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Fusion gene ID: 35770 |
FusionGeneSummary for SPP1_STAT6 |
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Fusion gene information | Fusion gene name: SPP1_STAT6 | Fusion gene ID: 35770 | Hgene | Tgene | Gene symbol | SPP1 | STAT6 | Gene ID | 30827 | 6778 |
Gene name | CXXC finger protein 1 | signal transducer and activator of transcription 6 | |
Synonyms | 2410002I16Rik|5830420C16Rik|CFP1|CGBP|HsT2645|PCCX1|PHF18|SPP1|ZCGPC1|hCGBP | D12S1644|IL-4-STAT|STAT6B|STAT6C | |
Cytomap | 18q21.1 | 12q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | CXXC-type zinc finger protein 1CXXC finger 1 (PHD domain)CpG binding proteinDNA-binding protein with PHD finger and CXXC domainPHD finger and CXXC domain-containing protein 1cpG-binding proteinzinc finger, CpG binding-type containing 1 | signal transducer and activator of transcription 6STAT, interleukin4-inducedsignal transducer and activator of transcription 6, interleukin-4 inducedtranscription factor IL-4 STAT | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P10451 | P42226 | |
Ensembl transtripts involved in fusion gene | ENST00000237623, ENST00000395080, ENST00000360804, ENST00000509659, | ENST00000300134, ENST00000538913, ENST00000543873, ENST00000556155, ENST00000537215, ENST00000454075, | |
Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 37 X 8 X 15=4440 |
# samples | 6 | 43 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(43/4440*10)=-3.36815111164801 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SPP1 [Title/Abstract] AND STAT6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SPP1 | GO:0006355 | regulation of transcription, DNA-templated | 10688657 |
Hgene | SPP1 | GO:0045893 | positive regulation of transcription, DNA-templated | 10688657 |
Hgene | SPP1 | GO:0051568 | histone H3-K4 methylation | 17355966 |
Tgene | STAT6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8810328 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | KICH | TCGA-KN-8418-01A | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000237623 | ENST00000300134 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
5CDS-intron | ENST00000237623 | ENST00000538913 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
5CDS-intron | ENST00000237623 | ENST00000543873 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
5CDS-intron | ENST00000237623 | ENST00000556155 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
5CDS-intron | ENST00000237623 | ENST00000537215 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
5CDS-intron | ENST00000237623 | ENST00000454075 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000395080 | ENST00000300134 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000395080 | ENST00000538913 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000395080 | ENST00000543873 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000395080 | ENST00000556155 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000395080 | ENST00000537215 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000395080 | ENST00000454075 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000360804 | ENST00000300134 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000360804 | ENST00000538913 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000360804 | ENST00000543873 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000360804 | ENST00000556155 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000360804 | ENST00000537215 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000360804 | ENST00000454075 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000509659 | ENST00000300134 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000509659 | ENST00000538913 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000509659 | ENST00000543873 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000509659 | ENST00000556155 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000509659 | ENST00000537215 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000509659 | ENST00000454075 | SPP1 | chr4 | 88904562 | + | STAT6 | chr12 | 57496773 | - |
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FusionProtFeatures for SPP1_STAT6 |
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Hgene | Tgene |
SPP1 | STAT6 |
Carries out a dual function: signal transduction andactivation of transcription. Involved in IL4/interleukin-4- andIL3/interleukin-3-mediated signaling.{ECO:0000269|PubMed:17210636}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SPP1_STAT6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SPP1_STAT6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SPP1 | SGTA, PDLIM7, CTNNBL1, IGFBP5, UBQLN4, BAG6, RBBP6, EIF3K, C1RL, COMMD1, COPS5, NCSTN, USP42, CISD2, USP8, AFF4, AMOTL2, DCX, EEF1A1, CEP162, MAP1A, MAP1B, MARCKS, NCKAP1, RANBP9, SEC24C, STAU1, TUBB, DNAJB1, TTC1, PRKACB, STK39, GRIPAP1, RAPGEF2, TPT1, TBC1D8, CC2D1B, CMTM3, MRPL23, RPL5, RPL13, RPL15, RPS13, RIMS4, SNAPIN, ATP2A2, CACNG4, CALM1, LRRC4, ATP5F1, CHD1, DNTTIP2, EPAS1, HMGN1, SLC39A6, ZNF638, BRD3, C2orf50, CYB5R3, DSEL, FTH1, HBA2, KCNIP1, MPPED1, PEMT, PLD3, NACA, SSB, TMEM168, TMEM30A, ZNF804A, APOA1, PEPD, PARP1, MEOX2, ITGAV, ITGB1, ITGB5, F2, TRAF3, RSC1A1 | STAT6 | NCOA1, CREBBP, IRF4, EP300, NFKB1, SND1, ANXA2, TP53, STAT3, TRIM24, DAZAP2, CEBPZ, WWP1, RLIM, ANKZF1, ZNF407, ZBTB2, ZNF92, PARP14, NCOA3, NCOA2, JUN, SFPQ, IGHE, FCER2, CEBPE, SSSCA1, SRXN1, PPM1G, RAD23B, SEC24A, NUBP2, AHCYL1, DSTN, IGBP1, SH3BGRL, PSAT1, STAT2, IFNAR1, IL4R, IFNG, JAK1, PTPN2, VKORC1, LITAF, JAK3, TRIM28, RCN3, EEF1A1, API5, EHD1, PDE12, PGGT1B, USP8, PPARG, KDM3A, AACS, GART, TSTA3, KIF22, POLK |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPP1_STAT6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPP1_STAT6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SPP1 | C0001418 | Adenocarcinoma | 2 | CTD_human |
Hgene | SPP1 | C0003949 | Asbestosis | 2 | CTD_human |
Hgene | SPP1 | C0006663 | Calcinosis | 2 | CTD_human |
Hgene | SPP1 | C0022650 | Kidney Calculi | 2 | CTD_human |
Hgene | SPP1 | C0024121 | Lung Neoplasms | 2 | CTD_human |
Hgene | SPP1 | C0025500 | Mesothelioma | 2 | CTD_human |
Hgene | SPP1 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Hgene | SPP1 | C2609414 | Acute kidney injury | 2 | CTD_human |
Hgene | SPP1 | C0006118 | Brain Neoplasms | 1 | CTD_human |
Hgene | SPP1 | C0017638 | Glioma | 1 | CTD_human |
Hgene | SPP1 | C0017668 | Focal glomerulosclerosis | 1 | CTD_human |
Hgene | SPP1 | C0018799 | Heart Diseases | 1 | CTD_human |
Hgene | SPP1 | C0018824 | Heart valve disease | 1 | CTD_human |
Hgene | SPP1 | C0020517 | Hypersensitivity | 1 | CTD_human |
Hgene | SPP1 | C0022658 | Kidney Diseases | 1 | CTD_human |
Hgene | SPP1 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | SPP1 | C0023896 | Alcoholic Liver Diseases | 1 | CTD_human |
Hgene | SPP1 | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
Hgene | SPP1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | SPP1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | SPP1 | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Hgene | SPP1 | C0030286 | Pancreatic Diseases | 1 | CTD_human |
Hgene | SPP1 | C0032229 | Pleural Neoplasms | 1 | CTD_human |
Hgene | SPP1 | C0032285 | Pneumonia | 1 | CTD_human |
Hgene | SPP1 | C0033687 | Proteinuria | 1 | CTD_human |
Hgene | SPP1 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
Hgene | SPP1 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Hgene | SPP1 | C0041948 | Uremia | 1 | CTD_human |
Hgene | SPP1 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
Hgene | SPP1 | C0221204 | Lytic lesion | 1 | CTD_human |
Hgene | SPP1 | C0270612 | Leukoencephalopathies | 1 | CTD_human |
Hgene | SPP1 | C0853897 | Diabetic Cardiomyopathies | 1 | CTD_human |
Hgene | SPP1 | C2937358 | Cerebral Hemorrhage | 1 | CTD_human |
Hgene | SPP1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | STAT6 | C1266119 | Solitary fibrous tumor | 2 | CTD_human |
Tgene | STAT6 | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
Tgene | STAT6 | C0013604 | Edema | 1 | CTD_human |
Tgene | STAT6 | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |