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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35919

FusionGeneSummary for SRCIN1_LASP1

check button Fusion gene summary
Fusion gene informationFusion gene name: SRCIN1_LASP1
Fusion gene ID: 35919
HgeneTgene
Gene symbol

SRCIN1

LASP1

Gene ID

80725

3927

Gene nameSRC kinase signaling inhibitor 1LIM and SH3 protein 1
SynonymsP140|SNIPLasp-1|MLN50
Cytomap

17q12

17q12

Type of geneprotein-codingprotein-coding
DescriptionSRC kinase signaling inhibitor 1P130Cas-associated proteinSNAP-25-interacting proteinSNAP25-interacting proteinp140CapLIM and SH3 domain protein 1metastatic lymph node gene 50 protein
Modification date2018051920180522
UniProtAcc

Q9C0H9

Q14847

Ensembl transtripts involved in fusion geneENST00000264659, ENST00000578925, 
ENST00000398579, 		ENST00000318008, 
ENST00000433206, ENST00000435347, 
Fusion gene scores* DoF score8 X 7 X 5=28013 X 12 X 7=1092
# samples 616
** MAII scorelog2(6/280*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1092*10)=-2.77082904603249
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRCIN1 [Title/Abstract] AND LASP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSRCIN1

GO:0061098

positive regulation of protein tyrosine kinase activity

17525734

HgeneSRCIN1

GO:0061099

negative regulation of protein tyrosine kinase activity

17525734


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVREADTCGA-EI-6509-01ASRCIN1chr17

36761937

-LASP1chr17

37070578

+
TCGALDREADTCGA-EI-6509-01ASRCIN1chr17

36761886

-LASP1chr17

37070578

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000264659ENST00000318008SRCIN1chr17

36761937

-LASP1chr17

37070578

+
In-frameENST00000264659ENST00000433206SRCIN1chr17

36761937

-LASP1chr17

37070578

+
In-frameENST00000264659ENST00000435347SRCIN1chr17

36761937

-LASP1chr17

37070578

+
In-frameENST00000578925ENST00000318008SRCIN1chr17

36761937

-LASP1chr17

37070578

+
In-frameENST00000578925ENST00000433206SRCIN1chr17

36761937

-LASP1chr17

37070578

+
In-frameENST00000578925ENST00000435347SRCIN1chr17

36761937

-LASP1chr17

37070578

+
intron-3CDSENST00000398579ENST00000318008SRCIN1chr17

36761937

-LASP1chr17

37070578

+
intron-3CDSENST00000398579ENST00000433206SRCIN1chr17

36761937

-LASP1chr17

37070578

+
intron-3CDSENST00000398579ENST00000435347SRCIN1chr17

36761937

-LASP1chr17

37070578

+
intron-3CDSENST00000264659ENST00000318008SRCIN1chr17

36761886

-LASP1chr17

37070578

+
intron-3CDSENST00000264659ENST00000433206SRCIN1chr17

36761886

-LASP1chr17

37070578

+
intron-3CDSENST00000264659ENST00000435347SRCIN1chr17

36761886

-LASP1chr17

37070578

+
intron-3CDSENST00000578925ENST00000318008SRCIN1chr17

36761886

-LASP1chr17

37070578

+
intron-3CDSENST00000578925ENST00000433206SRCIN1chr17

36761886

-LASP1chr17

37070578

+
intron-3CDSENST00000578925ENST00000435347SRCIN1chr17

36761886

-LASP1chr17

37070578

+
intron-3CDSENST00000398579ENST00000318008SRCIN1chr17

36761886

-LASP1chr17

37070578

+
intron-3CDSENST00000398579ENST00000433206SRCIN1chr17

36761886

-LASP1chr17

37070578

+
intron-3CDSENST00000398579ENST00000435347SRCIN1chr17

36761886

-LASP1chr17

37070578

+

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FusionProtFeatures for SRCIN1_LASP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SRCIN1

Q9C0H9

LASP1

Q14847

Acts as a negative regulator of SRC by activating CSKwhich inhibits SRC activity and downstream signaling, leading toimpaired cell spreading and migration. Regulates dendritic spinemorphology. Involved in calcium-dependent exocytosis. May play arole in neurotransmitter release or synapse maintenance.{ECO:0000269|PubMed:14657239, ECO:0000269|PubMed:17525734,ECO:0000269|PubMed:19146815}. Plays an important role in the regulation of dynamicactin-based, cytoskeletal activities. Agonist-dependent changes inLASP1 phosphorylation may also serve to regulate actin-associatedion transport activities, not only in the parietal cell but alsoin certain other F-actin-rich secretory epithelial cell types (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLASP1chr17:36761937chr17:37070578ENST00000318008+37201_204119262Compositional biasNote=Poly-Gly
TgeneLASP1chr17:36761937chr17:37070578ENST00000435347+38201_204119708Compositional biasNote=Poly-Gly
TgeneLASP1chr17:36761937chr17:37070578ENST00000318008+37202_261119262DomainSH3
TgeneLASP1chr17:36761937chr17:37070578ENST00000435347+38202_261119708DomainSH3

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRCIN1chr17:36761937chr17:37070578ENST00000264659-119654_67471184Coiled coilOntology_term=ECO:0000255
HgeneSRCIN1chr17:36761937chr17:37070578ENST00000264659-119726_74671184Coiled coilOntology_term=ECO:0000255
HgeneSRCIN1chr17:36761937chr17:37070578ENST00000264659-119471_50471184Compositional biasNote=Pro-rich
HgeneSRCIN1chr17:36761937chr17:37070578ENST00000264659-119956_101471184Compositional biasNote=Pro-rich
TgeneLASP1chr17:36761937chr17:37070578ENST00000318008+375_56119262DomainLIM zinc-binding
TgeneLASP1chr17:36761937chr17:37070578ENST00000435347+385_56119708DomainLIM zinc-binding
TgeneLASP1chr17:36761937chr17:37070578ENST00000318008+3761_95119262RepeatNote=Nebulin 1
TgeneLASP1chr17:36761937chr17:37070578ENST00000318008+3797_131119262RepeatNote=Nebulin 2
TgeneLASP1chr17:36761937chr17:37070578ENST00000435347+3861_95119708RepeatNote=Nebulin 1
TgeneLASP1chr17:36761937chr17:37070578ENST00000435347+3897_131119708RepeatNote=Nebulin 2


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FusionGeneSequence for SRCIN1_LASP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SRCIN1_ENST00000264659_chr17_36761937_-_LASP1_ENST00000318008_chr17_37070578_+_150aa
MGNAPSQDKIP_GV_EEPHGP_RGRGHGARASGFTGRQQLPAAPGAAAASPHPDQCPGLPAAPAAAGGPVLWWLQGACSPSLHTAQRPRW

>In-frame_SRCIN1_ENST00000264659_chr17_36761937_-_LASP1_ENST00000433206_chr17_37070578_+_150aa
MGNAPSQDKIP_GV_EEPHGP_RGRGHGARASGFTGRQQLPAAPGAAAASPHPDQCPGLPAAPAAAGGPVLWWLQGACSPSLHTAQRPRW

>In-frame_SRCIN1_ENST00000264659_chr17_36761937_-_LASP1_ENST00000435347_chr17_37070578_+_150aa
MGNAPSQDKIP_GV_EEPHGP_RGRGHGARASGFTGRQQLPAAPGAAAASPHPDQCPGLPAAPAAAGGPVLWWLQGACSPSLHTAQRPRW

>In-frame_SRCIN1_ENST00000578925_chr17_36761937_-_LASP1_ENST00000318008_chr17_37070578_+_150aa
MGNAPSQDKIP_GV_EEPHGP_RGRGHGARASGFTGRQQLPAAPGAAAASPHPDQCPGLPAAPAAAGGPVLWWLQGACSPSLHTAQRPRW

>In-frame_SRCIN1_ENST00000578925_chr17_36761937_-_LASP1_ENST00000433206_chr17_37070578_+_150aa
MGNAPSQDKIP_GV_EEPHGP_RGRGHGARASGFTGRQQLPAAPGAAAASPHPDQCPGLPAAPAAAGGPVLWWLQGACSPSLHTAQRPRW

>In-frame_SRCIN1_ENST00000578925_chr17_36761937_-_LASP1_ENST00000435347_chr17_37070578_+_150aa
MGNAPSQDKIP_GV_EEPHGP_RGRGHGARASGFTGRQQLPAAPGAAAASPHPDQCPGLPAAPAAAGGPVLWWLQGACSPSLHTAQRPRW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SRCIN1_ENST00000264659_chr17_36761937_-_LASP1_ENST00000318008_chr17_37070578_+_451nt
ATGGGGAACGCTCCGTCCCAAGATAAAATACCATGAGGAGTTTGAGAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAGCCAGA
GCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTGGAGCAGCAGCAGCCTCACCACATCCCGACCAGTGCCCCGGTTTACCA
GCAGCCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTACAAGGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGG
TGGCGGGAAGCGGTACCGCGCGGTGTATGACTACAGCGCCGCCGACGAGGACGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAACGT
GCAGCAGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGCACCGGCGACACGGGGATGCTGCCGGCCAACTACGTGGAGGCCATCTG

>In-frame_SRCIN1_ENST00000264659_chr17_36761937_-_LASP1_ENST00000433206_chr17_37070578_+_451nt
ATGGGGAACGCTCCGTCCCAAGATAAAATACCATGAGGAGTTTGAGAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAGCCAGA
GCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTGGAGCAGCAGCAGCCTCACCACATCCCGACCAGTGCCCCGGTTTACCA
GCAGCCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTACAAGGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGG
TGGCGGGAAGCGGTACCGCGCGGTGTATGACTACAGCGCCGCCGACGAGGACGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAACGT
GCAGCAGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGCACCGGCGACACGGGGATGCTGCCGGCCAACTACGTGGAGGCCATCTG

>In-frame_SRCIN1_ENST00000264659_chr17_36761937_-_LASP1_ENST00000435347_chr17_37070578_+_451nt
ATGGGGAACGCTCCGTCCCAAGATAAAATACCATGAGGAGTTTGAGAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAGCCAGA
GCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTGGAGCAGCAGCAGCCTCACCACATCCCGACCAGTGCCCCGGTTTACCA
GCAGCCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTACAAGGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGG
TGGCGGGAAGCGGTACCGCGCGGTGTATGACTACAGCGCCGCCGACGAGGACGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAACGT
GCAGCAGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGCACCGGCGACACGGGGATGCTGCCGGCCAACTACGTGGAGGCCATCTG

>In-frame_SRCIN1_ENST00000578925_chr17_36761937_-_LASP1_ENST00000318008_chr17_37070578_+_451nt
ATGGGGAACGCTCCGTCCCAAGATAAAATACCATGAGGAGTTTGAGAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAGCCAGA
GCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTGGAGCAGCAGCAGCCTCACCACATCCCGACCAGTGCCCCGGTTTACCA
GCAGCCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTACAAGGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGG
TGGCGGGAAGCGGTACCGCGCGGTGTATGACTACAGCGCCGCCGACGAGGACGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAACGT
GCAGCAGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGCACCGGCGACACGGGGATGCTGCCGGCCAACTACGTGGAGGCCATCTG

>In-frame_SRCIN1_ENST00000578925_chr17_36761937_-_LASP1_ENST00000433206_chr17_37070578_+_451nt
ATGGGGAACGCTCCGTCCCAAGATAAAATACCATGAGGAGTTTGAGAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAGCCAGA
GCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTGGAGCAGCAGCAGCCTCACCACATCCCGACCAGTGCCCCGGTTTACCA
GCAGCCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTACAAGGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGG
TGGCGGGAAGCGGTACCGCGCGGTGTATGACTACAGCGCCGCCGACGAGGACGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAACGT
GCAGCAGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGCACCGGCGACACGGGGATGCTGCCGGCCAACTACGTGGAGGCCATCTG

>In-frame_SRCIN1_ENST00000578925_chr17_36761937_-_LASP1_ENST00000435347_chr17_37070578_+_451nt
ATGGGGAACGCTCCGTCCCAAGATAAAATACCATGAGGAGTTTGAGAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAGCCAGA
GCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTGGAGCAGCAGCAGCCTCACCACATCCCGACCAGTGCCCCGGTTTACCA
GCAGCCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTACAAGGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGG
TGGCGGGAAGCGGTACCGCGCGGTGTATGACTACAGCGCCGCCGACGAGGACGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAACGT
GCAGCAGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGCACCGGCGACACGGGGATGCTGCCGGCCAACTACGTGGAGGCCATCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_SRCIN1_ENST00000264659_chr17_36761937_-_LASP1_ENST00000318008_chr17_37070578_+_3668nt
ACACTCGCTCTCGCACACTCGGTGACACGCCCGCGCGCGCGCTCACCCACACGCCCGGCCGCCGGCGCCCTCCCAGCTGGTCCACCCCGG
CGGGGCCCGCGCCCCCGGCCCGCCCGCCTGGCACCGCGCCCCGGGGCTGGGGCCGAGCGAGGAGCCCGCGAGGCGGCGAGAGGGCGAGCG
CCAGGCAGGCCGGCCCGGGGCCCCCGCCCCCCGCGCCCCCGCCCGATGGGGAACGCTCCGTCCCAAGATAAAATACCATGAGGAGTTTGA
GAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAGCCAGAGCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTGGA
GCAGCAGCAGCCTCACCACATCCCGACCAGTGCCCCGGTTTACCAGCAGCCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTACAA
GGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGGTGGCGGGAAGCGGTACCGCGCGGTGTATGACTACAGCGCCGCCGA
CGAGGACGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAACGTGCAGCAGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGCAC
CGGCGACACGGGGATGCTGCCGGCCAACTACGTGGAGGCCATCTGAACCCGCAGCGCCCCCATCTGTCTTCAGCACATTCCACGGCATCG
CATCCGTCCTGGGCGTGACCCGTCCATTCTTCAGTGTCTCTGTTTTTTAAAACCTGCGACAGCTTGTGATTCCTACCCCTCTTCCAGCTT
CTTTTGCCAACTGAAGCCTTCTTCTGCCACTTCTGCGGGCTCCCTCCTCTGGCAGGCTTCCCCCTTGATCGACTTCTTGGTTTTCTCTCT
GGATGGAACGGGCATGGGCCTCTCTGGGGGAGGCAGGGCTGGAATGGGAGACCTGTTGGCCTGTGGGCCTCACCTGCCCCTCTGTTCTCT
CCCCTCACATCCTCCTGCCCAGCTCCTCACATACCCACACATTCCAGGGCTGGGGTGAGCCTGACTGCCAGGACCCCAGGTCAGGGGCTC
CCTACATTCCCCAGAGTGGGATCCACTTCTTGGTTCCTGGGATGGCGATGGGGACTCTGCCGCTGTGTAGGGACCAGTGGGATGGGCTCT
ACCTCTCTTTCTCAAAGAGGGGGCTCTGCCCACCTGGGGTCTCTCTCCCTACCTCCCTCCTCAGGGGCAACAACAGGAGAATGGGGTTCC
TGCTGTGGGGCGAATTCATCCCCTCCCCGCGCGTTCCTTCGCACACTGTGATTTTGCCCTCCTGCCCACGCAGACCTGCAGCGGGCAAAG
AGCTCCCGAGGAAGCACAGCTTGGGTCAGGTTCTTGCCTTTCTTAATTTTAGGGACAGCTACCGGAAGGAGGGGAACAAGGAGTTCTCTT
CCGCAGCCCCTTTCCCCACGCCCACCCCCAGTCTCCAGGGACCCTTGCCTGCCTCCTAGGCTGGAAGCCATGGTCCCGAAGTGTAGGGCA
AGGGTGCCTCAGGACCTTTTGGTCTTCAGCCTCCCTCAGCCCCCAGGATCTGGGTTAGGTGGCCGCTCCTCCCTGCTCCTCATGGGAAGA
TGTCTCAGAGCCTTCCATGACCTCCCCTCCCCAGCCCAATGCCAAGTGGACTTGGAGCTGCACAAAGTCAGCAGGGACCACTAAATCTCC
AAGACCTGGTGTGCGGAGGCAGGAGCATGTATGTCTGCAGGTGTCTGACACGCAAGTGTGTGAGTGTGAGTGTGAGAGATGGGGCGGGGG
TGTGTCTGTAGGTGTCTCTGGGCCTGTGTGTGGGTGGGGTTATGTGAGGGTATGAAGAGCTGTCTTCCCCTGAGAGTTTCCTCAGAACCC
ACAGTGAGAGGGGAGGGCTCCTGGGGCAGAGAAGTTCCTTAGGTTTTCTTTGGAATGAAATTCCTCCTTCCCCCCATCTCTGAGTGGAGG
AAGCCCACCAATCTGCCCTTTGCAGTGTGCAGGGTGGAAGGTAAGAGGTTGGTGTGGAGTTGGGGCTGCCATAGGGTCTGCAGCCTGCTG
GGGCTAAGCGGTGGAGGAAGGCTCTGTCACTCCAGGCATATGTTTCCCCATCTCTGTCTGGGGCTACAGAATAGGGTGGCAGAAGTGTCA
CCCTGTGGGTGTCTCCCTCGGGGGCTCTTCCCCTAGACCTCCCCCTCACTTACATAAAGCTCCCTTGAAGCAAGAAAGAGGGTCCCAGGG
CTGCAAAACTGGAAGCACAGCCTCGGGGATGGGGAGGGAAAGACGGTGCTATATCCAGTTCCTGCTCTCTGCTCATGGGTGGCTGTGACA
ACCCTGGCCTCACTTGATTCATCTCTGGTTTTCTTGCCACCCTCTGGGAGTCCCCATCCCATTTTCATCCTGAGCCCAACCAGGCCCTGC
CATTGGCCTCTTGTCCCTTGGCACACTTGTACCCACAGGTGAGGGGCAGGACCTGAAGGTATTGGCCTGTTCAACAATCAGTCATCATGG
GTGTTTTTGTCAACTGCTTGTTAATTGATTTGGGGATGTTTGCCCCGAATGAGAGGTTGAGGAAAAGACTGTGGGTGGGGAGGCCCTGCC
TGACCCATCCCTTTTCCTTTCTGGCCCCAGCCTAGGTGGAGGCAAGTGGAATATCTTATATTGGGCGATTTGGGGGCTCGGGGAGGCAGA
GAATCTCTTGGGAGTCTTGGGTGGCGCTGGTGCATTCTGTTTCCTCTTGATCTCAAAGCACAATGTGGATTTGGGGACCAAAGGTCAGGG
ACACATCCCCTTAGAGGACCTGAGTTTGGGAGAGTGGTGAGTGGAAGGGAGGAGCAGCAAGAAGCAGCCTGTTTTCACTCAGCTTAATTC
TCCTTCCCAGATAAGGCAAGCCAGTCATGGAATCTTGCTGCAGGCCCTCCCTCTACTCTTCCTGTCCTAAAAATAGGGGCCGTTTTCTTA
CACACCCCCAGAGAGAGGAGGGACTGTCACACTGGTGCTGAGTGACCGGGGGCTGCTGGGCGTCTGTTCTTTACCAAAACCATCCATCCC
TAGAAGAGCACAGAGCCCTGAGGGGCTGGGCTGGGCTGGGCTGAGCCCCTGGTCTTCTCTACAGTTCACAGAGGTCTTTCAGCTCATTTA
ATCCCAGGAAAGAGGCATCAAAGCTAGAATGTGAATATAACTTTTGTGGACCAATACTAAGAATAACAAGAAGCCCAGTGGTGAGGAAAG
TGCGTTCTCCCAGCACTGCCTCCTGTTTTCTCCCTCTCATGTCCCTCCAGGGAAAATGACTTTATTGCTTAATTTCTGCCTTTCCCCCCT
CACACATGCACTTTTGGGCCTTTTTTTATAGCTGGAAAAAACAAAATACCACCCTACAAACCTGTATTTAAAAAGAAACAGAAATGACCA
CGTGAAATTTGCCTCTGTCCAAACATTTCATCCGTGTGTATGTGTATGTGTGTGAGTGTGTGAAGCCGCCAGTTCATCTTTTTATATGGG
GTTGTTGTCTCATTTTGGTCTGTTTTGGTCCCCTCCCTCGTGGGCTTGTGCTCGGGATCAAACCTTTCTGGCCTGTTATGATTCTGAACA

>In-frame_SRCIN1_ENST00000264659_chr17_36761937_-_LASP1_ENST00000433206_chr17_37070578_+_1224nt
ACACTCGCTCTCGCACACTCGGTGACACGCCCGCGCGCGCGCTCACCCACACGCCCGGCCGCCGGCGCCCTCCCAGCTGGTCCACCCCGG
CGGGGCCCGCGCCCCCGGCCCGCCCGCCTGGCACCGCGCCCCGGGGCTGGGGCCGAGCGAGGAGCCCGCGAGGCGGCGAGAGGGCGAGCG
CCAGGCAGGCCGGCCCGGGGCCCCCGCCCCCCGCGCCCCCGCCCGATGGGGAACGCTCCGTCCCAAGATAAAATACCATGAGGAGTTTGA
GAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAGCCAGAGCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTGGA
GCAGCAGCAGCCTCACCACATCCCGACCAGTGCCCCGGTTTACCAGCAGCCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTACAA
GGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGGTGGCGGGAAGCGGTACCGCGCGGTGTATGACTACAGCGCCGCCGA
CGAGGACGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAACGTGCAGCAGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGCAC
CGGCGACACGGGGATGCTGCCGGCCAACTACGTGGAGGCCATCTGAACCCGCAGCGCCCCCATCTGTCTTCAGCACATTCCACGGCATCG
CATCCGTCCTGGGCGTGACCCGTCCATTCTTCAGTGTCTCTGTTTTTTAAAACCTGCGACAGCTTGTGATTCCTACCCCTCTTCCAGCTT
CTTTTGCCAACTGAAGCCTTCTTCTGCCACTTCTGCGGGCTCCCTCCTCTGGCAGGCTTCCCCCTTGATCGACTTCTTGGTTTTCTCTCT
GGATGGAACGGGCATGGGCCTCTCTGGGGGAGGCAGGGCTGGAATGGGAGACCTGTTGGCCTGTGGGCCTCACCTGCCCCTCTGTTCTCT
CCCCTCACATCCTCCTGCCCAGCTCCTCACATACCCACACATTCCAGGGCTGGGGTGAGCCTGACTGCCAGGACCCCAGGTCAGGGGCTC
CCTACATTCCCCAGAGTGGGATCCACTTCTTGGTTCCTGGGATGGCGATGGGGACTCTGCCGCTGTGTAGGGACCAGTGGGATGGGCTCT

>In-frame_SRCIN1_ENST00000264659_chr17_36761937_-_LASP1_ENST00000435347_chr17_37070578_+_3335nt
ACACTCGCTCTCGCACACTCGGTGACACGCCCGCGCGCGCGCTCACCCACACGCCCGGCCGCCGGCGCCCTCCCAGCTGGTCCACCCCGG
CGGGGCCCGCGCCCCCGGCCCGCCCGCCTGGCACCGCGCCCCGGGGCTGGGGCCGAGCGAGGAGCCCGCGAGGCGGCGAGAGGGCGAGCG
CCAGGCAGGCCGGCCCGGGGCCCCCGCCCCCCGCGCCCCCGCCCGATGGGGAACGCTCCGTCCCAAGATAAAATACCATGAGGAGTTTGA
GAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAGCCAGAGCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTGGA
GCAGCAGCAGCCTCACCACATCCCGACCAGTGCCCCGGTTTACCAGCAGCCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTACAA
GGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGGTGGCGGGAAGCGGTACCGCGCGGTGTATGACTACAGCGCCGCCGA
CGAGGACGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAACGTGCAGCAGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGCAC
CGGCGACACGGGGATGCTGCCGGCCAACTACGTGGAGGCCATCTGAACCCGCAGCGCCCCCATCTGTCTTCAGCACATTCCACGGCATCG
CATCCGTCCTGGGCGTGACCCGTCCATTCTTCAGTGTCTCTGTTTTTTAAAACCTGCGACAGCTTGTGATTCCTACCCCTCTTCCAGCTT
CTTTTGCCAACTGAAGCCTTCTTCTGCCACTTCTGCGGGCTCCCTCCTCTGGCAGGCTTCCCCCTTGATCGACTTCTTGGTTTTCTCTCT
GGATGGAACGGGCATGGGCCTCTCTGGGGGAGGCAGGGCTGGAATGGGAGACCTGTTGGCCTGTGGGCCTCACCTGCCCCTCTGTTCTCT
CCCCTCACATCCTCCTGCCCAGCTCCTCACATACCCACACATTCCAGGGCTGGGGTGAGCCTGACTGCCAGGACCCCAGGTCAGGGGCTC
CCTACATTCCCCAGAGTGGGATCCACTTCTTGGTTCCTGGGATGGCGATGGGGACTCTGCCGCTGTGTAGGGACCAGTGGGATGGGCTCT
ACCTCTCTTTCTCAAAGAGGGGGCTCTGCCCACCTGGGGTCTCTCTCCCTACCTCCCTCCTCAGGGGCAACAACAGGAGAATGGGGTTCC
TGCTGTGGGGCGAATTCATCCCCTCCCCGCGCGTTCCTTCGCACACTGTGATTTTGCCCTCCTGCCCACGCAGACCTGCAGCGGGCAAAG
AGCTCCCGAGGAAGCACAGCTTGGGTCAGGTTCTTGCCTTTCTTAATTTTAGGGACAGCTACCGGAAGGAGGGGAACAAGGAGTTCTCTT
CCGCAGCCCCTTTCCCCACGCCCACCCCCAGTCTCCAGGGACCCTTGCCTGCCTCCTAGGCTGGAAGCCATGGTCCCGAAGTGTAGGGCA
AGGGTGCCTCAGGACCTTTTGGTCTTCAGCCTCCCTCAGCCCCCAGGATCTGGGTTAGGTGGCCGCTCCTCCCTGCTCCTCATGGGAAGA
TGTCTCAGAGCCTTCCATGACCTCCCCTCCCCAGCCCAATGCCAAGTGGACTTGGAGCTGCACAAAGTCAGCAGGGACCACTAAATCTCC
AAGACCTGGTGTGCGGAGGCAGGAGCATGTATGTCTGCAGGTGTCTGACACGCAAGTGTGTGAGTGTGAGTGTGAGAGATGGGGCGGGGG
TGTGTCTGTAGGTGTCTCTGGGCCTGTGTGTGGGTGGGGTTATGTGAGGGTATGAAGAGCTGTCTTCCCCTGAGAGTTTCCTCACTTACA
TAAAGCTCCCTTGAAGCAAGAAAGAGGGTCCCAGGGCTGCAAAACTGGAAGCACAGCCTCGGGGATGGGGAGGGAAAGACGGTGCTATAT
CCAGTTCCTGCTCTCTGCTCATGGGTGGCTGTGACAACCCTGGCCTCACTTGATTCATCTCTGGTTTTCTTGCCACCCTCTGGGAGTCCC
CATCCCATTTTCATCCTGAGCCCAACCAGGCCCTGCCATTGGCCTCTTGTCCCTTGGCACACTTGTACCCACAGGTGAGGGGCAGGACCT
GAAGGTATTGGCCTGTTCAACAATCAGTCATCATGGGTGTTTTTGTCAACTGCTTGTTAATTGATTTGGGGATGTTTGCCCCGAATGAGA
GGTTGAGGAAAAGACTGTGGGTGGGGAGGCCCTGCCTGACCCATCCCTTTTCCTTTCTGGCCCCAGCCTAGGTGGAGGCAAGTGGAATAT
CTTATATTGGGCGATTTGGGGGCTCGGGGAGGCAGAGAATCTCTTGGGAGTCTTGGGTGGCGCTGGTGCATTCTGTTTCCTCTTGATCTC
AAAGCACAATGTGGATTTGGGGACCAAAGGTCAGGGACACATCCCCTTAGAGGACCTGAGTTTGGGAGAGTGGTGAGTGGAAGGGAGGAG
CAGCAAGAAGCAGCCTGTTTTCACTCAGCTTAATTCTCCTTCCCAGATAAGGCAAGCCAGTCATGGAATCTTGCTGCAGGCCCTCCCTCT
ACTCTTCCTGTCCTAAAAATAGGGGCCGTTTTCTTACACACCCCCAGAGAGAGGAGGGACTGTCACACTGGTGCTGAGTGACCGGGGGCT
GCTGGGCGTCTGTTCTTTACCAAAACCATCCATCCCTAGAAGAGCACAGAGCCCTGAGGGGCTGGGCTGGGCTGGGCTGAGCCCCTGGTC
TTCTCTACAGTTCACAGAGGTCTTTCAGCTCATTTAATCCCAGGAAAGAGGCATCAAAGCTAGAATGTGAATATAACTTTTGTGGACCAA
TACTAAGAATAACAAGAAGCCCAGTGGTGAGGAAAGTGCGTTCTCCCAGCACTGCCTCCTGTTTTCTCCCTCTCATGTCCCTCCAGGGAA
AATGACTTTATTGCTTAATTTCTGCCTTTCCCCCCTCACACATGCACTTTTGGGCCTTTTTTTATAGCTGGAAAAAACAAAATACCACCC
TACAAACCTGTATTTAAAAAGAAACAGAAATGACCACGTGAAATTTGCCTCTGTCCAAACATTTCATCCGTGTGTATGTGTATGTGTGTG
AGTGTGTGAAGCCGCCAGTTCATCTTTTTATATGGGGTTGTTGTCTCATTTTGGTCTGTTTTGGTCCCCTCCCTCGTGGGCTTGTGCTCG
GGATCAAACCTTTCTGGCCTGTTATGATTCTGAACATTTGACTTGAACCACAAGTGAATCTTTCTCCTGGTGACTCAAATAAAAGTATAA

