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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35797

FusionGeneSummary for SPRED1_SPRED1

check button Fusion gene summary
Fusion gene informationFusion gene name: SPRED1_SPRED1
Fusion gene ID: 35797
HgeneTgene
Gene symbol

SPRED1

SPRED1

Gene ID

161742

161742

Gene namesprouty related EVH1 domain containing 1sprouty related EVH1 domain containing 1
SynonymsNFLS|PPP1R147|hSpred1|spred-1NFLS|PPP1R147|hSpred1|spred-1
Cytomap

15q14

15q14

Type of geneprotein-codingprotein-coding
Descriptionsprouty-related, EVH1 domain-containing protein 1protein phosphatase 1, regulatory subunit 147suppressor of Ras/MAPK activationsprouty-related, EVH1 domain-containing protein 1protein phosphatase 1, regulatory subunit 147suppressor of Ras/MAPK activation
Modification date2018051920180519
UniProtAcc

Q7Z699

Q7Z699

Ensembl transtripts involved in fusion geneENST00000299084, ENST00000561205, 
ENST00000299084, ENST00000561205, 
Fusion gene scores* DoF score6 X 4 X 5=1205 X 5 X 2=50
# samples 96
** MAII scorelog2(9/120*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SPRED1 [Title/Abstract] AND SPRED1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPRED1

GO:0006469

negative regulation of protein kinase activity

18216281

HgeneSPRED1

GO:0010923

negative regulation of phosphatase activity

19389623

TgeneSPRED1

GO:0006469

negative regulation of protein kinase activity

18216281

TgeneSPRED1

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW898783SPRED1chr15

38558563

+SPRED1chr15

38551729

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000299084ENST00000299084SPRED1chr15

38558563

+SPRED1chr15

38551729

+
intron-intronENST00000299084ENST00000561205SPRED1chr15

38558563

+SPRED1chr15

38551729

+
intron-intronENST00000561205ENST00000299084SPRED1chr15

38558563

+SPRED1chr15

38551729

+
intron-intronENST00000561205ENST00000561205SPRED1chr15

38558563

+SPRED1chr15

38551729

+

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FusionProtFeatures for SPRED1_SPRED1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPRED1

Q7Z699

SPRED1

Q7Z699

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulateshematopoiesis of bone marrow (By similarity). {ECO:0000250}. Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulateshematopoiesis of bone marrow (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPRED1_SPRED1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPRED1_SPRED1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPRED1_SPRED1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPRED1_SPRED1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPRED1C1969623NEUROFIBROMATOSIS, TYPE 1-LIKE SYNDROME2CTD_human;ORPHANET;UNIPROT
HgeneSPRED1C0027831Neurofibromatosis 11CTD_human
HgeneSPRED1C0221263Cafe-au-Lait Spots1CTD_human
HgeneSPRED1C0497552Congenital neurologic anomalies1CTD_human
TgeneSPRED1C1969623NEUROFIBROMATOSIS, TYPE 1-LIKE SYNDROME2CTD_human;ORPHANET;UNIPROT
TgeneSPRED1C0027831Neurofibromatosis 11CTD_human
TgeneSPRED1C0221263Cafe-au-Lait Spots1CTD_human
TgeneSPRED1C0497552Congenital neurologic anomalies1CTD_human