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Fusion gene ID: 35815 |
FusionGeneSummary for SPRY1_SPRY1 |
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Fusion gene information | Fusion gene name: SPRY1_SPRY1 | Fusion gene ID: 35815 | Hgene | Tgene | Gene symbol | SPRY1 | SPRY1 | Gene ID | 10252 | 10252 |
Gene name | sprouty RTK signaling antagonist 1 | sprouty RTK signaling antagonist 1 | |
Synonyms | hSPRY1 | hSPRY1 | |
Cytomap | 4q28.1 | 4q28.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein sprouty homolog 1sprouty homolog 1, antagonist of FGF signalingsprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling)spry-1 | protein sprouty homolog 1sprouty homolog 1, antagonist of FGF signalingsprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling)spry-1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O43609 | O43609 | |
Ensembl transtripts involved in fusion gene | ENST00000339241, ENST00000515726, ENST00000394339, | ENST00000339241, ENST00000515726, ENST00000394339, | |
Fusion gene scores | * DoF score | 1 X 2 X 1=2 | 1 X 2 X 1=2 |
# samples | 2 | 2 | |
** MAII score | log2(2/2*10)=3.32192809488736 | log2(2/2*10)=3.32192809488736 | |
Context | PubMed: SPRY1 [Title/Abstract] AND SPRY1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AU185671 | SPRY1 | chr4 | 124318926 | - | SPRY1 | chr4 | 124324252 | - | ||
ChiTaRS3.1 | AA747227 | SPRY1 | chr4 | 124324749 | + | SPRY1 | chr4 | 124324830 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000339241 | ENST00000339241 | SPRY1 | chr4 | 124318926 | - | SPRY1 | chr4 | 124324252 | - |
intron-intron | ENST00000339241 | ENST00000515726 | SPRY1 | chr4 | 124318926 | - | SPRY1 | chr4 | 124324252 | - |
intron-3UTR | ENST00000339241 | ENST00000394339 | SPRY1 | chr4 | 124318926 | - | SPRY1 | chr4 | 124324252 | - |
3UTR-3UTR | ENST00000515726 | ENST00000339241 | SPRY1 | chr4 | 124318926 | - | SPRY1 | chr4 | 124324252 | - |
3UTR-intron | ENST00000515726 | ENST00000515726 | SPRY1 | chr4 | 124318926 | - | SPRY1 | chr4 | 124324252 | - |
3UTR-3UTR | ENST00000515726 | ENST00000394339 | SPRY1 | chr4 | 124318926 | - | SPRY1 | chr4 | 124324252 | - |
intron-3UTR | ENST00000394339 | ENST00000339241 | SPRY1 | chr4 | 124318926 | - | SPRY1 | chr4 | 124324252 | - |
intron-intron | ENST00000394339 | ENST00000515726 | SPRY1 | chr4 | 124318926 | - | SPRY1 | chr4 | 124324252 | - |
intron-3UTR | ENST00000394339 | ENST00000394339 | SPRY1 | chr4 | 124318926 | - | SPRY1 | chr4 | 124324252 | - |
3UTR-3UTR | ENST00000339241 | ENST00000339241 | SPRY1 | chr4 | 124324749 | + | SPRY1 | chr4 | 124324830 | - |
3UTR-intron | ENST00000339241 | ENST00000515726 | SPRY1 | chr4 | 124324749 | + | SPRY1 | chr4 | 124324830 | - |
3UTR-3UTR | ENST00000339241 | ENST00000394339 | SPRY1 | chr4 | 124324749 | + | SPRY1 | chr4 | 124324830 | - |
intron-3UTR | ENST00000515726 | ENST00000339241 | SPRY1 | chr4 | 124324749 | + | SPRY1 | chr4 | 124324830 | - |
intron-intron | ENST00000515726 | ENST00000515726 | SPRY1 | chr4 | 124324749 | + | SPRY1 | chr4 | 124324830 | - |
intron-3UTR | ENST00000515726 | ENST00000394339 | SPRY1 | chr4 | 124324749 | + | SPRY1 | chr4 | 124324830 | - |
3UTR-3UTR | ENST00000394339 | ENST00000339241 | SPRY1 | chr4 | 124324749 | + | SPRY1 | chr4 | 124324830 | - |
3UTR-intron | ENST00000394339 | ENST00000515726 | SPRY1 | chr4 | 124324749 | + | SPRY1 | chr4 | 124324830 | - |
3UTR-3UTR | ENST00000394339 | ENST00000394339 | SPRY1 | chr4 | 124324749 | + | SPRY1 | chr4 | 124324830 | - |
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FusionProtFeatures for SPRY1_SPRY1 |
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Hgene | Tgene |
SPRY1 | SPRY1 |
May function as an antagonist of fibroblast growthfactor (FGF) pathways and may negatively modulate respiratoryorganogenesis. | May function as an antagonist of fibroblast growthfactor (FGF) pathways and may negatively modulate respiratoryorganogenesis. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SPRY1_SPRY1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SPRY1_SPRY1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPRY1_SPRY1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPRY1_SPRY1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |