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Fusion gene ID: 35762 |
FusionGeneSummary for SPOP_TAOK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPOP_TAOK1 | Fusion gene ID: 35762 | Hgene | Tgene | Gene symbol | SPOP | TAOK1 | Gene ID | 8405 | 57551 |
| Gene name | speckle type BTB/POZ protein | TAO kinase 1 | |
| Synonyms | BTBD32|TEF2 | KFC-B|MAP3K16|MARKK|PSK-2|PSK2|TAO1|hKFC-B|hTAOK1 | |
| Cytomap | 17q21.33 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | speckle-type POZ proteinHIB homolog 1roadkill homolog 1 | serine/threonine-protein kinase TAO1MARK KinaseSTE20-like kinase PSK2kinase from chicken homolog Bmicrotubule affinity regulating kinase kinaseprostate-derived STE20-like kinase 2prostate-derived sterile 20-like kinase 2serine/threonine protein kin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O43791 | Q7L7X3 | |
| Ensembl transtripts involved in fusion gene | ENST00000393328, ENST00000393331, ENST00000347630, ENST00000504102, ENST00000503676, ENST00000513080, | ENST00000261716, ENST00000536202, | |
| Fusion gene scores | * DoF score | 20 X 8 X 13=2080 | 7 X 7 X 3=147 |
| # samples | 22 | 8 | |
| ** MAII score | log2(22/2080*10)=-3.24100809950379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SPOP [Title/Abstract] AND TAOK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TAOK1 | GO:0006974 | cellular response to DNA damage stimulus | 17396146 |
| Tgene | TAOK1 | GO:0046330 | positive regulation of JNK cascade | 16407310 |
| Tgene | TAOK1 | GO:0097194 | execution phase of apoptosis | 16407310 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A14V-01A | SPOP | chr17 | 47679227 | - | TAOK1 | chr17 | 27869579 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000393328 | ENST00000261716 | SPOP | chr17 | 47679227 | - | TAOK1 | chr17 | 27869579 | + |
| Frame-shift | ENST00000393328 | ENST00000536202 | SPOP | chr17 | 47679227 | - | TAOK1 | chr17 | 27869579 | + |
| Frame-shift | ENST00000393331 | ENST00000261716 | SPOP | chr17 | 47679227 | - | TAOK1 | chr17 | 27869579 | + |
| In-frame | ENST00000393331 | ENST00000536202 | SPOP | chr17 | 47679227 | - | TAOK1 | chr17 | 27869579 | + |
| Frame-shift | ENST00000347630 | ENST00000261716 | SPOP | chr17 | 47679227 | - | TAOK1 | chr17 | 27869579 | + |
| In-frame | ENST00000347630 | ENST00000536202 | SPOP | chr17 | 47679227 | - | TAOK1 | chr17 | 27869579 | + |
| Frame-shift | ENST00000504102 | ENST00000261716 | SPOP | chr17 | 47679227 | - | TAOK1 | chr17 | 27869579 | + |
| In-frame | ENST00000504102 | ENST00000536202 | SPOP | chr17 | 47679227 | - | TAOK1 | chr17 | 27869579 | + |
| In-frame | ENST00000503676 | ENST00000261716 | SPOP | chr17 | 47679227 | - | TAOK1 | chr17 | 27869579 | + |
| Frame-shift | ENST00000503676 | ENST00000536202 | SPOP | chr17 | 47679227 | - | TAOK1 | chr17 | 27869579 | + |
| intron-3CDS | ENST00000513080 | ENST00000261716 | SPOP | chr17 | 47679227 | - | TAOK1 | chr17 | 27869579 | + |
| intron-3CDS | ENST00000513080 | ENST00000536202 | SPOP | chr17 | 47679227 | - | TAOK1 | chr17 | 27869579 | + |
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FusionProtFeatures for SPOP_TAOK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPOP | TAOK1 |
| Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3ubiquitin-protein ligase complex that mediates the ubiquitinationof target proteins, leading most often to their proteasomaldegradation. In complex with CUL3, involved in ubiquitination andproteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3.In complex with CUL3, involved in ubiquitination of H2AFY andBMI1; this does not lead to their proteasomal degradation.Inhibits transcriptional activation of PDX1/IPF1 targets, such asinsulin, by promoting PDX1/IPF1 degradation. The cullin-RING-basedBCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containinghomodimeric SPOP has higher ubiquitin ligase activity than thecomplex that contains the heterodimer formed by SPOP and SPOPL.{ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469,ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708,ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832}. | Serine/threonine-protein kinase involved in variousprocesses such as p38/MAPK14 stress-activated MAPK cascade, DNAdamage response and regulation of cytoskeleton stability.Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator ofthe p38/MAPK14 stress-activated MAPK cascade by mediatingphosphorylation and subsequent activation of the upstream MAP2K3and MAP2K6 kinases. Involved in G-protein coupled receptorsignaling to p38/MAPK14. In response to DNA damage, involved inthe G2/M transition DNA damage checkpoint by activating thep38/MAPK14 stress-activated MAPK cascade, probably by mediatingphosphorylation of MAP2K3 and MAP2K6. Acts as a regulator ofcytoskeleton stability by phosphorylating 'Thr-208' of MARK2,leading to activate MARK2 kinase activity and subsequentphosphorylation and detachment of MAPT/TAU from microtubules. Alsoacts as a regulator of apoptosis: regulates apoptoticmorphological changes, including cell contraction, membraneblebbing and apoptotic bodies formation via activation of theMAPK8/JNK cascade. {ECO:0000269|PubMed:12665513,ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310,ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000347630 | - | 10 | 11 | 173_297 | 326 | 375 | Domain | BTB |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000347630 | - | 10 | 11 | 31_161 | 326 | 375 | Domain | MATH |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000393328 | - | 10 | 11 | 173_297 | 326 | 375 | Domain | BTB |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000393328 | - | 10 | 11 | 31_161 | 326 | 375 | Domain | MATH |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000393331 | - | 11 | 12 | 173_297 | 326 | 375 | Domain | BTB |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000393331 | - | 11 | 12 | 31_161 | 326 | 375 | Domain | MATH |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000503676 | - | 10 | 11 | 173_297 | 326 | 375 | Domain | BTB |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000503676 | - | 10 | 11 | 31_161 | 326 | 375 | Domain | MATH |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000504102 | - | 9 | 10 | 173_297 | 326 | 375 | Domain | BTB |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000504102 | - | 9 | 10 | 31_161 | 326 | 375 | Domain | MATH |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000347630 | - | 10 | 11 | 123_133 | 326 | 375 | Region | Note=Important for binding substrate proteins |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000347630 | - | 10 | 11 | 186_217 | 326 | 375 | Region | Note=Important for homodimerization |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000347630 | - | 10 | 11 | 71_191 | 326 | 375 | Region | Note=Required for nuclear localization |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000393328 | - | 10 | 11 | 123_133 | 326 | 375 | Region | Note=Important for binding substrate proteins |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000393328 | - | 10 | 11 | 186_217 | 326 | 375 | Region | Note=Important for homodimerization |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000393328 | - | 10 | 11 | 71_191 | 326 | 375 | Region | Note=Required for nuclear localization |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000393331 | - | 11 | 12 | 123_133 | 326 | 375 | Region | Note=Important for binding substrate proteins |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000393331 | - | 11 | 12 | 186_217 | 326 | 375 | Region | Note=Important for homodimerization |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000393331 | - | 11 | 12 | 71_191 | 326 | 375 | Region | Note=Required for nuclear localization |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000503676 | - | 10 | 11 | 123_133 | 326 | 375 | Region | Note=Important for binding substrate proteins |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000503676 | - | 10 | 11 | 186_217 | 326 | 375 | Region | Note=Important for homodimerization |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000503676 | - | 10 | 11 | 71_191 | 326 | 375 | Region | Note=Required for nuclear localization |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000504102 | - | 9 | 10 | 123_133 | 326 | 375 | Region | Note=Important for binding substrate proteins |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000504102 | - | 9 | 10 | 186_217 | 326 | 375 | Region | Note=Important for homodimerization |
| Hgene | SPOP | chr17:47679227 | chr17:27869579 | ENST00000504102 | - | 9 | 10 | 71_191 | 326 | 375 | Region | Note=Required for nuclear localization |
| Tgene | >TAOK1 | chr17:47679227 | chr17:27869579 | ENST00000536202 | + | 16 | 18 | 754_877 | 700 | 854 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SPOP | chr17:47679227 | chr17:27869579 | ENST00000347630 | - | 10 | 11 | 297_355 | 326 | 375 | Region | Note=Important for homodimerization |
| Hgene | >SPOP | chr17:47679227 | chr17:27869579 | ENST00000393328 | - | 10 | 11 | 297_355 | 326 | 375 | Region | Note=Important for homodimerization |
| Hgene | >SPOP | chr17:47679227 | chr17:27869579 | ENST00000393331 | - | 11 | 12 | 297_355 | 326 | 375 | Region | Note=Important for homodimerization |
| Hgene | >SPOP | chr17:47679227 | chr17:27869579 | ENST00000503676 | - | 10 | 11 | 297_355 | 326 | 375 | Region | Note=Important for homodimerization |
| Hgene | >SPOP | chr17:47679227 | chr17:27869579 | ENST00000504102 | - | 9 | 10 | 297_355 | 326 | 375 | Region | Note=Important for homodimerization |
| Tgene | TAOK1 | chr17:47679227 | chr17:27869579 | ENST00000261716 | + | 18 | 20 | 458_651 | 848 | 1002 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | TAOK1 | chr17:47679227 | chr17:27869579 | ENST00000261716 | + | 18 | 20 | 754_877 | 848 | 1002 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | TAOK1 | chr17:47679227 | chr17:27869579 | ENST00000536202 | + | 16 | 18 | 458_651 | 700 | 854 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | TAOK1 | chr17:47679227 | chr17:27869579 | ENST00000261716 | + | 18 | 20 | 330_334 | 848 | 1002 | Compositional bias | Note=Poly-Glu |
| Tgene | TAOK1 | chr17:47679227 | chr17:27869579 | ENST00000261716 | + | 18 | 20 | 347_379 | 848 | 1002 | Compositional bias | Note=Ser-rich |
| Tgene | TAOK1 | chr17:47679227 | chr17:27869579 | ENST00000536202 | + | 16 | 18 | 330_334 | 700 | 854 | Compositional bias | Note=Poly-Glu |
| Tgene | TAOK1 | chr17:47679227 | chr17:27869579 | ENST00000536202 | + | 16 | 18 | 347_379 | 700 | 854 | Compositional bias | Note=Ser-rich |
| Tgene | TAOK1 | chr17:47679227 | chr17:27869579 | ENST00000261716 | + | 18 | 20 | 28_281 | 848 | 1002 | Domain | Protein kinase |
| Tgene | TAOK1 | chr17:47679227 | chr17:27869579 | ENST00000536202 | + | 16 | 18 | 28_281 | 700 | 854 | Domain | Protein kinase |
| Tgene | TAOK1 | chr17:47679227 | chr17:27869579 | ENST00000261716 | + | 18 | 20 | 34_42 | 848 | 1002 | Nucleotide binding | ATP |
| Tgene | TAOK1 | chr17:47679227 | chr17:27869579 | ENST00000536202 | + | 16 | 18 | 34_42 | 700 | 854 | Nucleotide binding | ATP |
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FusionGeneSequence for SPOP_TAOK1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SPOP_ENST00000393328_chr17_47679227_-_TAOK1_ENST00000261716_chr17_27869579_+_154aa IEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQ >In-frame_SPOP_ENST00000393331_chr17_47679227_-_TAOK1_ENST00000536202_chr17_27869579_+_154aa IEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQ >In-frame_SPOP_ENST00000347630_chr17_47679227_-_TAOK1_ENST00000536202_chr17_27869579_+_154aa IEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQ >In-frame_SPOP_ENST00000504102_chr17_47679227_-_TAOK1_ENST00000536202_chr17_27869579_+_154aa IEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQ >In-frame_SPOP_ENST00000503676_chr17_47679227_-_TAOK1_ENST00000261716_chr17_27869579_+_154aa IEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SPOP_ENST00000393328_chr17_47679227_-_TAOK1_ENST00000261716_chr17_27869579_+_462nt ATTGAAGAAGAGATGTTGGCTTTGCAGAATGAGCGCACAGAACGAATACGAAGCCTGTTGGAACGTCAAGCCAGAGAGATTGAAGCTTTT GACTCTGAAAGCATGAGACTAGGTTTTAGTAATATGGTCCTTTCTAATCTCTCCCCTGAGGCATTCAGCCACAGCTACCCGGGAGCTTCT GGTTGGTCACACAACCCTACTGGGGGTCCAGGACCTCACTGGGGTCATCCCATGGGTGGCCCACCACAAGCTTGGGGCCATCCAATGCAA GGTGGACCCCAGCCATGGGGTCACCCTTCAGGGCCAATGCAAGGGGTACCTCGAGGTAGCAGTATGGGAGTCCGCAATAGCCCCCAGGCT CTGAGGCGGACAGCTTCTGGGGGACGGACGGAGCAGGGCATGAGCAGAAGCACGAGTGTCACTTCACAAATATCCAATGGGTCACACATG >In-frame_SPOP_ENST00000393331_chr17_47679227_-_TAOK1_ENST00000536202_chr17_27869579_+_462nt ATTGAAGAAGAGATGTTGGCTTTGCAGAATGAGCGCACAGAACGAATACGAAGCCTGTTGGAACGTCAAGCCAGAGAGATTGAAGCTTTT GACTCTGAAAGCATGAGACTAGGTTTTAGTAATATGGTCCTTTCTAATCTCTCCCCTGAGGCATTCAGCCACAGCTACCCGGGAGCTTCT GGTTGGTCACACAACCCTACTGGGGGTCCAGGACCTCACTGGGGTCATCCCATGGGTGGCCCACCACAAGCTTGGGGCCATCCAATGCAA GGTGGACCCCAGCCATGGGGTCACCCTTCAGGGCCAATGCAAGGGGTACCTCGAGGTAGCAGTATGGGAGTCCGCAATAGCCCCCAGGCT CTGAGGCGGACAGCTTCTGGGGGACGGACGGAGCAGGGCATGAGCAGAAGCACGAGTGTCACTTCACAAATATCCAATGGGTCACACATG >In-frame_SPOP_ENST00000347630_chr17_47679227_-_TAOK1_ENST00000536202_chr17_27869579_+_462nt ATTGAAGAAGAGATGTTGGCTTTGCAGAATGAGCGCACAGAACGAATACGAAGCCTGTTGGAACGTCAAGCCAGAGAGATTGAAGCTTTT GACTCTGAAAGCATGAGACTAGGTTTTAGTAATATGGTCCTTTCTAATCTCTCCCCTGAGGCATTCAGCCACAGCTACCCGGGAGCTTCT GGTTGGTCACACAACCCTACTGGGGGTCCAGGACCTCACTGGGGTCATCCCATGGGTGGCCCACCACAAGCTTGGGGCCATCCAATGCAA GGTGGACCCCAGCCATGGGGTCACCCTTCAGGGCCAATGCAAGGGGTACCTCGAGGTAGCAGTATGGGAGTCCGCAATAGCCCCCAGGCT CTGAGGCGGACAGCTTCTGGGGGACGGACGGAGCAGGGCATGAGCAGAAGCACGAGTGTCACTTCACAAATATCCAATGGGTCACACATG >In-frame_SPOP_ENST00000504102_chr17_47679227_-_TAOK1_ENST00000536202_chr17_27869579_+_462nt ATTGAAGAAGAGATGTTGGCTTTGCAGAATGAGCGCACAGAACGAATACGAAGCCTGTTGGAACGTCAAGCCAGAGAGATTGAAGCTTTT GACTCTGAAAGCATGAGACTAGGTTTTAGTAATATGGTCCTTTCTAATCTCTCCCCTGAGGCATTCAGCCACAGCTACCCGGGAGCTTCT GGTTGGTCACACAACCCTACTGGGGGTCCAGGACCTCACTGGGGTCATCCCATGGGTGGCCCACCACAAGCTTGGGGCCATCCAATGCAA GGTGGACCCCAGCCATGGGGTCACCCTTCAGGGCCAATGCAAGGGGTACCTCGAGGTAGCAGTATGGGAGTCCGCAATAGCCCCCAGGCT CTGAGGCGGACAGCTTCTGGGGGACGGACGGAGCAGGGCATGAGCAGAAGCACGAGTGTCACTTCACAAATATCCAATGGGTCACACATG >In-frame_SPOP_ENST00000503676_chr17_47679227_-_TAOK1_ENST00000261716_chr17_27869579_+_462nt ATTGAAGAAGAGATGTTGGCTTTGCAGAATGAGCGCACAGAACGAATACGAAGCCTGTTGGAACGTCAAGCCAGAGAGATTGAAGCTTTT GACTCTGAAAGCATGAGACTAGGTTTTAGTAATATGGTCCTTTCTAATCTCTCCCCTGAGGCATTCAGCCACAGCTACCCGGGAGCTTCT GGTTGGTCACACAACCCTACTGGGGGTCCAGGACCTCACTGGGGTCATCCCATGGGTGGCCCACCACAAGCTTGGGGCCATCCAATGCAA GGTGGACCCCAGCCATGGGGTCACCCTTCAGGGCCAATGCAAGGGGTACCTCGAGGTAGCAGTATGGGAGTCCGCAATAGCCCCCAGGCT CTGAGGCGGACAGCTTCTGGGGGACGGACGGAGCAGGGCATGAGCAGAAGCACGAGTGTCACTTCACAAATATCCAATGGGTCACACATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SPOP_ENST00000393328_chr17_47679227_-_TAOK1_ENST00000261716_chr17_27869579_+_10690nt GTGCTGACGCCATGACGCCCCGGCTGGTGTGTGTCGGTGTGTATGTGTGTGTGTGAGTGTGCGCGCTCCGAGTGTGTGTGTATTTGTGTA TCGGCGGTCCCGCAGGTCCCGGATGTTGCGGACAGTATGAGGCAAGCGCAGGGGGACGGGGACCAGCAGCTGTCGCCGCCGCTCTCAGAT CGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCCACCTTTGCCTCCTGGGTTCAAGCGATTCTTCTG CCTCAGCCTCCCGAGTAGCTGGGATTACAGGGTGAAGAGGGAACAGAAATCTTTGCCCCCTGACTTTGGAAATCTCGTTTAACCTTCAAA CTGGCGATGTCAAGGGTTCCAAGTCCTCCACCTCCGGCAGAAATGTCGAGTGGCCCCGTAGCTGAGAGTTGGTGCTACACACAGATCAAG GTAGTGAAATTCTCCTACATGTGGACCATCAATAACTTTAGCTTTTGCCGGGAGGAAATGGGTGAAGTCATTAAAAGTTCTACATTTTCA TCAGGAGCAAATGATAAACTGAAATGGTGTTTGCGAGTAAACCCCAAAGGGTTAGATGAAGAAAGCAAAGATTACCTGTCACTTTACCTG TTACTGGTCAGCTGTCCAAAGAGTGAAGTTCGGGCAAAATTCAAATTCTCCATCCTGAATGCCAAGGGAGAAGAAACCAAAGCTATGGAG AGTCAACGGGCATATAGGTTTGTGCAAGGCAAAGACTGGGGATTCAAGAAATTCATCCGTAGAGATTTTCTTTTGGATGAGGCCAACGGG CTTCTCCCTGATGACAAGCTTACCCTCTTCTGCGAGGTGAGTGTTGTGCAAGATTCTGTCAACATTTCTGGCCAGAATACCATGAACATG GTAAAGGTTCCTGAGTGCCGGCTGGCAGATGAGTTAGGAGGACTGTGGGAGAATTCCCGGTTCACAGACTGCTGCTTGTGTGTTGCCGGC CAGGAATTCCAGGCTCACAAGGCTATCTTAGCAGCTCGTTCTCCGGTTTTTAGTGCCATGTTTGAACATGAAATGGAGGAGAGCAAAAAG AATCGAGTTGAAATCAATGATGTGGAGCCTGAAGTTTTTAAGGAAATGATGTGCTTCATTTACACGGGGAAGGCTCCAAACCTCGACAAA ATGGCTGATGATTTGCTGGCAGCTGCTGACAAGTATGCCCTGGAGCGCTTAAAGGTCATGTGTGAGGATGCCCTCTGCAGTAACCTGTCC GTGGAGAACGCTGCAGAAATTCTCATCCTGGCCGACCTCCACAGTGCAGATCAGTTGAAAACTCAGGCAGTGGATTTCATCAACTAATTG AAGAAGAGATGTTGGCTTTGCAGAATGAGCGCACAGAACGAATACGAAGCCTGTTGGAACGTCAAGCCAGAGAGATTGAAGCTTTTGACT CTGAAAGCATGAGACTAGGTTTTAGTAATATGGTCCTTTCTAATCTCTCCCCTGAGGCATTCAGCCACAGCTACCCGGGAGCTTCTGGTT GGTCACACAACCCTACTGGGGGTCCAGGACCTCACTGGGGTCATCCCATGGGTGGCCCACCACAAGCTTGGGGCCATCCAATGCAAGGTG GACCCCAGCCATGGGGTCACCCTTCAGGGCCAATGCAAGGGGTACCTCGAGGTAGCAGTATGGGAGTCCGCAATAGCCCCCAGGCTCTGA GGCGGACAGCTTCTGGGGGACGGACGGAGCAGGGCATGAGCAGAAGCACGAGTGTCACTTCACAAATATCCAATGGGTCACACATGTCTT ATACATAACTTAATAATTGAGAGTGGCAATTCCGCTGGAGCTGTCTGCCAAAAGAAACTGCCTACAGACATCATCACAGCAGCCTCCTCA CTTGGGTACTACAGTGTGGAAGCTGAGTGCATATGGTATATTTTATTCATTTTTGTAAAGCGTTCTGTTTTGTGTTTACTAATTGGGATG TCATAGTACTTGGCTGCCGGGTTTGTTTGTTTTTGGGGAAATTTTGAAAAGTGGAGTTGATATTAAAAATAAATGTGTATGTGTGTACAT ATATATACACACACATACACATATATTATGCATGTGGTGAAAAGAATTGGCTAGATAGGGGATTTTTCTGAACACTGCAAAAATAGAACG TAGCAAAATGGCTTCAGTTATCACTTTTGGGTGTCTGTATCCTAAGAAGTTTCTGAAAAGATCTAAAGCCTTTTTATCCCATATCCCAAA TTCTTATGAGCCACTCACAGCAGGCAGCATATGTTGAAATAAGTTATTACTGGTACACACCTGCATTGCCTCACCAGTGTATTTATTTGT TATTAAATTGATCTGACTTCTCAGCCTCATTTGGACTAAAAAAAGAAAGCAGAAATCCATGAACACATTGCTTCTCGGCCTTTTGGCTAA GATCAAGTGTAGAAATCCATGAACACTAAAGGACTTCATTGATTTTTTCAGAGAGTAGAAAACAACTTAGTTTTTCTTTTTTCCTGAATG CGTCATAGGCTTGTGAGTGATTTTTGTCCATTCAATTGTGCCTTCTTTGTATTATGATAAGATGGGGGTACTTAAGGAGATCACAAGTTG TGTGAGGATTGCATTAACAAACCTATGAGCCTTCAATGGGGAAGACCAGAAGGGTGAGAGGGGCCCTGAAAGTTCATATGGTGGGTATGT CCCGCAGCAGAGTGAGGAGATGAAGCTTACGTGTCCTGACGTTTTGTTGCTTATACTGTGATATCTCATCCTAGCTAAGCTCTATAATGC CCAAGACCCCAAACAGTACTTTTACTTTGTTTGTACAAAAACAAAGACATATAGCCAATACAAATCAAATGCCGGAGGTGTTTGATGCCA TATTTGCAAATTGCCATCTATTGAAATTCTCGTCACACTACATAGACATAATTGTTATCTCCTTTTGGCTTATGTGATTTTCTGTTTACA AGTAGAATAGCCAATTATTTAAATGTTTAGTTGCCACAGTGAACCAGGAGTCACTGAGCCAATGACTTTACCAGCTGCTGACTAATCTTC ATCACCACTGTAGATTTTGCTGCATGTGCAGGTCCTCTATTTTTAATTGCTGTTTTCGTTGCTGCAGTACTTTACAAACTTCTAGTTCGT TGAGACTTAGTGACCATTTGGCATCAAGTTAACATCACACAATAGGAAACACCACTTCCACAAGTCTCAAGCCTCAGTGCTAAAGTACTA CTGAAAAGGAACTAGGAAGTTTGGCCAATTAAAAAAAAAAAGTAAAATAAGTTATAGTGGTCAGGGAATCTCTTGACGAAAGCTAACTCT TATTTTTCAGGGGGCACATGTTTTGTTTTGTTATGTTTTGTTGTACAATGAAGGATGAACCCAATGCTAAAAAGTCAGTTATTTTCTTGG TTTTCCATTTCTTGTATATAAATTGTGTTGGAGGTGGGTAGGAAGCTGTGAGTATGACTTGAAGAAAAATATCCTTTTCAGTGACAAATC AGAGTTTCTTACAAGTTATTGTCCTGCTCCCTTCCAAGTTGTCTTGAAGAATCCTTGCTGCTAACTCTGGATCCTGCTTTTCCTATAGTC AGAGGGCTCCAAGGTAGAACTCTCTAAGTCCCTCTCAATGGCACTCTTTGCCTAGACCAAACTAATGACCAAACAGTAATCAATCTATCA CTGTTGAAGTCCTGGTTTTCTCAACCAAATTTTAAGTCTTTCCCAGGTATGTCAGTCGAGTTGCCATGAATCCTCACCTGTAGGAGTTTC TGGGATTCATTTTAAGGAAACTGGAAGAAAATTAATGTTTTAATGTAAATGTTTTTAAAACCAAGATCACCATAGAGTTCACACAAAATT TTAGGCAGTGTTTCAAGAAGCACTCTTATGTGTTGTTCTTTCAGCCCATGCTCCAGGTCACCGGTTTTTAGGTAAACATGACATGACATG TACTTGTAATATCAGTGAAAGGGGCTTTTAGTCGTCTCAGTATCTTTTTTGCATTCAGGTATTATAGCGTTTCCAACAAATTGAGAAATT ACTTATTTGGTGTAAAATGACGAGAGAGCTTTAGAATTTAATAAAATGTCAAAAATACAATTTGATACCCTTAAAAATTATTCATAGATC TGGCTGCTCTGTACTACTGGATGGGTGGAATAGGGAAGCAGATCACTTTTGCATACAAAAACTCTTTCAAACCCAAAATATTATTGGTGG TACATTTTAAAGTCCAATTGTGGACTTAAATTAGTCAAATTGAGAGTTACTGAGTCCATTCAGATCTCCAGTAGGGTTTTGTATCTAATG TATTTGGCCACCAGTTTTACATGTAGGTCATGACTATACCTGGATTTTATCATTAAGTTAACTTTAAAGTATATACAGTTTGCAAAAAAT GATTCAAATTAATTGGTTTGTATATGTTTGTGAGATCTAGCTTCTGAGGAATCTCATACATAGTAGGAACCATCATAGAGTAAAGCTTGT AGCAGAAAAATTGGAAGGGTTTTGAGATATCCTAGAGAAAGAGCAAGCACTTTCTGAATCAGTGGGGAAATATCAATATTTGATCAAATT AACACTACCTCCTTCCCAGTGTTGGTGTTCACTCACTATATGTCTTTAAGAAAATTAAAACTATGGAAAATTTGTCTAGCATATCAGAAG TTGTAAATGCTATATCTGGTATCCAGAGGCTGGCTGTAAAAAGTTCCTTGGGGTCACTCTATCTCACATTTTTTTTGGTTAGCATTTTAA AAATGCAAAGCCACATACTTTGAAATATATTATTCCAAATTGAGCTCCCTTCCCTTTGCACATATTTTTTCCTCCCCTTATTGAAGTCAG CTCTAACCCCAAATTCTAGTATCCAAAAGTATTTTTATTTGTATAATGCTATCTGAAAAATGTGTTTATATTATATTTTCAGAGCTGCAA TTCTTATTCGCCATTTCAATACCTAGAGATAGAGAGTCTTGTATTTGAAGCCACACACACTGGTGTAATATGCTTAGTACTCTAGGTCAA GGATTTGTTGGTAAATGGAACATTTTAGCATAGTCATGATTTTTGGTTGCCTAGACATCAGGTAAACATTCAGTACACTAAAGAAACTAT CCTGGACACTCCCTCCTGCTTCCACCAATTTTTTTCTCACCCCCTTTTCAAAAATTGAAAACTCTATGAGTGTCTTTTTGAGACCATAAA GCAGACTTTAGTAACTTTCTATTTCTGTAAGTACTAAATGTCTGGCATTTTAAACTTTTGTAGAATACATTATGTTGGACACTGGAATAA TACTATTTATTTTCACCTGTGAAAAATGACTTCATTGTACTTGAAACACCTCCTTTGCATTTCTCCATTTGTGCCATTCACTAGTGGAAA TAAATTGTATTATACCATGATCTACTGGCTTTTTAAAACTGTATTAAATATGCACATTTTTGGTATAGCTATTATCATTTGTATGTATAT ATTGTATATACATATGAGTGTCTGTATGTGTGTATAGATGGATGGATGTAACTCATACTGTACATTTCCATCAGGGCACTTAAAAGTTCT GTTATTTTTGTTTGGTTTTGTTATTTCAGTCCTCAGTTAAGGCAAGAATGCATGTGTTTCTTAAGAATGAGTACTCTGCGTTGATGTTTA TGAGAAGGTGGTCATTAGATGCAGTCTTTTCCTTTTTAATCCCCTCTTAGCACTTCTGTGAGTGGAGAGGACATTAAGTAAAATTTGGAA TCATAAGTTGCAATGCAGTAAAATGGTGCTGGGGAAGGAGCCAGTTAGTGTTTCTGTGAGTTTGTGTTGTGATGCAATAAGAGATAAGTA ATGCAGAGAGAAATGAACCATGGAAAGTAAGAACACTGATGGTGATTCCTCTGCAAAGATGATAAGAAAAAGAACCAATAAATCACACAA TCTTTATGTGCTTTCTATATGTATTTCTTAGTAGTGATACCATTGATCCTCTTACTTTTTTTACTCCATTAATACTAATAATTATATACT TTGCTGAGGATCAAAACAGCCAAGAAAGGAATTACTGCTAAAGCATCTAAGATTCTCCTGAACTGTAAAATCAACAGGAAATGGCCACTG GGAGAGAAGGATTTGGTATTGGGTGAGGGGCTTTCTCCCTTTACCTGCCTCTTCTTGCTTGCTAATAGTAAGTTCTTTGTGCACCTTCCA CCACTTCTGAGCCACTACTATTCAAGTAGAGATTTGCCCCAACACATTAACTTTTTCCTTGGAGATTTATATGGTCCTGCATTTTGTCCT GTGCTCACAATGTGAAGTGTCTTCTGTATTCAAATCAAAAAATAATATATTTAAGGTATATAAGTGTGAATCTCCTATAATGATGGAAGA AGAGGTTCTCTTGTCTTAGATAGAAAAGAGCCTTCTCCAAGAGCAATGTCAAAACTTGGGCTGTCATCTTTGAGCTGTTTACCAAAATAC AGACCATTATTGAAGAAAAACAAATTATCTATTTTGTTTTCCCCCATCTAACATGATAGTGCCCCCAACCAGGTTGTAGCATTGCCTTTT AAAAGAGACTCACTCACTCTTAGTTTTTAAGAACTGGAAATTTCCCATCCTCAGATCCCTTAAAGGATGAAGAGTTGGCTGTACACTTAG CGGACTTGCCTCTTGTATGCAAGGACTACTGATTGAAGTCTGTTTTGCTGTGTCTGGTTATGTTGTCTGCACTTTTATGAAATCACTACA ATAGGTCTGCATTGGAAATGACTATTAATTTGTAAAGAAGTAAGTTTTATTAAACACTGTCTAGAAAAAGAAAGTGAAGCTGAGAACTCT TCCTTTATTGTGCATTTATATTTTCTGCTGAATTCCGGTAGTTCCCTTTAAAGTCATGTTGACTAATGTTTTCCTCCTTGTTTGTATTCA GATTTCCAAAATTTCACTCATACAAGGGAAGAGACTCCATTTAGCTTAACGGTAGTCTTTAGATCATAAGAAATATATAAATTAGTATGC ACCTTATCTGCCTGTTGTGGGTTTCTTAAACTTGCACTTCCTACCCACCCAAAGATAGATATCCTTTAAAGAAAATAAAGGCAGAGAATT AAAACTGGGGAGCCATTTACTATGTCACCATCACTGTTAACTGTTTCCCAGCAATCTAAACTTTTTGAAGTTTCAGAGGTGTATTTTTTT TTTGTATATATGTCTGTGTGATTGTATTGTTTTGTTTCTAAATATACAAGGAATTCTTTAAATAGAGAAAAAGGTTAATCCTCACTGAAA CACCAGGATGCCCACTGGATATACTAATCTGAACATCTGTAGGTAGTTTGTCATGAAAAAGTGGAGAGAAGATGAGACTTTTGAATGAAT GAAAAAGGGTATCTTGATACCCAGAATTCCCCCCAAAGTACGGGTAATTCAACCTGCACAGTTTTCTTTCACTCAAAGTGTTCAGCACTT GTGAGTGAAAAATCATGTAATTATCTGTAAATATGTAGCTAACAAATTGACCTAGTTTCTGTATTTTTTTGTTTTTGTACTAAAGTTTAT AGGTCTGTGCCAGCTAGAGAGAAGTTGCTGTCATTACCAGTTGTGGTCCTAGCATCTAACCCTGAAACCATCCTAGGTGACATTTTTAGA ATTAATACTTAAATGTTAAACAGGGGGAAATGAAGCTTAATCATGGTCAGGTTTGAGATCTTTTGCAGTGAAATAATTTTATTTAATATA AATGATCACATGTCCTCAATCATGAATGAGGTAGGGAGCCTCTCTCCCCCAGTGGCCATGTTTACAAAAGTGTGTTTTGTCTATAAAGTG CAAGTGTTTTAATGTTTATGTAAATTATGCAGGTGATAACATGGTTTGGAACTGTTTATTGGGCTCTTTAACTGAATTTTCAAATGAAAT GAACTATGCTTATTGCTGGCACATTGATCCCATTTCTGGAACATTTTTCCTATTTCCAGAGTTACATATGTTCTTTTGTCATTACCCAAT TTAACCTCCCTTTCTCTGATATGCCTTGTAGCCAAAGTATTAAAGGCTGATGAACATAGACAAGGGAAATGCATTTCTTAGAAATCCGTG AACCCTCAGTTGTATGCTTTCAGTACTCGTGTTAATATGTTTCTATGGCAACTCTGAGGTCAGTGGTTTAGAAATGAGATACCAGTGTTA ATGAAAAGTGTGTGCTCTTTGCTTTTGCATGGCTTGGCTTAGTATCCAAGGTATATTAGGGCCACTTGAAAGCATGAAGACCAGTTATAT AGGGAACAGGTTTCTCTCAGTGGCACATTTTGCTTTTTCTGAGCCCCAAATACATTGCCTGGGCATGAACATTGTTACCGTAAATTGCAC ATGGTCATGGACTGAATTATGTGACTTTAAAGGATGTAACTGCCCAACATTTGCAGATTCTGGGTGGTCTATGTGACCATTTGTCTCGTA TCCAAAAACCCCGGGGCTATTGGAACCCTTCCAACACTTTTTCCTTTGTCATAGACAAGTTTATATATAACTTACCAAGATGTTGGCTGT CCTGGTGTATTGCCAGACAGCTCTCTTTTGGTTCCCATTCCAAATGTGCTGCTGTCCTTCTTTGCATTTCACAATATCAAAGAAACCACC ACCCTTCTTCCTAACAGCATTTTATGCCTTTTATTCCACATTAAATGGGAATTGTGCCTACTTAGGAGTGCCCCTCCAATTAATTACATG TGTCCAAGAATAATCCAAGCTAGAGACACAAGGTGGGAAAACATTTCAAAAAAAAAAAGTCCTCTTAAGGCCAGTAATTTATCTGAAAAG GTATTTTATCACACCTTGACACCTTATATATGAGCCTATTAGGAGCTGCAGGTGGTTTCATAGGGTAAAATCCAAGAAAAGAGAAGGATG TGTGGGGTTTCTATTAGAAGATAATTTTGTTCTCATTTTACCTTTTCTTTTATGATCCTTCTCTGCTAGAACAGGTTAATTCTCCAAATT TGTTTTGTTTTGTTTTGTTATTTTTTAGGGAACTCTTTTGCAAAAGCAATGGTCGGATGTAAATAACATTTAAAGTATAGTGCACATAAC TTCCCCGGACTGTTCCAATCTGATAATTTGTAAATGCTTTAGAGTTTTTTTAATTAACACTTGTGTTGCTAAATTCTATTTATGTAAGTC TGCTAAAGTTTTTTAGCCCACTTAAAACTTAAGACAACCATTTAAAATAATGGATGGGTTACTATGAGCAATTTCGCTTTCAGAACCCCC TTGTTTTAGTATATGAAAAAGCCTAATGCGCATTAATGAGGTTGAAGAGACTATGAGAAATATGTATAGTGTATATTTTAAAACAGCTTT GCTTGTATTGTGAAGATTTAAAAACAAACTTGAGATTTTTAACGTAACTATTAACACAGTTTTAACATAAGTTATCCCACTGGGTTTAAG AGCATCTTGAATGTATAATCCTTTTTGTAACCCAGGTTGGTTTCTACTTTTACCAGTCACCCAAACATATTTATGTTTTTAGTTTTATGT ACTCATTTCCCTTTGTTTTCCTCAAACAGCATGATTTTTTTGCACATGTAGAAATTTTTTAAAAGAAAGAAATTAGTACATCATTTTCTC TGGATTTTCTTCACTTCCCTCTTCCTTTCTACTAACTCCTTCCTTAAAGGCCATATCACTCCATTTGCATTATTTGTGCAAATGCCAGGG TTGGTTTTTATTTTTATTTTTGCTATTTACCTAAAAAAAGAAAATGCTTCAGTCAATTGCTTTTTTATTTAAAAAAAAAAAGAAAAAAAG CTGTAACCTTATCATTTCTGAGTAGACCATTGAGCGATGAATGCACACCTGTAGTAGCCCAGGACCAGCTGTGGTGGCTAAAGGGAATAT GTTAATTAAGCAAGAGGTTCTTTTCTAAAAGTGGTATCTGTTATCCACAATGTATTTTAGTTATTCCCACAAGTCAGGGGTCCAGATAAA ATGAGGGTTATCAGCTAACTGATATGCTATCATTGAGGTTCATCAATGAATTTGTACATTTCTAGTTCCCTTTGGTGAAGGGAAAAATGA TGATTTTGCAAGACCTAGATTTTGGCTTGGTTTCTTGCCTCCTTTTTTGGCAGCCTTCATCTTCTCATCTCCCAAACCCCCTGAGCCCGT AGGGTTTTCATAGTGGACAAAGAACTTGTGGTCTTTTAAAACTGGGACTGATACTTTTTTGAGAGAGTATCGTGTCGAAAGTGTGATGTT CTACCACTTTACCAATAACTAATTTTAAATACACATTGTCCTCTCGATTTTTGGACCAAACAGACGCTCACAGTGGAGGCTTATCAAGGG TTGCATTGGGGAAGAAGCCTCTCCCTCTCTGTCAGCACCAGCTGGTAAAGGTGACTGTACAGATGTGCATTTTCCTTTTGGTATAAATGG TCCACAGCACTAACTGGTAAGGCTTATTGTACAGTATATTGTCAGTATTCTTCTGGTTCAGCATACCTTATAGTTCATATATAACCTGTA TTAATTGTATAGATTGTGCATTAAAAGCTGTTACCAAGTTGTCAGAACATAAGAGCGAAAACAAGGTCATATGTAATATTTTGTTTGTAA >In-frame_SPOP_ENST00000393331_chr17_47679227_-_TAOK1_ENST00000536202_chr17_27869579_+_3231nt GGGGAGGAGGCCGCGCGGGGTGGGGTCTGGCGGTACGCGCTGGCTGCGTCGACGTGCTGACGCCATGACGCCCCGGCTGGTGTGTGTCGG TGTGTATGTGTGTGTGTGAGTGTGCGCGCTCCGAGTGTGTGTGTATTTGTGTATCGGCGGTCCCGCAGGTCCCGGATGTTGCGGACAGTA TGAGGCAAGCGCAGGGGGACGGGGACCAGCAGCTGTCGCCGCCGCTCTCAGATCGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGG CGCGATCTCAGCTCACTGCCACCTTTGCCTCCTGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCTCTGG GAACCACCCTTCTACTTTCTGTCTCTAGGAATTTCACTACTCTAGGGTGAAGAGGGAACAGAAATCTTTGCCCCCTGACTTTGGAAATCT CGTTTAACCTTCAAACTGGCGATGTCAAGGGTTCCAAGTCCTCCACCTCCGGCAGAAATGTCGAGTGGCCCCGTAGCTGAGAGTTGGTGC TACACACAGATCAAGGTAGTGAAATTCTCCTACATGTGGACCATCAATAACTTTAGCTTTTGCCGGGAGGAAATGGGTGAAGTCATTAAA AGTTCTACATTTTCATCAGGAGCAAATGATAAACTGAAATGGTGTTTGCGAGTAAACCCCAAAGGGTTAGATGAAGAAAGCAAAGATTAC CTGTCACTTTACCTGTTACTGGTCAGCTGTCCAAAGAGTGAAGTTCGGGCAAAATTCAAATTCTCCATCCTGAATGCCAAGGGAGAAGAA ACCAAAGCTATGGAGAGTCAACGGGCATATAGGTTTGTGCAAGGCAAAGACTGGGGATTCAAGAAATTCATCCGTAGAGATTTTCTTTTG GATGAGGCCAACGGGCTTCTCCCTGATGACAAGCTTACCCTCTTCTGCGAGGTGAGTGTTGTGCAAGATTCTGTCAACATTTCTGGCCAG AATACCATGAACATGGTAAAGGTTCCTGAGTGCCGGCTGGCAGATGAGTTAGGAGGACTGTGGGAGAATTCCCGGTTCACAGACTGCTGC TTGTGTGTTGCCGGCCAGGAATTCCAGGCTCACAAGGCTATCTTAGCAGCTCGTTCTCCGGTTTTTAGTGCCATGTTTGAACATGAAATG GAGGAGAGCAAAAAGAATCGAGTTGAAATCAATGATGTGGAGCCTGAAGTTTTTAAGGAAATGATGTGCTTCATTTACACGGGGAAGGCT CCAAACCTCGACAAAATGGCTGATGATTTGCTGGCAGCTGCTGACAAGTATGCCCTGGAGCGCTTAAAGGTCATGTGTGAGGATGCCCTC TGCAGTAACCTGTCCGTGGAGAACGCTGCAGAAATTCTCATCCTGGCCGACCTCCACAGTGCAGATCAGTTGAAAACTCAGGCAGTGGAT TTCATCAACTAATTGAAGAAGAGATGTTGGCTTTGCAGAATGAGCGCACAGAACGAATACGAAGCCTGTTGGAACGTCAAGCCAGAGAGA TTGAAGCTTTTGACTCTGAAAGCATGAGACTAGGTTTTAGTAATATGGTCCTTTCTAATCTCTCCCCTGAGGCATTCAGCCACAGCTACC CGGGAGCTTCTGGTTGGTCACACAACCCTACTGGGGGTCCAGGACCTCACTGGGGTCATCCCATGGGTGGCCCACCACAAGCTTGGGGCC ATCCAATGCAAGGTGGACCCCAGCCATGGGGTCACCCTTCAGGGCCAATGCAAGGGGTACCTCGAGGTAGCAGTATGGGAGTCCGCAATA GCCCCCAGGCTCTGAGGCGGACAGCTTCTGGGGGACGGACGGAGCAGGGCATGAGCAGAAGCACGAGTGTCACTTCACAAATATCCAATG GGTCACACATGTCTTATACATAACTTAATAATTGAGAGTGGCAATTCCGCTGGAGCTGTCTGCCAAAAGAAACTGCCTACAGACATCATC ACAGCAGCCTCCTCACTTGGGTACTACAGTGTGGAAGCTGAGTGCATATGGTATATTTTATTCATTTTTGTAAAGCGTTCTGTTTTGTGT TTACTAATTGGGATGTCATAGTACTTGGCTGCCGGGTTTGTTTGTTTTTGGGGAAATTTTGAAAAGTGGAGTTGATATTAAAAATAAATG TGTATGTGTGTACATATATATACACACACATACACATATATTATGCATGTGGTGAAAAGAATTGGCTAGATAGGGGATTTTTCTGAACAC TGCAAAAATAGAACGTAGCAAAATGGCTTCAGTTATCACTTTTGGGTGTCTGTATCCTAAGAAGTTTCTGAAAAGATCTAAAGCCTTTTT ATCCCATATCCCAAATTCTTATGAGCCACTCACAGCAGGCAGCATATGTTGAAATAAGTTATTACTGGTACACACCTGCATTGCCTCACC AGTGTATTTATTTGTTATTAAATTGATCTGACTTCTCAGCCTCATTTGGACTAAAAAAAGAAAGCAGAAATCCATGAACACATTGCTTCT CGGCCTTTTGGCTAAGATCAAGTGTAGAAATCCATGAACACTAAAGGACTTCATTGATTTTTTCAGAGAGTAGAAAACAACTTAGTTTTT CTTTTTTCCTGAATGCGTCATAGGCTTGTGAGTGATTTTTGTCCATTCAATTGTGCCTTCTTTGTATTATGATAAGATGGGGGTACTTAA GGAGATCACAAGTTGTGTGAGGATTGCATTAACAAACCTATGAGCCTTCAATGGGGAAGACCAGAAGGGTGAGAGGGGCCCTGAAAGTTC ATATGGTGGGTATGTCCCGCAGCAGAGTGAGGAGATGAAGCTTACGTGTCCTGACGTTTTGTTGCTTATACTGTGATATCTCATCCTAGC TAAGCTCTATAATGCCCAAGACCCCAAACAGTACTTTTACTTTGTTTGTACAAAAACAAAGACATATAGCCAATACAAATCAAATGCCGG AGGTGTTTGATGCCATATTTGCAAATTGCCATCTATTGAAATTCTCGTCACACTACATAGACATAATTGTTATCTCCTTTTGGCTTATGT GATTTTCTGTTTACAAGTAGAATAGCCAATTATTTAAATGTTTAGTTGCCACAGTGAACCAGGAGTCACTGAGCCAATGACTTTACCAGC >In-frame_SPOP_ENST00000347630_chr17_47679227_-_TAOK1_ENST00000536202_chr17_27869579_+_3108nt GGGGAGGAGGCCGCGCGGGGTGGGGTCTGGCGGTACGCGCTGGCTGCGTCGACGTGCTGACGCCATGACGCCCCGGCTGGTGTGTGTCGG TGTGTATGTGTGTGTGTGAGTGTGCGCGCTCCGAGTGTGTGTGTATTTGTGTATCGGCGGTCCCGCAGGTCCCGGATGTTGCGGACAGTA TGAGGCAAGCGCAGGGGGACGGGGACCAGCAGCTGTCGCCGCCGCTCTCAGAGATTTCCTGTTAGACAAGACAAATTAGAGTTTTCCTAC TGACTTAACTTGGGTGAAGAGGGAACAGAAATCTTTGCCCCCTGACTTTGGAAATCTCGTTTAACCTTCAAACTGGCGATGTCAAGGGTT CCAAGTCCTCCACCTCCGGCAGAAATGTCGAGTGGCCCCGTAGCTGAGAGTTGGTGCTACACACAGATCAAGGTAGTGAAATTCTCCTAC ATGTGGACCATCAATAACTTTAGCTTTTGCCGGGAGGAAATGGGTGAAGTCATTAAAAGTTCTACATTTTCATCAGGAGCAAATGATAAA CTGAAATGGTGTTTGCGAGTAAACCCCAAAGGGTTAGATGAAGAAAGCAAAGATTACCTGTCACTTTACCTGTTACTGGTCAGCTGTCCA