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Fusion gene ID: 35868 |
FusionGeneSummary for SPTBN5_MGA |
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Fusion gene information | Fusion gene name: SPTBN5_MGA | Fusion gene ID: 35868 | Hgene | Tgene | Gene symbol | SPTBN5 | MGA | Gene ID | 51332 | 23269 |
Gene name | spectrin beta, non-erythrocytic 5 | MGA, MAX dimerization protein | |
Synonyms | BSPECV|HUBSPECV|HUSPECV | MAD5|MXD5 | |
Cytomap | 15q15.1 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | spectrin beta chain, non-erythrocytic 5beta V spectrinspectrin beta chain, brain 4spectrin, non-erythroid beta chain 4 | MAX gene-associated proteinMAX dimerization protein 5 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9NRC6 | Q8IWI9 | |
Ensembl transtripts involved in fusion gene | ENST00000320955, | ENST00000568630, ENST00000545763, ENST00000389936, ENST00000219905, ENST00000566586, ENST00000570161, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 3=27 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SPTBN5 [Title/Abstract] AND MGA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SPTBN5 | GO:0051260 | protein homooligomerization | 23704327 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-85-8479-01A | SPTBN5 | chr15 | 42153617 | - | MGA | chr15 | 42053937 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000320955 | ENST00000568630 | SPTBN5 | chr15 | 42153617 | - | MGA | chr15 | 42053937 | + |
5CDS-intron | ENST00000320955 | ENST00000545763 | SPTBN5 | chr15 | 42153617 | - | MGA | chr15 | 42053937 | + |
5CDS-intron | ENST00000320955 | ENST00000389936 | SPTBN5 | chr15 | 42153617 | - | MGA | chr15 | 42053937 | + |
5CDS-intron | ENST00000320955 | ENST00000219905 | SPTBN5 | chr15 | 42153617 | - | MGA | chr15 | 42053937 | + |
5CDS-intron | ENST00000320955 | ENST00000566586 | SPTBN5 | chr15 | 42153617 | - | MGA | chr15 | 42053937 | + |
5CDS-intron | ENST00000320955 | ENST00000570161 | SPTBN5 | chr15 | 42153617 | - | MGA | chr15 | 42053937 | + |
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FusionProtFeatures for SPTBN5_MGA |
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Hgene | Tgene |
SPTBN5 | MGA |
Functions as a dual-specificity transcription factor,regulating the expression of both MAX-network and T-box familytarget genes. Functions as a repressor or an activator. Binds to5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulateMYC-MAX target genes. Suppresses transcriptional activation by MYCand inhibits MYC-dependent cell transformation. Function activatedby heterodimerization with MAX. This heterodimerization serves thedual function of both generating an E-box-binding heterodimer andsimultaneously blocking interaction of a corepressor (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SPTBN5_MGA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SPTBN5_MGA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SPTBN5 | SPTAN1, KRAS, FBF1, GAN | MGA | E2F1, E2F3, E2F4, CBX3, MAX, PCGF3, PCGF6, RNF2, CBX2, CBX4, RYBP, YAF2, CD2BP2, SMAD1, LSM8, HIST3H3, OBSL1, EED, PSME3, RFPL4B, E2F6, WBP2NL, WDR5, CARD8, LTBR, PSMC3, MIER2, UNK, NIN, HIST1H3E, HDAC1, ZMYND8, KDM5C, ALKBH3, RC3H1, ATOH1, L3MBTL2, ZNF692, KLHL40, MLX, CDC16, CDH19, ASB6, DYNC1I1, CYLD |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPTBN5_MGA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPTBN5_MGA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MGA | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Tgene | MGA | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
Tgene | MGA | C0079772 | T-Cell Lymphoma | 1 | CTD_human |