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Fusion gene ID: 35959 |
FusionGeneSummary for SREK1IP1_CCDC112 |
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Fusion gene information | Fusion gene name: SREK1IP1_CCDC112 | Fusion gene ID: 35959 | Hgene | Tgene | Gene symbol | SREK1IP1 | CCDC112 | Gene ID | 285672 | 153733 |
Gene name | SREK1 interacting protein 1 | coiled-coil domain containing 112 | |
Synonyms | P18SRP|SFRS12IP1 | MBC1 | |
Cytomap | 5q12.3 | 5q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein SREK1IP1SFRS12-interacting protein 1p18 splicing regulatory proteinprotein SFRS12IP1splicing regulatory protein of 18 kDa | coiled-coil domain-containing protein 112mutated in bladder cancer 1mutated in bladder cancer protein 1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8N9Q2 | Q8NEF3 | |
Ensembl transtripts involved in fusion gene | ENST00000513458, ENST00000506252, | ENST00000379611, ENST00000512261, ENST00000506442, ENST00000395557, ENST00000503027, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 2=18 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SREK1IP1 [Title/Abstract] AND CCDC112 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-D3-A51N-06A | SREK1IP1 | chr5 | 64060802 | - | CCDC112 | chr5 | 114612751 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000513458 | ENST00000379611 | SREK1IP1 | chr5 | 64060802 | - | CCDC112 | chr5 | 114612751 | - |
intron-3CDS | ENST00000513458 | ENST00000512261 | SREK1IP1 | chr5 | 64060802 | - | CCDC112 | chr5 | 114612751 | - |
intron-3CDS | ENST00000513458 | ENST00000506442 | SREK1IP1 | chr5 | 64060802 | - | CCDC112 | chr5 | 114612751 | - |
intron-3CDS | ENST00000513458 | ENST00000395557 | SREK1IP1 | chr5 | 64060802 | - | CCDC112 | chr5 | 114612751 | - |
intron-5UTR | ENST00000513458 | ENST00000503027 | SREK1IP1 | chr5 | 64060802 | - | CCDC112 | chr5 | 114612751 | - |
intron-3CDS | ENST00000506252 | ENST00000379611 | SREK1IP1 | chr5 | 64060802 | - | CCDC112 | chr5 | 114612751 | - |
intron-3CDS | ENST00000506252 | ENST00000512261 | SREK1IP1 | chr5 | 64060802 | - | CCDC112 | chr5 | 114612751 | - |
intron-3CDS | ENST00000506252 | ENST00000506442 | SREK1IP1 | chr5 | 64060802 | - | CCDC112 | chr5 | 114612751 | - |
intron-3CDS | ENST00000506252 | ENST00000395557 | SREK1IP1 | chr5 | 64060802 | - | CCDC112 | chr5 | 114612751 | - |
intron-5UTR | ENST00000506252 | ENST00000503027 | SREK1IP1 | chr5 | 64060802 | - | CCDC112 | chr5 | 114612751 | - |
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FusionProtFeatures for SREK1IP1_CCDC112 |
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Hgene | Tgene |
SREK1IP1 | CCDC112 |
Possible splicing regulator involved in the control ofcellular survival. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SREK1IP1_CCDC112 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SREK1IP1_CCDC112 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SREK1IP1 | NME1, SDCBP, RBM39, SDCBP2, HSD17B14, PPCDC, STAC3, RP9P, CEP135, OFD1, PCM1, RAPGEF2, GATAD1, MAP1A, CSNK2A2, CSNK2A1, RABL6, C1orf131, FTL, NOS1AP, NUP153, KPNA5, KPNA6, EEF1A2, FAM115A, SRRM2, KPNA1, NKAP | CCDC112 | CCDC85B, TEX9, LURAP1, KRT31, TNIP1, FSD2, KRT40, LTBR, KRAS, PCM1, CEP128, NINL, TNFRSF8, TRIM44 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SREK1IP1_CCDC112 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SREK1IP1_CCDC112 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |