![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 359 |
FusionGeneSummary for ACBD3_BOLA2 |
![]() |
Fusion gene information | Fusion gene name: ACBD3_BOLA2 | Fusion gene ID: 359 | Hgene | Tgene | Gene symbol | ACBD3 | BOLA2 | Gene ID | 64746 | 654483 |
Gene name | acyl-CoA binding domain containing 3 | bolA family member 2B | |
Synonyms | GCP60|GOCAP1|GOLPH1|PAP7 | BOLA2 | |
Cytomap | 1q42.12 | 16p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | Golgi resident protein GCP60PBR- and PKA-associated protein 7PKA (RIalpha)-associated proteinacyl-Coenzyme A binding domain containing 3golgi complex associated protein 1, 60kDagolgi phosphoprotein 1peripheral benzodiazepine receptor-associated prot | bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9H3P7 | Q9H3K6 | |
Ensembl transtripts involved in fusion gene | ENST00000366812, ENST00000464927, | ENST00000330978, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 19 X 26 X 1=494 |
# samples | 2 | 28 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(28/494*10)=-0.819084214639711 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACBD3 [Title/Abstract] AND BOLA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BOLA2 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
Tgene | BOLA2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ017904 | ACBD3 | chr1 | 226374170 | + | BOLA2 | chr16 | 30096550 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000366812 | ENST00000330978 | ACBD3 | chr1 | 226374170 | + | BOLA2 | chr16 | 30096550 | + |
intron-intron | ENST00000464927 | ENST00000330978 | ACBD3 | chr1 | 226374170 | + | BOLA2 | chr16 | 30096550 | + |
Top |
FusionProtFeatures for ACBD3_BOLA2 |
![]() |
Hgene | Tgene |
ACBD3 | BOLA2 |
Involved in the maintenance of Golgi structure byinteracting with giantin, affecting protein transport between theendoplasmic reticulum and Golgi (PubMed:11590181). Involved inhormone-induced steroid biosynthesis in testicular Leydig cells(By similarity). Recruits PI4KB to the Golgi apparatus membrane;enhances the enzyme activity of PI4KB activity via its membranerecruitment thereby increasing the local concentration of thesubstrate in the vicinity of the kinase (PubMed:27009356).{ECO:0000250|UniProtKB:Q8BMP6, ECO:0000269|PubMed:11590181,ECO:0000269|PubMed:27009356}. (Microbial infection) Sensitizes PI4KB activation byKobuviral (Aichi) 3A protein. {ECO:0000269|PubMed:27989622}. | Acts as a cytosolic iron-sulfur (Fe-S) cluster assemblyfactor that facilitates [2Fe-2S] cluster insertion into a subsetof cytosolic proteins (PubMed:26613676, PubMed:27519415). Actstogether with the monothiol glutaredoxin GLRX3 (PubMed:26613676,PubMed:27519415). {ECO:0000269|PubMed:26613676,ECO:0000269|PubMed:27519415}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ACBD3_BOLA2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ACBD3_BOLA2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ACBD3_BOLA2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ACBD3_BOLA2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |