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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35830

FusionGeneSummary for SPTAN1_CADPS2

check button Fusion gene summary
Fusion gene informationFusion gene name: SPTAN1_CADPS2
Fusion gene ID: 35830
HgeneTgene
Gene symbol

SPTAN1

CADPS2

Gene ID

6709

93664

Gene namespectrin alpha, non-erythrocytic 1calcium dependent secretion activator 2
SynonymsEIEE5|NEAS|SPTA2CAPS2
Cytomap

9q34.11

7q31.32

Type of geneprotein-codingprotein-coding
Descriptionspectrin alpha chain, non-erythrocytic 1alpha-II spectrinalpha-fodrinfodrin alpha chainspectrin, non-erythroid alpha chainspectrin, non-erythroid alpha subunitcalcium-dependent secretion activator 2CAPS-2Ca++-dependent secretion activator 2Ca2+ dependent secretion activator 2Ca2+-dependent activator protein for secretion 2calcium-dependent activator protein for secretion 2
Modification date2018052920180519
UniProtAcc

Q13813

Q86UW7

Ensembl transtripts involved in fusion geneENST00000358161, ENST00000372739, 
ENST00000372731, ENST00000475367, 
ENST00000313070, ENST00000334010, 
ENST00000412584, ENST00000449022, 
ENST00000476131, 
Fusion gene scores* DoF score17 X 15 X 10=25506 X 4 X 3=72
# samples 215
** MAII scorelog2(21/2550*10)=-3.6020360140801
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPTAN1 [Title/Abstract] AND CADPS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-D8-A1JI-01ASPTAN1chr9

131314975

+CADPS2chr7

122377122

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000358161ENST00000313070SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
5UTR-3CDSENST00000358161ENST00000334010SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
5UTR-3CDSENST00000358161ENST00000412584SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
5UTR-3CDSENST00000358161ENST00000449022SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
5UTR-intronENST00000358161ENST00000476131SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
5UTR-3CDSENST00000372739ENST00000313070SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
5UTR-3CDSENST00000372739ENST00000334010SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
5UTR-3CDSENST00000372739ENST00000412584SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
5UTR-3CDSENST00000372739ENST00000449022SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
5UTR-intronENST00000372739ENST00000476131SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
5UTR-3CDSENST00000372731ENST00000313070SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
5UTR-3CDSENST00000372731ENST00000334010SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
5UTR-3CDSENST00000372731ENST00000412584SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
5UTR-3CDSENST00000372731ENST00000449022SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
5UTR-intronENST00000372731ENST00000476131SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
intron-3CDSENST00000475367ENST00000313070SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
intron-3CDSENST00000475367ENST00000334010SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
intron-3CDSENST00000475367ENST00000412584SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
intron-3CDSENST00000475367ENST00000449022SPTAN1chr9

131314975

+CADPS2chr7

122377122

-
intron-intronENST00000475367ENST00000476131SPTAN1chr9

131314975

+CADPS2chr7

122377122

-

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FusionProtFeatures for SPTAN1_CADPS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPTAN1

Q13813

CADPS2

Q86UW7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPTAN1_CADPS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPTAN1_CADPS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPTAN1FANCA, FANCC, FANCG, ERCC4, PTOV1, PIN4, DDX24, TSSC4, DES, ABL1, NEFL, SHANK3, SHANK1, EPB41, SPTB, GRIA2, EPB42, PLEC, VIM, LMNB1, ACTA1, MSN, TAF10, SOS1, STAT1, PLEKHA5, EMD, FANCF, HES1, TERF1, POT1, AGO3, TJP1, DISC1, CEP63, EXOC1, MAPK6, ARRB1, ARRB2, SIRT7, ERG, CUL3, CDK2, CUL1, COPS5, NEDD8, GRK5, CBL, UBASH3B, SHC1, SPTBN1, MYH9, SPTBN2, SARS2, PRKCDBP, PPT2, ILF2, GSPT1, RABL2A, HNRNPR, STRIP1, SFXN3, KIAA0368, MCAT, DNAJA1, HSPA5, HNRNPK, CLPTM1L, MAPRE1, DBN1, ACTA2, NENF, DDX19A, ESR1, EIF4A3, MAGOH, SMURF1, EVL, TES, HSP90AA1, HSP90AB1, MLH1, GRIN1, GRIN2A, GRIN2B, UBL4A, SVIL, PAN2, CAPN1, CASP3, CASP7, MAPK9, SAV1, CRYZ, EHBP1L1, NUP188, PLS1, PPFIA1, PPP4R1, RPS24, FAU, GPHN, PTBP1, RPA3, RPA2, RPA1, ZBTB1, STAU1, CEP57, CEP76, VCP, CANX, DHX9, NCAPD3, NUCB2, PXDN, PXDNL, RPN2, SF3B3, SPTBN5, NTRK1, PDE4D, PTEN, MED4, MED20, EWSR1, HIST1H3E, ADD1, CAPZA2, CENPE, FLNA, GAK, MYH7, MYO1C, PPP1CB, VCL, IQGAP1, PDLIM7, SYNPO, LIMA1, ANLN, MYO5C, MYO19, MYO18A, ZSCAN26, GAN, SNW1, CDC5L, U2AF2, CDH1, PDP1, PPM1B, PTP4A2, STYXL1, SPTBN4, KALRN, KARS, AKIP1, TAF1, ZNF333, FANCD2, CYLD, LASP1, TRIM25, BRCA1CADPS2UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2N, UBE2U, UBE2W, ASB6, ASB12, BZRAP1, SRPK2, C19orf45


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPTAN1_CADPS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCADPS2Q86UW7DB11093Calcium CitrateCalcium-dependent secretion activator 2small moleculeapproved
TgeneCADPS2Q86UW7DB11348Calcium PhosphateCalcium-dependent secretion activator 2small moleculeapproved

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RelatedDiseases for SPTAN1_CADPS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPTAN1C0524851Neurodegenerative Disorders1CTD_human
TgeneCADPS2C0004352Autistic Disorder1CTD_human
TgeneCADPS2C0008370Cholestasis1CTD_human
TgeneCADPS2C0036341Schizophrenia1PSYGENET
TgeneCADPS2C0236969Substance-Related Disorders1CTD_human
TgeneCADPS2C4277682Chemical and Drug Induced Liver Injury1CTD_human