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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36174

FusionGeneSummary for SSR1_AVL9

check button Fusion gene summary
Fusion gene informationFusion gene name: SSR1_AVL9
Fusion gene ID: 36174
HgeneTgene
Gene symbol

SSR1

AVL9

Gene ID

6745

23080

Gene namesignal sequence receptor subunit 1AVL9 cell migration associated
SynonymsTRAPAKIAA0241
Cytomap

6p24.3

7p14.3

Type of geneprotein-codingprotein-coding
Descriptiontranslocon-associated protein subunit alphaSSR alpha subunitSSR-alphaTRAP alphasignal sequence receptor subunit alphasignal sequence receptor, alphatranslocon-associated protein alpha subunitlate secretory pathway protein AVL9 homologAVL9 homolog (S. cerevisiase)
Modification date2018052320180523
UniProtAcc

P43307

Q8NBF6

Ensembl transtripts involved in fusion geneENST00000488834, ENST00000474597, 
ENST00000244763, ENST00000397511, 
ENST00000534851, ENST00000489567, 
ENST00000479365, ENST00000462112, 
ENST00000404479, ENST00000318709, 
ENST00000459629, ENST00000409301, 
Fusion gene scores* DoF score10 X 11 X 4=4408 X 9 X 3=216
# samples 119
** MAII scorelog2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SSR1 [Title/Abstract] AND AVL9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAVL9

GO:0016477

cell migration

22595670


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF818212SSR1chr6

7284535

-AVL9chr7

33042369

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000488834ENST00000404479SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000488834ENST00000318709SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000488834ENST00000459629SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000488834ENST00000409301SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000474597ENST00000404479SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000474597ENST00000318709SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000474597ENST00000459629SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000474597ENST00000409301SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000244763ENST00000404479SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000244763ENST00000318709SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000244763ENST00000459629SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000244763ENST00000409301SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000397511ENST00000404479SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000397511ENST00000318709SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000397511ENST00000459629SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000397511ENST00000409301SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000534851ENST00000404479SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000534851ENST00000318709SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000534851ENST00000459629SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000534851ENST00000409301SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000489567ENST00000404479SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000489567ENST00000318709SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000489567ENST00000459629SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000489567ENST00000409301SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000479365ENST00000404479SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000479365ENST00000318709SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000479365ENST00000459629SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000479365ENST00000409301SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000462112ENST00000404479SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000462112ENST00000318709SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000462112ENST00000459629SSR1chr6

7284535

-AVL9chr7

33042369

+
intron-intronENST00000462112ENST00000409301SSR1chr6

7284535

-AVL9chr7

33042369

+

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FusionProtFeatures for SSR1_AVL9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SSR1

P43307

AVL9

Q8NBF6

Functions in cell migration.{ECO:0000269|PubMed:22595670}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SSR1_AVL9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SSR1_AVL9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SSR1_AVL9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SSR1_AVL9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAVL9C3495559Juvenile arthritis1CTD_human