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Fusion gene ID: 36087 |
FusionGeneSummary for SRSF1_SKA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SRSF1_SKA2 | Fusion gene ID: 36087 | Hgene | Tgene | Gene symbol | SRSF1 | SKA2 | Gene ID | 6426 | 348235 |
| Gene name | serine and arginine rich splicing factor 1 | spindle and kinetochore associated complex subunit 2 | |
| Synonyms | ASF|SF2|SF2p33|SFRS1|SRp30a | FAM33A | |
| Cytomap | 17q22 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/arginine-rich splicing factor 1SR splicing factor 1alternative-splicing factor 1pre-mRNA-splicing factor SF2, P33 subunitsplicing factor 2splicing factor, arginine/serine-rich, 30-KD, A | spindle and kinetochore-associated protein 2family with sequence similarity 33, member Aspindle and KT (kinetochore) associated 2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q07955 | Q8WVK7 | |
| Ensembl transtripts involved in fusion gene | ENST00000582730, ENST00000581497, ENST00000584773, ENST00000585096, ENST00000258962, | ENST00000330137, ENST00000580541, ENST00000578105, ENST00000583927, ENST00000581068, ENST00000437036, ENST00000583380, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 3 X 2 X 2=12 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SRSF1 [Title/Abstract] AND SKA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SRSF1 | GO:0000380 | alternative mRNA splicing, via spliceosome | 8940107 |
| Hgene | SRSF1 | GO:0000395 | mRNA 5'-splice site recognition | 8940107|9885563 |
| Tgene | SKA2 | GO:0031110 | regulation of microtubule polymerization or depolymerization | 19289083 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A1FM-01A | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000582730 | ENST00000330137 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| In-frame | ENST00000582730 | ENST00000580541 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| Frame-shift | ENST00000582730 | ENST00000578105 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000582730 | ENST00000583927 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000582730 | ENST00000581068 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000582730 | ENST00000437036 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000582730 | ENST00000583380 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| intron-3CDS | ENST00000581497 | ENST00000330137 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| intron-3CDS | ENST00000581497 | ENST00000580541 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| intron-3CDS | ENST00000581497 | ENST00000578105 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| intron-5UTR | ENST00000581497 | ENST00000583927 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| intron-5UTR | ENST00000581497 | ENST00000581068 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| intron-5UTR | ENST00000581497 | ENST00000437036 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| intron-5UTR | ENST00000581497 | ENST00000583380 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| In-frame | ENST00000584773 | ENST00000330137 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| In-frame | ENST00000584773 | ENST00000580541 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| Frame-shift | ENST00000584773 | ENST00000578105 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000584773 | ENST00000583927 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000584773 | ENST00000581068 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000584773 | ENST00000437036 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000584773 | ENST00000583380 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| In-frame | ENST00000585096 | ENST00000330137 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| In-frame | ENST00000585096 | ENST00000580541 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| Frame-shift | ENST00000585096 | ENST00000578105 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000585096 | ENST00000583927 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000585096 | ENST00000581068 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000585096 | ENST00000437036 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000585096 | ENST00000583380 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| In-frame | ENST00000258962 | ENST00000330137 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| In-frame | ENST00000258962 | ENST00000580541 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| Frame-shift | ENST00000258962 | ENST00000578105 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000258962 | ENST00000583927 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000258962 | ENST00000581068 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000258962 | ENST00000437036 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
| 5CDS-5UTR | ENST00000258962 | ENST00000583380 | SRSF1 | chr17 | 56084305 | - | SKA2 | chr17 | 57189706 | - |
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FusionProtFeatures for SRSF1_SKA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SRSF1 | SKA2 |
| Plays a role in preventing exon skipping, ensuring theaccuracy of splicing and regulating alternative splicing.Interacts with other spliceosomal components, via the RS domains,to form a bridge between the 5'- and 3'-splice site bindingcomponents, U1 snRNP and U2AF. Can stimulate binding of U1 snRNPto a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNAsequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or thedecamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitutea powerful splicing enhancer in vitro, the ASF/SF2 splicingenhancer (ASE) which can specifically activate ASE-dependentsplicing. Isoform ASF-2 and isoform ASF-3 act as splicingrepressors. May function as export adapter involved in mRNAnuclear export through the TAP/NXF1 pathway.{ECO:0000269|PubMed:8139654}. | Component of the SKA1 complex, a microtubule-bindingsubcomplex of the outer kinetochore that is essential for properchromosome segregation (PubMed:17093495, PubMed:19289083,PubMed:23085020). Required for timely anaphase onset duringmitosis, when chromosomes undergo bipolar attachment on spindlemicrotubules leading to silencing of the spindle checkpoint(PubMed:17093495). The SKA1 complex is a direct component of thekinetochore-microtubule interface and directly associates withmicrotubules as oligomeric assemblies (PubMed:19289083). Thecomplex facilitates the processive movement of microspheres alonga microtubule in a depolymerization-coupled manner(PubMed:17093495, PubMed:19289083). In the complex, it is requiredfor SKA1 localization (PubMed:19289083). Affinity for microtubulesis synergistically enhanced in the presence of the ndc-80 complexand may allow the ndc-80 complex to track depolymerizingmicrotubules (PubMed:23085020). {ECO:0000269|PubMed:17093495,ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:23085020}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SRSF1 | chr17:56084305 | chr17:57189706 | ENST00000258962 | - | 1 | 4 | 198_247 | 64 | 249 | Compositional bias | Note=Arg/Ser-rich (RS domain) |
| Hgene | >SRSF1 | chr17:56084305 | chr17:57189706 | ENST00000258962 | - | 1 | 4 | 94_113 | 64 | 249 | Compositional bias | Note=Gly-rich (hinge region) |
| Hgene | >SRSF1 | chr17:56084305 | chr17:57189706 | ENST00000582730 | - | 1 | 3 | 198_247 | 64 | 202 | Compositional bias | Note=Arg/Ser-rich (RS domain) |
| Hgene | >SRSF1 | chr17:56084305 | chr17:57189706 | ENST00000582730 | - | 1 | 3 | 94_113 | 64 | 202 | Compositional bias | Note=Gly-rich (hinge region) |
| Hgene | >SRSF1 | chr17:56084305 | chr17:57189706 | ENST00000258962 | - | 1 | 4 | 121_195 | 64 | 249 | Domain | RRM 2 |
| Hgene | >SRSF1 | chr17:56084305 | chr17:57189706 | ENST00000258962 | - | 1 | 4 | 16_91 | 64 | 249 | Domain | RRM 1 |
| Hgene | >SRSF1 | chr17:56084305 | chr17:57189706 | ENST00000582730 | - | 1 | 3 | 121_195 | 64 | 202 | Domain | RRM 2 |
| Hgene | >SRSF1 | chr17:56084305 | chr17:57189706 | ENST00000582730 | - | 1 | 3 | 16_91 | 64 | 202 | Domain | RRM 1 |
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FusionGeneSequence for SRSF1_SKA2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SRSF1_ENST00000582730_chr17_56084305_-_SKA2_ENST00000330137_chr17_57189706_-_87aa >In-frame_SRSF1_ENST00000582730_chr17_56084305_-_SKA2_ENST00000580541_chr17_57189706_-_69aa >In-frame_SRSF1_ENST00000584773_chr17_56084305_-_SKA2_ENST00000330137_chr17_57189706_-_87aa >In-frame_SRSF1_ENST00000584773_chr17_56084305_-_SKA2_ENST00000580541_chr17_57189706_-_69aa >In-frame_SRSF1_ENST00000585096_chr17_56084305_-_SKA2_ENST00000330137_chr17_57189706_-_87aa >In-frame_SRSF1_ENST00000585096_chr17_56084305_-_SKA2_ENST00000580541_chr17_57189706_-_69aa >In-frame_SRSF1_ENST00000258962_chr17_56084305_-_SKA2_ENST00000330137_chr17_57189706_-_87aa >In-frame_SRSF1_ENST00000258962_chr17_56084305_-_SKA2_ENST00000580541_chr17_57189706_-_69aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SRSF1_ENST00000582730_chr17_56084305_-_SKA2_ENST00000330137_chr17_57189706_-_263nt ATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTACGTGGGTAACTTACCTCCAGACATCCGAACCAAG GACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACATCGACCTCAAGAATCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAG >In-frame_SRSF1_ENST00000582730_chr17_56084305_-_SKA2_ENST00000580541_chr17_57189706_-_207nt ATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTACGTGGGTAACTTACCTCCAGACATCCGAACCAAG GACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACATCGACCTCAAGAATCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAG >In-frame_SRSF1_ENST00000584773_chr17_56084305_-_SKA2_ENST00000330137_chr17_57189706_-_263nt ATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTACGTGGGTAACTTACCTCCAGACATCCGAACCAAG GACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACATCGACCTCAAGAATCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAG >In-frame_SRSF1_ENST00000584773_chr17_56084305_-_SKA2_ENST00000580541_chr17_57189706_-_207nt ATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTACGTGGGTAACTTACCTCCAGACATCCGAACCAAG GACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACATCGACCTCAAGAATCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAG >In-frame_SRSF1_ENST00000585096_chr17_56084305_-_SKA2_ENST00000330137_chr17_57189706_-_263nt ATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTACGTGGGTAACTTACCTCCAGACATCCGAACCAAG GACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACATCGACCTCAAGAATCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAG >In-frame_SRSF1_ENST00000585096_chr17_56084305_-_SKA2_ENST00000580541_chr17_57189706_-_207nt ATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTACGTGGGTAACTTACCTCCAGACATCCGAACCAAG GACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACATCGACCTCAAGAATCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAG >In-frame_SRSF1_ENST00000258962_chr17_56084305_-_SKA2_ENST00000330137_chr17_57189706_-_263nt ATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTACGTGGGTAACTTACCTCCAGACATCCGAACCAAG GACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACATCGACCTCAAGAATCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAG >In-frame_SRSF1_ENST00000258962_chr17_56084305_-_SKA2_ENST00000580541_chr17_57189706_-_207nt ATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTACGTGGGTAACTTACCTCCAGACATCCGAACCAAG GACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACATCGACCTCAAGAATCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SRSF1_ENST00000582730_chr17_56084305_-_SKA2_ENST00000330137_chr17_57189706_-_2713nt CGAGCTGATAAAGGCGCCATTTTGGAGGGGCCGCGGGAGACGTGGTGCCGCTGCGGGCTCGCTCTGCCGTGCGCTAGGCTTGGTGGGAAG GCCTGTTCTCGAGTCCGCGCTTTTCGTCACCGCCATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTA CGTGGGTAACTTACCTCCAGACATCCGAACCAAGGACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACATCGACCTCAAGAA TCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAGTTCGAGGACCCGCGCTGTCACCACTGACTAAAGAAGAGAAAACTGCGGCAGAGCAA TTCAAATTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGAGAAGAGCTTAATTCCGGAGAAATTTAGGAAG ATGTCTTGTTAACCCTTGATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCAATGACTGGATAATGATATCTTTCATGAGAGA GATTATAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGAGAATAAAACGATTTAAATATATGTACACACG CATGCACACACACACTTAGTCTTGTAATTTCAGGCCAGAAATTCTCAACACTATTTTGCATCTGTTTTCTTTTTCTAAGTCATGATAATA TAGATGTTCTGGTCTATCATAAAAGAATGTTTATGTACATTTCAGTCATTCGGTATGTGGCTTTGTAAATTAAAGTATAGGCAAAACATT TGTGTTATACATGATATATAATTTCATTTTGTAAATGTTGATTGCACATGTGGTCACATTATTGTTGAGACTGCTTTTATGTGACCTGTA GTCTCCCACAGAACCTAAAGTAATAAGCTGGCTTTTCTGTGATAGCCACGTTTGCGTATTTCTTTCCCTATTTCCCTTGCCTGCTAATGT TGAACAGCATGAACTTGCTTTCTGATGCTGTTTTAGACTGTCCCTGTTGTATCTCAATAATATCTTTGTTTTCCTTCAGCCTTTATTACT ATAATTGTTCATTCTACATGAAAGCTAGGAAACTGAAATTAGAAGAGCACTTATCTGCTACTTGCCAGTTTTGCGTGAGTGTGTTATATG TATGTGTCAATTTCCCTTTAAAATAACTATTTATTTTAAAATAACTATTGGCAATAAGGAAACTGTTCAAAGTAGAGGCAGATCTTGATA GAAAGATGTTAATCACAGGGTTGTTTATAATAGCAATATACATACACATTTGGCTAGTACTAGGTGAATAGGAAAATAAATCATGCTGTA TGTATACAATAAGAGGTCAAGTTGCCAATAAATTATTACTGTTAATGTTCTGGGAAATGCTGAAACTATGCTAAGTGGGGGAGAGGGAAA GCAGGTATTGCAGTTTTGTAGTGAAGATTGGGCTTTGGAGTCATATCTGAGATGTAAGTAGCAGCTTTTAAATTCTAGCTATGACCCTGT GCAGATCACTTAACTTTTGAGTGTCAGGATGTTTGGAAGGACAAGACAGGAAAGTGTTTTAATACAGGGTTCAGTATTTAGTAAGCCTTC AATAAGTGATATTACATACATGTAATAAAAACTAAGCATTGAAAGGACTAGGAAAAATGCATCAAATGTTAGTTCTGCAGGTTATAGAAT TATACTTTTATGTAATTTTAAAATTTCAGTTATGAACATGTTTGTCCATTAACAAACTTATAATAGCTGAAAAACAGGGTTGTGAGAACA GCTTCAGTTAAAATTGTCCTGTCTAGTTTGAATATTTCAAGAACAGAAAGCCTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCAC TCTGTTGCCCAGGCTGGAATGCAGTGGTACGCTCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCAGTTCTCTGCCCCACCCTCC CGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTATTTTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATCTTGACCAGGC TGGTCTTTAACTCCTGATGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCTACCGTGCCTGGCCCCCTTTT TTTTAATTACAGAGAAATAAGTTACACCTTAGTATCAGATATTAATTTTCTTCAGTGTTCAGGCAATTAGTATTTAGAAAGCTCTTGTCA TGAGATGGCTCTGGGATGTGATGATGATTGTTGGGATTGAAAAAACGGTAGTATCATGGAGAGATCATAATAAATTCTTAGTATTAAAAG TGGTTTTGCTTTCAGTTAGGGAGAAAAATTAGATTGTACTATTTTTCCTCTATGATTTCCTTCAGTTATCTTCCAAATGTTGTTTTTTCC CCACAGCCCCCTTAACATTGTTCTCTATGCACTTCTCAATACATTTTCATTTGTTTCTCAAGCCTCTTTGTGGATGACTCCTAAATATAA CTTCTTCCACTAGCTCTAGATCCGTATTTCCAATAAAATCCCCTACCTGAATATTCAAGTTAAACATGTCCAGAATACTTACTGATTTTA TTGTTAATAGCCACTATTCTGTTGTCTGGAATTAAAACCTGTATAACTAATTTGCATCCCTTTATCTTCTTAGTCAATAAAACCTACAAT >In-frame_SRSF1_ENST00000582730_chr17_56084305_-_SKA2_ENST00000580541_chr17_57189706_-_778nt CGAGCTGATAAAGGCGCCATTTTGGAGGGGCCGCGGGAGACGTGGTGCCGCTGCGGGCTCGCTCTGCCGTGCGCTAGGCTTGGTGGGAAG GCCTGTTCTCGAGTCCGCGCTTTTCGTCACCGCCATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTA CGTGGGTAACTTACCTCCAGACATCCGAACCAAGGACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACATCGACCTCAAGAA TCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAGTTCGAGGACCCGCGCTGTCACCACTGACTAAAGAAGAGAAAACTGCGGCAGAGCAA TTCAAATTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGAGAAGAGCTTAATTCCGGAGAAATTTAGGAAG ATGTCTTGTTAACCCTTGATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCAATGACTGGATAATGATATCTTTCATGAGAGA GATTATAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGAGAATAAAACGATTTAAATATATGTACACACG CATGCACACACACACTTAGTCTTGTAATTTCAGGCCAGAAATTCTCAACACTATTTTGCATCTGTTTTCTTTTTCTAAGTCATGATAATA >In-frame_SRSF1_ENST00000584773_chr17_56084305_-_SKA2_ENST00000330137_chr17_57189706_-_2713nt CGAGCTGATAAAGGCGCCATTTTGGAGGGGCCGCGGGAGACGTGGTGCCGCTGCGGGCTCGCTCTGCCGTGCGCTAGGCTTGGTGGGAAG GCCTGTTCTCGAGTCCGCGCTTTTCGTCACCGCCATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTA CGTGGGTAACTTACCTCCAGACATCCGAACCAAGGACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACATCGACCTCAAGAA TCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAGTTCGAGGACCCGCGCTGTCACCACTGACTAAAGAAGAGAAAACTGCGGCAGAGCAA TTCAAATTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGAGAAGAGCTTAATTCCGGAGAAATTTAGGAAG ATGTCTTGTTAACCCTTGATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCAATGACTGGATAATGATATCTTTCATGAGAGA GATTATAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGAGAATAAAACGATTTAAATATATGTACACACG CATGCACACACACACTTAGTCTTGTAATTTCAGGCCAGAAATTCTCAACACTATTTTGCATCTGTTTTCTTTTTCTAAGTCATGATAATA TAGATGTTCTGGTCTATCATAAAAGAATGTTTATGTACATTTCAGTCATTCGGTATGTGGCTTTGTAAATTAAAGTATAGGCAAAACATT TGTGTTATACATGATATATAATTTCATTTTGTAAATGTTGATTGCACATGTGGTCACATTATTGTTGAGACTGCTTTTATGTGACCTGTA GTCTCCCACAGAACCTAAAGTAATAAGCTGGCTTTTCTGTGATAGCCACGTTTGCGTATTTCTTTCCCTATTTCCCTTGCCTGCTAATGT TGAACAGCATGAACTTGCTTTCTGATGCTGTTTTAGACTGTCCCTGTTGTATCTCAATAATATCTTTGTTTTCCTTCAGCCTTTATTACT ATAATTGTTCATTCTACATGAAAGCTAGGAAACTGAAATTAGAAGAGCACTTATCTGCTACTTGCCAGTTTTGCGTGAGTGTGTTATATG TATGTGTCAATTTCCCTTTAAAATAACTATTTATTTTAAAATAACTATTGGCAATAAGGAAACTGTTCAAAGTAGAGGCAGATCTTGATA GAAAGATGTTAATCACAGGGTTGTTTATAATAGCAATATACATACACATTTGGCTAGTACTAGGTGAATAGGAAAATAAATCATGCTGTA TGTATACAATAAGAGGTCAAGTTGCCAATAAATTATTACTGTTAATGTTCTGGGAAATGCTGAAACTATGCTAAGTGGGGGAGAGGGAAA GCAGGTATTGCAGTTTTGTAGTGAAGATTGGGCTTTGGAGTCATATCTGAGATGTAAGTAGCAGCTTTTAAATTCTAGCTATGACCCTGT GCAGATCACTTAACTTTTGAGTGTCAGGATGTTTGGAAGGACAAGACAGGAAAGTGTTTTAATACAGGGTTCAGTATTTAGTAAGCCTTC AATAAGTGATATTACATACATGTAATAAAAACTAAGCATTGAAAGGACTAGGAAAAATGCATCAAATGTTAGTTCTGCAGGTTATAGAAT TATACTTTTATGTAATTTTAAAATTTCAGTTATGAACATGTTTGTCCATTAACAAACTTATAATAGCTGAAAAACAGGGTTGTGAGAACA GCTTCAGTTAAAATTGTCCTGTCTAGTTTGAATATTTCAAGAACAGAAAGCCTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCAC TCTGTTGCCCAGGCTGGAATGCAGTGGTACGCTCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCAGTTCTCTGCCCCACCCTCC CGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTATTTTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATCTTGACCAGGC TGGTCTTTAACTCCTGATGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCTACCGTGCCTGGCCCCCTTTT TTTTAATTACAGAGAAATAAGTTACACCTTAGTATCAGATATTAATTTTCTTCAGTGTTCAGGCAATTAGTATTTAGAAAGCTCTTGTCA TGAGATGGCTCTGGGATGTGATGATGATTGTTGGGATTGAAAAAACGGTAGTATCATGGAGAGATCATAATAAATTCTTAGTATTAAAAG TGGTTTTGCTTTCAGTTAGGGAGAAAAATTAGATTGTACTATTTTTCCTCTATGATTTCCTTCAGTTATCTTCCAAATGTTGTTTTTTCC