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Fusion gene ID: 35953 |
FusionGeneSummary for SREBF2_PPAPDC1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SREBF2_PPAPDC1A | Fusion gene ID: 35953 | Hgene | Tgene | Gene symbol | SREBF2 | PPAPDC1A | Gene ID | 6721 | 196051 |
| Gene name | sterol regulatory element binding transcription factor 2 | phospholipid phosphatase 4 | |
| Synonyms | SREBP-2|SREBP2|bHLHd2 | DPPL2|PPAPDC1|PPAPDC1A | |
| Cytomap | 22q13.2 | 10q26.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sterol regulatory element-binding protein 2class D basic helix-loop-helix protein 2 | phospholipid phosphatase 4diacylglycerol pyrophosphate like 2diacylglycerol pyrophosphate phosphatase-like 2phosphatidate phosphatase PPAPDC1Aphosphatidic acid phosphatase type 2 domain containing 1Aphosphatidic acid phosphatase type 2 domain-contain | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q12772 | ||
| Ensembl transtripts involved in fusion gene | ENST00000361204, ENST00000491541, | ENST00000398250, ENST00000439221, ENST00000398248, ENST00000541332, ENST00000369073, ENST00000496437, | |
| Fusion gene scores | * DoF score | 19 X 18 X 5=1710 | 6 X 3 X 6=108 |
| # samples | 21 | 8 | |
| ** MAII score | log2(21/1710*10)=-3.02553509210714 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/108*10)=-0.432959407276106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SREBF2 [Title/Abstract] AND PPAPDC1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SREBF2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15358760|19098903 |
| Hgene | SREBF2 | GO:0010886 | positive regulation of cholesterol storage | 15358760 |
| Hgene | SREBF2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12242332|12446768 |
| Hgene | SREBF2 | GO:0072368 | regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter | 15358760 |
| Hgene | SREBF2 | GO:0090370 | negative regulation of cholesterol efflux | 15358760 |
| Tgene | PPAPDC1A | GO:0046839 | phospholipid dephosphorylation | 17590538 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-97-8175-01A | SREBF2 | chr22 | 42229362 | + | PPAPDC1A | chr10 | 122334643 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361204 | ENST00000398250 | SREBF2 | chr22 | 42229362 | + | PPAPDC1A | chr10 | 122334643 | + |
| In-frame | ENST00000361204 | ENST00000439221 | SREBF2 | chr22 | 42229362 | + | PPAPDC1A | chr10 | 122334643 | + |
| 5CDS-intron | ENST00000361204 | ENST00000398248 | SREBF2 | chr22 | 42229362 | + | PPAPDC1A | chr10 | 122334643 | + |
| 5CDS-intron | ENST00000361204 | ENST00000541332 | SREBF2 | chr22 | 42229362 | + | PPAPDC1A | chr10 | 122334643 | + |
| 5CDS-intron | ENST00000361204 | ENST00000369073 | SREBF2 | chr22 | 42229362 | + | PPAPDC1A | chr10 | 122334643 | + |
| 5CDS-intron | ENST00000361204 | ENST00000496437 | SREBF2 | chr22 | 42229362 | + | PPAPDC1A | chr10 | 122334643 | + |
| intron-3CDS | ENST00000491541 | ENST00000398250 | SREBF2 | chr22 | 42229362 | + | PPAPDC1A | chr10 | 122334643 | + |
| intron-3CDS | ENST00000491541 | ENST00000439221 | SREBF2 | chr22 | 42229362 | + | PPAPDC1A | chr10 | 122334643 | + |
| intron-intron | ENST00000491541 | ENST00000398248 | SREBF2 | chr22 | 42229362 | + | PPAPDC1A | chr10 | 122334643 | + |
| intron-intron | ENST00000491541 | ENST00000541332 | SREBF2 | chr22 | 42229362 | + | PPAPDC1A | chr10 | 122334643 | + |
| intron-intron | ENST00000491541 | ENST00000369073 | SREBF2 | chr22 | 42229362 | + | PPAPDC1A | chr10 | 122334643 | + |
| intron-intron | ENST00000491541 | ENST00000496437 | SREBF2 | chr22 | 42229362 | + | PPAPDC1A | chr10 | 122334643 | + |
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FusionProtFeatures for SREBF2_PPAPDC1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SREBF2 | PPAPDC1A |
| Transcriptional activator required for lipidhomeostasis. Regulates transcription of the LDL receptor gene aswell as the cholesterol and to a lesser degree the fatty acidsynthesis pathway (By similarity). Binds the sterol regulatoryelement 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking regionof the LDRL and HMG-CoA synthase genes. {ECO:0000250}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398248 | + | 0 | 3 | 102_110 | -118 | 97 | Region | Note=Phosphatase sequence motif I |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398248 | + | 0 | 3 | 143_146 | -118 | 97 | Region | Note=Phosphatase sequence motif II |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398248 | + | 0 | 3 | 195_205 | -118 | 97 | Region | Note=Phosphatase sequence motif III |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398250 | + | 4 | 7 | 195_205 | 148 | 272 | Region | Note=Phosphatase sequence motif III |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000439221 | + | 2 | 5 | 102_110 | 85 | 209 | Region | Note=Phosphatase sequence motif I |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000439221 | + | 2 | 5 | 143_146 | 85 | 209 | Region | Note=Phosphatase sequence motif II |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000439221 | + | 2 | 5 | 195_205 | 85 | 209 | Region | Note=Phosphatase sequence motif III |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398248 | + | 0 | 3 | 142_162 | -118 | 97 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398248 | + | 0 | 3 | 179_199 | -118 | 97 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398248 | + | 0 | 3 | 202_222 | -118 | 97 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398248 | + | 0 | 3 | 49_69 | -118 | 97 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398248 | + | 0 | 3 | 4_24 | -118 | 97 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398248 | + | 0 | 3 | 84_104 | -118 | 97 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398250 | + | 4 | 7 | 179_199 | 148 | 272 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398250 | + | 4 | 7 | 202_222 | 148 | 272 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000439221 | + | 2 | 5 | 142_162 | 85 | 209 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000439221 | + | 2 | 5 | 179_199 | 85 | 209 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000439221 | + | 2 | 5 | 202_222 | 85 | 209 | Transmembrane | Helical |
| Tgene | >PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000439221 | + | 2 | 5 | 84_104 | 85 | 209 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SREBF2 | chr22:42229362 | chr10:122334643 | ENST00000361204 | + | 1 | 19 | 125_244 | 29 | 1142 | Compositional bias | Note=Gln-rich |
| Hgene | >SREBF2 | chr22:42229362 | chr10:122334643 | ENST00000361204 | + | 1 | 19 | 52_124 | 29 | 1142 | Compositional bias | Note=Gly/Pro/Ser-rich |
| Hgene | >SREBF2 | chr22:42229362 | chr10:122334643 | ENST00000361204 | + | 1 | 19 | 330_380 | 29 | 1142 | Domain | bHLH |
| Hgene | >SREBF2 | chr22:42229362 | chr10:122334643 | ENST00000361204 | + | 1 | 19 | 1_50 | 29 | 1142 | Region | Note=Transcriptional activation (acidic) |
| Hgene | >SREBF2 | chr22:42229362 | chr10:122334643 | ENST00000361204 | + | 1 | 19 | 380_401 | 29 | 1142 | Region | Note=Leucine-zipper |
| Hgene | >SREBF2 | chr22:42229362 | chr10:122334643 | ENST00000361204 | + | 1 | 19 | 1_479 | 29 | 1142 | Topological domain | Cytoplasmic |
| Hgene | >SREBF2 | chr22:42229362 | chr10:122334643 | ENST00000361204 | + | 1 | 19 | 501_533 | 29 | 1142 | Topological domain | Lumenal |
| Hgene | >SREBF2 | chr22:42229362 | chr10:122334643 | ENST00000361204 | + | 1 | 19 | 555_1139 | 29 | 1142 | Topological domain | Cytoplasmic |
| Hgene | >SREBF2 | chr22:42229362 | chr10:122334643 | ENST00000361204 | + | 1 | 19 | 480_500 | 29 | 1142 | Transmembrane | Helical |
| Hgene | >SREBF2 | chr22:42229362 | chr10:122334643 | ENST00000361204 | + | 1 | 19 | 534_554 | 29 | 1142 | Transmembrane | Helical |
| Tgene | PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398250 | + | 4 | 7 | 102_110 | 148 | 272 | Region | Note=Phosphatase sequence motif I |
| Tgene | PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398250 | + | 4 | 7 | 143_146 | 148 | 272 | Region | Note=Phosphatase sequence motif II |
| Tgene | PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398250 | + | 4 | 7 | 142_162 | 148 | 272 | Transmembrane | Helical |
| Tgene | PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398250 | + | 4 | 7 | 49_69 | 148 | 272 | Transmembrane | Helical |
| Tgene | PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398250 | + | 4 | 7 | 4_24 | 148 | 272 | Transmembrane | Helical |
| Tgene | PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000398250 | + | 4 | 7 | 84_104 | 148 | 272 | Transmembrane | Helical |
| Tgene | PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000439221 | + | 2 | 5 | 49_69 | 85 | 209 | Transmembrane | Helical |
| Tgene | PPAPDC1A | chr22:42229362 | chr10:122334643 | ENST00000439221 | + | 2 | 5 | 4_24 | 85 | 209 | Transmembrane | Helical |
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FusionGeneSequence for SREBF2_PPAPDC1A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SREBF2_ENST00000361204_chr22_42229362_+_PPAPDC1A_ENST00000398250_chr10_122334643_+_153aa MDDSGELGGLETMETLTELGDELTLGDIDVAFSGLGFTTFYLAGKLHCFTESGRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDSFV >In-frame_SREBF2_ENST00000361204_chr22_42229362_+_PPAPDC1A_ENST00000439221_chr10_122334643_+_153aa MDDSGELGGLETMETLTELGDELTLGDIDVAFSGLGFTTFYLAGKLHCFTESGRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDSFV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SREBF2_ENST00000361204_chr22_42229362_+_PPAPDC1A_ENST00000398250_chr10_122334643_+_459nt ATGGACGACAGCGGCGAGCTGGGTGGTCTGGAGACCATGGAGACCCTCACGGAGCTGGGCGACGAGCTGACCCTGGGAGACATCGACGTT GCCTTTTCGGGCCTTGGCTTCACGACGTTCTACTTGGCGGGCAAGCTGCACTGCTTCACCGAGAGTGGGCGGGGAAAGAGCTGGCGGCTC TGTGCTGCCATCCTGCCCTTGTACTGCGCCATGATGATTGCCCTGTCCCGCATGTGCGACTACAAGCATCACTGGCAAGATTCCTTTGTG GGTGGAGTCATCGGCCTCATTTTTGCATACATTTGCTACAGACAGCACTATCCTCCTCTGGCCAACACAGCTTGCCATAAACCCTACGTT AGTCTGCGAGTCCCAGCCTCACTGAAGAAAGAGGAGAGGCCCACAGCTGACAGCGCACCCAGCTTGCCTCTGGAGGGGATCACCGAAGGC >In-frame_SREBF2_ENST00000361204_chr22_42229362_+_PPAPDC1A_ENST00000439221_chr10_122334643_+_459nt ATGGACGACAGCGGCGAGCTGGGTGGTCTGGAGACCATGGAGACCCTCACGGAGCTGGGCGACGAGCTGACCCTGGGAGACATCGACGTT GCCTTTTCGGGCCTTGGCTTCACGACGTTCTACTTGGCGGGCAAGCTGCACTGCTTCACCGAGAGTGGGCGGGGAAAGAGCTGGCGGCTC TGTGCTGCCATCCTGCCCTTGTACTGCGCCATGATGATTGCCCTGTCCCGCATGTGCGACTACAAGCATCACTGGCAAGATTCCTTTGTG GGTGGAGTCATCGGCCTCATTTTTGCATACATTTGCTACAGACAGCACTATCCTCCTCTGGCCAACACAGCTTGCCATAAACCCTACGTT AGTCTGCGAGTCCCAGCCTCACTGAAGAAAGAGGAGAGGCCCACAGCTGACAGCGCACCCAGCTTGCCTCTGGAGGGGATCACCGAAGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SREBF2_ENST00000361204_chr22_42229362_+_PPAPDC1A_ENST00000398250_chr10_122334643_+_978nt CTTTCTGTGCGGCGCCCGGGCGCAACGCAAACATGGCGGCGGGTGGCACCCGTCGGTGAGGCGGTGCCGGGCGGGGGTTGTCGGGTGTCA TGGGCGGTGGCGACGGCACCGCCCCCGCGTCTCCCTGAGCGGGACGGCAGGGGGGGCTTCTGCGCTGAGCCGGGCGATGGACGACAGCGG CGAGCTGGGTGGTCTGGAGACCATGGAGACCCTCACGGAGCTGGGCGACGAGCTGACCCTGGGAGACATCGACGTTGCCTTTTCGGGCCT TGGCTTCACGACGTTCTACTTGGCGGGCAAGCTGCACTGCTTCACCGAGAGTGGGCGGGGAAAGAGCTGGCGGCTCTGTGCTGCCATCCT GCCCTTGTACTGCGCCATGATGATTGCCCTGTCCCGCATGTGCGACTACAAGCATCACTGGCAAGATTCCTTTGTGGGTGGAGTCATCGG CCTCATTTTTGCATACATTTGCTACAGACAGCACTATCCTCCTCTGGCCAACACAGCTTGCCATAAACCCTACGTTAGTCTGCGAGTCCC AGCCTCACTGAAGAAAGAGGAGAGGCCCACAGCTGACAGCGCACCCAGCTTGCCTCTGGAGGGGATCACCGAAGGCCCGGTATGACCAGT GTCCTGGGAGGATGGACACTAAGCCCTGGGCACATCTGCCACCCTGACATCATAACACAATAGAAATGGTTTTCTGTAGTGTATTTTTCA TCAGTTGTTTCTCAAAGTCATCGTACTTCTGCTTCTGTTTCACTGATGGTGTTCCTGCTACTTTAAATGTCTACTTCCAACATCCTTGAA TTTGCAAGTGAAGGACAACAATCTCTGAGAGACGTGTGGAAGAGGCTGTGAAGGTGGGGTTTGGGGAGCTTGGCCGATTCGTCTATCTGA >In-frame_SREBF2_ENST00000361204_chr22_42229362_+_PPAPDC1A_ENST00000439221_chr10_122334643_+_978nt CTTTCTGTGCGGCGCCCGGGCGCAACGCAAACATGGCGGCGGGTGGCACCCGTCGGTGAGGCGGTGCCGGGCGGGGGTTGTCGGGTGTCA TGGGCGGTGGCGACGGCACCGCCCCCGCGTCTCCCTGAGCGGGACGGCAGGGGGGGCTTCTGCGCTGAGCCGGGCGATGGACGACAGCGG CGAGCTGGGTGGTCTGGAGACCATGGAGACCCTCACGGAGCTGGGCGACGAGCTGACCCTGGGAGACATCGACGTTGCCTTTTCGGGCCT TGGCTTCACGACGTTCTACTTGGCGGGCAAGCTGCACTGCTTCACCGAGAGTGGGCGGGGAAAGAGCTGGCGGCTCTGTGCTGCCATCCT GCCCTTGTACTGCGCCATGATGATTGCCCTGTCCCGCATGTGCGACTACAAGCATCACTGGCAAGATTCCTTTGTGGGTGGAGTCATCGG CCTCATTTTTGCATACATTTGCTACAGACAGCACTATCCTCCTCTGGCCAACACAGCTTGCCATAAACCCTACGTTAGTCTGCGAGTCCC AGCCTCACTGAAGAAAGAGGAGAGGCCCACAGCTGACAGCGCACCCAGCTTGCCTCTGGAGGGGATCACCGAAGGCCCGGTATGACCAGT GTCCTGGGAGGATGGACACTAAGCCCTGGGCACATCTGCCACCCTGACATCATAACACAATAGAAATGGTTTTCTGTAGTGTATTTTTCA TCAGTTGTTTCTCAAAGTCATCGTACTTCTGCTTCTGTTTCACTGATGGTGTTCCTGCTACTTTAAATGTCTACTTCCAACATCCTTGAA TTTGCAAGTGAAGGACAACAATCTCTGAGAGACGTGTGGAAGAGGCTGTGAAGGTGGGGTTTGGGGAGCTTGGCCGATTCGTCTATCTGA |
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FusionGenePPI for SREBF2_PPAPDC1A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SREBF2 | INSIG1, UBE2I, CREBBP, EP300, KPNB1, SREBF2, SP1, CASP3, MAPK3, MAPK1, ARRB1, EGR1, FHL3, GOLGB1, HSPA5, ITGB4, ABLIM1, NFYA, PSMD4, ATXN1, SPTBN1, NFYC, CREB1, TTC1, ZMYM2, ZYX, PIAS1, SLC4A4, PIAS2, ARHGEF1, CASP8AP2, PIAS3, OS9, COPS5, ZDHHC17, ATF7IP, ABLIM2, LZTR1, KLF13, ATF6, HNF4A, SMAD3, RNF139, HINFP, NPAT, TRRAP, SREBF1, SCAP, PARK7, NAE1, MRPS6, ERLIN2, HDAC3, SPINT2, HLA-DPA1, NRG1, CGRRF1, PTH1R, SLC39A4, AURKA, CDH5, ZNRF4, TMCO3, DKK3, CHRND, IL17RC, CD79B, SLC4A8, SLC39A12, MTNR1B | PPAPDC1A | PPAPDC1A, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SREBF2 | chr22:42229362 | chr10:122334643 | ENST00000361204 | + | 1 | 19 | 237_491 | 29 | 1142 | LMNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SREBF2_PPAPDC1A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SREBF2_PPAPDC1A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SREBF2 | C0021655 | Insulin Resistance | 1 | CTD_human |
| Hgene | SREBF2 | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
| Hgene | SREBF2 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | SREBF2 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Hgene | SREBF2 | C2239176 | Liver carcinoma | 1 | CTD_human |
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