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Fusion gene ID: 36167 |
FusionGeneSummary for SSH2_TNFAIP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SSH2_TNFAIP1 | Fusion gene ID: 36167 | Hgene | Tgene | Gene symbol | SSH2 | TNFAIP1 | Gene ID | 85464 | 7126 |
| Gene name | slingshot protein phosphatase 2 | TNF alpha induced protein 1 | |
| Synonyms | SSH-2|SSH-2L | B12|B61|BTBD34|EDP1|hBACURD2 | |
| Cytomap | 17q11.2 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein phosphatase Slingshot homolog 2SSH-like protein 2 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2BTB/POZ domain-containing protein TNFAIP1tumor necrosis factor, alpha induced protein 1tumor necrosis factor, alpha-induced protein 1 (endothelial) | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q76I76 | Q13829 | |
| Ensembl transtripts involved in fusion gene | ENST00000269033, ENST00000540801, ENST00000324677, ENST00000582084, ENST00000590153, ENST00000579954, | ENST00000544907, ENST00000226225, ENST00000583213, | |
| Fusion gene scores | * DoF score | 24 X 11 X 6=1584 | 3 X 3 X 2=18 |
| # samples | 24 | 3 | |
| ** MAII score | log2(24/1584*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SSH2 [Title/Abstract] AND TNFAIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TNFAIP1 | GO:0016567 | protein ubiquitination | 19782033 |
| Tgene | TNFAIP1 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 19782033 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AN-A0XW-01A | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000269033 | ENST00000544907 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| 5CDS-5UTR | ENST00000269033 | ENST00000226225 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| 5CDS-intron | ENST00000269033 | ENST00000583213 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| 5CDS-intron | ENST00000540801 | ENST00000544907 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| 5CDS-5UTR | ENST00000540801 | ENST00000226225 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| 5CDS-intron | ENST00000540801 | ENST00000583213 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| intron-intron | ENST00000324677 | ENST00000544907 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| intron-5UTR | ENST00000324677 | ENST00000226225 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| intron-intron | ENST00000324677 | ENST00000583213 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| intron-intron | ENST00000582084 | ENST00000544907 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| intron-5UTR | ENST00000582084 | ENST00000226225 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| intron-intron | ENST00000582084 | ENST00000583213 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| intron-intron | ENST00000590153 | ENST00000544907 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| intron-5UTR | ENST00000590153 | ENST00000226225 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| intron-intron | ENST00000590153 | ENST00000583213 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| intron-intron | ENST00000579954 | ENST00000544907 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| intron-5UTR | ENST00000579954 | ENST00000226225 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
| intron-intron | ENST00000579954 | ENST00000583213 | SSH2 | chr17 | 28120912 | - | TNFAIP1 | chr17 | 26666434 | + |
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FusionProtFeatures for SSH2_TNFAIP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SSH2 | TNFAIP1 |
| Protein phosphatase which regulates actin filamentdynamics. Dephosphorylates and activates the actinbinding/depolymerizing factor cofilin, which subsequently binds toactin filaments and stimulates their disassembly. Inhibitoryphosphorylation of cofilin is mediated by LIMK1, which may also bedephosphorylated and inactivated by this protein.{ECO:0000269|PubMed:11832213}. | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3ubiquitin-protein ligase complex involved in regulation ofcytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligasecomplex mediates the ubiquitination of RHOA, leading to itsdegradation by the proteasome, thereby regulating the actincytoskeleton and cell migration. Its interaction with RHOB mayregulate apoptosis. May enhance the PCNA-dependent DNA polymerasedelta activity. {ECO:0000269|PubMed:19637314,ECO:0000269|PubMed:19782033}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SSH2_TNFAIP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SSH2_TNFAIP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SSH2 | ACTB, ELAVL1, BAG3, XPO1, CAPZA2, DBN1, FLNA, MYH9, PPP1CB, IQGAP1, KIF3A, SYNPO, LIMA1, ANLN, MYO19, MYO18A, GAN, FBXW7, MYO1D, TRIM25 | TNFAIP1 | KCTD13, SVIL, KCTD10, RIN3, CUL3, DCUN1D1, CSNK2B, PCNA, RHOB, POLR1C, ARNT, KDM1A, SUV39H1, RHOA, PSMA1, TNFAIP1, HAT1, STK16, EPM2AIP1, CAPN7, EXOSC5, CARD9, ARMC7, NXF1, TUBB4A, ZDHHC17, UBXN1, HSPA1L, FLNC, BAG3, CLPSL1, DAPP1, ZMYND19, XPO1, CAPZA2, DVL2, MYH9, PPP1CB, EMC2, SYNPO, LIMA1, ANLN, ENTHD2, MYO18A, UBXN7, FAF1, ARIH1, USP25, NRP1, SMARCB1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SSH2_TNFAIP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SSH2_TNFAIP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TNFAIP1 | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
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