00000331010SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-intronENST00000462112ENST00000535299SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-intronENST00000462112ENST00000423158SSR1chr6

7290101

-NTF3chr12

5603360

+
intron-5UTRENST00000462112ENST00000331010SSR1chr6

7290101

-NTF3chr12

5603360

+

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FusionProtFeatures for SSR1_NTF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SSR1

P43307

NTF3

P20783

Seems to promote the survival of visceral andproprioceptive sensory neurons.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SSR1_NTF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SSR1_NTF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SSR1DKC1, UTP14A, EEF1A1, PTN, HSPA13, HDGF, ELAVL1, CUL3, CAND1, FBXO6, ACAD9, FLOT2, CCT2, ABCC2, SFXN1, ILF3, FKBP8, HNRNPM, TCP1, CCT5, ATP6V1C1, CCT4, SRSF1, PSAP, HM13, MDC1, SERPINA1, EDEM1, HSPA5, MYC, ODC1, SERPINF2, ILK, HUWE1, RPS6KB2, NTRK1, ATP5C1, CYC1, DDOST, PHB, ATAD3A, ATAD3B, ATP5L, ATP6V0D1, LMAN1, MAGT1, COX2, NDUFA9, NDUFB8, PHB2, RPN1, SSR3, TECR, TMX1, VDAC3, SSR4, UQCRC2, MED23, TCTN3, TMEM216, EZH2, SORT1, SEC61B, LTN1, ERBB3, ESRRB, DUSP23, ERGIC3, EDEM3NTF3NTRK1, NTRK2, NTRK3, MEOX2, LAMB1, PYGB, PYGL, ITIH3, MAD2L1BP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SSR1_NTF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SSR1_NTF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNTF3C0005586Bipolar Disorder2PSYGENET
TgeneNTF3C0027746Nerve Degeneration2CTD_human
TgeneNTF3C0004352Autistic Disorder1CTD_human
TgeneNTF3C0011882Diabetic Neuropathies1CTD_human
TgeneNTF3C0013080Down Syndrome1CTD_human
TgeneNTF3C0014549Tonic-Clonic Epilepsy1CTD_human
TgeneNTF3C0020429Hyperalgesia1CTD_human
TgeneNTF3C0036341Schizophrenia1CTD_human
TgeneNTF3C0038220Status Epilepticus1CTD_human
TgeneNTF3C0041696Unipolar Depression1PSYGENET
TgeneNTF3C0525045Mood Disorders1PSYGENET
TgeneNTF3C1269683Major Depressive Disorder1PSYGENET
TgeneNTF3C1384666hearing impairment1CTD_human