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Fusion gene ID: 35772 |
FusionGeneSummary for SPP1_TYK2 |
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Fusion gene information | Fusion gene name: SPP1_TYK2 | Fusion gene ID: 35772 | Hgene | Tgene | Gene symbol | SPP1 | TYK2 | Gene ID | 30827 | 7297 |
Gene name | CXXC finger protein 1 | tyrosine kinase 2 | |
Synonyms | 2410002I16Rik|5830420C16Rik|CFP1|CGBP|HsT2645|PCCX1|PHF18|SPP1|ZCGPC1|hCGBP | IMD35|JTK1 | |
Cytomap | 18q21.1 | 19p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | CXXC-type zinc finger protein 1CXXC finger 1 (PHD domain)CpG binding proteinDNA-binding protein with PHD finger and CXXC domainPHD finger and CXXC domain-containing protein 1cpG-binding proteinzinc finger, CpG binding-type containing 1 | non-receptor tyrosine-protein kinase TYK2 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P10451 | P29597 | |
Ensembl transtripts involved in fusion gene | ENST00000237623, ENST00000395080, ENST00000360804, ENST00000509659, | ENST00000264818, ENST00000524462, ENST00000525621, ENST00000529370, ENST00000529422, | |
Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 42 X 7 X 17=4998 |
# samples | 6 | 43 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(43/4998*10)=-3.53894233649724 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SPP1 [Title/Abstract] AND TYK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SPP1 | GO:0006355 | regulation of transcription, DNA-templated | 10688657 |
Hgene | SPP1 | GO:0045893 | positive regulation of transcription, DNA-templated | 10688657 |
Hgene | SPP1 | GO:0051568 | histone H3-K4 methylation | 17355966 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | KIRC | TCGA-AK-3444-01A | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000237623 | ENST00000264818 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
5CDS-intron | ENST00000237623 | ENST00000524462 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
5CDS-intron | ENST00000237623 | ENST00000525621 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
5CDS-intron | ENST00000237623 | ENST00000529370 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
5CDS-intron | ENST00000237623 | ENST00000529422 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000395080 | ENST00000264818 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000395080 | ENST00000524462 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000395080 | ENST00000525621 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000395080 | ENST00000529370 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000395080 | ENST00000529422 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000360804 | ENST00000264818 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000360804 | ENST00000524462 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000360804 | ENST00000525621 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000360804 | ENST00000529370 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000360804 | ENST00000529422 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000509659 | ENST00000264818 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000509659 | ENST00000524462 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000509659 | ENST00000525621 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000509659 | ENST00000529370 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
intron-intron | ENST00000509659 | ENST00000529422 | SPP1 | chr4 | 88904562 | + | TYK2 | chr19 | 10491352 | - |
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FusionProtFeatures for SPP1_TYK2 |
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Hgene | Tgene |
SPP1 | TYK2 |
Probably involved in intracellular signal transductionby being involved in the initiation of type I IFN signaling.Phosphorylates the interferon-alpha/beta receptor alpha chain.{ECO:0000269|PubMed:7526154}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SPP1_TYK2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SPP1_TYK2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SPP1 | SGTA, PDLIM7, CTNNBL1, IGFBP5, UBQLN4, BAG6, RBBP6, EIF3K, C1RL, COMMD1, COPS5, NCSTN, USP42, CISD2, USP8, AFF4, AMOTL2, DCX, EEF1A1, CEP162, MAP1A, MAP1B, MARCKS, NCKAP1, RANBP9, SEC24C, STAU1, TUBB, DNAJB1, TTC1, PRKACB, STK39, GRIPAP1, RAPGEF2, TPT1, TBC1D8, CC2D1B, CMTM3, MRPL23, RPL5, RPL13, RPL15, RPS13, RIMS4, SNAPIN, ATP2A2, CACNG4, CALM1, LRRC4, ATP5F1, CHD1, DNTTIP2, EPAS1, HMGN1, SLC39A6, ZNF638, BRD3, C2orf50, CYB5R3, DSEL, FTH1, HBA2, KCNIP1, MPPED1, PEMT, PLD3, NACA, SSB, TMEM168, TMEM30A, ZNF804A, APOA1, PEPD, PARP1, MEOX2, ITGAV, ITGB1, ITGB5, F2, TRAF3, RSC1A1 | TYK2 | GNB2L1, STAT1, PRMT5, XRCC5, VAV1, IFNAR1, CRKL, JAK1, TYK2, ELP2, IL13RA1, LYN, CBL, PTPN6, PLAUR, IL6ST, FYN, PTPN1, STAM2, GHR, IRS2, DNM2, TK1, SOCS1, KLF10, LNX1, PTAFR, EIF2AK2, HSP90AA1, JAK3, COPS5, FHL3, HNRNPK, TRAF4, KRT40, KHDRBS2, SIVA1, SHMT2, MOV10, NXF1, BAG2, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8, DDX5, HNRNPH1, HSPB1, CEP170B, RAN, RUVBL1, RUVBL2, SLC2A1, TCP1, ALYREF, TRIM28, TUBA4A, WDR20, EFNB2, PIH1D1, TGFBR2, LRRC46, LPAR6, RNF13, ZNF333, MIER2, SIAH2, UBE2L6, LRP8, IFT43, PMEL, TNFRSF19, GMNN, IL4R, TMCO3, GPR156, CDH8, CD79A, TNFRSF13B, HAVCR2, PROSER2, LGALS3BP, C16orf71, MAS1, NLGN3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPP1_TYK2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | TYK2 | P29597 | DB08895 | Tofacitinib | Non-receptor tyrosine-protein kinase TYK2 | small molecule | approved|investigational |
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RelatedDiseases for SPP1_TYK2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SPP1 | C0001418 | Adenocarcinoma | 2 | CTD_human |
Hgene | SPP1 | C0003949 | Asbestosis | 2 | CTD_human |
Hgene | SPP1 | C0006663 | Calcinosis | 2 | CTD_human |
Hgene | SPP1 | C0022650 | Kidney Calculi | 2 | CTD_human |
Hgene | SPP1 | C0024121 | Lung Neoplasms | 2 | CTD_human |
Hgene | SPP1 | C0025500 | Mesothelioma | 2 | CTD_human |
Hgene | SPP1 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Hgene | SPP1 | C2609414 | Acute kidney injury | 2 | CTD_human |
Hgene | SPP1 | C0006118 | Brain Neoplasms | 1 | CTD_human |
Hgene | SPP1 | C0017638 | Glioma | 1 | CTD_human |
Hgene | SPP1 | C0017668 | Focal glomerulosclerosis | 1 | CTD_human |
Hgene | SPP1 | C0018799 | Heart Diseases | 1 | CTD_human |
Hgene | SPP1 | C0018824 | Heart valve disease | 1 | CTD_human |
Hgene | SPP1 | C0020517 | Hypersensitivity | 1 | CTD_human |
Hgene | SPP1 | C0022658 | Kidney Diseases | 1 | CTD_human |
Hgene | SPP1 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | SPP1 | C0023896 | Alcoholic Liver Diseases | 1 | CTD_human |
Hgene | SPP1 | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
Hgene | SPP1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | SPP1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | SPP1 | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Hgene | SPP1 | C0030286 | Pancreatic Diseases | 1 | CTD_human |
Hgene | SPP1 | C0032229 | Pleural Neoplasms | 1 | CTD_human |
Hgene | SPP1 | C0032285 | Pneumonia | 1 | CTD_human |
Hgene | SPP1 | C0033687 | Proteinuria | 1 | CTD_human |
Hgene | SPP1 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
Hgene | SPP1 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Hgene | SPP1 | C0041948 | Uremia | 1 | CTD_human |
Hgene | SPP1 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
Hgene | SPP1 | C0221204 | Lytic lesion | 1 | CTD_human |
Hgene | SPP1 | C0270612 | Leukoencephalopathies | 1 | CTD_human |
Hgene | SPP1 | C0853897 | Diabetic Cardiomyopathies | 1 | CTD_human |
Hgene | SPP1 | C2937358 | Cerebral Hemorrhage | 1 | CTD_human |
Hgene | SPP1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | TYK2 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Tgene | TYK2 | C0010346 | Crohn Disease | 1 | CTD_human |
Tgene | TYK2 | C0023892 | Biliary cirrhosis | 1 | CTD_human |
Tgene | TYK2 | C0026769 | Multiple Sclerosis | 1 | CTD_human |
Tgene | TYK2 | C0033860 | Psoriasis | 1 | CTD_human |
Tgene | TYK2 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | TYK2 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
Tgene | TYK2 | C0344315 | Depressed mood | 1 | PSYGENET |
Tgene | TYK2 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | TYK2 | C1456784 | Paranoia | 1 | CTD_human |