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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35767

FusionGeneSummary for SPP1_ANXA2

check button Fusion gene summary
Fusion gene informationFusion gene name: SPP1_ANXA2
Fusion gene ID: 35767
HgeneTgene
Gene symbol

SPP1

ANXA2

Gene ID

30827

302

Gene nameCXXC finger protein 1annexin A2
Synonyms2410002I16Rik|5830420C16Rik|CFP1|CGBP|HsT2645|PCCX1|PHF18|SPP1|ZCGPC1|hCGBPANX2|ANX2L4|CAL1H|HEL-S-270|LIP2|LPC2|LPC2D|P36|PAP-IV
Cytomap

18q21.1

15q22.2

Type of geneprotein-codingprotein-coding
DescriptionCXXC-type zinc finger protein 1CXXC finger 1 (PHD domain)CpG binding proteinDNA-binding protein with PHD finger and CXXC domainPHD finger and CXXC domain-containing protein 1cpG-binding proteinzinc finger, CpG binding-type containing 1annexin A2annexin IIannexin-2calpactin I heavy chaincalpactin I heavy polypeptidecalpactin-1 heavy chainchromobindin 8epididymis secretory protein Li 270lipocortin IIplacental anticoagulant protein IVprotein I
Modification date2018052320180522
UniProtAcc

P10451

P07355

Ensembl transtripts involved in fusion geneENST00000237623, ENST00000395080, 
ENST00000360804, ENST00000509659, 
ENST00000396024, ENST00000451270, 
ENST00000332680, ENST00000421017, 
ENST00000557937, 
Fusion gene scores* DoF score6 X 4 X 5=1206 X 6 X 2=72
# samples 67
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPP1 [Title/Abstract] AND ANXA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPP1

GO:0006355

regulation of transcription, DNA-templated

10688657

HgeneSPP1

GO:0045893

positive regulation of transcription, DNA-templated

10688657

HgeneSPP1

GO:0051568

histone H3-K4 methylation

17355966

TgeneANXA2

GO:0001921

positive regulation of receptor recycling

22848640

TgeneANXA2

GO:0031340

positive regulation of vesicle fusion

2138016

TgeneANXA2

GO:0032804

negative regulation of low-density lipoprotein particle receptor catabolic process

22848640

TgeneANXA2

GO:0036035

osteoclast development

7961821

TgeneANXA2

GO:0051290

protein heterotetramerization

23091277|23861394

TgeneANXA2

GO:1905581

positive regulation of low-density lipoprotein particle clearance

22848640

TgeneANXA2

GO:1905597

positive regulation of low-density lipoprotein particle receptor binding

22848640

TgeneANXA2

GO:1905602

positive regulation of receptor-mediated endocytosis involved in cholesterol transport

22848640


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ314733SPP1chr4

88904055

+ANXA2chr15

60658036

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000237623ENST00000396024SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000237623ENST00000451270SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000237623ENST00000332680SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000237623ENST00000421017SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000237623ENST00000557937SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000395080ENST00000396024SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000395080ENST00000451270SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000395080ENST00000332680SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000395080ENST00000421017SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000395080ENST00000557937SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000360804ENST00000396024SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000360804ENST00000451270SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000360804ENST00000332680SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000360804ENST00000421017SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000360804ENST00000557937SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000509659ENST00000396024SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000509659ENST00000451270SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000509659ENST00000332680SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000509659ENST00000421017SPP1chr4

88904055

+ANXA2chr15

60658036

-
3UTR-intronENST00000509659ENST00000557937SPP1chr4

88904055

+ANXA2chr15

60658036

-

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FusionProtFeatures for SPP1_ANXA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPP1

P10451

ANXA2

P07355

Calcium-regulated membrane-binding protein whoseaffinity for calcium is greatly enhanced by anionic phospholipids.It binds two calcium ions with high affinity. May be involved inheat-stress response. Inhibits PCSK9-enhanced LDLR degradation,probably reduces PCSK9 protein levels via a translationalmechanism but also competes with LDLR for binding with PCSK9(PubMed:18799458, PubMed:24808179, PubMed:22848640).{ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640,ECO:0000269|PubMed:24808179}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPP1_ANXA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPP1_ANXA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPP1_ANXA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneANXA2P07355DB00031TenecteplaseAnnexin A2biotechapproved
TgeneANXA2P07355DB11638ArtenimolAnnexin A2small moleculeapproved|investigational

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RelatedDiseases for SPP1_ANXA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPP1C0001418Adenocarcinoma2CTD_human
HgeneSPP1C0003949Asbestosis2CTD_human
HgeneSPP1C0006663Calcinosis2CTD_human
HgeneSPP1C0022650Kidney Calculi2CTD_human
HgeneSPP1C0024121Lung Neoplasms2CTD_human
HgeneSPP1C0025500Mesothelioma2CTD_human
HgeneSPP1C1458155Mammary Neoplasms2CTD_human
HgeneSPP1C2609414Acute kidney injury2CTD_human
HgeneSPP1C0006118Brain Neoplasms1CTD_human
HgeneSPP1C0017638Glioma1CTD_human
HgeneSPP1C0017668Focal glomerulosclerosis1CTD_human
HgeneSPP1C0018799Heart Diseases1CTD_human
HgeneSPP1C0018824Heart valve disease1CTD_human
HgeneSPP1C0020517Hypersensitivity1CTD_human
HgeneSPP1C0022658Kidney Diseases1CTD_human
HgeneSPP1C0023890Liver Cirrhosis1CTD_human
HgeneSPP1C0023896Alcoholic Liver Diseases1CTD_human
HgeneSPP1C0023904Liver Neoplasms, Experimental1CTD_human
HgeneSPP1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneSPP1C0027627Neoplasm Metastasis1CTD_human
HgeneSPP1C0027659Neoplasms, Experimental1CTD_human
HgeneSPP1C0030286Pancreatic Diseases1CTD_human
HgeneSPP1C0032229Pleural Neoplasms1CTD_human
HgeneSPP1C0032285Pneumonia1CTD_human
HgeneSPP1C0033687Proteinuria1CTD_human
HgeneSPP1C0034069Pulmonary Fibrosis1CTD_human
HgeneSPP1C0041755Adverse reaction to drug1CTD_human
HgeneSPP1C0041948Uremia1CTD_human
HgeneSPP1C0162820Dermatitis, Allergic Contact1CTD_human
HgeneSPP1C0221204Lytic lesion1CTD_human
HgeneSPP1C0270612Leukoencephalopathies1CTD_human
HgeneSPP1C0853897Diabetic Cardiomyopathies1CTD_human
HgeneSPP1C2937358Cerebral Hemorrhage1CTD_human
HgeneSPP1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneANXA2C0007137Squamous cell carcinoma1CTD_human
TgeneANXA2C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneANXA2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneANXA2C0023903Liver neoplasms1CTD_human
TgeneANXA2C0024121Lung Neoplasms1CTD_human
TgeneANXA2C0024667Animal Mammary Neoplasms1CTD_human
TgeneANXA2C0026640Mouth Neoplasms1CTD_human
TgeneANXA2C0027626Neoplasm Invasiveness1CTD_human
TgeneANXA2C0029456Osteoporosis1CTD_human
TgeneANXA2C0043094Weight Gain1CTD_human
TgeneANXA2C0345967Malignant mesothelioma1CTD_human
TgeneANXA2C4277682Chemical and Drug Induced Liver Injury1CTD_human