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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36084

FusionGeneSummary for SRSF11_LAP3

check button Fusion gene summary
Fusion gene informationFusion gene name: SRSF11_LAP3
Fusion gene ID: 36084
HgeneTgene
Gene symbol

SRSF11

LAP3

Gene ID

9295

51056

Gene nameserine and arginine rich splicing factor 11leucine aminopeptidase 3
SynonymsNET2|SFRS11|dJ677H15.2|p54HEL-S-106|LAP|LAPEP|PEPS
Cytomap

1p31.1

4p15.32

Type of geneprotein-codingprotein-coding
Descriptionserine/arginine-rich splicing factor 11SR splicing factor 11arginine-rich 54 kDa nuclear proteinsplicing factor p54splicing factor, arginine/serine-rich 11cytosol aminopeptidaseLAP-3epididymis secretory protein Li 106leucyl aminopeptidasepeptidase Sproline aminopeptidaseprolyl aminopeptidase
Modification date2018052320180519
UniProtAcc

Q05519

P28838

Ensembl transtripts involved in fusion geneENST00000370951, ENST00000405432, 
ENST00000370950, ENST00000454435, 
ENST00000436161, ENST00000484162, 
ENST00000370949, 
ENST00000226299, 
ENST00000606142, ENST00000503467, 
Fusion gene scores* DoF score5 X 8 X 2=805 X 4 X 5=100
# samples 105
** MAII scorelog2(10/80*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRSF11 [Title/Abstract] AND LAP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-MP-A4SW-01ASRSF11chr1

70671463

+LAP3chr4

17590442

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000370951ENST00000226299SRSF11chr1

70671463

+LAP3chr4

17590442

+
5UTR-3CDSENST00000370951ENST00000606142SRSF11chr1

70671463

+LAP3chr4

17590442

+
5UTR-3UTRENST00000370951ENST00000503467SRSF11chr1

70671463

+LAP3chr4

17590442

+
5UTR-3CDSENST00000405432ENST00000226299SRSF11chr1

70671463

+LAP3chr4

17590442

+
5UTR-3CDSENST00000405432ENST00000606142SRSF11chr1

70671463

+LAP3chr4

17590442

+
5UTR-3UTRENST00000405432ENST00000503467SRSF11chr1

70671463

+LAP3chr4

17590442

+
5UTR-3CDSENST00000370950ENST00000226299SRSF11chr1

70671463

+LAP3chr4

17590442

+
5UTR-3CDSENST00000370950ENST00000606142SRSF11chr1

70671463

+LAP3chr4

17590442

+
5UTR-3UTRENST00000370950ENST00000503467SRSF11chr1

70671463

+LAP3chr4

17590442

+
5UTR-3CDSENST00000454435ENST00000226299SRSF11chr1

70671463

+LAP3chr4

17590442

+
5UTR-3CDSENST00000454435ENST00000606142SRSF11chr1

70671463

+LAP3chr4

17590442

+
5UTR-3UTRENST00000454435ENST00000503467SRSF11chr1

70671463

+LAP3chr4

17590442

+
intron-3CDSENST00000436161ENST00000226299SRSF11chr1

70671463

+LAP3chr4

17590442

+
intron-3CDSENST00000436161ENST00000606142SRSF11chr1

70671463

+LAP3chr4

17590442

+
intron-3UTRENST00000436161ENST00000503467SRSF11chr1

70671463

+LAP3chr4

17590442

+
intron-3CDSENST00000484162ENST00000226299SRSF11chr1

70671463

+LAP3chr4

17590442

+
intron-3CDSENST00000484162ENST00000606142SRSF11chr1

70671463

+LAP3chr4

17590442

+
intron-3UTRENST00000484162ENST00000503467SRSF11chr1

70671463

+LAP3chr4

17590442

+
intron-3CDSENST00000370949ENST00000226299SRSF11chr1

70671463

+LAP3chr4

17590442

+
intron-3CDSENST00000370949ENST00000606142SRSF11chr1

70671463

+LAP3chr4

17590442

+
intron-3UTRENST00000370949ENST00000503467SRSF11chr1

70671463

+LAP3chr4

17590442

+

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FusionProtFeatures for SRSF11_LAP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SRSF11

Q05519

LAP3

P28838

May function in pre-mRNA splicing. Presumably involved in the processing and regularturnover of intracellular proteins. Catalyzes the removal ofunsubstituted N-terminal amino acids from various peptides.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SRSF11_LAP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SRSF11_LAP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SRSF11PUF60, SRSF2, SRSF1, U2AF2, TOP1, TERF2, MME, CUL3, CAND1, SRSF9, SRSF7, NHP2L1, SF3B6, SNRPA, SRSF3, HNRNPU, HNRNPK, TCERG1, IK, USP39, SART1, SMU1, DDX46, PRPF19, SAP18, MSH2, PPP1CA, TRMT112, TRIM55, UTP14A, NCSTN, VTN, PHGDH, TOX4, TPBG, RBM14, AGMAT, SHCBP1, VASN, ZNF592, S100A9, THRAP3, FLNA, TFPI, SON, VCP, CSNK2A1, CDK6, DDOST, THAP11, ETS1, PIN1, SDCBP, RBM39, TANK, ARL6IP4, HYI, SREK1, GATC, OBSL1, ZRANB2, LUC7L, ARGLU1, EEF1A1, HEXIM1, LUC7L2, PNISR, RBM25, RUVBL1, SF3B2, SRRM2, DHX15, SNRNP70, TPR, NTRK1, RNPS1, EWSR1, MDM2, SRPK2, LNX2, SNW1, ZNF207, CRBN, EGFR, JMJD6, CD2BP2, INO80B, TRIM25LAP3DDA1, UBA5, TAB1, ISG15, APP, LIG4, AARSD1, AGFG1, ALAD, ARPC2, NIF3L1, OGT, SH3GL1, SH3GLB1, TPRKB, RAPGEF2, RNF2, FUBP1, MIF, PRDX1, PRDX2, TKT, VARS, NTRK1, TP53, NDUFS5, RAB7A, RBM39, ZCCHC17, U2AF2, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SRSF11_LAP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SRSF11_LAP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource