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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36072

FusionGeneSummary for SRRM2_SRRM2

check button Fusion gene summary
Fusion gene informationFusion gene name: SRRM2_SRRM2
Fusion gene ID: 36072
HgeneTgene
Gene symbol

SRRM2

SRRM2

Gene ID

23524

23524

Gene nameserine/arginine repetitive matrix 2serine/arginine repetitive matrix 2
Synonyms300-KD|CWF21|Cwc21|HSPC075|SRL300|SRm300300-KD|CWF21|Cwc21|HSPC075|SRL300|SRm300
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionserine/arginine repetitive matrix protein 2300 kDa nuclear matrix antigenRNA binding proteinSR-related nuclear matrix protein of 300 kDaser/Arg-related nuclear matrix protein of 300 kDaserine/arginine-rich splicing factor-related nuclear matrix proteserine/arginine repetitive matrix protein 2300 kDa nuclear matrix antigenRNA binding proteinSR-related nuclear matrix protein of 300 kDaser/Arg-related nuclear matrix protein of 300 kDaserine/arginine-rich splicing factor-related nuclear matrix prote
Modification date2018052220180522
UniProtAcc

Q9UQ35

Q9UQ35

Ensembl transtripts involved in fusion geneENST00000301740, ENST00000574593, 
ENST00000301740, ENST00000574593, 
Fusion gene scores* DoF score14 X 18 X 5=126010 X 17 X 4=680
# samples 2521
** MAII scorelog2(25/1260*10)=-2.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/680*10)=-1.69514541847158
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRRM2 [Title/Abstract] AND SRRM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSRRM2

GO:0000398

mRNA splicing, via spliceosome

28076346

TgeneSRRM2

GO:0000398

mRNA splicing, via spliceosome

28076346


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF876344SRRM2chr16

2821035

+SRRM2chr16

2819030

+
ChiTaRS3.1BF592846SRRM2chr16

2806484

-SRRM2chr16

2815366

-
ChiTaRS3.1BF876112SRRM2chr16

2821035

+SRRM2chr16

2819030

+
ChiTaRS3.1BG470971SRRM2chr16

2819227

+SRRM2chr16

2806464

+
ChiTaRS3.1BF930781SRRM2chr16

2818201

-SRRM2chr16

2820888

-
ChiTaRS3.1BG952632SRRM2chr16

2812285

-SRRM2chr16

2812344

+
ChiTaRS3.1BF062308SRRM2chr16

2806484

-SRRM2chr16

2815366

-
ChiTaRS3.1BX647088SRRM2chr16

2807794

-SRRM2chr16

2806505

+
ChiTaRS3.1BQ028758SRRM2chr16

2821108

-SRRM2chr16

2816143

+
ChiTaRS3.1AI655799SRRM2chr16

2806484

-SRRM2chr16

2815366

-
ChiTaRS3.1AW889746SRRM2chr16

2811975

-SRRM2chr16

2816438

+
ChiTaRS3.1AW889684SRRM2chr16

2811975

-SRRM2chr16

2816438

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000301740ENST00000301740SRRM2chr16

2821035

+SRRM2chr16

2819030

+
3UTR-3UTRENST00000301740ENST00000574593SRRM2chr16

2821035

+SRRM2chr16

2819030

+
intron-3CDSENST00000574593ENST00000301740SRRM2chr16

2821035

+SRRM2chr16

2819030

+
intron-3UTRENST00000574593ENST00000574593SRRM2chr16

2821035

+SRRM2chr16

2819030

+
Frame-shiftENST00000301740ENST00000301740SRRM2chr16

2806484

-SRRM2chr16

2815366

-
5CDS-intronENST00000301740ENST00000574593SRRM2chr16

2806484

-SRRM2chr16

2815366

-
intron-3CDSENST00000574593ENST00000301740SRRM2chr16

2806484

-SRRM2chr16

2815366

-
intron-intronENST00000574593ENST00000574593SRRM2chr16

2806484

-SRRM2chr16

2815366

-
In-frameENST00000301740ENST00000301740SRRM2chr16

2819227

+SRRM2chr16

2806464

+
5CDS-intronENST00000301740ENST00000574593SRRM2chr16

2819227

+SRRM2chr16

2806464

+
3UTR-3CDSENST00000574593ENST00000301740SRRM2chr16

2819227

+SRRM2chr16

2806464

+
3UTR-intronENST00000574593ENST00000574593SRRM2chr16

2819227

+SRRM2chr16

2806464

+
5CDS-3UTRENST00000301740ENST00000301740SRRM2chr16

2818201

-SRRM2chr16

2820888

-
5CDS-intronENST00000301740ENST00000574593SRRM2chr16

2818201

-SRRM2chr16

2820888

-
3UTR-3UTRENST00000574593ENST00000301740SRRM2chr16

2818201

-SRRM2chr16

2820888

-
3UTR-intronENST00000574593ENST00000574593SRRM2chr16

2818201

-SRRM2chr16

2820888

-
Frame-shiftENST00000301740ENST00000301740SRRM2chr16

2812285

-SRRM2chr16

2812344

+
5CDS-intronENST00000301740ENST00000574593SRRM2chr16

2812285

-SRRM2chr16

2812344

+
intron-3CDSENST00000574593ENST00000301740SRRM2chr16

2812285

-SRRM2chr16

2812344

+
intron-intronENST00000574593ENST00000574593SRRM2chr16

2812285

-SRRM2chr16

2812344

+
In-frameENST00000301740ENST00000301740SRRM2chr16

2807794

-SRRM2chr16

2806505

+
5CDS-intronENST00000301740ENST00000574593SRRM2chr16

2807794

-SRRM2chr16

2806505

+
intron-3CDSENST00000574593ENST00000301740SRRM2chr16

2807794

-SRRM2chr16

2806505

+
intron-intronENST00000574593ENST00000574593SRRM2chr16

2807794

-SRRM2chr16

2806505

+
3UTR-3CDSENST00000301740ENST00000301740SRRM2chr16

2821108

-SRRM2chr16

2816143

+
3UTR-intronENST00000301740ENST00000574593SRRM2chr16

2821108

-SRRM2chr16

2816143

+
intron-3CDSENST00000574593ENST00000301740SRRM2chr16

2821108

-SRRM2chr16

2816143

+
intron-intronENST00000574593ENST00000574593SRRM2chr16

2821108

-SRRM2chr16

2816143

+
Frame-shiftENST00000301740ENST00000301740SRRM2chr16

2811975

-SRRM2chr16

2816438

+
5CDS-intronENST00000301740ENST00000574593SRRM2chr16

2811975

-SRRM2chr16

2816438

+
intron-3CDSENST00000574593ENST00000301740SRRM2chr16

2811975

-SRRM2chr16

2816438

+
intron-intronENST00000574593ENST00000574593SRRM2chr16

2811975

-SRRM2chr16

2816438

+

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FusionProtFeatures for SRRM2_SRRM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SRRM2

Q9UQ35

SRRM2

Q9UQ35


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SRRM2_SRRM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SRRM2_SRRM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SRRM2_SRRM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SRRM2_SRRM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource