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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36

FusionGeneSummary for AAK1_RPIA

check button Fusion gene summary
Fusion gene informationFusion gene name: AAK1_RPIA
Fusion gene ID: 36
HgeneTgene
Gene symbol

AAK1

RPIA

Gene ID

22848

22934

Gene nameAP2 associated kinase 1ribose 5-phosphate isomerase A
Synonyms-RPI|RPIAD
Cytomap

2p13.3

2p11.2

Type of geneprotein-codingprotein-coding
DescriptionAP2-associated protein kinase 1adaptor-associated kinase 1ribose-5-phosphate isomerasephosphoriboisomeraseribose 5-phosphate epimerase
Modification date2018052320180523
UniProtAcc

Q2M2I8

P49247

Ensembl transtripts involved in fusion geneENST00000409068, ENST00000409085, 
ENST00000406297, ENST00000470281, 
ENST00000283646, 
Fusion gene scores* DoF score9 X 6 X 7=3781 X 1 X 1=1
# samples 91
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: AAK1 [Title/Abstract] AND RPIA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAAK1

GO:0006468

protein phosphorylation

17494869|18657069

HgeneAAK1

GO:0032880

regulation of protein localization

18657069

HgeneAAK1

GO:0045747

positive regulation of Notch signaling pathway

21464124

HgeneAAK1

GO:0050821

protein stabilization

21464124

HgeneAAK1

GO:2000369

regulation of clathrin-dependent endocytosis

18657069


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-DD-A3A5-01AAAK1chr2

69783992

-RPIAchr2

89028796

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000409068ENST00000283646AAK1chr2

69783992

-RPIAchr2

89028796

+
In-frameENST00000409085ENST00000283646AAK1chr2

69783992

-RPIAchr2

89028796

+
In-frameENST00000406297ENST00000283646AAK1chr2

69783992

-RPIAchr2

89028796

+
intron-3CDSENST00000470281ENST00000283646AAK1chr2

69783992

-RPIAchr2

89028796

+

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FusionProtFeatures for AAK1_RPIA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AAK1

Q2M2I8

RPIA

P49247

Regulates clathrin-mediated endocytosis byphosphorylating the AP2M1/mu2 subunit of the adaptor proteincomplex 2 (AP-2) which ensures high affinity binding of AP-2 tocargo membrane proteins during the initial stages of endocytosis.Isoform 1 and isoform 2 display similar levels of kinase activitytowards AP2M1. Regulates phosphorylation of other AP-2 subunits aswell as AP-2 localization and AP-2-mediated internalization ofligand complexes. Phosphorylates NUMB and regulates its cellularlocalization, promoting NUMB localization to endosomes. Binds toand stabilizes the activated form of NOTCH1, increases itslocalization in endosomes and regulates its transcriptionalactivity. {ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAK1chr2:69783992chr2:89028796ENST00000406297-31812_4294864Compositional biasNote=Gly-rich
HgeneAAK1chr2:69783992chr2:89028796ENST00000409085-32212_4294962Compositional biasNote=Gly-rich
HgeneAAK1chr2:69783992chr2:89028796ENST00000406297-31852_6094864Nucleotide bindingATP
HgeneAAK1chr2:69783992chr2:89028796ENST00000409085-32252_6094962Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAK1chr2:69783992chr2:89028796ENST00000406297-318397_61494864Compositional biasNote=Gln-rich
HgeneAAK1chr2:69783992chr2:89028796ENST00000406297-318658_66394864Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69783992chr2:89028796ENST00000409085-322397_61494962Compositional biasNote=Gln-rich
HgeneAAK1chr2:69783992chr2:89028796ENST00000409085-322658_66394962Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69783992chr2:89028796ENST00000406297-31846_31594864DomainProtein kinase
HgeneAAK1chr2:69783992chr2:89028796ENST00000409085-32246_31594962DomainProtein kinase


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FusionGeneSequence for AAK1_RPIA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AAK1_ENST00000409068_chr2_69783992_-_RPIA_ENST00000283646_chr2_89028796_+_272aa
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKRE
IQIMARQLILQYGLTLSDLDRHPEIDLAIDGADEVDADLNLIKGGGGCLTQEKIVAGYASRFIVIADFRKDSKNLGDQWHKGIPIEVIPM
AYVPVSRAVSQKFGGVVELRMAVNKAGPVVTDNGNFILDWKFDRVHKWSEVNTAIKMIPGVVDTGLFINMAERVYFGMQDGSVNMREKPF

>In-frame_AAK1_ENST00000409085_chr2_69783992_-_RPIA_ENST00000283646_chr2_89028796_+_272aa
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKRE
IQIMARQLILQYGLTLSDLDRHPEIDLAIDGADEVDADLNLIKGGGGCLTQEKIVAGYASRFIVIADFRKDSKNLGDQWHKGIPIEVIPM
AYVPVSRAVSQKFGGVVELRMAVNKAGPVVTDNGNFILDWKFDRVHKWSEVNTAIKMIPGVVDTGLFINMAERVYFGMQDGSVNMREKPF

>In-frame_AAK1_ENST00000406297_chr2_69783992_-_RPIA_ENST00000283646_chr2_89028796_+_272aa
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKRE
IQIMARQLILQYGLTLSDLDRHPEIDLAIDGADEVDADLNLIKGGGGCLTQEKIVAGYASRFIVIADFRKDSKNLGDQWHKGIPIEVIPM
AYVPVSRAVSQKFGGVVELRMAVNKAGPVVTDNGNFILDWKFDRVHKWSEVNTAIKMIPGVVDTGLFINMAERVYFGMQDGSVNMREKPF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AAK1_ENST00000409068_chr2_69783992_-_RPIA_ENST00000283646_chr2_89028796_+_816nt
ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTG
GGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGGATTTGCTATTGTA
TTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCCAGGTGTGCAAGAGAGAA
ATCCAGATAATGGCCCGCCAGCTCATCCTGCAGTATGGCTTGACCCTCAGTGATCTGGATCGACACCCAGAGATCGACCTTGCCATCGAT
GGTGCTGATGAAGTAGATGCTGATCTCAATCTCATCAAGGGTGGCGGAGGCTGCCTGACCCAGGAGAAGATTGTGGCTGGCTATGCTAGT
CGCTTCATCGTGATCGCTGATTTCAGGAAAGATTCGAAGAATCTCGGGGATCAGTGGCACAAGGGAATCCCCATCGAGGTCATCCCAATG
GCCTATGTCCCAGTGAGCCGAGCTGTGAGCCAGAAGTTTGGGGGCGTGGTTGAACTTCGAATGGCTGTCAACAAGGCTGGTCCTGTGGTG
ACAGATAATGGGAATTTTATCTTGGACTGGAAGTTTGACCGGGTACACAAATGGAGTGAAGTGAATACAGCTATCAAAATGATCCCAGGT
GTGGTGGACACAGGCCTATTCATCAACATGGCTGAGAGAGTCTACTTTGGGATGCAGGATGGCTCAGTGAACATGAGGGAGAAGCCTTTC

>In-frame_AAK1_ENST00000409085_chr2_69783992_-_RPIA_ENST00000283646_chr2_89028796_+_816nt
ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTG
GGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGGATTTGCTATTGTA
TTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCCAGGTGTGCAAGAGAGAA
ATCCAGATAATGGCCCGCCAGCTCATCCTGCAGTATGGCTTGACCCTCAGTGATCTGGATCGACACCCAGAGATCGACCTTGCCATCGAT
GGTGCTGATGAAGTAGATGCTGATCTCAATCTCATCAAGGGTGGCGGAGGCTGCCTGACCCAGGAGAAGATTGTGGCTGGCTATGCTAGT
CGCTTCATCGTGATCGCTGATTTCAGGAAAGATTCGAAGAATCTCGGGGATCAGTGGCACAAGGGAATCCCCATCGAGGTCATCCCAATG
GCCTATGTCCCAGTGAGCCGAGCTGTGAGCCAGAAGTTTGGGGGCGTGGTTGAACTTCGAATGGCTGTCAACAAGGCTGGTCCTGTGGTG
ACAGATAATGGGAATTTTATCTTGGACTGGAAGTTTGACCGGGTACACAAATGGAGTGAAGTGAATACAGCTATCAAAATGATCCCAGGT
GTGGTGGACACAGGCCTATTCATCAACATGGCTGAGAGAGTCTACTTTGGGATGCAGGATGGCTCAGTGAACATGAGGGAGAAGCCTTTC

>In-frame_AAK1_ENST00000406297_chr2_69783992_-_RPIA_ENST00000283646_chr2_89028796_+_816nt
ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTG
GGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGGATTTGCTATTGTA
TTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCCAGGTGTGCAAGAGAGAA
ATCCAGATAATGGCCCGCCAGCTCATCCTGCAGTATGGCTTGACCCTCAGTGATCTGGATCGACACCCAGAGATCGACCTTGCCATCGAT
GGTGCTGATGAAGTAGATGCTGATCTCAATCTCATCAAGGGTGGCGGAGGCTGCCTGACCCAGGAGAAGATTGTGGCTGGCTATGCTAGT
CGCTTCATCGTGATCGCTGATTTCAGGAAAGATTCGAAGAATCTCGGGGATCAGTGGCACAAGGGAATCCCCATCGAGGTCATCCCAATG
GCCTATGTCCCAGTGAGCCGAGCTGTGAGCCAGAAGTTTGGGGGCGTGGTTGAACTTCGAATGGCTGTCAACAAGGCTGGTCCTGTGGTG
ACAGATAATGGGAATTTTATCTTGGACTGGAAGTTTGACCGGGTACACAAATGGAGTGAAGTGAATACAGCTATCAAAATGATCCCAGGT
GTGGTGGACACAGGCCTATTCATCAACATGGCTGAGAGAGTCTACTTTGGGATGCAGGATGGCTCAGTGAACATGAGGGAGAAGCCTTTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_AAK1_ENST00000409068_chr2_69783992_-_RPIA_ENST00000283646_chr2_89028796_+_1987nt
CTCTGCGTCGCAGGCCGGCCCGGCGGCCGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTT
ACACGAATCGCTTTCTGGAGGAGGAGGGGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCAC
GGCCGGATTCGGGTGGCTCCTCTCCGAGGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAAT
CTAGAAACCATCGGTATTTTGCTTTGCTGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCC
TGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGG
TCACAGTGGACGAGGTGTTGGCGGAAGGTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCA
TGTTTGTCAACAATGAGCATGATCTCCAGGTGTGCAAGAGAGAAATCCAGATAATGGCCCGCCAGCTCATCCTGCAGTATGGCTTGACCC
TCAGTGATCTGGATCGACACCCAGAGATCGACCTTGCCATCGATGGTGCTGATGAAGTAGATGCTGATCTCAATCTCATCAAGGGTGGCG
GAGGCTGCCTGACCCAGGAGAAGATTGTGGCTGGCTATGCTAGTCGCTTCATCGTGATCGCTGATTTCAGGAAAGATTCGAAGAATCTCG
GGGATCAGTGGCACAAGGGAATCCCCATCGAGGTCATCCCAATGGCCTATGTCCCAGTGAGCCGAGCTGTGAGCCAGAAGTTTGGGGGCG
TGGTTGAACTTCGAATGGCTGTCAACAAGGCTGGTCCTGTGGTGACAGATAATGGGAATTTTATCTTGGACTGGAAGTTTGACCGGGTAC
ACAAATGGAGTGAAGTGAATACAGCTATCAAAATGATCCCAGGTGTGGTGGACACAGGCCTATTCATCAACATGGCTGAGAGAGTCTACT
TTGGGATGCAGGATGGCTCAGTGAACATGAGGGAGAAGCCTTTCTGTTGACCCTGCAAGGAGCAGAGTGTGTTCACCTTGAGTCTCCAGC
CCACAGCCAAGGTGGACGTACCTCTCCAGGAGCCTTTGCCTTAATGTATCTCTGCCTGGACAACTTGTGGTGGGGGGTGGGGGGAAGAGT
GGGAGGGGGAGTTAAATCCAGTCTTATGAAGTATTGTTATTAAATGTCTTTTTAAAAAGAGAAATATAAACATATATTTTTACTATTAAA
ATATTCAGTTTTTTAAATGAAGTAGAACTTGAGTTCATGTTTTATATGAAATATTTACCAAAAAAAAAAAATGAGGTAAACTGTATTTAA
AACCTTTGACTTGAGTCTGCTGGTAAAGCTTCTGAATATTGAGTTTGCTGAGAAATAAAAATCAAAACTTCTTTAAGCTGGTAAAGTGAG
GGGCCCACCAGCAGTGATCTCCTGATGCCTTACTGGAAACTTTGTTTACTTGTCTGCTACCCTCTGATTTGTTTTTAGTTAGTTTTTATT
GTGAGCACACATAGTACCTAGTTACATCTTAAGATCAGGTTTATAAAACTGTGGAGTGGAGCGGTATGGTATGGAATGACTTGGAATGTA
AGCTGTCAGGGAGAAAATGTTGTTACACTTTTGCTAAGATCTGGGGGTTTCTTCATATTCCTGCTGTTGGAAGCAGTTGACCAGAAATGC
TTGCCAGTACTGCCAAAGCACTGCTGTGAAATGTGAAGTACTTTGTTTTTTTATTTTTAATGATTTTCTTTTTGTTATTAATATTTTTCT
CTGTTCCTTTGTTATTACTTGCATGGTTTGGCGTCAGAAGTCCTTACCTCTTTATATTGTTTGCAGGTTTAAATAAAACAGTGTGGTGCC

>In-frame_AAK1_ENST00000409085_chr2_69783992_-_RPIA_ENST00000283646_chr2_89028796_+_2050nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCC
AGGTGTGCAAGAGAGAAATCCAGATAATGGCCCGCCAGCTCATCCTGCAGTATGGCTTGACCCTCAGTGATCTGGATCGACACCCAGAGA
TCGACCTTGCCATCGATGGTGCTGATGAAGTAGATGCTGATCTCAATCTCATCAAGGGTGGCGGAGGCTGCCTGACCCAGGAGAAGATTG
TGGCTGGCTATGCTAGTCGCTTCATCGTGATCGCTGATTTCAGGAAAGATTCGAAGAATCTCGGGGATCAGTGGCACAAGGGAATCCCCA
TCGAGGTCATCCCAATGGCCTATGTCCCAGTGAGCCGAGCTGTGAGCCAGAAGTTTGGGGGCGTGGTTGAACTTCGAATGGCTGTCAACA
AGGCTGGTCCTGTGGTGACAGATAATGGGAATTTTATCTTGGACTGGAAGTTTGACCGGGTACACAAATGGAGTGAAGTGAATACAGCTA
TCAAAATGATCCCAGGTGTGGTGGACACAGGCCTATTCATCAACATGGCTGAGAGAGTCTACTTTGGGATGCAGGATGGCTCAGTGAACA
TGAGGGAGAAGCCTTTCTGTTGACCCTGCAAGGAGCAGAGTGTGTTCACCTTGAGTCTCCAGCCCACAGCCAAGGTGGACGTACCTCTCC
AGGAGCCTTTGCCTTAATGTATCTCTGCCTGGACAACTTGTGGTGGGGGGTGGGGGGAAGAGTGGGAGGGGGAGTTAAATCCAGTCTTAT
GAAGTATTGTTATTAAATGTCTTTTTAAAAAGAGAAATATAAACATATATTTTTACTATTAAAATATTCAGTTTTTTAAATGAAGTAGAA
CTTGAGTTCATGTTTTATATGAAATATTTACCAAAAAAAAAAAATGAGGTAAACTGTATTTAAAACCTTTGACTTGAGTCTGCTGGTAAA
GCTTCTGAATATTGAGTTTGCTGAGAAATAAAAATCAAAACTTCTTTAAGCTGGTAAAGTGAGGGGCCCACCAGCAGTGATCTCCTGATG
CCTTACTGGAAACTTTGTTTACTTGTCTGCTACCCTCTGATTTGTTTTTAGTTAGTTTTTATTGTGAGCACACATAGTACCTAGTTACAT
CTTAAGATCAGGTTTATAAAACTGTGGAGTGGAGCGGTATGGTATGGAATGACTTGGAATGTAAGCTGTCAGGGAGAAAATGTTGTTACA
CTTTTGCTAAGATCTGGGGGTTTCTTCATATTCCTGCTGTTGGAAGCAGTTGACCAGAAATGCTTGCCAGTACTGCCAAAGCACTGCTGT
GAAATGTGAAGTACTTTGTTTTTTTATTTTTAATGATTTTCTTTTTGTTATTAATATTTTTCTCTGTTCCTTTGTTATTACTTGCATGGT

>In-frame_AAK1_ENST00000406297_chr2_69783992_-_RPIA_ENST00000283646_chr2_89028796_+_2050nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCC
AGGTGTGCAAGAGAGAAATCCAGATAATGGCCCGCCAGCTCATCCTGCAGTATGGCTTGACCCTCAGTGATCTGGATCGACACCCAGAGA
TCGACCTTGCCATCGATGGTGCTGATGAAGTAGATGCTGATCTCAATCTCATCAAGGGTGGCGGAGGCTGCCTGACCCAGGAGAAGATTG
TGGCTGGCTATGCTAGTCGCTTCATCGTGATCGCTGATTTCAGGAAAGATTCGAAGAATCTCGGGGATCAGTGGCACAAGGGAATCCCCA
TCGAGGTCATCCCAATGGCCTATGTCCCAGTGAGCCGAGCTGTGAGCCAGAAGTTTGGGGGCGTGGTTGAACTTCGAATGGCTGTCAACA
AGGCTGGTCCTGTGGTGACAGATAATGGGAATTTTATCTTGGACTGGAAGTTTGACCGGGTACACAAATGGAGTGAAGTGAATACAGCTA
TCAAAATGATCCCAGGTGTGGTGGACACAGGCCTATTCATCAACATGGCTGAGAGAGTCTACTTTGGGATGCAGGATGGCTCAGTGAACA
TGAGGGAGAAGCCTTTCTGTTGACCCTGCAAGGAGCAGAGTGTGTTCACCTTGAGTCTCCAGCCCACAGCCAAGGTGGACGTACCTCTCC
AGGAGCCTTTGCCTTAATGTATCTCTGCCTGGACAACTTGTGGTGGGGGGTGGGGGGAAGAGTGGGAGGGGGAGTTAAATCCAGTCTTAT
GAAGTATTGTTATTAAATGTCTTTTTAAAAAGAGAAATATAAACATATATTTTTACTATTAAAATATTCAGTTTTTTAAATGAAGTAGAA
CTTGAGTTCATGTTTTATATGAAATATTTACCAAAAAAAAAAAATGAGGTAAACTGTATTTAAAACCTTTGACTTGAGTCTGCTGGTAAA
GCTTCTGAATATTGAGTTTGCTGAGAAATAAAAATCAAAACTTCTTTAAGCTGGTAAAGTGAGGGGCCCACCAGCAGTGATCTCCTGATG
CCTTACTGGAAACTTTGTTTACTTGTCTGCTACCCTCTGATTTGTTTTTAGTTAGTTTTTATTGTGAGCACACATAGTACCTAGTTACAT
CTTAAGATCAGGTTTATAAAACTGTGGAGTGGAGCGGTATGGTATGGAATGACTTGGAATGTAAGCTGTCAGGGAGAAAATGTTGTTACA
CTTTTGCTAAGATCTGGGGGTTTCTTCATATTCCTGCTGTTGGAAGCAGTTGACCAGAAATGCTTGCCAGTACTGCCAAAGCACTGCTGT
GAAATGTGAAGTACTTTGTTTTTTTATTTTTAATGATTTTCTTTTTGTTATTAATATTTTTCTCTGTTCCTTTGTTATTACTTGCATGGT


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FusionGenePPI for AAK1_RPIA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AAK1AP2M1, ATP13A2, APP, AP2A1, AP2B1, NTRK1, DYNLT1, XPO1, CLTB, CLTC, GAK, HSPA5, GTSE1, ANLN, CDH1, AP2S1, REPS1, RUNDC3A, RALBP1, PLEC, PPIP5K2, SEC24B, CCDC88A, EYA4, UBE2D2, LUZP1, URGCP, NUP88, DVL3, QSER1, WNK1RPIALNX1, VTA1, WDYHV1, RPIA, NIF3L1, STK16, FXR2, ELAVL1, FOXP2, PCMT1, PTPN11, TXN2, GORASP2, ATPAF2, CENPP, RNF208, MOV10, NXF1, ST8SIA1, TRPV5, AURKA, GMPS, PEPD, RPE, PAICS, TKT, TXNRD1, DUSP3, WDR5B, DHH, ERP44, MARK4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AAK1_RPIA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AAK1_RPIA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRPIAC1291609Ribose 5-Phosphate Isomerase Deficiency1CTD_human;ORPHANET;UNIPROT