AAGAGTGAAGTTCGGGCAAAATTCAAATTCTCCATCCTGAATGCCAAGGGAGAAGAAACCAAAGCTATGGAGAGTCAACGGGCATATAGG TTTGTGCAAGGCAAAGACTGGGGATTCAAGAAATTCATCCGTAGAGATTTTCTTTTGGATGAGGCCAACGGGCTTCTCCCTGATGACAAG CTTACCCTCTTCTGCGAGGTGAGTGTTGTGCAAGATTCTGTCAACATTTCTGGCCAGAATACCATGAACATGGTAAAGGTTCCTGAGTGC CGGCTGGCAGATGAGTTAGGAGGACTGTGGGAGAATTCCCGGTTCACAGACTGCTGCTTGTGTGTTGCCGGCCAGGAATTCCAGGCTCAC AAGGCTATCTTAGCAGCTCGTTCTCCGGTTTTTAGTGCCATGTTTGAACATGAAATGGAGGAGAGCAAAAAGAATCGAGTTGAAATCAAT GATGTGGAGCCTGAAGTTTTTAAGGAAATGATGTGCTTCATTTACACGGGGAAGGCTCCAAACCTCGACAAAATGGCTGATGATTTGCTG GCAGCTGCTGACAAGTATGCCCTGGAGCGCTTAAAGGTCATGTGTGAGGATGCCCTCTGCAGTAACCTGTCCGTGGAGAACGCTGCAGAA ATTCTCATCCTGGCCGACCTCCACAGTGCAGATCAGTTGAAAACTCAGGCAGTGGATTTCATCAACTAATTGAAGAAGAGATGTTGGCTT TGCAGAATGAGCGCACAGAACGAATACGAAGCCTGTTGGAACGTCAAGCCAGAGAGATTGAAGCTTTTGACTCTGAAAGCATGAGACTAG GTTTTAGTAATATGGTCCTTTCTAATCTCTCCCCTGAGGCATTCAGCCACAGCTACCCGGGAGCTTCTGGTTGGTCACACAACCCTACTG GGGGTCCAGGACCTCACTGGGGTCATCCCATGGGTGGCCCACCACAAGCTTGGGGCCATCCAATGCAAGGTGGACCCCAGCCATGGGGTC ACCCTTCAGGGCCAATGCAAGGGGTACCTCGAGGTAGCAGTATGGGAGTCCGCAATAGCCCCCAGGCTCTGAGGCGGACAGCTTCTGGGG GACGGACGGAGCAGGGCATGAGCAGAAGCACGAGTGTCACTTCACAAATATCCAATGGGTCACACATGTCTTATACATAACTTAATAATT GAGAGTGGCAATTCCGCTGGAGCTGTCTGCCAAAAGAAACTGCCTACAGACATCATCACAGCAGCCTCCTCACTTGGGTACTACAGTGTG GAAGCTGAGTGCATATGGTATATTTTATTCATTTTTGTAAAGCGTTCTGTTTTGTGTTTACTAATTGGGATGTCATAGTACTTGGCTGCC GGGTTTGTTTGTTTTTGGGGAAATTTTGAAAAGTGGAGTTGATATTAAAAATAAATGTGTATGTGTGTACATATATATACACACACATAC ACATATATTATGCATGTGGTGAAAAGAATTGGCTAGATAGGGGATTTTTCTGAACACTGCAAAAATAGAACGTAGCAAAATGGCTTCAGT TATCACTTTTGGGTGTCTGTATCCTAAGAAGTTTCTGAAAAGATCTAAAGCCTTTTTATCCCATATCCCAAATTCTTATGAGCCACTCAC AGCAGGCAGCATATGTTGAAATAAGTTATTACTGGTACACACCTGCATTGCCTCACCAGTGTATTTATTTGTTATTAAATTGATCTGACT TCTCAGCCTCATTTGGACTAAAAAAAGAAAGCAGAAATCCATGAACACATTGCTTCTCGGCCTTTTGGCTAAGATCAAGTGTAGAAATCC ATGAACACTAAAGGACTTCATTGATTTTTTCAGAGAGTAGAAAACAACTTAGTTTTTCTTTTTTCCTGAATGCGTCATAGGCTTGTGAGT GATTTTTGTCCATTCAATTGTGCCTTCTTTGTATTATGATAAGATGGGGGTACTTAAGGAGATCACAAGTTGTGTGAGGATTGCATTAAC AAACCTATGAGCCTTCAATGGGGAAGACCAGAAGGGTGAGAGGGGCCCTGAAAGTTCATATGGTGGGTATGTCCCGCAGCAGAGTGAGGA GATGAAGCTTACGTGTCCTGACGTTTTGTTGCTTATACTGTGATATCTCATCCTAGCTAAGCTCTATAATGCCCAAGACCCCAAACAGTA CTTTTACTTTGTTTGTACAAAAACAAAGACATATAGCCAATACAAATCAAATGCCGGAGGTGTTTGATGCCATATTTGCAAATTGCCATC TATTGAAATTCTCGTCACACTACATAGACATAATTGTTATCTCCTTTTGGCTTATGTGATTTTCTGTTTACAAGTAGAATAGCCAATTAT TTAAATGTTTAGTTGCCACAGTGAACCAGGAGTCACTGAGCCAATGACTTTACCAGCTGCTGACTAATCTTCATCACCACTGTAGATTTT >In-frame_SPOP_ENST00000504102_chr17_47679227_-_TAOK1_ENST00000536202_chr17_27869579_+_3128nt AAGATAGGCGGAGTCTTGAGGGAGGAGGAGCAGGGAAACCCAGGGAGGGGAGGGGAGGAGAAGGGAGTAATGGGGAGGAGGCCGCGCGGG GTGGGGTCTGGCGGTACGCGCTGGCTGCGTCGACGTGCTGACGCCATGACGCCCCGGCTGGTGTGTGTCGGTGTGTATGTGTGTGTGTGA GTGTGCGCGCTCCGAGTGTGTGTGTATTTGTGTATCGGCGGTCCCGCAGGTCCCGGATGTTGCGGACAGTATGAGGCAAGCGCAGGGGGA CGGGGACCAGCAGCTGTCGCCGCCGCTCTCAGGGTGAAGAGGGAACAGAAATCTTTGCCCCCTGACTTTGGAAATCTCGTTTAACCTTCA AACTGGCGATGTCAAGGGTTCCAAGTCCTCCACCTCCGGCAGAAATGTCGAGTGGCCCCGTAGCTGAGAGTTGGTGCTACACACAGATCA AGGTAGTGAAATTCTCCTACATGTGGACCATCAATAACTTTAGCTTTTGCCGGGAGGAAATGGGTGAAGTCATTAAAAGTTCTACATTTT CATCAGGAGCAAATGATAAACTGAAATGGTGTTTGCGAGTAAACCCCAAAGGGTTAGATGAAGAAAGCAAAGATTACCTGTCACTTTACC TGTTACTGGTCAGCTGTCCAAAGAGTGAAGTTCGGGCAAAATTCAAATTCTCCATCCTGAATGCCAAGGGAGAAGAAACCAAAGCTATGG AGAGTCAACGGGCATATAGGTTTGTGCAAGGCAAAGACTGGGGATTCAAGAAATTCATCCGTAGAGATTTTCTTTTGGATGAGGCCAACG GGCTTCTCCCTGATGACAAGCTTACCCTCTTCTGCGAGGTGAGTGTTGTGCAAGATTCTGTCAACATTTCTGGCCAGAATACCATGAACA TGGTAAAGGTTCCTGAGTGCCGGCTGGCAGATGAGTTAGGAGGACTGTGGGAGAATTCCCGGTTCACAGACTGCTGCTTGTGTGTTGCCG GCCAGGAATTCCAGGCTCACAAGGCTATCTTAGCAGCTCGTTCTCCGGTTTTTAGTGCCATGTTTGAACATGAAATGGAGGAGAGCAAAA AGAATCGAGTTGAAATCAATGATGTGGAGCCTGAAGTTTTTAAGGAAATGATGTGCTTCATTTACACGGGGAAGGCTCCAAACCTCGACA AAATGGCTGATGATTTGCTGGCAGCTGCTGACAAGTATGCCCTGGAGCGCTTAAAGGTCATGTGTGAGGATGCCCTCTGCAGTAACCTGT CCGTGGAGAACGCTGCAGAAATTCTCATCCTGGCCGACCTCCACAGTGCAGATCAGTTGAAAACTCAGGCAGTGGATTTCATCAACTAAT TGAAGAAGAGATGTTGGCTTTGCAGAATGAGCGCACAGAACGAATACGAAGCCTGTTGGAACGTCAAGCCAGAGAGATTGAAGCTTTTGA CTCTGAAAGCATGAGACTAGGTTTTAGTAATATGGTCCTTTCTAATCTCTCCCCTGAGGCATTCAGCCACAGCTACCCGGGAGCTTCTGG TTGGTCACACAACCCTACTGGGGGTCCAGGACCTCACTGGGGTCATCCCATGGGTGGCCCACCACAAGCTTGGGGCCATCCAATGCAAGG TGGACCCCAGCCATGGGGTCACCCTTCAGGGCCAATGCAAGGGGTACCTCGAGGTAGCAGTATGGGAGTCCGCAATAGCCCCCAGGCTCT GAGGCGGACAGCTTCTGGGGGACGGACGGAGCAGGGCATGAGCAGAAGCACGAGTGTCACTTCACAAATATCCAATGGGTCACACATGTC TTATACATAACTTAATAATTGAGAGTGGCAATTCCGCTGGAGCTGTCTGCCAAAAGAAACTGCCTACAGACATCATCACAGCAGCCTCCT CACTTGGGTACTACAGTGTGGAAGCTGAGTGCATATGGTATATTTTATTCATTTTTGTAAAGCGTTCTGTTTTGTGTTTACTAATTGGGA TGTCATAGTACTTGGCTGCCGGGTTTGTTTGTTTTTGGGGAAATTTTGAAAAGTGGAGTTGATATTAAAAATAAATGTGTATGTGTGTAC ATATATATACACACACATACACATATATTATGCATGTGGTGAAAAGAATTGGCTAGATAGGGGATTTTTCTGAACACTGCAAAAATAGAA CGTAGCAAAATGGCTTCAGTTATCACTTTTGGGTGTCTGTATCCTAAGAAGTTTCTGAAAAGATCTAAAGCCTTTTTATCCCATATCCCA AATTCTTATGAGCCACTCACAGCAGGCAGCATATGTTGAAATAAGTTATTACTGGTACACACCTGCATTGCCTCACCAGTGTATTTATTT GTTATTAAATTGATCTGACTTCTCAGCCTCATTTGGACTAAAAAAAGAAAGCAGAAATCCATGAACACATTGCTTCTCGGCCTTTTGGCT AAGATCAAGTGTAGAAATCCATGAACACTAAAGGACTTCATTGATTTTTTCAGAGAGTAGAAAACAACTTAGTTTTTCTTTTTTCCTGAA TGCGTCATAGGCTTGTGAGTGATTTTTGTCCATTCAATTGTGCCTTCTTTGTATTATGATAAGATGGGGGTACTTAAGGAGATCACAAGT TGTGTGAGGATTGCATTAACAAACCTATGAGCCTTCAATGGGGAAGACCAGAAGGGTGAGAGGGGCCCTGAAAGTTCATATGGTGGGTAT GTCCCGCAGCAGAGTGAGGAGATGAAGCTTACGTGTCCTGACGTTTTGTTGCTTATACTGTGATATCTCATCCTAGCTAAGCTCTATAAT GCCCAAGACCCCAAACAGTACTTTTACTTTGTTTGTACAAAAACAAAGACATATAGCCAATACAAATCAAATGCCGGAGGTGTTTGATGC CATATTTGCAAATTGCCATCTATTGAAATTCTCGTCACACTACATAGACATAATTGTTATCTCCTTTTGGCTTATGTGATTTTCTGTTTA CAAGTAGAATAGCCAATTATTTAAATGTTTAGTTGCCACAGTGAACCAGGAGTCACTGAGCCAATGACTTTACCAGCTGCTGACTAATCT >In-frame_SPOP_ENST00000503676_chr17_47679227_-_TAOK1_ENST00000261716_chr17_27869579_+_10956nt ATATAGCTTAAAGCATTTAACTGGAAAGGACCTTGGAAATCCTTTTAAAGGAGGATGGGGGTGGAAATGCACAGGTTGCTTCTCTCTCTC TCTCTCTTTTTTTTTTTTTTTGAGACGGTCACCCAGGCTGTAGTGCAGTGGCGTGATCTCGGCTCACTGTGGCCTCCACCTCCCAAGTAG CTGGGATTACAGGCTTGCGCCATCATGCAGGGCTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCATCATGTTGGCCAGGCTGGTCTGG AACTCCTGACCTCAAGTGATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTAAAGGCATGAGCCACCACGCCTGGCCTAGGTTGTTCC TCTACTGTGAATCTTGAGGTTATGGTTTCCACTAGACTATAGTGCTCAACTATAGTGGCCTATTTTAAGTGGCCTTATAATTCCTAACCA AAGTGACTTGTGAAACAGAGGACCCTGGATAAATTTAAATGTTATAAAGATGATAAAATGTACAGAGATTTCCTGTTAGACAAGACAAAT TAGAGTTTTCCTACTGACTTAACTTGGGTGAAGAGGGAACAGAAATCTTTGCCCCCTGACTTTGGAAATCTCGTTTAACCTTCAAACTGG CGATGTCAAGGGTTCCAAGTCCTCCACCTCCGGCAGAAATGTCGAGTGGCCCCGTAGCTGAGAGTTGGTGCTACACACAGATCAAGGTAG TGAAATTCTCCTACATGTGGACCATCAATAACTTTAGCTTTTGCCGGGAGGAAATGGGTGAAGTCATTAAAAGTTCTACATTTTCATCAG GAGCAAATGATAAACTGAAATGGTGTTTGCGAGTAAACCCCAAAGGGTTAGATGAAGAAAGCAAAGATTACCTGTCACTTTACCTGTTAC TGGTCAGCTGTCCAAAGAGTGAAGTTCGGGCAAAATTCAAATTCTCCATCCTGAATGCCAAGGGAGAAGAAACCAAAGCTATGGAGAGTC AACGGGCATATAGGTTTGTGCAAGGCAAAGACTGGGGATTCAAGAAATTCATCCGTAGAGATTTTCTTTTGGATGAGGCCAACGGGCTTC TCCCTGATGACAAGCTTACCCTCTTCTGCGAGGTGAGTGTTGTGCAAGATTCTGTCAACATTTCTGGCCAGAATACCATGAACATGGTAA AGGTTCCTGAGTGCCGGCTGGCAGATGAGTTAGGAGGACTGTGGGAGAATTCCCGGTTCACAGACTGCTGCTTGTGTGTTGCCGGCCAGG AATTCCAGGCTCACAAGGCTATCTTAGCAGCTCGTTCTCCGGTTTTTAGTGCCATGTTTGAACATGAAATGGAGGAGAGCAAAAAGAATC GAGTTGAAATCAATGATGTGGAGCCTGAAGTTTTTAAGGAAATGATGTGCTTCATTTACACGGGGAAGGCTCCAAACCTCGACAAAATGG CTGATGATTTGCTGGCAGCTGCTGACAAGTATGCCCTGGAGCGCTTAAAGGTCATGTGTGAGGATGCCCTCTGCAGTAACCTGTCCGTGG AGAACGCTGCAGAAATTCTCATCCTGGCCGACCTCCACAGTGCAGATCAGTTGAAAACTCAGGCAGTGGATTTCATCAACTAATTGAAGA AGAGATGTTGGCTTTGCAGAATGAGCGCACAGAACGAATACGAAGCCTGTTGGAACGTCAAGCCAGAGAGATTGAAGCTTTTGACTCTGA AAGCATGAGACTAGGTTTTAGTAATATGGTCCTTTCTAATCTCTCCCCTGAGGCATTCAGCCACAGCTACCCGGGAGCTTCTGGTTGGTC ACACAACCCTACTGGGGGTCCAGGACCTCACTGGGGTCATCCCATGGGTGGCCCACCACAAGCTTGGGGCCATCCAATGCAAGGTGGACC CCAGCCATGGGGTCACCCTTCAGGGCCAATGCAAGGGGTACCTCGAGGTAGCAGTATGGGAGTCCGCAATAGCCCCCAGGCTCTGAGGCG GACAGCTTCTGGGGGACGGACGGAGCAGGGCATGAGCAGAAGCACGAGTGTCACTTCACAAATATCCAATGGGTCACACATGTCTTATAC ATAACTTAATAATTGAGAGTGGCAATTCCGCTGGAGCTGTCTGCCAAAAGAAACTGCCTACAGACATCATCACAGCAGCCTCCTCACTTG GGTACTACAGTGTGGAAGCTGAGTGCATATGGTATATTTTATTCATTTTTGTAAAGCGTTCTGTTTTGTGTTTACTAATTGGGATGTCAT AGTACTTGGCTGCCGGGTTTGTTTGTTTTTGGGGAAATTTTGAAAAGTGGAGTTGATATTAAAAATAAATGTGTATGTGTGTACATATAT ATACACACACATACACATATATTATGCATGTGGTGAAAAGAATTGGCTAGATAGGGGATTTTTCTGAACACTGCAAAAATAGAACGTAGC AAAATGGCTTCAGTTATCACTTTTGGGTGTCTGTATCCTAAGAAGTTTCTGAAAAGATCTAAAGCCTTTTTATCCCATATCCCAAATTCT TATGAGCCACTCACAGCAGGCAGCATATGTTGAAATAAGTTATTACTGGTACACACCTGCATTGCCTCACCAGTGTATTTATTTGTTATT AAATTGATCTGACTTCTCAGCCTCATTTGGACTAAAAAAAGAAAGCAGAAATCCATGAACACATTGCTTCTCGGCCTTTTGGCTAAGATC AAGTGTAGAAATCCATGAACACTAAAGGACTTCATTGATTTTTTCAGAGAGTAGAAAACAACTTAGTTTTTCTTTTTTCCTGAATGCGTC ATAGGCTTGTGAGTGATTTTTGTCCATTCAATTGTGCCTTCTTTGTATTATGATAAGATGGGGGTACTTAAGGAGATCACAAGTTGTGTG AGGATTGCATTAACAAACCTATGAGCCTTCAATGGGGAAGACCAGAAGGGTGAGAGGGGCCCTGAAAGTTCATATGGTGGGTATGTCCCG CAGCAGAGTGAGGAGATGAAGCTTACGTGTCCTGACGTTTTGTTGCTTATACTGTGATATCTCATCCTAGCTAAGCTCTATAATGCCCAA GACCCCAAACAGTACTTTTACTTTGTTTGTACAAAAACAAAGACATATAGCCAATACAAATCAAATGCCGGAGGTGTTTGATGCCATATT TGCAAATTGCCATCTATTGAAATTCTCGTCACACTACATAGACATAATTGTTATCTCCTTTTGGCTTATGTGATTTTCTGTTTACAAGTA GAATAGCCAATTATTTAAATGTTTAGTTGCCACAGTGAACCAGGAGTCACTGAGCCAATGACTTTACCAGCTGCTGACTAATCTTCATCA CCACTGTAGATTTTGCTGCATGTGCAGGTCCTCTATTTTTAATTGCTGTTTTCGTTGCTGCAGTACTTTACAAACTTCTAGTTCGTTGAG ACTTAGTGACCATTTGGCATCAAGTTAACATCACACAATAGGAAACACCACTTCCACAAGTCTCAAGCCTCAGTGCTAAAGTACTACTGA AAAGGAACTAGGAAGTTTGGCCAATTAAAAAAAAAAAGTAAAATAAGTTATAGTGGTCAGGGAATCTCTTGACGAAAGCTAACTCTTATT TTTCAGGGGGCACATGTTTTGTTTTGTTATGTTTTGTTGTACAATGAAGGATGAACCCAATGCTAAAAAGTCAGTTATTTTCTTGGTTTT CCATTTCTTGTATATAAATTGTGTTGGAGGTGGGTAGGAAGCTGTGAGTATGACTTGAAGAAAAATATCCTTTTCAGTGACAAATCAGAG TTTCTTACAAGTTATTGTCCTGCTCCCTTCCAAGTTGTCTTGAAGAATCCTTGCTGCTAACTCTGGATCCTGCTTTTCCTATAGTCAGAG GGCTCCAAGGTAGAACTCTCTAAGTCCCTCTCAATGGCACTCTTTGCCTAGACCAAACTAATGACCAAACAGTAATCAATCTATCACTGT TGAAGTCCTGGTTTTCTCAACCAAATTTTAAGTCTTTCCCAGGTATGTCAGTCGAGTTGCCATGAATCCTCACCTGTAGGAGTTTCTGGG ATTCATTTTAAGGAAACTGGAAGAAAATTAATGTTTTAATGTAAATGTTTTTAAAACCAAGATCACCATAGAGTTCACACAAAATTTTAG GCAGTGTTTCAAGAAGCACTCTTATGTGTTGTTCTTTCAGCCCATGCTCCAGGTCACCGGTTTTTAGGTAAACATGACATGACATGTACT TGTAATATCAGTGAAAGGGGCTTTTAGTCGTCTCAGTATCTTTTTTGCATTCAGGTATTATAGCGTTTCCAACAAATTGAGAAATTACTT ATTTGGTGTAAAATGACGAGAGAGCTTTAGAATTTAATAAAATGTCAAAAATACAATTTGATACCCTTAAAAATTATTCATAGATCTGGC TGCTCTGTACTACTGGATGGGTGGAATAGGGAAGCAGATCACTTTTGCATACAAAAACTCTTTCAAACCCAAAATATTATTGGTGGTACA TTTTAAAGTCCAATTGTGGACTTAAATTAGTCAAATTGAGAGTTACTGAGTCCATTCAGATCTCCAGTAGGGTTTTGTATCTAATGTATT TGGCCACCAGTTTTACATGTAGGTCATGACTATACCTGGATTTTATCATTAAGTTAACTTTAAAGTATATACAGTTTGCAAAAAATGATT CAAATTAATTGGTTTGTATATGTTTGTGAGATCTAGCTTCTGAGGAATCTCATACATAGTAGGAACCATCATAGAGTAAAGCTTGTAGCA GAAAAATTGGAAGGGTTTTGAGATATCCTAGAGAAAGAGCAAGCACTTTCTGAATCAGTGGGGAAATATCAATATTTGATCAAATTAACA CTACCTCCTTCCCAGTGTTGGTGTTCACTCACTATATGTCTTTAAGAAAATTAAAACTATGGAAAATTTGTCTAGCATATCAGAAGTTGT AAATGCTATATCTGGTATCCAGAGGCTGGCTGTAAAAAGTTCCTTGGGGTCACTCTATCTCACATTTTTTTTGGTTAGCATTTTAAAAAT GCAAAGCCACATACTTTGAAATATATTATTCCAAATTGAGCTCCCTTCCCTTTGCACATATTTTTTCCTCCCCTTATTGAAGTCAGCTCT AACCCCAAATTCTAGTATCCAAAAGTATTTTTATTTGTATAATGCTATCTGAAAAATGTGTTTATATTATATTTTCAGAGCTGCAATTCT TATTCGCCATTTCAATACCTAGAGATAGAGAGTCTTGTATTTGAAGCCACACACACTGGTGTAATATGCTTAGTACTCTAGGTCAAGGAT TTGTTGGTAAATGGAACATTTTAGCATAGTCATGATTTTTGGTTGCCTAGACATCAGGTAAACATTCAGTACACTAAAGAAACTATCCTG GACACTCCCTCCTGCTTCCACCAATTTTTTTCTCACCCCCTTTTCAAAAATTGAAAACTCTATGAGTGTCTTTTTGAGACCATAAAGCAG ACTTTAGTAACTTTCTATTTCTGTAAGTACTAAATGTCTGGCATTTTAAACTTTTGTAGAATACATTATGTTGGACACTGGAATAATACT ATTTATTTTCACCTGTGAAAAATGACTTCATTGTACTTGAAACACCTCCTTTGCATTTCTCCATTTGTGCCATTCACTAGTGGAAATAAA TTGTATTATACCATGATCTACTGGCTTTTTAAAACTGTATTAAATATGCACATTTTTGGTATAGCTATTATCATTTGTATGTATATATTG TATATACATATGAGTGTCTGTATGTGTGTATAGATGGATGGATGTAACTCATACTGTACATTTCCATCAGGGCACTTAAAAGTTCTGTTA TTTTTGTTTGGTTTTGTTATTTCAGTCCTCAGTTAAGGCAAGAATGCATGTGTTTCTTAAGAATGAGTACTCTGCGTTGATGTTTATGAG AAGGTGGTCATTAGATGCAGTCTTTTCCTTTTTAATCCCCTCTTAGCACTTCTGTGAGTGGAGAGGACATTAAGTAAAATTTGGAATCAT AAGTTGCAATGCAGTAAAATGGTGCTGGGGAAGGAGCCAGTTAGTGTTTCTGTGAGTTTGTGTTGTGATGCAATAAGAGATAAGTAATGC AGAGAGAAATGAACCATGGAAAGTAAGAACACTGATGGTGATTCCTCTGCAAAGATGATAAGAAAAAGAACCAATAAATCACACAATCTT TATGTGCTTTCTATATGTATTTCTTAGTAGTGATACCATTGATCCTCTTACTTTTTTTACTCCATTAATACTAATAATTATATACTTTGC TGAGGATCAAAACAGCCAAGAAAGGAATTACTGCTAAAGCATCTAAGATTCTCCTGAACTGTAAAATCAACAGGAAATGGCCACTGGGAG AGAAGGATTTGGTATTGGGTGAGGGGCTTTCTCCCTTTACCTGCCTCTTCTTGCTTGCTAATAGTAAGTTCTTTGTGCACCTTCCACCAC TTCTGAGCCACTACTATTCAAGTAGAGATTTGCCCCAACACATTAACTTTTTCCTTGGAGATTTATATGGTCCTGCATTTTGTCCTGTGC TCACAATGTGAAGTGTCTTCTGTATTCAAATCAAAAAATAATATATTTAAGGTATATAAGTGTGAATCTCCTATAATGATGGAAGAAGAG GTTCTCTTGTCTTAGATAGAAAAGAGCCTTCTCCAAGAGCAATGTCAAAACTTGGGCTGTCATCTTTGAGCTGTTTACCAAAATACAGAC CATTATTGAAGAAAAACAAATTATCTATTTTGTTTTCCCCCATCTAACATGATAGTGCCCCCAACCAGGTTGTAGCATTGCCTTTTAAAA GAGACTCACTCACTCTTAGTTTTTAAGAACTGGAAATTTCCCATCCTCAGATCCCTTAAAGGATGAAGAGTTGGCTGTACACTTAGCGGA CTTGCCTCTTGTATGCAAGGACTACTGATTGAAGTCTGTTTTGCTGTGTCTGGTTATGTTGTCTGCACTTTTATGAAATCACTACAATAG GTCTGCATTGGAAATGACTATTAATTTGTAAAGAAGTAAGTTTTATTAAACACTGTCTAGAAAAAGAAAGTGAAGCTGAGAACTCTTCCT TTATTGTGCATTTATATTTTCTGCTGAATTCCGGTAGTTCCCTTTAAAGTCATGTTGACTAATGTTTTCCTCCTTGTTTGTATTCAGATT TCCAAAATTTCACTCATACAAGGGAAGAGACTCCATTTAGCTTAACGGTAGTCTTTAGATCATAAGAAATATATAAATTAGTATGCACCT TATCTGCCTGTTGTGGGTTTCTTAAACTTGCACTTCCTACCCACCCAAAGATAGATATCCTTTAAAGAAAATAAAGGCAGAGAATTAAAA CTGGGGAGCCATTTACTATGTCACCATCACTGTTAACTGTTTCCCAGCAATCTAAACTTTTTGAAGTTTCAGAGGTGTATTTTTTTTTTG TATATATGTCTGTGTGATTGTATTGTTTTGTTTCTAAATATACAAGGAATTCTTTAAATAGAGAAAAAGGTTAATCCTCACTGAAACACC AGGATGCCCACTGGATATACTAATCTGAACATCTGTAGGTAGTTTGTCATGAAAAAGTGGAGAGAAGATGAGACTTTTGAATGAATGAAA AAGGGTATCTTGATACCCAGAATTCCCCCCAAAGTACGGGTAATTCAACCTGCACAGTTTTCTTTCACTCAAAGTGTTCAGCACTTGTGA GTGAAAAATCATGTAATTATCTGTAAATATGTAGCTAACAAATTGACCTAGTTTCTGTATTTTTTTGTTTTTGTACTAAAGTTTATAGGT CTGTGCCAGCTAGAGAGAAGTTGCTGTCATTACCAGTTGTGGTCCTAGCATCTAACCCTGAAACCATCCTAGGTGACATTTTTAGAATTA ATACTTAAATGTTAAACAGGGGGAAATGAAGCTTAATCATGGTCAGGTTTGAGATCTTTTGCAGTGAAATAATTTTATTTAATATAAATG ATCACATGTCCTCAATCATGAATGAGGTAGGGAGCCTCTCTCCCCCAGTGGCCATGTTTACAAAAGTGTGTTTTGTCTATAAAGTGCAAG TGTTTTAATGTTTATGTAAATTATGCAGGTGATAACATGGTTTGGAACTGTTTATTGGGCTCTTTAACTGAATTTTCAAATGAAATGAAC TATGCTTATTGCTGGCACATTGATCCCATTTCTGGAACATTTTTCCTATTTCCAGAGTTACATATGTTCTTTTGTCATTACCCAATTTAA CCTCCCTTTCTCTGATATGCCTTGTAGCCAAAGTATTAAAGGCTGATGAACATAGACAAGGGAAATGCATTTCTTAGAAATCCGTGAACC CTCAGTTGTATGCTTTCAGTACTCGTGTTAATATGTTTCTATGGCAACTCTGAGGTCAGTGGTTTAGAAATGAGATACCAGTGTTAATGA AAAGTGTGTGCTCTTTGCTTTTGCATGGCTTGGCTTAGTATCCAAGGTATATTAGGGCCACTTGAAAGCATGAAGACCAGTTATATAGGG AACAGGTTTCTCTCAGTGGCACATTTTGCTTTTTCTGAGCCCCAAATACATTGCCTGGGCATGAACATTGTTACCGTAAATTGCACATGG TCATGGACTGAATTATGTGACTTTAAAGGATGTAACTGCCCAACATTTGCAGATTCTGGGTGGTCTATGTGACCATTTGTCTCGTATCCA AAAACCCCGGGGCTATTGGAACCCTTCCAACACTTTTTCCTTTGTCATAGACAAGTTTATATATAACTTACCAAGATGTTGGCTGTCCTG GTGTATTGCCAGACAGCTCTCTTTTGGTTCCCATTCCAAATGTGCTGCTGTCCTTCTTTGCATTTCACAATATCAAAGAAACCACCACCC TTCTTCCTAACAGCATTTTATGCCTTTTATTCCACATTAAATGGGAATTGTGCCTACTTAGGAGTGCCCCTCCAATTAATTACATGTGTC CAAGAATAATCCAAGCTAGAGACACAAGGTGGGAAAACATTTCAAAAAAAAAAAGTCCTCTTAAGGCCAGTAATTTATCTGAAAAGGTAT TTTATCACACCTTGACACCTTATATATGAGCCTATTAGGAGCTGCAGGTGGTTTCATAGGGTAAAATCCAAGAAAAGAGAAGGATGTGTG GGGTTTCTATTAGAAGATAATTTTGTTCTCATTTTACCTTTTCTTTTATGATCCTTCTCTGCTAGAACAGGTTAATTCTCCAAATTTGTT TTGTTTTGTTTTGTTATTTTTTAGGGAACTCTTTTGCAAAAGCAATGGTCGGATGTAAATAACATTTAAAGTATAGTGCACATAACTTCC CCGGACTGTTCCAATCTGATAATTTGTAAATGCTTTAGAGTTTTTTTAATTAACACTTGTGTTGCTAAATTCTATTTATGTAAGTCTGCT AAAGTTTTTTAGCCCACTTAAAACTTAAGACAACCATTTAAAATAATGGATGGGTTACTATGAGCAATTTCGCTTTCAGAACCCCCTTGT TTTAGTATATGAAAAAGCCTAATGCGCATTAATGAGGTTGAAGAGACTATGAGAAATATGTATAGTGTATATTTTAAAACAGCTTTGCTT GTATTGTGAAGATTTAAAAACAAACTTGAGATTTTTAACGTAACTATTAACACAGTTTTAACATAAGTTATCCCACTGGGTTTAAGAGCA TCTTGAATGTATAATCCTTTTTGTAACCCAGGTTGGTTTCTACTTTTACCAGTCACCCAAACATATTTATGTTTTTAGTTTTATGTACTC ATTTCCCTTTGTTTTCCTCAAACAGCATGATTTTTTTGCACATGTAGAAATTTTTTAAAAGAAAGAAATTAGTACATCATTTTCTCTGGA TTTTCTTCACTTCCCTCTTCCTTTCTACTAACTCCTTCCTTAAAGGCCATATCACTCCATTTGCATTATTTGTGCAAATGCCAGGGTTGG TTTTTATTTTTATTTTTGCTATTTACCTAAAAAAAGAAAATGCTTCAGTCAATTGCTTTTTTATTTAAAAAAAAAAAGAAAAAAAGCTGT AACCTTATCATTTCTGAGTAGACCATTGAGCGATGAATGCACACCTGTAGTAGCCCAGGACCAGCTGTGGTGGCTAAAGGGAATATGTTA ATTAAGCAAGAGGTTCTTTTCTAAAAGTGGTATCTGTTATCCACAATGTATTTTAGTTATTCCCACAAGTCAGGGGTCCAGATAAAATGA GGGTTATCAGCTAACTGATATGCTATCATTGAGGTTCATCAATGAATTTGTACATTTCTAGTTCCCTTTGGTGAAGGGAAAAATGATGAT TTTGCAAGACCTAGATTTTGGCTTGGTTTCTTGCCTCCTTTTTTGGCAGCCTTCATCTTCTCATCTCCCAAACCCCCTGAGCCCGTAGGG TTTTCATAGTGGACAAAGAACTTGTGGTCTTTTAAAACTGGGACTGATACTTTTTTGAGAGAGTATCGTGTCGAAAGTGTGATGTTCTAC CACTTTACCAATAACTAATTTTAAATACACATTGTCCTCTCGATTTTTGGACCAAACAGACGCTCACAGTGGAGGCTTATCAAGGGTTGC ATTGGGGAAGAAGCCTCTCCCTCTCTGTCAGCACCAGCTGGTAAAGGTGACTGTACAGATGTGCATTTTCCTTTTGGTATAAATGGTCCA CAGCACTAACTGGTAAGGCTTATTGTACAGTATATTGTCAGTATTCTTCTGGTTCAGCATACCTTATAGTTCATATATAACCTGTATTAA TTGTATAGATTGTGCATTAAAAGCTGTTACCAAGTTGTCAGAACATAAGAGCGAAAACAAGGTCATATGTAATATTTTGTTTGTAAGTAT |
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FusionGenePPI for SPOP_TAOK1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SPOP | ZBTB16, DPPA2, RXRB, DDIT3, RTN3, MYD88, SIRT2, DOK2, KPNA6, GDI1, PIP5K1B, TRAF1, TRAF6, AR, BMI1, NCOA3, CUL3, ESR1, DAXX, SPOP, PIP4K2B, UBE2E3, FADD, PIAS1, GIT2, SRRM1, ATM, GLI2, DEK, BRMS1, NUP50, RTN4, GCC1, ERG, ERF, PGR, GLI3, UBE2D1, UBE2D2, NANOG, PTEN, DUSP7, EGLN2, RFWD2, SOST, ARIH1, MSRB3, BRD4, BRD3, BRD2 | TAOK1 | STK4, CSNK1E, DYNC1I1, GEMIN7, WT1, C8orf33, SRBD1, MAP3K7, STK25, STK26, NTRK1, SNW1, FAM206A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPOP_TAOK1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPOP_TAOK1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SPOP | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Hgene | SPOP | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | TAOK1 | C0018781 | Noise-induced hearing loss | 1 | CTD_human |
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