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Fusion gene ID: 36011 |
FusionGeneSummary for SRP54_THRSP |
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Fusion gene information | Fusion gene name: SRP54_THRSP | Fusion gene ID: 36011 | Hgene | Tgene | Gene symbol | SRP54 | THRSP | Gene ID | 6729 | 7069 |
Gene name | signal recognition particle 54 | thyroid hormone responsive | |
Synonyms | - | LPGP1|Lpgp|S14|SPOT14|THRP | |
Cytomap | 14q13.2 | 11q14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | signal recognition particle 54 kDa proteinsignal recognition particle 54kDsignal recognition particle 54kDa | thyroid hormone-inducible hepatic proteinSPOT14 homologlipogenic protein 1spot 14 proteinthyroid hormone responsive (SPOT14 homolog, rat)thyroid hormone responsive SPOT14 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | P61011 | Q92748 | |
Ensembl transtripts involved in fusion gene | ENST00000556994, ENST00000546080, ENST00000216774, ENST00000555557, ENST00000555535, | ENST00000281030, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 9 X 1 X 5=45 |
# samples | 2 | 9 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(9/45*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SRP54 [Title/Abstract] AND THRSP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SRP54 | GO:0042493 | response to drug | 18089836 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-MN-A4N1-01A | SRP54 | chr14 | 35452421 | + | THRSP | chr11 | 77778705 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3UTR | ENST00000556994 | ENST00000281030 | SRP54 | chr14 | 35452421 | + | THRSP | chr11 | 77778705 | + |
5UTR-3UTR | ENST00000546080 | ENST00000281030 | SRP54 | chr14 | 35452421 | + | THRSP | chr11 | 77778705 | + |
5UTR-3UTR | ENST00000216774 | ENST00000281030 | SRP54 | chr14 | 35452421 | + | THRSP | chr11 | 77778705 | + |
5UTR-3UTR | ENST00000555557 | ENST00000281030 | SRP54 | chr14 | 35452421 | + | THRSP | chr11 | 77778705 | + |
intron-3UTR | ENST00000555535 | ENST00000281030 | SRP54 | chr14 | 35452421 | + | THRSP | chr11 | 77778705 | + |
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FusionProtFeatures for SRP54_THRSP |
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Hgene | Tgene |
SRP54 | THRSP |
Binds to the signal sequence of presecretory proteinwhen they emerge from the ribosomes and transfers them to TRAM(translocating chain-associating membrane protein). | Plays a role in the regulation of lipogenesis,especially in lactating mammary gland. Important for thebiosynthesis of triglycerides with medium-length fatty acidchains. May modulate lipogenesis by interacting with MID1IP1 andpreventing its interaction with ACACA (By similarity). Mayfunction as transcriptional coactivator. May modulate thetranscription factor activity of THRB. {ECO:0000250,ECO:0000269|PubMed:17418816, ECO:0000269|PubMed:18299245}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SRP54_THRSP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SRP54_THRSP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SRP54 | SRP54, RNF185, XRCC4, TFAP4, PRKDC, SF3B6, SF3A1, SRP9, SRP68, SRP14, SMN1, GEMIN2, DDX20, GEMIN4, GEMIN5, SOX2, TARBP2, SMC2, SMC4, SRP19, NTRK1, MED23, XPO1, SNW1, CDC5L, HSPA8, GIMAP8, CCDC102B, DUSP22, CHDC2, MRPS11, TES | THRSP | THRSP, AKT1, AURKA, BAG4, BCAR3, BRMS1, FZR1, ERBB2, FGFR4, HMMR, IGF1R, KRAS, LSP1, PALB2, PARP1, PIK3CA, PTPN1, RB1CC1, SMAD4, STK11, TGFB1, TSG101, WT1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SRP54_THRSP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SRP54_THRSP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | THRSP | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | THRSP | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |