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Fusion gene ID: 35881 |
FusionGeneSummary for SPTSSA_SPTSSA |
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Fusion gene information | Fusion gene name: SPTSSA_SPTSSA | Fusion gene ID: 35881 | Hgene | Tgene | Gene symbol | SPTSSA | SPTSSA | Gene ID | 171546 | 171546 |
Gene name | serine palmitoyltransferase small subunit A | serine palmitoyltransferase small subunit A | |
Synonyms | C14orf147|SSSPTA | C14orf147|SSSPTA | |
Cytomap | 14q13.1 | 14q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | serine palmitoyltransferase small subunit Asmall subunit of serine palmitoyltransferase A | serine palmitoyltransferase small subunit Asmall subunit of serine palmitoyltransferase A | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q969W0 | Q969W0 | |
Ensembl transtripts involved in fusion gene | ENST00000298130, | ENST00000298130, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 2 X 4=32 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SPTSSA [Title/Abstract] AND SPTSSA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SPTSSA | GO:0046513 | ceramide biosynthetic process | 25691431 |
Tgene | SPTSSA | GO:0046513 | ceramide biosynthetic process | 25691431 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CD240239 | SPTSSA | chr14 | 34903383 | - | SPTSSA | chr14 | 34903519 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000298130 | ENST00000298130 | SPTSSA | chr14 | 34903383 | - | SPTSSA | chr14 | 34903519 | + |
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FusionProtFeatures for SPTSSA_SPTSSA |
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Hgene | Tgene |
SPTSSA | SPTSSA |
Stimulates the activity of serine palmitoyltransferase(SPT). The composition of the serine palmitoyltransferase (SPT)complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate,while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA.{ECO:0000269|PubMed:19416851}. | Stimulates the activity of serine palmitoyltransferase(SPT). The composition of the serine palmitoyltransferase (SPT)complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate,while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA.{ECO:0000269|PubMed:19416851}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SPTSSA_SPTSSA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SPTSSA_SPTSSA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPTSSA_SPTSSA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPTSSA_SPTSSA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |