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Fusion gene ID: 35917 |
FusionGeneSummary for SRCIN1_FNDC8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SRCIN1_FNDC8 | Fusion gene ID: 35917 | Hgene | Tgene | Gene symbol | SRCIN1 | FNDC8 | Gene ID | 80725 | 54752 |
| Gene name | SRC kinase signaling inhibitor 1 | fibronectin type III domain containing 8 | |
| Synonyms | P140|SNIP | - | |
| Cytomap | 17q12 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SRC kinase signaling inhibitor 1P130Cas-associated proteinSNAP-25-interacting proteinSNAP25-interacting proteinp140Cap | fibronectin type III domain-containing protein 8 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9C0H9 | Q8TC99 | |
| Ensembl transtripts involved in fusion gene | ENST00000264659, ENST00000578925, ENST00000398579, | ENST00000158009, | |
| Fusion gene scores | * DoF score | 8 X 7 X 5=280 | 2 X 1 X 2=4 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/280*10)=-2.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: SRCIN1 [Title/Abstract] AND FNDC8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SRCIN1 | GO:0061098 | positive regulation of protein tyrosine kinase activity | 17525734 |
| Hgene | SRCIN1 | GO:0061099 | negative regulation of protein tyrosine kinase activity | 17525734 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E9-A1RF-01A | SRCIN1 | chr17 | 36717699 | - | FNDC8 | chr17 | 33454061 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264659 | ENST00000158009 | SRCIN1 | chr17 | 36717699 | - | FNDC8 | chr17 | 33454061 | + |
| In-frame | ENST00000578925 | ENST00000158009 | SRCIN1 | chr17 | 36717699 | - | FNDC8 | chr17 | 33454061 | + |
| 5UTR-3CDS | ENST00000398579 | ENST00000158009 | SRCIN1 | chr17 | 36717699 | - | FNDC8 | chr17 | 33454061 | + |
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FusionProtFeatures for SRCIN1_FNDC8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SRCIN1 | FNDC8 |
| Acts as a negative regulator of SRC by activating CSKwhich inhibits SRC activity and downstream signaling, leading toimpaired cell spreading and migration. Regulates dendritic spinemorphology. Involved in calcium-dependent exocytosis. May play arole in neurotransmitter release or synapse maintenance.{ECO:0000269|PubMed:14657239, ECO:0000269|PubMed:17525734,ECO:0000269|PubMed:19146815}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SRCIN1 | chr17:36717699 | chr17:33454061 | ENST00000264659 | - | 7 | 19 | 471_504 | 566 | 1184 | Compositional bias | Note=Pro-rich |
| Tgene | >FNDC8 | chr17:36717699 | chr17:33454061 | ENST00000158009 | + | 0 | 4 | 179_280 | 69 | 325 | Domain | Fibronectin type-III |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SRCIN1 | chr17:36717699 | chr17:33454061 | ENST00000264659 | - | 7 | 19 | 654_674 | 566 | 1184 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SRCIN1 | chr17:36717699 | chr17:33454061 | ENST00000264659 | - | 7 | 19 | 726_746 | 566 | 1184 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SRCIN1 | chr17:36717699 | chr17:33454061 | ENST00000264659 | - | 7 | 19 | 956_1014 | 566 | 1184 | Compositional bias | Note=Pro-rich |
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FusionGeneSequence for SRCIN1_FNDC8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SRCIN1_ENST00000264659_chr17_36717699_-_FNDC8_ENST00000158009_chr17_33454061_+_822aa MGNAPSQDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSK YPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSP GVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGS HLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQG VSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDS LYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPP SELFPGPGERSLVGFGPPVPAKDTETRKPLPVEDSDCSSDETSISAFSSTLLNPIKLAVTQPNSSFFAGMLEGELNKLSFSPMAKNAENE DLALGPCPCPSKSQMATRGLLDLDNPELETETSSTHSESSVVVDLPDTPFIFEHTVNNSTAVISWTYALGKQPVSFYQLLLQEVAKTQEN ELPEAKNRPWIFNKILGTTVKLMELKPNTCYCLSVRAANTAGVGKWCKPYKFATLATDFSSFPENYPIQITVRRKEPRQKIVSIGPEEMR >In-frame_SRCIN1_ENST00000578925_chr17_36717699_-_FNDC8_ENST00000158009_chr17_33454061_+_856aa MGNAPSQDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSK YPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAPSGAGQPAQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLET MSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEA RNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPS RSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGD PFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVR QSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRKPLPVEDSDCSSDETSISAFSSTLLNPIK LAVTQPNSSFFAGMLEGELNKLSFSPMAKNAENEDLALGPCPCPSKSQMATRGLLDLDNPELETETSSTHSESSVVVDLPDTPFIFEHTV NNSTAVISWTYALGKQPVSFYQLLLQEVAKTQENELPEAKNRPWIFNKILGTTVKLMELKPNTCYCLSVRAANTAGVGKWCKPYKFATLA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SRCIN1_ENST00000264659_chr17_36717699_-_FNDC8_ENST00000158009_chr17_33454061_+_2466nt ATGGGGAACGCTCCGTCCCAAGATCCGGAGCGGAGCAGCCCCCCCATGCTGTCTGCGGACGATGCGGAGTACCCGCGGGAGTACCGGACC CTGGGGGGCGGGGGCGGCGGGGGCAGCGGGGGCCGGCGCTTCTCCAACGTGGGGCTGGTGCACACGTCCGAGCGGCGGCACACGGTGATC GCGGCCCAGAGTCTGGAGGCGCTCAGCGGGCTCCAGAAGGCGGACGCCGACCGCAAGCGTGATGCCTTCATGGACCACCTGAAGAGCAAG TACCCACAGCACGCCCTGGCCCTGCGAGGCCAGCAGGACAGGATGCGAGAGCAGCCAAACTACTGGAGTTTCAAGACCCGCAGCTCACGC CACACTCAGGGAGCCCAGCCCGGGCTGGCAGACCAGGCGGCAAAGCTGTCCTACGCCTCCGCCGAGTCGCTGGAGACCATGTCGGAGGCC GAGCTGCCCCTGGGCTTCAGCAGGATGAACCGCTTCCGACAGAGCCTGCCTCTCTCCCGCTCGGCCAGCCAGACCAAGCTGCGCTCCCCA GGGGTGCTGTTCCTGCAGTTCGGGGAGGAGACTCGGCGCGTGCACATCACGCACGAGGTCAGCAGCCTGGACACGCTGCACGCACTCATC GCGCACATGTTCCCGCAGAAGCTCACCATGGGCATGCTTAAGTCGCCCAATACCGCCATCCTCATCAAAGACGAGGCTCGCAACGTCTTC TACGAGCTGGAGGACGTCCGGGACATCCAGGACCGCAGTATTATCAAGATCTACAGAAAGGAGCCCCTCTACGCTGCCTTCCCTGGCTCA CATCTCACCAACGGGGACCTCCGGAGAGAGATGGTGTACGCATCGCGGGAGTCCTCGCCCACGCGGCGCCTCAACAACCTGTCACCAGCG CCGCACCTGGCATCCGGCTCGCCGCCGCCCGGGCTGCCGTCGGGGCTGCCGTCCGGGCTGCAGTCCGGTTCGCCGTCGCGTTCGCGCCTA TCGTACGCCGGGGGGCGCCCGCCTTCGTACGCCGGCAGCCCGGTGCACCACGCGGCCGAGAGGCTGGGAGGCGCCCCGGCCGCCCAGGGC GTCAGCCCCAGCCCCAGCGCCATCCTGGAGCGGCGCGACGTGAAGCCGGACGAGGACCTGGCGAGCAAGGCGGGCGGCATGGTGCTGGTG AAAGGCGAGGGCCTCTATGCTGACCCCTACGGGCTGCTGCACGAGGGCCGTCTGAGCCTGGCCGCGGCCGCCGGCGACCCGTTCGCCTAC CCGGGCGCCGGCGGCCTCTACAAGCGCGGCTCGGTGCGCTCGCTCAGCACCTACTCGGCCGCCGCGCTGCAGTCCGATCTGGAGGACTCC CTGTACAAGGCGGCGGGCGGCGGCGGCCCGCTGTACGGCGACGGCTACGGCTTCCGCCTGCCGCCTTCGTCACCGCAGAAGCTGGCCGAC GTGGCAGCACCCCCCGGAGGTCCCCCGCCACCGCACAGCCCCTACTCGGGGCCGCCCAGCCGCGGCTCGCCAGTGCGCCAGTCCTTCCGC AAGGACTCGGGCTCCTCGTCCGTCTTTGCCGAGAGTCCTGGAGGGAAGACCCGCAGCGCGGGGAGCGCCTCGACGGCCGGAGCTCCCCCT TCGGAGCTCTTCCCTGGGCCTGGGGAACGCTCGCTGGTTGGGTTCGGGCCGCCAGTGCCAGCCAAGGACACGGAGACCAGGAAGCCGCTG CCAGTAGAGGATTCAGACTGCAGCTCTGATGAGACCAGCATCTCTGCCTTCTCATCCACCTTGCTGAACCCCATCAAATTAGCTGTGACC CAGCCCAACAGCAGCTTCTTTGCAGGGATGCTGGAGGGGGAGCTGAACAAACTCAGCTTCTCCCCAATGGCCAAGAATGCAGAAAATGAG GACCTGGCGCTCGGCCCCTGCCCATGCCCATCGAAGTCCCAGATGGCCACAAGGGGCCTGCTGGACCTTGACAACCCTGAGCTGGAGACA GAAACCTCCTCAACGCACTCAGAATCTTCTGTGGTTGTGGACCTGCCGGACACCCCCTTCATCTTTGAGCACACCGTCAACAATTCCACA GCTGTGATTTCCTGGACCTACGCCTTGGGCAAGCAGCCGGTCAGTTTCTACCAGCTCCTGTTACAGGAGGTGGCCAAGACACAGGAGAAT GAGTTGCCCGAGGCAAAGAATCGTCCATGGATCTTCAACAAGATTTTGGGCACTACTGTCAAGCTGATGGAGCTAAAGCCTAACACGTGT TACTGCCTCAGTGTCCGTGCAGCCAACACAGCTGGGGTGGGGAAGTGGTGCAAGCCCTACAAATTTGCAACCCTGGCCACTGACTTCAGC AGCTTTCCTGAGAACTACCCCATCCAGATCACCGTGCGGCGCAAGGAACCCCGGCAAAAGATCGTGTCCATCGGGCCGGAGGAGATGCGG >In-frame_SRCIN1_ENST00000578925_chr17_36717699_-_FNDC8_ENST00000158009_chr17_33454061_+_2568nt ATGGGGAACGCTCCGTCCCAAGATCCGGAGCGGAGCAGCCCCCCCATGCTGTCTGCGGACGATGCGGAGTACCCGCGGGAGTACCGGACC CTGGGGGGCGGGGGCGGCGGGGGCAGCGGGGGCCGGCGCTTCTCCAACGTGGGGCTGGTGCACACGTCCGAGCGGCGGCACACGGTGATC GCGGCCCAGAGTCTGGAGGCGCTCAGCGGGCTCCAGAAGGCGGACGCCGACCGCAAGCGTGATGCCTTCATGGACCACCTGAAGAGCAAG TACCCACAGCACGCCCTGGCCCTGCGAGGCCAGCAGGACAGGATGCGAGAGCAGGTTGGCGGCTGGACCGTGGACCCCGTATGCCTCCTC AGCTCCCTCTGCTCCCACCTCCATGGCGACTCCGCCCCCTCCGGGGCTGGCCAGCCGGCCCAGCAGCCAAACTACTGGAGTTTCAAGACC CGCAGCTCACGCCACACTCAGGGAGCCCAGCCCGGGCTGGCAGACCAGGCGGCAAAGCTGTCCTACGCCTCCGCCGAGTCGCTGGAGACC ATGTCGGAGGCCGAGCTGCCCCTGGGCTTCAGCAGGATGAACCGCTTCCGACAGAGCCTGCCTCTCTCCCGCTCGGCCAGCCAGACCAAG CTGCGCTCCCCAGGGGTGCTGTTCCTGCAGTTCGGGGAGGAGACTCGGCGCGTGCACATCACGCACGAGGTCAGCAGCCTGGACACGCTG CACGCACTCATCGCGCACATGTTCCCGCAGAAGCTCACCATGGGCATGCTTAAGTCGCCCAATACCGCCATCCTCATCAAAGACGAGGCT CGCAACGTCTTCTACGAGCTGGAGGACGTCCGGGACATCCAGGACCGCAGTATTATCAAGATCTACAGAAAGGAGCCCCTCTACGCTGCC TTCCCTGGCTCACATCTCACCAACGGGGACCTCCGGAGAGAGATGGTGTACGCATCGCGGGAGTCCTCGCCCACGCGGCGCCTCAACAAC CTGTCACCAGCGCCGCACCTGGCATCCGGCTCGCCGCCGCCCGGGCTGCCGTCGGGGCTGCCGTCCGGGCTGCAGTCCGGTTCGCCGTCG CGTTCGCGCCTATCGTACGCCGGGGGGCGCCCGCCTTCGTACGCCGGCAGCCCGGTGCACCACGCGGCCGAGAGGCTGGGAGGCGCCCCG GCCGCCCAGGGCGTCAGCCCCAGCCCCAGCGCCATCCTGGAGCGGCGCGACGTGAAGCCGGACGAGGACCTGGCGAGCAAGGCGGGCGGC ATGGTGCTGGTGAAAGGCGAGGGCCTCTATGCTGACCCCTACGGGCTGCTGCACGAGGGCCGTCTGAGCCTGGCCGCGGCCGCCGGCGAC CCGTTCGCCTACCCGGGCGCCGGCGGCCTCTACAAGCGCGGCTCGGTGCGCTCGCTCAGCACCTACTCGGCCGCCGCGCTGCAGTCCGAT CTGGAGGACTCCCTGTACAAGGCGGCGGGCGGCGGCGGCCCGCTGTACGGCGACGGCTACGGCTTCCGCCTGCCGCCTTCGTCACCGCAG AAGCTGGCCGACGTGGCAGCACCCCCCGGAGGTCCCCCGCCACCGCACAGCCCCTACTCGGGGCCGCCCAGCCGCGGCTCGCCAGTGCGC CAGTCCTTCCGCAAGGACTCGGGCTCCTCGTCCGTCTTTGCCGAGAGTCCTGGAGGGAAGACCCGCAGCGCGGGGAGCGCCTCGACGGCC GGAGCTCCCCCTTCGGAGCTCTTCCCTGGGCCTGGGGAACGCTCGCTGGTTGGGTTCGGGCCGCCAGTGCCAGCCAAGGACACGGAGACC AGGAAGCCGCTGCCAGTAGAGGATTCAGACTGCAGCTCTGATGAGACCAGCATCTCTGCCTTCTCATCCACCTTGCTGAACCCCATCAAA TTAGCTGTGACCCAGCCCAACAGCAGCTTCTTTGCAGGGATGCTGGAGGGGGAGCTGAACAAACTCAGCTTCTCCCCAATGGCCAAGAAT GCAGAAAATGAGGACCTGGCGCTCGGCCCCTGCCCATGCCCATCGAAGTCCCAGATGGCCACAAGGGGCCTGCTGGACCTTGACAACCCT GAGCTGGAGACAGAAACCTCCTCAACGCACTCAGAATCTTCTGTGGTTGTGGACCTGCCGGACACCCCCTTCATCTTTGAGCACACCGTC AACAATTCCACAGCTGTGATTTCCTGGACCTACGCCTTGGGCAAGCAGCCGGTCAGTTTCTACCAGCTCCTGTTACAGGAGGTGGCCAAG ACACAGGAGAATGAGTTGCCCGAGGCAAAGAATCGTCCATGGATCTTCAACAAGATTTTGGGCACTACTGTCAAGCTGATGGAGCTAAAG CCTAACACGTGTTACTGCCTCAGTGTCCGTGCAGCCAACACAGCTGGGGTGGGGAAGTGGTGCAAGCCCTACAAATTTGCAACCCTGGCC ACTGACTTCAGCAGCTTTCCTGAGAACTACCCCATCCAGATCACCGTGCGGCGCAAGGAACCCCGGCAAAAGATCGTGTCCATCGGGCCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SRCIN1_ENST00000264659_chr17_36717699_-_FNDC8_ENST00000158009_chr17_33454061_+_2989nt ACACTCGCTCTCGCACACTCGGTGACACGCCCGCGCGCGCGCTCACCCACACGCCCGGCCGCCGGCGCCCTCCCAGCTGGTCCACCCCGG CGGGGCCCGCGCCCCCGGCCCGCCCGCCTGGCACCGCGCCCCGGGGCTGGGGCCGAGCGAGGAGCCCGCGAGGCGGCGAGAGGGCGAGCG CCAGGCAGGCCGGCCCGGGGCCCCCGCCCCCCGCGCCCCCGCCCGATGGGGAACGCTCCGTCCCAAGATCCGGAGCGGAGCAGCCCCCCC ATGCTGTCTGCGGACGATGCGGAGTACCCGCGGGAGTACCGGACCCTGGGGGGCGGGGGCGGCGGGGGCAGCGGGGGCCGGCGCTTCTCC AACGTGGGGCTGGTGCACACGTCCGAGCGGCGGCACACGGTGATCGCGGCCCAGAGTCTGGAGGCGCTCAGCGGGCTCCAGAAGGCGGAC GCCGACCGCAAGCGTGATGCCTTCATGGACCACCTGAAGAGCAAGTACCCACAGCACGCCCTGGCCCTGCGAGGCCAGCAGGACAGGATG CGAGAGCAGCCAAACTACTGGAGTTTCAAGACCCGCAGCTCACGCCACACTCAGGGAGCCCAGCCCGGGCTGGCAGACCAGGCGGCAAAG CTGTCCTACGCCTCCGCCGAGTCGCTGGAGACCATGTCGGAGGCCGAGCTGCCCCTGGGCTTCAGCAGGATGAACCGCTTCCGACAGAGC CTGCCTCTCTCCCGCTCGGCCAGCCAGACCAAGCTGCGCTCCCCAGGGGTGCTGTTCCTGCAGTTCGGGGAGGAGACTCGGCGCGTGCAC ATCACGCACGAGGTCAGCAGCCTGGACACGCTGCACGCACTCATCGCGCACATGTTCCCGCAGAAGCTCACCATGGGCATGCTTAAGTCG CCCAATACCGCCATCCTCATCAAAGACGAGGCTCGCAACGTCTTCTACGAGCTGGAGGACGTCCGGGACATCCAGGACCGCAGTATTATC AAGATCTACAGAAAGGAGCCCCTCTACGCTGCCTTCCCTGGCTCACATCTCACCAACGGGGACCTCCGGAGAGAGATGGTGTACGCATCG CGGGAGTCCTCGCCCACGCGGCGCCTCAACAACCTGTCACCAGCGCCGCACCTGGCATCCGGCTCGCCGCCGCCCGGGCTGCCGTCGGGG CTGCCGTCCGGGCTGCAGTCCGGTTCGCCGTCGCGTTCGCGCCTATCGTACGCCGGGGGGCGCCCGCCTTCGTACGCCGGCAGCCCGGTG CACCACGCGGCCGAGAGGCTGGGAGGCGCCCCGGCCGCCCAGGGCGTCAGCCCCAGCCCCAGCGCCATCCTGGAGCGGCGCGACGTGAAG CCGGACGAGGACCTGGCGAGCAAGGCGGGCGGCATGGTGCTGGTGAAAGGCGAGGGCCTCTATGCTGACCCCTACGGGCTGCTGCACGAG GGCCGTCTGAGCCTGGCCGCGGCCGCCGGCGACCCGTTCGCCTACCCGGGCGCCGGCGGCCTCTACAAGCGCGGCTCGGTGCGCTCGCTC AGCACCTACTCGGCCGCCGCGCTGCAGTCCGATCTGGAGGACTCCCTGTACAAGGCGGCGGGCGGCGGCGGCCCGCTGTACGGCGACGGC TACGGCTTCCGCCTGCCGCCTTCGTCACCGCAGAAGCTGGCCGACGTGGCAGCACCCCCCGGAGGTCCCCCGCCACCGCACAGCCCCTAC TCGGGGCCGCCCAGCCGCGGCTCGCCAGTGCGCCAGTCCTTCCGCAAGGACTCGGGCTCCTCGTCCGTCTTTGCCGAGAGTCCTGGAGGG AAGACCCGCAGCGCGGGGAGCGCCTCGACGGCCGGAGCTCCCCCTTCGGAGCTCTTCCCTGGGCCTGGGGAACGCTCGCTGGTTGGGTTC GGGCCGCCAGTGCCAGCCAAGGACACGGAGACCAGGAAGCCGCTGCCAGTAGAGGATTCAGACTGCAGCTCTGATGAGACCAGCATCTCT GCCTTCTCATCCACCTTGCTGAACCCCATCAAATTAGCTGTGACCCAGCCCAACAGCAGCTTCTTTGCAGGGATGCTGGAGGGGGAGCTG AACAAACTCAGCTTCTCCCCAATGGCCAAGAATGCAGAAAATGAGGACCTGGCGCTCGGCCCCTGCCCATGCCCATCGAAGTCCCAGATG GCCACAAGGGGCCTGCTGGACCTTGACAACCCTGAGCTGGAGACAGAAACCTCCTCAACGCACTCAGAATCTTCTGTGGTTGTGGACCTG CCGGACACCCCCTTCATCTTTGAGCACACCGTCAACAATTCCACAGCTGTGATTTCCTGGACCTACGCCTTGGGCAAGCAGCCGGTCAGT TTCTACCAGCTCCTGTTACAGGAGGTGGCCAAGACACAGGAGAATGAGTTGCCCGAGGCAAAGAATCGTCCATGGATCTTCAACAAGATT TTGGGCACTACTGTCAAGCTGATGGAGCTAAAGCCTAACACGTGTTACTGCCTCAGTGTCCGTGCAGCCAACACAGCTGGGGTGGGGAAG TGGTGCAAGCCCTACAAATTTGCAACCCTGGCCACTGACTTCAGCAGCTTTCCTGAGAACTACCCCATCCAGATCACCGTGCGGCGCAAG GAACCCCGGCAAAAGATCGTGTCCATCGGGCCGGAGGAGATGCGGAGGCTGGAGGATCTGGAATACCTATTTCCCTGTTAAGGGGGAGGG CCCCAGGACACCCCTCACCTACTTTCAGCTTCAACCCCAGGCCCTCAGAAACCAGAGCCATGAGACCTACCATACCACCAGCACCCTGCG GGCCCGGGGTCTGGCAGAGTGGTATGGGCACCCCACCCCTGGGCTGGGGCCAAGGCTACATAGGGGCCCCATTCACCTGGAGGCATCTCA GGCCAGGCCATGCCAGGCTCAGCCACTGCCCACAGCTGCTAGACTCCCTCCTCCTCCAAATCTGGGCTGGGTCTAGGTCCCTCATTAAAG >In-frame_SRCIN1_ENST00000578925_chr17_36717699_-_FNDC8_ENST00000158009_chr17_33454061_+_3003nt GGCGGGGCCCGCGCCCCCGGCCCGCCCGCCTGGCACCGCGCCCCGGGGCTGGGGCCGAGCGAGGAGCCCGCGAGGCGGCGAGAGGGCGAG CGCCAGGCAGGCCGGCCCGGGGCCCCCGCCCCCCGCGCCCCCGCCCGATGGGGAACGCTCCGTCCCAAGATCCGGAGCGGAGCAGCCCCC CCATGCTGTCTGCGGACGATGCGGAGTACCCGCGGGAGTACCGGACCCTGGGGGGCGGGGGCGGCGGGGGCAGCGGGGGCCGGCGCTTCT CCAACGTGGGGCTGGTGCACACGTCCGAGCGGCGGCACACGGTGATCGCGGCCCAGAGTCTGGAGGCGCTCAGCGGGCTCCAGAAGGCGG ACGCCGACCGCAAGCGTGATGCCTTCATGGACCACCTGAAGAGCAAGTACCCACAGCACGCCCTGGCCCTGCGAGGCCAGCAGGACAGGA TGCGAGAGCAGGTTGGCGGCTGGACCGTGGACCCCGTATGCCTCCTCAGCTCCCTCTGCTCCCACCTCCATGGCGACTCCGCCCCCTCCG GGGCTGGCCAGCCGGCCCAGCAGCCAAACTACTGGAGTTTCAAGACCCGCAGCTCACGCCACACTCAGGGAGCCCAGCCCGGGCTGGCAG ACCAGGCGGCAAAGCTGTCCTACGCCTCCGCCGAGTCGCTGGAGACCATGTCGGAGGCCGAGCTGCCCCTGGGCTTCAGCAGGATGAACC GCTTCCGACAGAGCCTGCCTCTCTCCCGCTCGGCCAGCCAGACCAAGCTGCGCTCCCCAGGGGTGCTGTTCCTGCAGTTCGGGGAGGAGA CTCGGCGCGTGCACATCACGCACGAGGTCAGCAGCCTGGACACGCTGCACGCACTCATCGCGCACATGTTCCCGCAGAAGCTCACCATGG GCATGCTTAAGTCGCCCAATACCGCCATCCTCATCAAAGACGAGGCTCGCAACGTCTTCTACGAGCTGGAGGACGTCCGGGACATCCAGG ACCGCAGTATTATCAAGATCTACAGAAAGGAGCCCCTCTACGCTGCCTTCCCTGGCTCACATCTCACCAACGGGGACCTCCGGAGAGAGA TGGTGTACGCATCGCGGGAGTCCTCGCCCACGCGGCGCCTCAACAACCTGTCACCAGCGCCGCACCTGGCATCCGGCTCGCCGCCGCCCG GGCTGCCGTCGGGGCTGCCGTCCGGGCTGCAGTCCGGTTCGCCGTCGCGTTCGCGCCTATCGTACGCCGGGGGGCGCCCGCCTTCGTACG CCGGCAGCCCGGTGCACCACGCGGCCGAGAGGCTGGGAGGCGCCCCGGCCGCCCAGGGCGTCAGCCCCAGCCCCAGCGCCATCCTGGAGC GGCGCGACGTGAAGCCGGACGAGGACCTGGCGAGCAAGGCGGGCGGCATGGTGCTGGTGAAAGGCGAGGGCCTCTATGCTGACCCCTACG GGCTGCTGCACGAGGGCCGTCTGAGCCTGGCCGCGGCCGCCGGCGACCCGTTCGCCTACCCGGGCGCCGGCGGCCTCTACAAGCGCGGCT CGGTGCGCTCGCTCAGCACCTACTCGGCCGCCGCGCTGCAGTCCGATCTGGAGGACTCCCTGTACAAGGCGGCGGGCGGCGGCGGCCCGC TGTACGGCGACGGCTACGGCTTCCGCCTGCCGCCTTCGTCACCGCAGAAGCTGGCCGACGTGGCAGCACCCCCCGGAGGTCCCCCGCCAC CGCACAGCCCCTACTCGGGGCCGCCCAGCCGCGGCTCGCCAGTGCGCCAGTCCTTCCGCAAGGACTCGGGCTCCTCGTCCGTCTTTGCCG AGAGTCCTGGAGGGAAGACCCGCAGCGCGGGGAGCGCCTCGACGGCCGGAGCTCCCCCTTCGGAGCTCTTCCCTGGGCCTGGGGAACGCT CGCTGGTTGGGTTCGGGCCGCCAGTGCCAGCCAAGGACACGGAGACCAGGAAGCCGCTGCCAGTAGAGGATTCAGACTGCAGCTCTGATG AGACCAGCATCTCTGCCTTCTCATCCACCTTGCTGAACCCCATCAAATTAGCTGTGACCCAGCCCAACAGCAGCTTCTTTGCAGGGATGC TGGAGGGGGAGCTGAACAAACTCAGCTTCTCCCCAATGGCCAAGAATGCAGAAAATGAGGACCTGGCGCTCGGCCCCTGCCCATGCCCAT CGAAGTCCCAGATGGCCACAAGGGGCCTGCTGGACCTTGACAACCCTGAGCTGGAGACAGAAACCTCCTCAACGCACTCAGAATCTTCTG TGGTTGTGGACCTGCCGGACACCCCCTTCATCTTTGAGCACACCGTCAACAATTCCACAGCTGTGATTTCCTGGACCTACGCCTTGGGCA AGCAGCCGGTCAGTTTCTACCAGCTCCTGTTACAGGAGGTGGCCAAGACACAGGAGAATGAGTTGCCCGAGGCAAAGAATCGTCCATGGA TCTTCAACAAGATTTTGGGCACTACTGTCAAGCTGATGGAGCTAAAGCCTAACACGTGTTACTGCCTCAGTGTCCGTGCAGCCAACACAG CTGGGGTGGGGAAGTGGTGCAAGCCCTACAAATTTGCAACCCTGGCCACTGACTTCAGCAGCTTTCCTGAGAACTACCCCATCCAGATCA CCGTGCGGCGCAAGGAACCCCGGCAAAAGATCGTGTCCATCGGGCCGGAGGAGATGCGGAGGCTGGAGGATCTGGAATACCTATTTCCCT GTTAAGGGGGAGGGCCCCAGGACACCCCTCACCTACTTTCAGCTTCAACCCCAGGCCCTCAGAAACCAGAGCCATGAGACCTACCATACC ACCAGCACCCTGCGGGCCCGGGGTCTGGCAGAGTGGTATGGGCACCCCACCCCTGGGCTGGGGCCAAGGCTACATAGGGGCCCCATTCAC CTGGAGGCATCTCAGGCCAGGCCATGCCAGGCTCAGCCACTGCCCACAGCTGCTAGACTCCCTCCTCCTCCAAATCTGGGCTGGGTCTAG |
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FusionGenePPI for SRCIN1_FNDC8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SRCIN1 | BCAR1, CRK, SNAP25, SRC, CSK, SORBS3, SYP, NUFIP1, BCAS4, CKAP5, CDH1 | FNDC8 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SRCIN1 | chr17:36717699 | chr17:33454061 | ENST00000264659 | - | 7 | 19 | 647_697 | 566 | 1184 | SNAP25 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SRCIN1_FNDC8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SRCIN1_FNDC8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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