CCACAGCCCCCTTAACATTGTTCTCTATGCACTTCTCAATACATTTTCATTTGTTTCTCAAGCCTCTTTGTGGATGACTCCTAAATATAA CTTCTTCCACTAGCTCTAGATCCGTATTTCCAATAAAATCCCCTACCTGAATATTCAAGTTAAACATGTCCAGAATACTTACTGATTTTA TTGTTAATAGCCACTATTCTGTTGTCTGGAATTAAAACCTGTATAACTAATTTGCATCCCTTTATCTTCTTAGTCAATAAAACCTACAAT >In-frame_SRSF1_ENST00000584773_chr17_56084305_-_SKA2_ENST00000580541_chr17_57189706_-_778nt CGAGCTGATAAAGGCGCCATTTTGGAGGGGCCGCGGGAGACGTGGTGCCGCTGCGGGCTCGCTCTGCCGTGCGCTAGGCTTGGTGGGAAG GCCTGTTCTCGAGTCCGCGCTTTTCGTCACCGCCATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTA CGTGGGTAACTTACCTCCAGACATCCGAACCAAGGACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACATCGACCTCAAGAA TCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAGTTCGAGGACCCGCGCTGTCACCACTGACTAAAGAAGAGAAAACTGCGGCAGAGCAA TTCAAATTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGAGAAGAGCTTAATTCCGGAGAAATTTAGGAAG ATGTCTTGTTAACCCTTGATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCAATGACTGGATAATGATATCTTTCATGAGAGA GATTATAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGAGAATAAAACGATTTAAATATATGTACACACG CATGCACACACACACTTAGTCTTGTAATTTCAGGCCAGAAATTCTCAACACTATTTTGCATCTGTTTTCTTTTTCTAAGTCATGATAATA >In-frame_SRSF1_ENST00000585096_chr17_56084305_-_SKA2_ENST00000330137_chr17_57189706_-_2725nt ATATCCGTGCGCCGAGCTGATAAAGGCGCCATTTTGGAGGGGCCGCGGGAGACGTGGTGCCGCTGCGGGCTCGCTCTGCCGTGCGCTAGG CTTGGTGGGAAGGCCTGTTCTCGAGTCCGCGCTTTTCGTCACCGCCATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGA TTGCCGCATCTACGTGGGTAACTTACCTCCAGACATCCGAACCAAGGACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACAT CGACCTCAAGAATCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAGTTCGAGGACCCGCGCTGTCACCACTGACTAAAGAAGAGAAAACT GCGGCAGAGCAATTCAAATTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGAGAAGAGCTTAATTCCGGAG AAATTTAGGAAGATGTCTTGTTAACCCTTGATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCAATGACTGGATAATGATATC TTTCATGAGAGAGATTATAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGAGAATAAAACGATTTAAATA TATGTACACACGCATGCACACACACACTTAGTCTTGTAATTTCAGGCCAGAAATTCTCAACACTATTTTGCATCTGTTTTCTTTTTCTAA GTCATGATAATATAGATGTTCTGGTCTATCATAAAAGAATGTTTATGTACATTTCAGTCATTCGGTATGTGGCTTTGTAAATTAAAGTAT AGGCAAAACATTTGTGTTATACATGATATATAATTTCATTTTGTAAATGTTGATTGCACATGTGGTCACATTATTGTTGAGACTGCTTTT ATGTGACCTGTAGTCTCCCACAGAACCTAAAGTAATAAGCTGGCTTTTCTGTGATAGCCACGTTTGCGTATTTCTTTCCCTATTTCCCTT GCCTGCTAATGTTGAACAGCATGAACTTGCTTTCTGATGCTGTTTTAGACTGTCCCTGTTGTATCTCAATAATATCTTTGTTTTCCTTCA GCCTTTATTACTATAATTGTTCATTCTACATGAAAGCTAGGAAACTGAAATTAGAAGAGCACTTATCTGCTACTTGCCAGTTTTGCGTGA GTGTGTTATATGTATGTGTCAATTTCCCTTTAAAATAACTATTTATTTTAAAATAACTATTGGCAATAAGGAAACTGTTCAAAGTAGAGG CAGATCTTGATAGAAAGATGTTAATCACAGGGTTGTTTATAATAGCAATATACATACACATTTGGCTAGTACTAGGTGAATAGGAAAATA AATCATGCTGTATGTATACAATAAGAGGTCAAGTTGCCAATAAATTATTACTGTTAATGTTCTGGGAAATGCTGAAACTATGCTAAGTGG GGGAGAGGGAAAGCAGGTATTGCAGTTTTGTAGTGAAGATTGGGCTTTGGAGTCATATCTGAGATGTAAGTAGCAGCTTTTAAATTCTAG CTATGACCCTGTGCAGATCACTTAACTTTTGAGTGTCAGGATGTTTGGAAGGACAAGACAGGAAAGTGTTTTAATACAGGGTTCAGTATT TAGTAAGCCTTCAATAAGTGATATTACATACATGTAATAAAAACTAAGCATTGAAAGGACTAGGAAAAATGCATCAAATGTTAGTTCTGC AGGTTATAGAATTATACTTTTATGTAATTTTAAAATTTCAGTTATGAACATGTTTGTCCATTAACAAACTTATAATAGCTGAAAAACAGG GTTGTGAGAACAGCTTCAGTTAAAATTGTCCTGTCTAGTTTGAATATTTCAAGAACAGAAAGCCTTTTTTTTTTTTTTTTTTTTTTTGAG ACGGAGTCTCACTCTGTTGCCCAGGCTGGAATGCAGTGGTACGCTCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCAGTTCTCT GCCCCACCCTCCCGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTATTTTTTTGTATTTTTAGTAGAGATGGGGCTTCACCA TCTTGACCAGGCTGGTCTTTAACTCCTGATGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCTACCGTGCC TGGCCCCCTTTTTTTTAATTACAGAGAAATAAGTTACACCTTAGTATCAGATATTAATTTTCTTCAGTGTTCAGGCAATTAGTATTTAGA AAGCTCTTGTCATGAGATGGCTCTGGGATGTGATGATGATTGTTGGGATTGAAAAAACGGTAGTATCATGGAGAGATCATAATAAATTCT TAGTATTAAAAGTGGTTTTGCTTTCAGTTAGGGAGAAAAATTAGATTGTACTATTTTTCCTCTATGATTTCCTTCAGTTATCTTCCAAAT GTTGTTTTTTCCCCACAGCCCCCTTAACATTGTTCTCTATGCACTTCTCAATACATTTTCATTTGTTTCTCAAGCCTCTTTGTGGATGAC TCCTAAATATAACTTCTTCCACTAGCTCTAGATCCGTATTTCCAATAAAATCCCCTACCTGAATATTCAAGTTAAACATGTCCAGAATAC TTACTGATTTTATTGTTAATAGCCACTATTCTGTTGTCTGGAATTAAAACCTGTATAACTAATTTGCATCCCTTTATCTTCTTAGTCAAT >In-frame_SRSF1_ENST00000585096_chr17_56084305_-_SKA2_ENST00000580541_chr17_57189706_-_790nt ATATCCGTGCGCCGAGCTGATAAAGGCGCCATTTTGGAGGGGCCGCGGGAGACGTGGTGCCGCTGCGGGCTCGCTCTGCCGTGCGCTAGG CTTGGTGGGAAGGCCTGTTCTCGAGTCCGCGCTTTTCGTCACCGCCATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGA TTGCCGCATCTACGTGGGTAACTTACCTCCAGACATCCGAACCAAGGACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACAT CGACCTCAAGAATCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAGTTCGAGGACCCGCGCTGTCACCACTGACTAAAGAAGAGAAAACT GCGGCAGAGCAATTCAAATTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGAGAAGAGCTTAATTCCGGAG AAATTTAGGAAGATGTCTTGTTAACCCTTGATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCAATGACTGGATAATGATATC TTTCATGAGAGAGATTATAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGAGAATAAAACGATTTAAATA TATGTACACACGCATGCACACACACACTTAGTCTTGTAATTTCAGGCCAGAAATTCTCAACACTATTTTGCATCTGTTTTCTTTTTCTAA >In-frame_SRSF1_ENST00000258962_chr17_56084305_-_SKA2_ENST00000330137_chr17_57189706_-_2798nt GTTGCGCTCCCGCGCGTGCGTGTTGGGATCGAATCGCTGTTTCCTTCCGCTTCTCTTCCTCTGTCTCCCCCCCATATCCGTGCGCCGAGC TGATAAAGGCGCCATTTTGGAGGGGCCGCGGGAGACGTGGTGCCGCTGCGGGCTCGCTCTGCCGTGCGCTAGGCTTGGTGGGAAGGCCTG TTCTCGAGTCCGCGCTTTTCGTCACCGCCATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTACGTGG GTAACTTACCTCCAGACATCCGAACCAAGGACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACATCGACCTCAAGAATCGCC GCGGGGGACCGCCCTTCGCCTTCGTTGAGTTCGAGGACCCGCGCTGTCACCACTGACTAAAGAAGAGAAAACTGCGGCAGAGCAATTCAA ATTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGAGAAGAGCTTAATTCCGGAGAAATTTAGGAAGATGTC TTGTTAACCCTTGATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCAATGACTGGATAATGATATCTTTCATGAGAGAGATTA TAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGAGAATAAAACGATTTAAATATATGTACACACGCATGC ACACACACACTTAGTCTTGTAATTTCAGGCCAGAAATTCTCAACACTATTTTGCATCTGTTTTCTTTTTCTAAGTCATGATAATATAGAT GTTCTGGTCTATCATAAAAGAATGTTTATGTACATTTCAGTCATTCGGTATGTGGCTTTGTAAATTAAAGTATAGGCAAAACATTTGTGT TATACATGATATATAATTTCATTTTGTAAATGTTGATTGCACATGTGGTCACATTATTGTTGAGACTGCTTTTATGTGACCTGTAGTCTC CCACAGAACCTAAAGTAATAAGCTGGCTTTTCTGTGATAGCCACGTTTGCGTATTTCTTTCCCTATTTCCCTTGCCTGCTAATGTTGAAC AGCATGAACTTGCTTTCTGATGCTGTTTTAGACTGTCCCTGTTGTATCTCAATAATATCTTTGTTTTCCTTCAGCCTTTATTACTATAAT TGTTCATTCTACATGAAAGCTAGGAAACTGAAATTAGAAGAGCACTTATCTGCTACTTGCCAGTTTTGCGTGAGTGTGTTATATGTATGT GTCAATTTCCCTTTAAAATAACTATTTATTTTAAAATAACTATTGGCAATAAGGAAACTGTTCAAAGTAGAGGCAGATCTTGATAGAAAG ATGTTAATCACAGGGTTGTTTATAATAGCAATATACATACACATTTGGCTAGTACTAGGTGAATAGGAAAATAAATCATGCTGTATGTAT ACAATAAGAGGTCAAGTTGCCAATAAATTATTACTGTTAATGTTCTGGGAAATGCTGAAACTATGCTAAGTGGGGGAGAGGGAAAGCAGG TATTGCAGTTTTGTAGTGAAGATTGGGCTTTGGAGTCATATCTGAGATGTAAGTAGCAGCTTTTAAATTCTAGCTATGACCCTGTGCAGA TCACTTAACTTTTGAGTGTCAGGATGTTTGGAAGGACAAGACAGGAAAGTGTTTTAATACAGGGTTCAGTATTTAGTAAGCCTTCAATAA GTGATATTACATACATGTAATAAAAACTAAGCATTGAAAGGACTAGGAAAAATGCATCAAATGTTAGTTCTGCAGGTTATAGAATTATAC TTTTATGTAATTTTAAAATTTCAGTTATGAACATGTTTGTCCATTAACAAACTTATAATAGCTGAAAAACAGGGTTGTGAGAACAGCTTC AGTTAAAATTGTCCTGTCTAGTTTGAATATTTCAAGAACAGAAAGCCTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGT TGCCCAGGCTGGAATGCAGTGGTACGCTCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCAGTTCTCTGCCCCACCCTCCCGAGT AGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTATTTTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATCTTGACCAGGCTGGTC TTTAACTCCTGATGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCTACCGTGCCTGGCCCCCTTTTTTTTA ATTACAGAGAAATAAGTTACACCTTAGTATCAGATATTAATTTTCTTCAGTGTTCAGGCAATTAGTATTTAGAAAGCTCTTGTCATGAGA TGGCTCTGGGATGTGATGATGATTGTTGGGATTGAAAAAACGGTAGTATCATGGAGAGATCATAATAAATTCTTAGTATTAAAAGTGGTT TTGCTTTCAGTTAGGGAGAAAAATTAGATTGTACTATTTTTCCTCTATGATTTCCTTCAGTTATCTTCCAAATGTTGTTTTTTCCCCACA GCCCCCTTAACATTGTTCTCTATGCACTTCTCAATACATTTTCATTTGTTTCTCAAGCCTCTTTGTGGATGACTCCTAAATATAACTTCT TCCACTAGCTCTAGATCCGTATTTCCAATAAAATCCCCTACCTGAATATTCAAGTTAAACATGTCCAGAATACTTACTGATTTTATTGTT AATAGCCACTATTCTGTTGTCTGGAATTAAAACCTGTATAACTAATTTGCATCCCTTTATCTTCTTAGTCAATAAAACCTACAATCCTCT >In-frame_SRSF1_ENST00000258962_chr17_56084305_-_SKA2_ENST00000580541_chr17_57189706_-_863nt GTTGCGCTCCCGCGCGTGCGTGTTGGGATCGAATCGCTGTTTCCTTCCGCTTCTCTTCCTCTGTCTCCCCCCCATATCCGTGCGCCGAGC TGATAAAGGCGCCATTTTGGAGGGGCCGCGGGAGACGTGGTGCCGCTGCGGGCTCGCTCTGCCGTGCGCTAGGCTTGGTGGGAAGGCCTG TTCTCGAGTCCGCGCTTTTCGTCACCGCCATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTACGTGG GTAACTTACCTCCAGACATCCGAACCAAGGACATTGAGGACGTGTTCTACAAATACGGCGCTATCCGCGACATCGACCTCAAGAATCGCC GCGGGGGACCGCCCTTCGCCTTCGTTGAGTTCGAGGACCCGCGCTGTCACCACTGACTAAAGAAGAGAAAACTGCGGCAGAGCAATTCAA ATTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGAGAAGAGCTTAATTCCGGAGAAATTTAGGAAGATGTC TTGTTAACCCTTGATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCAATGACTGGATAATGATATCTTTCATGAGAGAGATTA TAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGAGAATAAAACGATTTAAATATATGTACACACGCATGC ACACACACACTTAGTCTTGTAATTTCAGGCCAGAAATTCTCAACACTATTTTGCATCTGTTTTCTTTTTCTAAGTCATGATAATATAGAT |
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FusionGenePPI for SRSF1_SKA2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SRSF1 | LNX1, U2AF2, DIDO1, TCERG1, RNPS1, YWHAQ, DYRK1A, SRPK1, U2AF1, SRSF1, SRSF5, SNRNP70, C1QBP, SRSF2, SRSF11, TOP1, CLK1, SCAF11, SRPK2, LUC7L3, SF3A2, PSIP1, CDC5L, RRP1B, AIRE, XBP1, TADA2A, UBC, CACNA1A, HDAC5, RBM39, SMARCAD1, SREK1, HDGF, ELAVL1, HNRNPA1, UBE2I, TP53, PIAS1, CUL3, CUL4B, CUL2, CUL1, COPS5, CAND1, BRCA1, ALYREF, HIPK3, NXF1, GRK5, NPM1, APP, HNRNPR, SF3B1, SF3B3, HNRNPK, SNRPA1, HNRNPU, DHX9, SF3A1, EFTUD2, SNRNP200, HNRNPF, DHX15, HNRNPM, DDX5, DDX17, TRA2B, SYNCRIP, PRPF19, SMU1, SART1, IK, GCN1L1, EIF4A3, SRRM2, SAP18, HNRNPDL, HNRNPH3, UTP14A, VTN, NCSTN, LOC255308, GNAI2, SLC30A5, SURF4, IGBP1, ZNF326, SNAP23, VASN, TRIM55, AHCYL1, TRMT112, PHGDH, SLC30A1, TMEM43, SSR1, RBM14, ILVBL, TOMM20, WDR18, ESR1, HABP4, SRSF9, BARD1, ECT2, MDC1, PAXIP1, TP53BP1, MAGOH, SMURF1, FN1, HNRNPA0, SRSF4, SRSF10, PRPF4, CDK6, CIR1, MPG, PAN2, BCL10, YWHAE, SRPK3, FBXO6, PARK2, ZBTB1, STAU1, SPRTN, HUWE1, TRAF3IP2, SHMT2, MOV10, CUL7, OBSL1, EZH2, SUZ12, EED, RNF2, LUZP4, LUC7L2, SNIP1, TRAF5, TRAF2, CXCL1, ZMYND11, SRSF3, SRSF6, SRSF7, SUB1, UBR5, SFN, NTRK1, PRPF4B, EWSR1, XPO1, SNW1, ZNF746, ZC3H18, ELAVL2, C11orf57, ZC3H3, LUC7L, CDX1, GSPT2, CLK3, HIST1H1E, NR3C1, CYLD, CD2BP2, LMNA, MTF1 | SKA2 | PPP2R2B, SKA1, DSN1, SPC24, HMOX2, PRKD3, RALYL, KIAA0753, SPICE1, DCTN1, SKA3, HAUS1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SRSF1_SKA2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SRSF1_SKA2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SRSF1 | C0019693 | HIV Infections | 1 | CTD_human |
| Hgene | SRSF1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | SRSF1 | C0036341 | Schizophrenia | 1 | CTD_human |
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