>In-frame_SRCIN1_ENST00000578925_chr17_36761937_-_LASP1_ENST00000318008_chr17_37070578_+_3580nt
GGCGGGGCCCGCGCCCCCGGCCCGCCCGCCTGGCACCGCGCCCCGGGGCTGGGGCCGAGCGAGGAGCCCGCGAGGCGGCGAGAGGGCGAG
CGCCAGGCAGGCCGGCCCGGGGCCCCCGCCCCCCGCGCCCCCGCCCGATGGGGAACGCTCCGTCCCAAGATAAAATACCATGAGGAGTTT
GAGAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAGCCAGAGCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTG
GAGCAGCAGCAGCCTCACCACATCCCGACCAGTGCCCCGGTTTACCAGCAGCCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTAC
AAGGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGGTGGCGGGAAGCGGTACCGCGCGGTGTATGACTACAGCGCCGCC
GACGAGGACGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAACGTGCAGCAGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGC
ACCGGCGACACGGGGATGCTGCCGGCCAACTACGTGGAGGCCATCTGAACCCGCAGCGCCCCCATCTGTCTTCAGCACATTCCACGGCAT
CGCATCCGTCCTGGGCGTGACCCGTCCATTCTTCAGTGTCTCTGTTTTTTAAAACCTGCGACAGCTTGTGATTCCTACCCCTCTTCCAGC
TTCTTTTGCCAACTGAAGCCTTCTTCTGCCACTTCTGCGGGCTCCCTCCTCTGGCAGGCTTCCCCCTTGATCGACTTCTTGGTTTTCTCT
CTGGATGGAACGGGCATGGGCCTCTCTGGGGGAGGCAGGGCTGGAATGGGAGACCTGTTGGCCTGTGGGCCTCACCTGCCCCTCTGTTCT
CTCCCCTCACATCCTCCTGCCCAGCTCCTCACATACCCACACATTCCAGGGCTGGGGTGAGCCTGACTGCCAGGACCCCAGGTCAGGGGC
TCCCTACATTCCCCAGAGTGGGATCCACTTCTTGGTTCCTGGGATGGCGATGGGGACTCTGCCGCTGTGTAGGGACCAGTGGGATGGGCT
CTACCTCTCTTTCTCAAAGAGGGGGCTCTGCCCACCTGGGGTCTCTCTCCCTACCTCCCTCCTCAGGGGCAACAACAGGAGAATGGGGTT
CCTGCTGTGGGGCGAATTCATCCCCTCCCCGCGCGTTCCTTCGCACACTGTGATTTTGCCCTCCTGCCCACGCAGACCTGCAGCGGGCAA
AGAGCTCCCGAGGAAGCACAGCTTGGGTCAGGTTCTTGCCTTTCTTAATTTTAGGGACAGCTACCGGAAGGAGGGGAACAAGGAGTTCTC
TTCCGCAGCCCCTTTCCCCACGCCCACCCCCAGTCTCCAGGGACCCTTGCCTGCCTCCTAGGCTGGAAGCCATGGTCCCGAAGTGTAGGG
CAAGGGTGCCTCAGGACCTTTTGGTCTTCAGCCTCCCTCAGCCCCCAGGATCTGGGTTAGGTGGCCGCTCCTCCCTGCTCCTCATGGGAA
GATGTCTCAGAGCCTTCCATGACCTCCCCTCCCCAGCCCAATGCCAAGTGGACTTGGAGCTGCACAAAGTCAGCAGGGACCACTAAATCT
CCAAGACCTGGTGTGCGGAGGCAGGAGCATGTATGTCTGCAGGTGTCTGACACGCAAGTGTGTGAGTGTGAGTGTGAGAGATGGGGCGGG
GGTGTGTCTGTAGGTGTCTCTGGGCCTGTGTGTGGGTGGGGTTATGTGAGGGTATGAAGAGCTGTCTTCCCCTGAGAGTTTCCTCAGAAC
CCACAGTGAGAGGGGAGGGCTCCTGGGGCAGAGAAGTTCCTTAGGTTTTCTTTGGAATGAAATTCCTCCTTCCCCCCATCTCTGAGTGGA
GGAAGCCCACCAATCTGCCCTTTGCAGTGTGCAGGGTGGAAGGTAAGAGGTTGGTGTGGAGTTGGGGCTGCCATAGGGTCTGCAGCCTGC
TGGGGCTAAGCGGTGGAGGAAGGCTCTGTCACTCCAGGCATATGTTTCCCCATCTCTGTCTGGGGCTACAGAATAGGGTGGCAGAAGTGT
CACCCTGTGGGTGTCTCCCTCGGGGGCTCTTCCCCTAGACCTCCCCCTCACTTACATAAAGCTCCCTTGAAGCAAGAAAGAGGGTCCCAG
GGCTGCAAAACTGGAAGCACAGCCTCGGGGATGGGGAGGGAAAGACGGTGCTATATCCAGTTCCTGCTCTCTGCTCATGGGTGGCTGTGA
CAACCCTGGCCTCACTTGATTCATCTCTGGTTTTCTTGCCACCCTCTGGGAGTCCCCATCCCATTTTCATCCTGAGCCCAACCAGGCCCT
GCCATTGGCCTCTTGTCCCTTGGCACACTTGTACCCACAGGTGAGGGGCAGGACCTGAAGGTATTGGCCTGTTCAACAATCAGTCATCAT
GGGTGTTTTTGTCAACTGCTTGTTAATTGATTTGGGGATGTTTGCCCCGAATGAGAGGTTGAGGAAAAGACTGTGGGTGGGGAGGCCCTG
CCTGACCCATCCCTTTTCCTTTCTGGCCCCAGCCTAGGTGGAGGCAAGTGGAATATCTTATATTGGGCGATTTGGGGGCTCGGGGAGGCA
GAGAATCTCTTGGGAGTCTTGGGTGGCGCTGGTGCATTCTGTTTCCTCTTGATCTCAAAGCACAATGTGGATTTGGGGACCAAAGGTCAG
GGACACATCCCCTTAGAGGACCTGAGTTTGGGAGAGTGGTGAGTGGAAGGGAGGAGCAGCAAGAAGCAGCCTGTTTTCACTCAGCTTAAT
TCTCCTTCCCAGATAAGGCAAGCCAGTCATGGAATCTTGCTGCAGGCCCTCCCTCTACTCTTCCTGTCCTAAAAATAGGGGCCGTTTTCT
TACACACCCCCAGAGAGAGGAGGGACTGTCACACTGGTGCTGAGTGACCGGGGGCTGCTGGGCGTCTGTTCTTTACCAAAACCATCCATC
CCTAGAAGAGCACAGAGCCCTGAGGGGCTGGGCTGGGCTGGGCTGAGCCCCTGGTCTTCTCTACAGTTCACAGAGGTCTTTCAGCTCATT
TAATCCCAGGAAAGAGGCATCAAAGCTAGAATGTGAATATAACTTTTGTGGACCAATACTAAGAATAACAAGAAGCCCAGTGGTGAGGAA
AGTGCGTTCTCCCAGCACTGCCTCCTGTTTTCTCCCTCTCATGTCCCTCCAGGGAAAATGACTTTATTGCTTAATTTCTGCCTTTCCCCC
CTCACACATGCACTTTTGGGCCTTTTTTTATAGCTGGAAAAAACAAAATACCACCCTACAAACCTGTATTTAAAAAGAAACAGAAATGAC
CACGTGAAATTTGCCTCTGTCCAAACATTTCATCCGTGTGTATGTGTATGTGTGTGAGTGTGTGAAGCCGCCAGTTCATCTTTTTATATG
GGGTTGTTGTCTCATTTTGGTCTGTTTTGGTCCCCTCCCTCGTGGGCTTGTGCTCGGGATCAAACCTTTCTGGCCTGTTATGATTCTGAA

>In-frame_SRCIN1_ENST00000578925_chr17_36761937_-_LASP1_ENST00000433206_chr17_37070578_+_1136nt
GGCGGGGCCCGCGCCCCCGGCCCGCCCGCCTGGCACCGCGCCCCGGGGCTGGGGCCGAGCGAGGAGCCCGCGAGGCGGCGAGAGGGCGAG
CGCCAGGCAGGCCGGCCCGGGGCCCCCGCCCCCCGCGCCCCCGCCCGATGGGGAACGCTCCGTCCCAAGATAAAATACCATGAGGAGTTT
GAGAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAGCCAGAGCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTG
GAGCAGCAGCAGCCTCACCACATCCCGACCAGTGCCCCGGTTTACCAGCAGCCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTAC
AAGGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGGTGGCGGGAAGCGGTACCGCGCGGTGTATGACTACAGCGCCGCC
GACGAGGACGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAACGTGCAGCAGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGC
ACCGGCGACACGGGGATGCTGCCGGCCAACTACGTGGAGGCCATCTGAACCCGCAGCGCCCCCATCTGTCTTCAGCACATTCCACGGCAT
CGCATCCGTCCTGGGCGTGACCCGTCCATTCTTCAGTGTCTCTGTTTTTTAAAACCTGCGACAGCTTGTGATTCCTACCCCTCTTCCAGC
TTCTTTTGCCAACTGAAGCCTTCTTCTGCCACTTCTGCGGGCTCCCTCCTCTGGCAGGCTTCCCCCTTGATCGACTTCTTGGTTTTCTCT
CTGGATGGAACGGGCATGGGCCTCTCTGGGGGAGGCAGGGCTGGAATGGGAGACCTGTTGGCCTGTGGGCCTCACCTGCCCCTCTGTTCT
CTCCCCTCACATCCTCCTGCCCAGCTCCTCACATACCCACACATTCCAGGGCTGGGGTGAGCCTGACTGCCAGGACCCCAGGTCAGGGGC
TCCCTACATTCCCCAGAGTGGGATCCACTTCTTGGTTCCTGGGATGGCGATGGGGACTCTGCCGCTGTGTAGGGACCAGTGGGATGGGCT

>In-frame_SRCIN1_ENST00000578925_chr17_36761937_-_LASP1_ENST00000435347_chr17_37070578_+_3247nt
GGCGGGGCCCGCGCCCCCGGCCCGCCCGCCTGGCACCGCGCCCCGGGGCTGGGGCCGAGCGAGGAGCCCGCGAGGCGGCGAGAGGGCGAG
CGCCAGGCAGGCCGGCCCGGGGCCCCCGCCCCCCGCGCCCCCGCCCGATGGGGAACGCTCCGTCCCAAGATAAAATACCATGAGGAGTTT
GAGAAGAGCCGCATGGGCCCTAGCGGGGGCGAGGGCATGGAGCCAGAGCGTCGGGATTCACAGGACGGCAGCAGCTACCGGCGGCCCCTG
GAGCAGCAGCAGCCTCACCACATCCCGACCAGTGCCCCGGTTTACCAGCAGCCCCAGCAGCAGCCGGTGGCCCAGTCCTATGGTGGCTAC
AAGGAGCCTGCAGCCCCAGTCTCCATACAGCGCAGCGCCCCAGGTGGTGGCGGGAAGCGGTACCGCGCGGTGTATGACTACAGCGCCGCC
GACGAGGACGAGGTCTCCTTCCAGGACGGGGACACCATCGTCAACGTGCAGCAGATCGACGACGGCTGGATGTACGGGACGGTGGAGCGC
ACCGGCGACACGGGGATGCTGCCGGCCAACTACGTGGAGGCCATCTGAACCCGCAGCGCCCCCATCTGTCTTCAGCACATTCCACGGCAT
CGCATCCGTCCTGGGCGTGACCCGTCCATTCTTCAGTGTCTCTGTTTTTTAAAACCTGCGACAGCTTGTGATTCCTACCCCTCTTCCAGC
TTCTTTTGCCAACTGAAGCCTTCTTCTGCCACTTCTGCGGGCTCCCTCCTCTGGCAGGCTTCCCCCTTGATCGACTTCTTGGTTTTCTCT
CTGGATGGAACGGGCATGGGCCTCTCTGGGGGAGGCAGGGCTGGAATGGGAGACCTGTTGGCCTGTGGGCCTCACCTGCCCCTCTGTTCT
CTCCCCTCACATCCTCCTGCCCAGCTCCTCACATACCCACACATTCCAGGGCTGGGGTGAGCCTGACTGCCAGGACCCCAGGTCAGGGGC
TCCCTACATTCCCCAGAGTGGGATCCACTTCTTGGTTCCTGGGATGGCGATGGGGACTCTGCCGCTGTGTAGGGACCAGTGGGATGGGCT
CTACCTCTCTTTCTCAAAGAGGGGGCTCTGCCCACCTGGGGTCTCTCTCCCTACCTCCCTCCTCAGGGGCAACAACAGGAGAATGGGGTT
CCTGCTGTGGGGCGAATTCATCCCCTCCCCGCGCGTTCCTTCGCACACTGTGATTTTGCCCTCCTGCCCACGCAGACCTGCAGCGGGCAA
AGAGCTCCCGAGGAAGCACAGCTTGGGTCAGGTTCTTGCCTTTCTTAATTTTAGGGACAGCTACCGGAAGGAGGGGAACAAGGAGTTCTC
TTCCGCAGCCCCTTTCCCCACGCCCACCCCCAGTCTCCAGGGACCCTTGCCTGCCTCCTAGGCTGGAAGCCATGGTCCCGAAGTGTAGGG
CAAGGGTGCCTCAGGACCTTTTGGTCTTCAGCCTCCCTCAGCCCCCAGGATCTGGGTTAGGTGGCCGCTCCTCCCTGCTCCTCATGGGAA
GATGTCTCAGAGCCTTCCATGACCTCCCCTCCCCAGCCCAATGCCAAGTGGACTTGGAGCTGCACAAAGTCAGCAGGGACCACTAAATCT
CCAAGACCTGGTGTGCGGAGGCAGGAGCATGTATGTCTGCAGGTGTCTGACACGCAAGTGTGTGAGTGTGAGTGTGAGAGATGGGGCGGG
GGTGTGTCTGTAGGTGTCTCTGGGCCTGTGTGTGGGTGGGGTTATGTGAGGGTATGAAGAGCTGTCTTCCCCTGAGAGTTTCCTCACTTA
CATAAAGCTCCCTTGAAGCAAGAAAGAGGGTCCCAGGGCTGCAAAACTGGAAGCACAGCCTCGGGGATGGGGAGGGAAAGACGGTGCTAT
ATCCAGTTCCTGCTCTCTGCTCATGGGTGGCTGTGACAACCCTGGCCTCACTTGATTCATCTCTGGTTTTCTTGCCACCCTCTGGGAGTC
CCCATCCCATTTTCATCCTGAGCCCAACCAGGCCCTGCCATTGGCCTCTTGTCCCTTGGCACACTTGTACCCACAGGTGAGGGGCAGGAC
CTGAAGGTATTGGCCTGTTCAACAATCAGTCATCATGGGTGTTTTTGTCAACTGCTTGTTAATTGATTTGGGGATGTTTGCCCCGAATGA
GAGGTTGAGGAAAAGACTGTGGGTGGGGAGGCCCTGCCTGACCCATCCCTTTTCCTTTCTGGCCCCAGCCTAGGTGGAGGCAAGTGGAAT
ATCTTATATTGGGCGATTTGGGGGCTCGGGGAGGCAGAGAATCTCTTGGGAGTCTTGGGTGGCGCTGGTGCATTCTGTTTCCTCTTGATC
TCAAAGCACAATGTGGATTTGGGGACCAAAGGTCAGGGACACATCCCCTTAGAGGACCTGAGTTTGGGAGAGTGGTGAGTGGAAGGGAGG
AGCAGCAAGAAGCAGCCTGTTTTCACTCAGCTTAATTCTCCTTCCCAGATAAGGCAAGCCAGTCATGGAATCTTGCTGCAGGCCCTCCCT
CTACTCTTCCTGTCCTAAAAATAGGGGCCGTTTTCTTACACACCCCCAGAGAGAGGAGGGACTGTCACACTGGTGCTGAGTGACCGGGGG
CTGCTGGGCGTCTGTTCTTTACCAAAACCATCCATCCCTAGAAGAGCACAGAGCCCTGAGGGGCTGGGCTGGGCTGGGCTGAGCCCCTGG
TCTTCTCTACAGTTCACAGAGGTCTTTCAGCTCATTTAATCCCAGGAAAGAGGCATCAAAGCTAGAATGTGAATATAACTTTTGTGGACC
AATACTAAGAATAACAAGAAGCCCAGTGGTGAGGAAAGTGCGTTCTCCCAGCACTGCCTCCTGTTTTCTCCCTCTCATGTCCCTCCAGGG
AAAATGACTTTATTGCTTAATTTCTGCCTTTCCCCCCTCACACATGCACTTTTGGGCCTTTTTTTATAGCTGGAAAAAACAAAATACCAC
CCTACAAACCTGTATTTAAAAAGAAACAGAAATGACCACGTGAAATTTGCCTCTGTCCAAACATTTCATCCGTGTGTATGTGTATGTGTG
TGAGTGTGTGAAGCCGCCAGTTCATCTTTTTATATGGGGTTGTTGTCTCATTTTGGTCTGTTTTGGTCCCCTCCCTCGTGGGCTTGTGCT
CGGGATCAAACCTTTCTGGCCTGTTATGATTCTGAACATTTGACTTGAACCACAAGTGAATCTTTCTCCTGGTGACTCAAATAAAAGTAT


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FusionGenePPI for SRCIN1_LASP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SRCIN1BCAR1, CRK, SNAP25, SRC, CSK, SORBS3, SYP, NUFIP1, BCAS4, CKAP5, CDH1LASP1TRIP13, PLSCR1, FHL3, MDFI, ZYX, TERF1, TINF2, ACD, POT1, ATXN1, FN1, DAZAP2, CD81, GOLGA2, PSMA3, REL, TRIM27, TCF4, FXR2, SPRY2, ARHGEF15, ZC2HC1A, THAP1, SEPT3, LZTS2, RHOXF2, KRTAP4-2, ZBTB9, ZDHHC17, CCDC8, ILK, HAX1, DNAAF2, THAP8, FYTTD1, NFYA, OR10H3, RDH12, SLC25A32, SLC25A44, C11orf65, TAS2R41, AHNAK, ARFGAP1, DDB1, EIF4B, HSPB1, HSPE1, LGALS1, MAP4, NXF1, CRK, STAT3, SH2D2A, CEP170, FBF1, SCLT1, DCTN1, U2AF2, CDH1, ZNF764, SNRNP27, PGK1, EZR, SPTAN1, NCL, UHRF1, NAT10, PDIA5, API5, KRT18, KRT2, G3BP2, AP3M1, NCOR2, CDK12, MYO1C, ACTR3, CLTC, DNMT1, EHMT2, SNAI1, HIST1H3A, TRIM25, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSRCIN1chr17:36761937chr17:37070578ENST00000264659-119647_69771184SNAP25


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SRCIN1_LASP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SRCIN1_LASP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLASP1C0004352Autistic Disorder1CTD_human
TgeneLASP1C0036341Schizophrenia1PSYGENET