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Fusion gene ID: 35798 |
FusionGeneSummary for SPRED1_TMCO5A |
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Fusion gene information | Fusion gene name: SPRED1_TMCO5A | Fusion gene ID: 35798 | Hgene | Tgene | Gene symbol | SPRED1 | TMCO5A | Gene ID | 161742 | 145942 |
Gene name | sprouty related EVH1 domain containing 1 | transmembrane and coiled-coil domains 5A | |
Synonyms | NFLS|PPP1R147|hSpred1|spred-1 | TMCO5 | |
Cytomap | 15q14 | 15q14 | |
Type of gene | protein-coding | protein-coding | |
Description | sprouty-related, EVH1 domain-containing protein 1protein phosphatase 1, regulatory subunit 147suppressor of Ras/MAPK activation | transmembrane and coiled-coil domain-containing protein 5Atesticular tissue protein Li 205transmembrane and coiled-coil domains 5 | |
Modification date | 20180519 | 20180402 | |
UniProtAcc | Q7Z699 | Q8N6Q1 | |
Ensembl transtripts involved in fusion gene | ENST00000299084, ENST00000561205, | ENST00000559502, ENST00000558158, ENST00000540944, ENST00000319669, | |
Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 1 X 1 X 1=1 |
# samples | 9 | 1 | |
** MAII score | log2(9/120*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: SPRED1 [Title/Abstract] AND TMCO5A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SPRED1 | GO:0006469 | negative regulation of protein kinase activity | 18216281 |
Hgene | SPRED1 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-05-4427-01A | SPRED1 | chr15 | 38545418 | + | TMCO5A | chr15 | 38227458 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000299084 | ENST00000559502 | SPRED1 | chr15 | 38545418 | + | TMCO5A | chr15 | 38227458 | + |
5CDS-5UTR | ENST00000299084 | ENST00000558158 | SPRED1 | chr15 | 38545418 | + | TMCO5A | chr15 | 38227458 | + |
5CDS-5UTR | ENST00000299084 | ENST00000540944 | SPRED1 | chr15 | 38545418 | + | TMCO5A | chr15 | 38227458 | + |
5CDS-5UTR | ENST00000299084 | ENST00000319669 | SPRED1 | chr15 | 38545418 | + | TMCO5A | chr15 | 38227458 | + |
3UTR-5UTR | ENST00000561205 | ENST00000559502 | SPRED1 | chr15 | 38545418 | + | TMCO5A | chr15 | 38227458 | + |
3UTR-5UTR | ENST00000561205 | ENST00000558158 | SPRED1 | chr15 | 38545418 | + | TMCO5A | chr15 | 38227458 | + |
3UTR-5UTR | ENST00000561205 | ENST00000540944 | SPRED1 | chr15 | 38545418 | + | TMCO5A | chr15 | 38227458 | + |
3UTR-5UTR | ENST00000561205 | ENST00000319669 | SPRED1 | chr15 | 38545418 | + | TMCO5A | chr15 | 38227458 | + |
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FusionProtFeatures for SPRED1_TMCO5A |
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Hgene | Tgene |
SPRED1 | TMCO5A |
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulateshematopoiesis of bone marrow (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SPRED1_TMCO5A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SPRED1_TMCO5A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SPRED1 | TESK1, OSGEP, FAM118B, TTC19, DNAJB11, CDKN1A, NAGK, RCC1, TSC22D1, PPP1CA, ELAVL1, SUV39H1, ZDHHC17, FBXW7, CDH1, TRIM25 | TMCO5A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPRED1_TMCO5A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPRED1_TMCO5A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SPRED1 | C1969623 | NEUROFIBROMATOSIS, TYPE 1-LIKE SYNDROME | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | SPRED1 | C0027831 | Neurofibromatosis 1 | 1 | CTD_human |
Hgene | SPRED1 | C0221263 | Cafe-au-Lait Spots | 1 | CTD_human |
Hgene | SPRED1 | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |