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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 35854

FusionGeneSummary for SPTBN1_SPAG5

check button Fusion gene summary
Fusion gene informationFusion gene name: SPTBN1_SPAG5
Fusion gene ID: 35854
HgeneTgene
Gene symbol

SPTBN1

SPAG5

Gene ID

6711

10615

Gene namespectrin beta, non-erythrocytic 1sperm associated antigen 5
SynonymsELF|HEL102|SPTB2|betaSpIIDEEPEST|MAP126|hMAP126
Cytomap

2p16.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionspectrin beta chain, non-erythrocytic 1beta-G spectrinbeta-II spectrinbeta-fodrinbeta-spectrin 2beta-spectrin IIbeta-spectrin non-erythrocytic 1embryonic liver beta-fodrinepididymis luminal protein 102fodrin beta chainspectrin beta chain, brain sperm-associated antigen 5astrinmitotic spindle associated protein p126mitotic spindle coiled-coil related protein
Modification date2018052220180522
UniProtAcc

Q01082

Q96R06

Ensembl transtripts involved in fusion geneENST00000356805, ENST00000333896, 
ENST00000321765, 
Fusion gene scores* DoF score13 X 12 X 5=7804 X 6 X 5=120
# samples 157
** MAII scorelog2(15/780*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPTBN1 [Title/Abstract] AND SPAG5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-VQ-A922-01ASPTBN1chr2

54826380

+SPAG5chr17

26920084

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356805ENST00000321765SPTBN1chr2

54826380

+SPAG5chr17

26920084

-
In-frameENST00000333896ENST00000321765SPTBN1chr2

54826380

+SPAG5chr17

26920084

-

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FusionProtFeatures for SPTBN1_SPAG5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPTBN1

Q01082

SPAG5

Q96R06

Fodrin, which seems to be involved in secretion,interacts with calmodulin in a calcium-dependent manner and isthus candidate for the calcium-dependent movement of thecytoskeleton at the membrane. Essential component of the mitotic spindle required fornormal chromosome segregation and progression into anaphase(PubMed:11724960, PubMed:12356910, PubMed:27462074). Required forchromosome alignment, normal timing of sister chromatidsegregation, and maintenance of spindle pole architecture(PubMed:17664331, PubMed:27462074). In complex with SKAP, promotesstable microtubule-kinetochore attachments. May contribute to theregulation of separase activity. May regulate AURKA localizationto mitotic spindle, but not to centrosomes and CCNB1 localizationto both mitotic spindle and centrosomes (PubMed:18361916,PubMed:21402792). Involved in centriole duplication. Required forCDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization andpromotes the centrosomal localization of CDK2 (PubMed:26297806).In non-mitotic cells, upon stress induction, inhibits mammaliantarget of rapamycin complex 1 (mTORC1) association and recruitsthe mTORC1 component RPTOR to stress granules (SGs), therebypreventing mTORC1 hyperactivation-induced apoptosis(PubMed:23953116). May enhance GSK3B-mediated phosphorylation ofother substrates, such as MAPT/TAU (PubMed:18055457).{ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331,ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916,ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116,ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074,ECO:0000305|PubMed:11724960}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPAG5chr2:54826380chr17:26920084ENST00000321765-124545_608591194Coiled coilOntology_term=ECO:0000255
TgeneSPAG5chr2:54826380chr17:26920084ENST00000321765-124759_868591194Coiled coilOntology_term=ECO:0000255
TgeneSPAG5chr2:54826380chr17:26920084ENST00000321765-124979_1174591194Coiled coilOntology_term=ECO:0000255
TgeneSPAG5chr2:54826380chr17:26920084ENST00000321765-124617_789591194Compositional biasNote=Gln-rich

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231173_278872156DomainCalponin-homology (CH) 2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2312197_2307872156DomainPH
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+23154_158872156DomainCalponin-homology (CH) 1
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336173_2781002365DomainCalponin-homology (CH) 2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3362197_23071002365DomainPH
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+33654_1581002365DomainCalponin-homology (CH) 1
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2312_275872156RegionNote=Actin-binding
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3362_2751002365RegionNote=Actin-binding
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311063_1166872156RepeatSpectrin 8
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311170_1258872156RepeatSpectrin 9
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311276_1376872156RepeatSpectrin 10
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311381_1482872156RepeatSpectrin 11
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311486_1590872156RepeatSpectrin 12
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311592_1696872156RepeatSpectrin 13
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311698_1801872156RepeatSpectrin 14
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311805_1907872156RepeatSpectrin 15
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311914_2014872156RepeatSpectrin 16
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2312018_2097872156RepeatSpectrin 17
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231303_411872156RepeatSpectrin 1
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231423_525872156RepeatSpectrin 2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231530_636872156RepeatSpectrin 3
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231639_742872156RepeatSpectrin 4
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231745_847872156RepeatSpectrin 5
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231850_952872156RepeatSpectrin 6
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231957_1060872156RepeatSpectrin 7
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361063_11661002365RepeatSpectrin 8
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361170_12581002365RepeatSpectrin 9
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361276_13761002365RepeatSpectrin 10
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361381_14821002365RepeatSpectrin 11
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361486_15901002365RepeatSpectrin 12
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361592_16961002365RepeatSpectrin 13
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361698_18011002365RepeatSpectrin 14
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361805_19071002365RepeatSpectrin 15
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361914_20141002365RepeatSpectrin 16
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3362018_20971002365RepeatSpectrin 17
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336303_4111002365RepeatSpectrin 1
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336423_5251002365RepeatSpectrin 2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336530_6361002365RepeatSpectrin 3
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336639_7421002365RepeatSpectrin 4
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336745_8471002365RepeatSpectrin 5
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336850_9521002365RepeatSpectrin 6
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336957_10601002365RepeatSpectrin 7


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FusionGeneSequence for SPTBN1_SPAG5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SPTBN1_ENST00000356805_chr2_54826380_+_SPAG5_ENST00000321765_chr17_26920084_-_1235aa
MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIK
LLEVLSGERLEGSNNSSPVDFVNNKRTDLSSEHFSHSSKWLETCQHESDEQPLDPIPQISSTPKTSEEAVDPLGNYMVKTIVLVPSPLGQ
QQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGDRFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSKESLSSRTEAVR
EDLVPSESNAFLPSSVLWLSPSTALAADFRVNHVDPEEEIVEHGAMEEREMRFPTHPKESETEDQALVSSVEDILSTCLTPNLVEMESQE
APGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLRQSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLVGTK
HSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQ
ARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFC
AHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQE
RDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAA
QWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADN
QEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAF
TRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYK
NEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEM

>In-frame_SPTBN1_ENST00000333896_chr2_54826380_+_SPAG5_ENST00000321765_chr17_26920084_-_1222aa
MELQRTSSISGPLSPAYTGQVPYNYNQLEGRFKQLQDEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLEGS
NNSSPVDFVNNKRTDLSSEHFSHSSKWLETCQHESDEQPLDPIPQISSTPKTSEEAVDPLGNYMVKTIVLVPSPLGQQQDMIFEARLDTM
AETNSISLNGPLRTDDLVREEVAPCMGDRFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSKESLSSRTEAVREDLVPSESNAFLP
SSVLWLSPSTALAADFRVNHVDPEEEIVEHGAMEEREMRFPTHPKESETEDQALVSSVEDILSTCLTPNLVEMESQEAPGPAVEDVGRIL
GSDTESWMSPLAWLEKGVNTSVMLENLRQSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLVGTKHSTSETEQLLCGR
PPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISK
ELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQD
LASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSR
VLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQ
AELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQ
KLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAE
TPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQN
EKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SPTBN1_ENST00000356805_chr2_54826380_+_SPAG5_ENST00000321765_chr17_26920084_-_3705nt
ATGACGACCACAGTAGCCACAGACTATGACAACATTGAGATCCAGCAGCAGTACAGTGATGTCAACAACCGCTGGGATGTCGACGACTGG
GACAATGAGAACAGCTCTGCGCGGCTTTTTGAGCGGTCCCGCATCAAGGCTCTGGCAGATGAGCGTGAAGCCGTGCAGAAGAAGACCTTC
ACCAAGTGGGTCAATTCCCACCTTGCCCGTGTGTCCTGCCGGATCACAGACCTGTACACTGACCTTCGAGATGGACGGATGCTCATCAAG
CTGCTGGAGGTCCTCTCTGGAGAGAGGCTGGAAGGCAGCAACAACTCATCTCCAGTGGATTTTGTAAATAACAAGAGGACAGACTTATCT
TCAGAACATTTCAGTCATTCCTCAAAGTGGCTAGAAACTTGTCAGCATGAATCAGATGAGCAGCCTCTAGATCCAATTCCCCAAATTAGC
TCTACTCCTAAAACGTCTGAGGAAGCAGTAGACCCACTGGGCAATTATATGGTTAAAACCATCGTCCTTGTACCATCTCCACTGGGGCAG
CAACAAGACATGATATTTGAGGCCCGTTTAGATACCATGGCAGAGACAAACAGCATATCTTTAAATGGACCTTTGAGAACAGACGATCTG
GTGAGAGAGGAGGTGGCACCCTGCATGGGAGACAGGTTTTCAGAAGTTGCTGCTGTATCTGAGAAACCTATCTTTCAGGAATCTCCGTCC
CATCTCTTAGAGGAGTCTCCACCAAATCCCTGTTCTGAACAACTACATTGCTCCAAGGAAAGCCTGAGCAGTAGAACTGAGGCTGTGCGT
GAGGACTTAGTACCTTCTGAAAGTAACGCCTTCTTGCCTTCCTCTGTTCTCTGGCTTTCCCCTTCAACTGCCTTGGCAGCAGATTTCCGT
GTCAATCATGTGGACCCAGAGGAGGAAATTGTAGAGCATGGAGCTATGGAGGAAAGAGAAATGAGGTTTCCCACACATCCTAAGGAGTCT
GAAACAGAAGATCAAGCACTTGTCTCAAGTGTGGAAGATATTCTGTCCACATGCCTGACACCAAATCTAGTAGAAATGGAATCCCAAGAA
GCTCCAGGCCCAGCAGTAGAAGATGTTGGTAGGATTCTTGGCTCTGATACAGAGTCTTGGATGTCCCCACTGGCCTGGCTGGAAAAAGGT
GTAAATACCTCCGTCATGCTGGAAAATCTCCGCCAAAGCTTATCCCTTCCCTCGATGCTTCGGGATGCTGCAATTGGCACTACCCCTTTC
TCTACTTGCTCGGTGGGGACTTGGTTTACTCCTTCAGCACCACAGGAAAAGAGTACAAACACATCCCAGACAGGCCTGGTTGGCACCAAG
CACAGTACTTCTGAGACAGAGCAGCTCCTGTGTGGCCGGCCTCCAGATCTGACTGCCTTGTCTCGACATGACTTGGAAGATAACCTGCTG
AGCTCTCTTGTCATTCTGGAGGTTCTCTCCCGCCAGCTTCGGGACTGGAAGAGCCAGCTGGCTGTCCCTCACCCAGAAACCCAGGACAGT
AGCACACAGACTGACACATCTCACAGTGGGATAACTAATAAACTTCAGCATCTTAAGGAGAGCCATGAGATGGGACAGGCCCTACAGCAG
GCCAGAAATGTCATGCAATCATGGGTGCTTATCTCTAAAGAGCTGATATCCTTGCTTCACCTATCCCTGTTGCATTTAGAAGAAGATAAG
ACTACTGTGAGTCAGGAGTCTCGGCGTGCAGAAACATTGGTCTGTTGCTGTTTTGATTTGCTGAAGAAATTGAGGGCAAAGCTCCAGAGC
CTCAAAGCAGAAAGGGAGGAGGCAAGGCACAGAGAGGAAATGGCTCTCAGAGGCAAGGATGCGGCAGAGATAGTGTTGGAGGCTTTCTGT
GCACACGCCAGCCAGCGCATCAGCCAGCTGGAACAGGACCTAGCATCCATGCGGGAATTCAGAGGCCTTCTGAAGGATGCCCAGACCCAA
CTGGTAGGGCTTCATGCCAAGCAAGAAGAGCTGGTTCAGCAGACAGTGAGTCTTACTTCTACCTTGCAACAAGACTGGAGGTCCATGCAA
CTGGATTATACAACATGGACAGCTTTGCTGAGTCGGTCCCGACAACTCACAGAGAAACTCACAGTCAAGAGCCAGCAAGCCCTGCAGGAA
CGTGATGTGGCAATTGAGGAAAAGCAGGAGGTTTCTAGGGTGCTGGAACAAGTCTCTGCCCAGTTAGAGGAGTGCAAAGGCCAAACAGAA
CAACTGGAGTTGGAAAACAGTCGTCTAGCAACAGATCTCCGGGCTCAGTTGCAGATTCTGGCCAACATGGACAGCCAGCTAAAAGAGCTA
CAGAGTCAGCATACCCATTGTGCCCAGGACCTGGCTATGAAGGATGAGTTACTCTGCCAGCTTACCCAGAGCAATGAGGAGCAGGCTGCT
CAATGGCAAAAGGAAGAGATGGCACTAAAACACATGCAGGCAGAACTGCAGCAGCAACAAGCTGTCCTGGCCAAAGAGGTGCGGGACCTG
AAAGAGACCTTGGAGTTTGCAGACCAGGAGAATCAGGTTGCTCACCTGGAGCTGGGTCAGGTTGAGTGTCAATTGAAAACCACACTGGAA
GTGCTCCGGGAGCGCAGCTTGCAGTGTGAGAACCTCAAGGACACTGTAGAGAACCTAACGGCTAAACTGGCCAGCACCATAGCAGATAAC
CAGGAGCAAGATCTGGAGAAAACACGGCAGTACTCTCAAAAGCTAGGGCTGCTGACTGAGCAACTACAGAGCCTGACTCTCTTTCTACAG
ACAAAACTAAAGGAGAAGACTGAACAAGAGACCCTTCTGCTGAGTACAGCCTGTCCTCCCACCCAGGAACACCCTCTGCCTAATGACAGG
ACCTTCCTGGGAAGCATCTTGACAGCAGTGGCAGATGAAGAGCCAGAATCAACTCCTGTGCCCTTGCTTGGAAGTGACAAGAGTGCTTTC
ACCCGAGTAGCATCAATGGTTTCCCTTCAGCCCGCAGAGACCCCAGGCATGGAGGAGAGCCTGGCAGAAATGAGTATTATGACTACTGAG
CTTCAGAGTCTTTGTTCCCTGCTACAAGAGTCTAAAGAAGAAGCCATCAGGACTCTGCAGCGAAAAATTTGTGAGCTGCAAGCTAGGCTG
CAGGCCCAGGAAGAACAGCATCAGGAAGTCCAGAAGGCAAAAGAAGCAGACATAGAGAAGCTGAACCAGGCCTTGTGCTTGCGCTACAAG
AATGAAAAGGAGCTCCAGGAAGTGATACAGCAGCAGAATGAGAAGATCCTAGAACAGATAGACAAGAGTGGCGAGCTCATAAGCCTTAGA
GAGGAGGTGACCCACCTTACCCGCTCACTTCGGCGTGCGGAGACAGAGACCAAAGTGCTCCAGGAGGCCCTGGCAGGCCAGCTGGACTCC
AACTGCCAGCCTATGGCCACCAATTGGATCCAGGAGAAAGTGTGGCTCTCTCAGGAGGTGGACAAACTGAGAGTGATGTTCCTGGAGATG
AAAAATGAGAAGGAAAAACTCATGATCAAGTTCCAGAGCCATAGAAATATCCTAGAGGAGAACCTTCGGCGCTCTGACAAGGAGTTAGAA
AAACTAGATGACATTGTTCAGCATATTTATAAGACCCTGCTCTCTATTCCAGAGGTGGTGAGGGGATGCAAAGAACTACAGGGATTGCTG

>In-frame_SPTBN1_ENST00000333896_chr2_54826380_+_SPAG5_ENST00000321765_chr17_26920084_-_3666nt
ATGGAATTGCAGAGGACGTCTAGTATCTCCGGGCCGCTGTCGCCGGCGTACACGGGGCAGGTGCCTTACAACTACAACCAGCTGGAAGGC
AGATTCAAGCAGCTGCAAGATGAGCGTGAAGCCGTGCAGAAGAAGACCTTCACCAAGTGGGTCAATTCCCACCTTGCCCGTGTGTCCTGC
CGGATCACAGACCTGTACACTGACCTTCGAGATGGACGGATGCTCATCAAGCTGCTGGAGGTCCTCTCTGGAGAGAGGCTGGAAGGCAGC
AACAACTCATCTCCAGTGGATTTTGTAAATAACAAGAGGACAGACTTATCTTCAGAACATTTCAGTCATTCCTCAAAGTGGCTAGAAACT
TGTCAGCATGAATCAGATGAGCAGCCTCTAGATCCAATTCCCCAAATTAGCTCTACTCCTAAAACGTCTGAGGAAGCAGTAGACCCACTG
GGCAATTATATGGTTAAAACCATCGTCCTTGTACCATCTCCACTGGGGCAGCAACAAGACATGATATTTGAGGCCCGTTTAGATACCATG
GCAGAGACAAACAGCATATCTTTAAATGGACCTTTGAGAACAGACGATCTGGTGAGAGAGGAGGTGGCACCCTGCATGGGAGACAGGTTT
TCAGAAGTTGCTGCTGTATCTGAGAAACCTATCTTTCAGGAATCTCCGTCCCATCTCTTAGAGGAGTCTCCACCAAATCCCTGTTCTGAA
CAACTACATTGCTCCAAGGAAAGCCTGAGCAGTAGAACTGAGGCTGTGCGTGAGGACTTAGTACCTTCTGAAAGTAACGCCTTCTTGCCT
TCCTCTGTTCTCTGGCTTTCCCCTTCAACTGCCTTGGCAGCAGATTTCCGTGTCAATCATGTGGACCCAGAGGAGGAAATTGTAGAGCAT
GGAGCTATGGAGGAAAGAGAAATGAGGTTTCCCACACATCCTAAGGAGTCTGAAACAGAAGATCAAGCACTTGTCTCAAGTGTGGAAGAT
ATTCTGTCCACATGCCTGACACCAAATCTAGTAGAAATGGAATCCCAAGAAGCTCCAGGCCCAGCAGTAGAAGATGTTGGTAGGATTCTT
GGCTCTGATACAGAGTCTTGGATGTCCCCACTGGCCTGGCTGGAAAAAGGTGTAAATACCTCCGTCATGCTGGAAAATCTCCGCCAAAGC
TTATCCCTTCCCTCGATGCTTCGGGATGCTGCAATTGGCACTACCCCTTTCTCTACTTGCTCGGTGGGGACTTGGTTTACTCCTTCAGCA
CCACAGGAAAAGAGTACAAACACATCCCAGACAGGCCTGGTTGGCACCAAGCACAGTACTTCTGAGACAGAGCAGCTCCTGTGTGGCCGG
CCTCCAGATCTGACTGCCTTGTCTCGACATGACTTGGAAGATAACCTGCTGAGCTCTCTTGTCATTCTGGAGGTTCTCTCCCGCCAGCTT
CGGGACTGGAAGAGCCAGCTGGCTGTCCCTCACCCAGAAACCCAGGACAGTAGCACACAGACTGACACATCTCACAGTGGGATAACTAAT
AAACTTCAGCATCTTAAGGAGAGCCATGAGATGGGACAGGCCCTACAGCAGGCCAGAAATGTCATGCAATCATGGGTGCTTATCTCTAAA
GAGCTGATATCCTTGCTTCACCTATCCCTGTTGCATTTAGAAGAAGATAAGACTACTGTGAGTCAGGAGTCTCGGCGTGCAGAAACATTG
GTCTGTTGCTGTTTTGATTTGCTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTCAAAGCAGAAAGGGAGGAGGCAAGGCACAGAGAGGAA
ATGGCTCTCAGAGGCAAGGATGCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCACACGCCAGCCAGCGCATCAGCCAGCTGGAACAGGAC
CTAGCATCCATGCGGGAATTCAGAGGCCTTCTGAAGGATGCCCAGACCCAACTGGTAGGGCTTCATGCCAAGCAAGAAGAGCTGGTTCAG
CAGACAGTGAGTCTTACTTCTACCTTGCAACAAGACTGGAGGTCCATGCAACTGGATTATACAACATGGACAGCTTTGCTGAGTCGGTCC
CGACAACTCACAGAGAAACTCACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGTGATGTGGCAATTGAGGAAAAGCAGGAGGTTTCTAGG
GTGCTGGAACAAGTCTCTGCCCAGTTAGAGGAGTGCAAAGGCCAAACAGAACAACTGGAGTTGGAAAACAGTCGTCTAGCAACAGATCTC
CGGGCTCAGTTGCAGATTCTGGCCAACATGGACAGCCAGCTAAAAGAGCTACAGAGTCAGCATACCCATTGTGCCCAGGACCTGGCTATG
AAGGATGAGTTACTCTGCCAGCTTACCCAGAGCAATGAGGAGCAGGCTGCTCAATGGCAAAAGGAAGAGATGGCACTAAAACACATGCAG
GCAGAACTGCAGCAGCAACAAGCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAAGAGACCTTGGAGTTTGCAGACCAGGAGAATCAGGTT
GCTCACCTGGAGCTGGGTCAGGTTGAGTGTCAATTGAAAACCACACTGGAAGTGCTCCGGGAGCGCAGCTTGCAGTGTGAGAACCTCAAG
GACACTGTAGAGAACCTAACGGCTAAACTGGCCAGCACCATAGCAGATAACCAGGAGCAAGATCTGGAGAAAACACGGCAGTACTCTCAA
AAGCTAGGGCTGCTGACTGAGCAACTACAGAGCCTGACTCTCTTTCTACAGACAAAACTAAAGGAGAAGACTGAACAAGAGACCCTTCTG
CTGAGTACAGCCTGTCCTCCCACCCAGGAACACCCTCTGCCTAATGACAGGACCTTCCTGGGAAGCATCTTGACAGCAGTGGCAGATGAA
GAGCCAGAATCAACTCCTGTGCCCTTGCTTGGAAGTGACAAGAGTGCTTTCACCCGAGTAGCATCAATGGTTTCCCTTCAGCCCGCAGAG
ACCCCAGGCATGGAGGAGAGCCTGGCAGAAATGAGTATTATGACTACTGAGCTTCAGAGTCTTTGTTCCCTGCTACAAGAGTCTAAAGAA
GAAGCCATCAGGACTCTGCAGCGAAAAATTTGTGAGCTGCAAGCTAGGCTGCAGGCCCAGGAAGAACAGCATCAGGAAGTCCAGAAGGCA
AAAGAAGCAGACATAGAGAAGCTGAACCAGGCCTTGTGCTTGCGCTACAAGAATGAAAAGGAGCTCCAGGAAGTGATACAGCAGCAGAAT
GAGAAGATCCTAGAACAGATAGACAAGAGTGGCGAGCTCATAAGCCTTAGAGAGGAGGTGACCCACCTTACCCGCTCACTTCGGCGTGCG
GAGACAGAGACCAAAGTGCTCCAGGAGGCCCTGGCAGGCCAGCTGGACTCCAACTGCCAGCCTATGGCCACCAATTGGATCCAGGAGAAA
GTGTGGCTCTCTCAGGAGGTGGACAAACTGAGAGTGATGTTCCTGGAGATGAAAAATGAGAAGGAAAAACTCATGATCAAGTTCCAGAGC
CATAGAAATATCCTAGAGGAGAACCTTCGGCGCTCTGACAAGGAGTTAGAAAAACTAGATGACATTGTTCAGCATATTTATAAGACCCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_SPTBN1_ENST00000356805_chr2_54826380_+_SPAG5_ENST00000321765_chr17_26920084_-_4111nt
GGAATCAGTGCCGCTGTTGCCGTGCAGGCTGCGGATTCCTCCAGTCCCTCCCTCGGCCGCCTCTCCTCCCGGAGCGAGCGCGCAGCCCTG
CGCAGCAGCGCCCACTGGTCCCGTCCTGTGAGCCCCGGCCCCAGCCGCGGACAGACCCGCGGAGTCGCCTCCCGGCCCACCCGCCCGGCC
GCCGAGGAGCGGGAGGAGGACGGGACCCCGGCGCCCCCACCCCATCCCCGGGAGAACTCTAAGAAGGAGCTGATGTGGAGGAGCAGCTGA
GACAGTTCAAGATGACGACCACAGTAGCCACAGACTATGACAACATTGAGATCCAGCAGCAGTACAGTGATGTCAACAACCGCTGGGATG
TCGACGACTGGGACAATGAGAACAGCTCTGCGCGGCTTTTTGAGCGGTCCCGCATCAAGGCTCTGGCAGATGAGCGTGAAGCCGTGCAGA
AGAAGACCTTCACCAAGTGGGTCAATTCCCACCTTGCCCGTGTGTCCTGCCGGATCACAGACCTGTACACTGACCTTCGAGATGGACGGA
TGCTCATCAAGCTGCTGGAGGTCCTCTCTGGAGAGAGGCTGGAAGGCAGCAACAACTCATCTCCAGTGGATTTTGTAAATAACAAGAGGA
CAGACTTATCTTCAGAACATTTCAGTCATTCCTCAAAGTGGCTAGAAACTTGTCAGCATGAATCAGATGAGCAGCCTCTAGATCCAATTC
CCCAAATTAGCTCTACTCCTAAAACGTCTGAGGAAGCAGTAGACCCACTGGGCAATTATATGGTTAAAACCATCGTCCTTGTACCATCTC
CACTGGGGCAGCAACAAGACATGATATTTGAGGCCCGTTTAGATACCATGGCAGAGACAAACAGCATATCTTTAAATGGACCTTTGAGAA
CAGACGATCTGGTGAGAGAGGAGGTGGCACCCTGCATGGGAGACAGGTTTTCAGAAGTTGCTGCTGTATCTGAGAAACCTATCTTTCAGG
AATCTCCGTCCCATCTCTTAGAGGAGTCTCCACCAAATCCCTGTTCTGAACAACTACATTGCTCCAAGGAAAGCCTGAGCAGTAGAACTG
AGGCTGTGCGTGAGGACTTAGTACCTTCTGAAAGTAACGCCTTCTTGCCTTCCTCTGTTCTCTGGCTTTCCCCTTCAACTGCCTTGGCAG
CAGATTTCCGTGTCAATCATGTGGACCCAGAGGAGGAAATTGTAGAGCATGGAGCTATGGAGGAAAGAGAAATGAGGTTTCCCACACATC
CTAAGGAGTCTGAAACAGAAGATCAAGCACTTGTCTCAAGTGTGGAAGATATTCTGTCCACATGCCTGACACCAAATCTAGTAGAAATGG
AATCCCAAGAAGCTCCAGGCCCAGCAGTAGAAGATGTTGGTAGGATTCTTGGCTCTGATACAGAGTCTTGGATGTCCCCACTGGCCTGGC
TGGAAAAAGGTGTAAATACCTCCGTCATGCTGGAAAATCTCCGCCAAAGCTTATCCCTTCCCTCGATGCTTCGGGATGCTGCAATTGGCA
CTACCCCTTTCTCTACTTGCTCGGTGGGGACTTGGTTTACTCCTTCAGCACCACAGGAAAAGAGTACAAACACATCCCAGACAGGCCTGG
TTGGCACCAAGCACAGTACTTCTGAGACAGAGCAGCTCCTGTGTGGCCGGCCTCCAGATCTGACTGCCTTGTCTCGACATGACTTGGAAG
ATAACCTGCTGAGCTCTCTTGTCATTCTGGAGGTTCTCTCCCGCCAGCTTCGGGACTGGAAGAGCCAGCTGGCTGTCCCTCACCCAGAAA
CCCAGGACAGTAGCACACAGACTGACACATCTCACAGTGGGATAACTAATAAACTTCAGCATCTTAAGGAGAGCCATGAGATGGGACAGG
CCCTACAGCAGGCCAGAAATGTCATGCAATCATGGGTGCTTATCTCTAAAGAGCTGATATCCTTGCTTCACCTATCCCTGTTGCATTTAG
AAGAAGATAAGACTACTGTGAGTCAGGAGTCTCGGCGTGCAGAAACATTGGTCTGTTGCTGTTTTGATTTGCTGAAGAAATTGAGGGCAA
AGCTCCAGAGCCTCAAAGCAGAAAGGGAGGAGGCAAGGCACAGAGAGGAAATGGCTCTCAGAGGCAAGGATGCGGCAGAGATAGTGTTGG
AGGCTTTCTGTGCACACGCCAGCCAGCGCATCAGCCAGCTGGAACAGGACCTAGCATCCATGCGGGAATTCAGAGGCCTTCTGAAGGATG
CCCAGACCCAACTGGTAGGGCTTCATGCCAAGCAAGAAGAGCTGGTTCAGCAGACAGTGAGTCTTACTTCTACCTTGCAACAAGACTGGA
GGTCCATGCAACTGGATTATACAACATGGACAGCTTTGCTGAGTCGGTCCCGACAACTCACAGAGAAACTCACAGTCAAGAGCCAGCAAG
CCCTGCAGGAACGTGATGTGGCAATTGAGGAAAAGCAGGAGGTTTCTAGGGTGCTGGAACAAGTCTCTGCCCAGTTAGAGGAGTGCAAAG
GCCAAACAGAACAACTGGAGTTGGAAAACAGTCGTCTAGCAACAGATCTCCGGGCTCAGTTGCAGATTCTGGCCAACATGGACAGCCAGC
TAAAAGAGCTACAGAGTCAGCATACCCATTGTGCCCAGGACCTGGCTATGAAGGATGAGTTACTCTGCCAGCTTACCCAGAGCAATGAGG
AGCAGGCTGCTCAATGGCAAAAGGAAGAGATGGCACTAAAACACATGCAGGCAGAACTGCAGCAGCAACAAGCTGTCCTGGCCAAAGAGG
TGCGGGACCTGAAAGAGACCTTGGAGTTTGCAGACCAGGAGAATCAGGTTGCTCACCTGGAGCTGGGTCAGGTTGAGTGTCAATTGAAAA
CCACACTGGAAGTGCTCCGGGAGCGCAGCTTGCAGTGTGAGAACCTCAAGGACACTGTAGAGAACCTAACGGCTAAACTGGCCAGCACCA
TAGCAGATAACCAGGAGCAAGATCTGGAGAAAACACGGCAGTACTCTCAAAAGCTAGGGCTGCTGACTGAGCAACTACAGAGCCTGACTC
TCTTTCTACAGACAAAACTAAAGGAGAAGACTGAACAAGAGACCCTTCTGCTGAGTACAGCCTGTCCTCCCACCCAGGAACACCCTCTGC
CTAATGACAGGACCTTCCTGGGAAGCATCTTGACAGCAGTGGCAGATGAAGAGCCAGAATCAACTCCTGTGCCCTTGCTTGGAAGTGACA
AGAGTGCTTTCACCCGAGTAGCATCAATGGTTTCCCTTCAGCCCGCAGAGACCCCAGGCATGGAGGAGAGCCTGGCAGAAATGAGTATTA
TGACTACTGAGCTTCAGAGTCTTTGTTCCCTGCTACAAGAGTCTAAAGAAGAAGCCATCAGGACTCTGCAGCGAAAAATTTGTGAGCTGC
AAGCTAGGCTGCAGGCCCAGGAAGAACAGCATCAGGAAGTCCAGAAGGCAAAAGAAGCAGACATAGAGAAGCTGAACCAGGCCTTGTGCT
TGCGCTACAAGAATGAAAAGGAGCTCCAGGAAGTGATACAGCAGCAGAATGAGAAGATCCTAGAACAGATAGACAAGAGTGGCGAGCTCA
TAAGCCTTAGAGAGGAGGTGACCCACCTTACCCGCTCACTTCGGCGTGCGGAGACAGAGACCAAAGTGCTCCAGGAGGCCCTGGCAGGCC
AGCTGGACTCCAACTGCCAGCCTATGGCCACCAATTGGATCCAGGAGAAAGTGTGGCTCTCTCAGGAGGTGGACAAACTGAGAGTGATGT
TCCTGGAGATGAAAAATGAGAAGGAAAAACTCATGATCAAGTTCCAGAGCCATAGAAATATCCTAGAGGAGAACCTTCGGCGCTCTGACA
AGGAGTTAGAAAAACTAGATGACATTGTTCAGCATATTTATAAGACCCTGCTCTCTATTCCAGAGGTGGTGAGGGGATGCAAAGAACTAC
AGGGATTGCTGGAATTTCTGAGCTAAGAAACTGAAAGCCAGAATCTGCTTCACCTCTTTTTACCTGCAATACCCCCTTACCCCAATACCA

>In-frame_SPTBN1_ENST00000333896_chr2_54826380_+_SPAG5_ENST00000321765_chr17_26920084_-_4176nt
GGTGTGCGCGCTGCGCCCGCGAGCTCCCGGGCTCGGCAACCGTGGCATGCTTAGGATTGGCCATATTTAAAAGTTCTGAAGTAGAACCTG
CGCCTCCTCTCTGCTTCTCCCTCCTCCTCAGTAATTTATTTCGAGCTTCCAGGCAAGGGCCACGGAAGAAGGGAAAGCAAGAAATTAGAT
GCCTGTGTGGTAACTCCTCGCGGAGCTAAGGTGGACTCTCTTGCAGCCAACTTCCCATCAGATCACCCTGCTGGACTTGCAGACCGGAAT
GGGGCTCGCCTAAGGAGCCGAGCGCTGCGGAGGCTGCTGCGTGTTGGATGGGAGTGGGAGGGGGCTGGAGCGAGATTTCCAGGGCGCAGT
CCTCCGGGGCGTTACGCCGGGCATAATGGAATTGCAGAGGACGTCTAGTATCTCCGGGCCGCTGTCGCCGGCGTACACGGGGCAGGTGCC
TTACAACTACAACCAGCTGGAAGGCAGATTCAAGCAGCTGCAAGATGAGCGTGAAGCCGTGCAGAAGAAGACCTTCACCAAGTGGGTCAA
TTCCCACCTTGCCCGTGTGTCCTGCCGGATCACAGACCTGTACACTGACCTTCGAGATGGACGGATGCTCATCAAGCTGCTGGAGGTCCT
CTCTGGAGAGAGGCTGGAAGGCAGCAACAACTCATCTCCAGTGGATTTTGTAAATAACAAGAGGACAGACTTATCTTCAGAACATTTCAG
TCATTCCTCAAAGTGGCTAGAAACTTGTCAGCATGAATCAGATGAGCAGCCTCTAGATCCAATTCCCCAAATTAGCTCTACTCCTAAAAC
GTCTGAGGAAGCAGTAGACCCACTGGGCAATTATATGGTTAAAACCATCGTCCTTGTACCATCTCCACTGGGGCAGCAACAAGACATGAT
ATTTGAGGCCCGTTTAGATACCATGGCAGAGACAAACAGCATATCTTTAAATGGACCTTTGAGAACAGACGATCTGGTGAGAGAGGAGGT
GGCACCCTGCATGGGAGACAGGTTTTCAGAAGTTGCTGCTGTATCTGAGAAACCTATCTTTCAGGAATCTCCGTCCCATCTCTTAGAGGA
GTCTCCACCAAATCCCTGTTCTGAACAACTACATTGCTCCAAGGAAAGCCTGAGCAGTAGAACTGAGGCTGTGCGTGAGGACTTAGTACC
TTCTGAAAGTAACGCCTTCTTGCCTTCCTCTGTTCTCTGGCTTTCCCCTTCAACTGCCTTGGCAGCAGATTTCCGTGTCAATCATGTGGA
CCCAGAGGAGGAAATTGTAGAGCATGGAGCTATGGAGGAAAGAGAAATGAGGTTTCCCACACATCCTAAGGAGTCTGAAACAGAAGATCA
AGCACTTGTCTCAAGTGTGGAAGATATTCTGTCCACATGCCTGACACCAAATCTAGTAGAAATGGAATCCCAAGAAGCTCCAGGCCCAGC
AGTAGAAGATGTTGGTAGGATTCTTGGCTCTGATACAGAGTCTTGGATGTCCCCACTGGCCTGGCTGGAAAAAGGTGTAAATACCTCCGT
CATGCTGGAAAATCTCCGCCAAAGCTTATCCCTTCCCTCGATGCTTCGGGATGCTGCAATTGGCACTACCCCTTTCTCTACTTGCTCGGT
GGGGACTTGGTTTACTCCTTCAGCACCACAGGAAAAGAGTACAAACACATCCCAGACAGGCCTGGTTGGCACCAAGCACAGTACTTCTGA
GACAGAGCAGCTCCTGTGTGGCCGGCCTCCAGATCTGACTGCCTTGTCTCGACATGACTTGGAAGATAACCTGCTGAGCTCTCTTGTCAT
TCTGGAGGTTCTCTCCCGCCAGCTTCGGGACTGGAAGAGCCAGCTGGCTGTCCCTCACCCAGAAACCCAGGACAGTAGCACACAGACTGA
CACATCTCACAGTGGGATAACTAATAAACTTCAGCATCTTAAGGAGAGCCATGAGATGGGACAGGCCCTACAGCAGGCCAGAAATGTCAT
GCAATCATGGGTGCTTATCTCTAAAGAGCTGATATCCTTGCTTCACCTATCCCTGTTGCATTTAGAAGAAGATAAGACTACTGTGAGTCA
GGAGTCTCGGCGTGCAGAAACATTGGTCTGTTGCTGTTTTGATTTGCTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTCAAAGCAGAAAG
GGAGGAGGCAAGGCACAGAGAGGAAATGGCTCTCAGAGGCAAGGATGCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCACACGCCAGCCA
GCGCATCAGCCAGCTGGAACAGGACCTAGCATCCATGCGGGAATTCAGAGGCCTTCTGAAGGATGCCCAGACCCAACTGGTAGGGCTTCA
TGCCAAGCAAGAAGAGCTGGTTCAGCAGACAGTGAGTCTTACTTCTACCTTGCAACAAGACTGGAGGTCCATGCAACTGGATTATACAAC
ATGGACAGCTTTGCTGAGTCGGTCCCGACAACTCACAGAGAAACTCACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGTGATGTGGCAAT
TGAGGAAAAGCAGGAGGTTTCTAGGGTGCTGGAACAAGTCTCTGCCCAGTTAGAGGAGTGCAAAGGCCAAACAGAACAACTGGAGTTGGA
AAACAGTCGTCTAGCAACAGATCTCCGGGCTCAGTTGCAGATTCTGGCCAACATGGACAGCCAGCTAAAAGAGCTACAGAGTCAGCATAC
CCATTGTGCCCAGGACCTGGCTATGAAGGATGAGTTACTCTGCCAGCTTACCCAGAGCAATGAGGAGCAGGCTGCTCAATGGCAAAAGGA
AGAGATGGCACTAAAACACATGCAGGCAGAACTGCAGCAGCAACAAGCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAAGAGACCTTGGA
GTTTGCAGACCAGGAGAATCAGGTTGCTCACCTGGAGCTGGGTCAGGTTGAGTGTCAATTGAAAACCACACTGGAAGTGCTCCGGGAGCG
CAGCTTGCAGTGTGAGAACCTCAAGGACACTGTAGAGAACCTAACGGCTAAACTGGCCAGCACCATAGCAGATAACCAGGAGCAAGATCT
GGAGAAAACACGGCAGTACTCTCAAAAGCTAGGGCTGCTGACTGAGCAACTACAGAGCCTGACTCTCTTTCTACAGACAAAACTAAAGGA
GAAGACTGAACAAGAGACCCTTCTGCTGAGTACAGCCTGTCCTCCCACCCAGGAACACCCTCTGCCTAATGACAGGACCTTCCTGGGAAG
CATCTTGACAGCAGTGGCAGATGAAGAGCCAGAATCAACTCCTGTGCCCTTGCTTGGAAGTGACAAGAGTGCTTTCACCCGAGTAGCATC
AATGGTTTCCCTTCAGCCCGCAGAGACCCCAGGCATGGAGGAGAGCCTGGCAGAAATGAGTATTATGACTACTGAGCTTCAGAGTCTTTG
TTCCCTGCTACAAGAGTCTAAAGAAGAAGCCATCAGGACTCTGCAGCGAAAAATTTGTGAGCTGCAAGCTAGGCTGCAGGCCCAGGAAGA
ACAGCATCAGGAAGTCCAGAAGGCAAAAGAAGCAGACATAGAGAAGCTGAACCAGGCCTTGTGCTTGCGCTACAAGAATGAAAAGGAGCT
CCAGGAAGTGATACAGCAGCAGAATGAGAAGATCCTAGAACAGATAGACAAGAGTGGCGAGCTCATAAGCCTTAGAGAGGAGGTGACCCA
CCTTACCCGCTCACTTCGGCGTGCGGAGACAGAGACCAAAGTGCTCCAGGAGGCCCTGGCAGGCCAGCTGGACTCCAACTGCCAGCCTAT
GGCCACCAATTGGATCCAGGAGAAAGTGTGGCTCTCTCAGGAGGTGGACAAACTGAGAGTGATGTTCCTGGAGATGAAAAATGAGAAGGA
AAAACTCATGATCAAGTTCCAGAGCCATAGAAATATCCTAGAGGAGAACCTTCGGCGCTCTGACAAGGAGTTAGAAAAACTAGATGACAT
TGTTCAGCATATTTATAAGACCCTGCTCTCTATTCCAGAGGTGGTGAGGGGATGCAAAGAACTACAGGGATTGCTGGAATTTCTGAGCTA
AGAAACTGAAAGCCAGAATCTGCTTCACCTCTTTTTACCTGCAATACCCCCTTACCCCAATACCAAGACCAACTGGCATAGAGCCAACTG


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FusionGenePPI for SPTBN1_SPAG5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPTBN1EPB41L3, DCTN1, NF2, GRIA2, CTNNA1, SNCA, PJA1, MAPK14, MEF2C, STAT1, PLCB1, PYGO1, PACSIN1, SREBF2, GRB2, PLEKHA5, APC, CEBPA, SRRM2, AGO3, CDC5L, DISC1, CEP63, TRAF3IP1, SH3BP5, TNIK, ARRB2, SIRT7, CUL3, CDK2, CUL1, COPS5, NEDD8, GRK5, CBL, UBASH3B, PIK3R2, SHC1, AP2M1, SPTAN1, RBM8A, NENF, RABL2A, CDH2, DDX19A, SOD1, PSMA7, TXN2, POU2F1, DBN1, PRKCDBP, HSPA5, ESR1, EIF4A3, MAGOH, SMURF1, FN1, SMAD9, ZNF512B, UBL4A, SMAD3, ANK1, TPM1, TGFBR1, SMAD2, SMAD4, MYBL2, SVIL, PAN2, KIAA0101, FBXO6, EIF2B2, MOB4, TNKS1BP1, RPA1, RPA2, RPA3, TUBG1, WEE1, HSPB1, UNK, NCAPD3, MCM5, NXF1, NTRK1, PTEN, EWSR1, HIST1H3E, ADD1, CAPZA2, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, KATNA1, SYNPO, MAPRE1, LIMA1, ANLN, MYO5C, MYO19, MYO18A, SNW1, FBXW7, THAP3, SPTBN1, GLTSCR2, SEPT8, COPB1, ZNF251, STXBP1, GOLGA6L10, EIF3H, CDH1, PDP1, PPM1B, PTP4A2, STYXL1, CYLD, TRIM25, BRCA1, TESSPAG5SNAPIN, CDK1, CEBPD, ATN1, HECW2, ARNT2, FMR1, IQCE, BARD1, DCX, POLR2L, SMARCE1, EIF4E2, FBXO28, ORC6, AMOTL2, CCHCR1, CHCHD3, C1orf109, RBM41, LGALS14, TSHZ3, SH2D4A, TTC23, ZC2HC1C, CCDC33, LINGO1, HAUS1, SNAP47, ZMAT2, CDC20B, ZFC3H1, KANSL1, GOLGA8EP, GOLGA8F, CEP170, SRGAP3, DTNBP1, IFT57, C17orf59, CCDC67, KIAA0753, CCDC14, MED4, RPGRIP1L, OFD1, SPICE1, CEP44, DCTN1, ZNF385C, ZFYVE26, ENKD1, ZGPAT, DYNLL1, MAPRE1, MID1, MID2, NLGN3, RINT1, COPS7B, RIC8A, SYCE3, TSPYL1, CCDC89, MED21, RHPN1, BFSP2, EMILIN1, CCDC22, TSKS, KIAA1467, COG6, PLK1, SLC9C1, TUBA3C, MED1, NEURL4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSPAG5chr2:54826380chr17:26920084ENST00000321765-124482_850591194KNSTRN


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311563_2093872156ANK2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361563_20931002365ANK2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPTBN1_SPAG5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSPTBN1Q01082DB01373CalciumSpectrin beta chain, non-erythrocytic 1small moleculeapproved|nutraceutical

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RelatedDiseases for SPTBN1_SPAG5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPTBN1C0043094Weight Gain1CTD_human
TgeneSPAG5C0000786Spontaneous abortion1CTD_human