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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35837

FusionGeneSummary for SPTAN1_MEST

check button Fusion gene summary
Fusion gene informationFusion gene name: SPTAN1_MEST
Fusion gene ID: 35837
HgeneTgene
Gene symbol

SPTAN1

MEST

Gene ID

6709

4232

Gene namespectrin alpha, non-erythrocytic 1mesoderm specific transcript
SynonymsEIEE5|NEAS|SPTA2PEG1
Cytomap

9q34.11

7q32.2

Type of geneprotein-codingprotein-coding
Descriptionspectrin alpha chain, non-erythrocytic 1alpha-II spectrinalpha-fodrinfodrin alpha chainspectrin, non-erythroid alpha chainspectrin, non-erythroid alpha subunitmesoderm-specific transcript homolog proteinpaternally-expressed gene 1 protein
Modification date2018052920180523
UniProtAcc

Q13813

Q5EB52

Ensembl transtripts involved in fusion geneENST00000358161, ENST00000372739, 
ENST00000372731, ENST00000475367, 
ENST00000341441, ENST00000378576, 
ENST00000416162, ENST00000393187, 
ENST00000223215, ENST00000437945, 
ENST00000462132, 
Fusion gene scores* DoF score17 X 15 X 10=25503 X 3 X 1=9
# samples 213
** MAII scorelog2(21/2550*10)=-3.6020360140801
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SPTAN1 [Title/Abstract] AND MEST [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA368620SPTAN1chr9

131353900

+MESTchr7

130145187

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000358161ENST00000341441SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000358161ENST00000378576SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000358161ENST00000416162SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000358161ENST00000393187SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000358161ENST00000223215SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000358161ENST00000437945SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-intronENST00000358161ENST00000462132SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000372739ENST00000341441SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000372739ENST00000378576SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000372739ENST00000416162SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000372739ENST00000393187SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000372739ENST00000223215SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000372739ENST00000437945SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-intronENST00000372739ENST00000462132SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000372731ENST00000341441SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000372731ENST00000378576SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000372731ENST00000416162SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000372731ENST00000393187SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000372731ENST00000223215SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-3UTRENST00000372731ENST00000437945SPTAN1chr9

131353900

+MESTchr7

130145187

+
5CDS-intronENST00000372731ENST00000462132SPTAN1chr9

131353900

+MESTchr7

130145187

+
intron-3UTRENST00000475367ENST00000341441SPTAN1chr9

131353900

+MESTchr7

130145187

+
intron-3UTRENST00000475367ENST00000378576SPTAN1chr9

131353900

+MESTchr7

130145187

+
intron-3UTRENST00000475367ENST00000416162SPTAN1chr9

131353900

+MESTchr7

130145187

+
intron-3UTRENST00000475367ENST00000393187SPTAN1chr9

131353900

+MESTchr7

130145187

+
intron-3UTRENST00000475367ENST00000223215SPTAN1chr9

131353900

+MESTchr7

130145187

+
intron-3UTRENST00000475367ENST00000437945SPTAN1chr9

131353900

+MESTchr7

130145187

+
intron-intronENST00000475367ENST00000462132SPTAN1chr9

131353900

+MESTchr7

130145187

+

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FusionProtFeatures for SPTAN1_MEST


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPTAN1

Q13813

MEST

Q5EB52


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPTAN1_MEST


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPTAN1_MEST


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPTAN1_MEST


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPTAN1_MEST


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPTAN1C0524851Neurodegenerative Disorders1CTD_human
TgeneMESTC0043094Weight Gain1CTD_human