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Fusion gene ID: 36047 |
FusionGeneSummary for SRPRB_CCSER1 |
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Fusion gene information | Fusion gene name: SRPRB_CCSER1 | Fusion gene ID: 36047 | Hgene | Tgene | Gene symbol | SRPRB | CCSER1 | Gene ID | 58477 | 401145 |
Gene name | SRP receptor subunit beta | coiled-coil serine rich protein 1 | |
Synonyms | APMCF1 | FAM190A | |
Cytomap | 3q22.1 | 4q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | signal recognition particle receptor subunit betaSR-betaSRP receptor beta subunitsignal recognition particle receptor, B subunitsignal recognition particle receptor, beta subunit | serine-rich coiled-coil domain-containing protein 1family with sequence similarity 190, member Aprotein FAM190A | |
Modification date | 20180520 | 20180519 | |
UniProtAcc | Q9Y5M8 | Q9C0I3 | |
Ensembl transtripts involved in fusion gene | ENST00000466490, | ENST00000509176, ENST00000333691, ENST00000432775, ENST00000504150, | |
Fusion gene scores | * DoF score | 2 X 3 X 1=6 | 6 X 5 X 4=120 |
# samples | 3 | 6 | |
** MAII score | log2(3/6*10)=2.32192809488736 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SRPRB [Title/Abstract] AND CCSER1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU603871 | SRPRB | chr3 | 133538550 | + | CCSER1 | chr4 | 91759819 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000466490 | ENST00000509176 | SRPRB | chr3 | 133538550 | + | CCSER1 | chr4 | 91759819 | - |
5CDS-intron | ENST00000466490 | ENST00000333691 | SRPRB | chr3 | 133538550 | + | CCSER1 | chr4 | 91759819 | - |
5CDS-intron | ENST00000466490 | ENST00000432775 | SRPRB | chr3 | 133538550 | + | CCSER1 | chr4 | 91759819 | - |
5CDS-intron | ENST00000466490 | ENST00000504150 | SRPRB | chr3 | 133538550 | + | CCSER1 | chr4 | 91759819 | - |
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FusionProtFeatures for SRPRB_CCSER1 |
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Hgene | Tgene |
SRPRB | CCSER1 |
Component of the SRP (signal recognition particle)receptor. Ensures, in conjunction with the signal recognitionparticle, the correct targeting of the nascent secretory proteinsto the endoplasmic reticulum membrane system. Has GTPase activity.May mediate the membrane association of SRPR (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SRPRB_CCSER1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SRPRB_CCSER1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SRPRB_CCSER1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SRPRB_CCSER1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CCSER1 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |