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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 35756

FusionGeneSummary for SPOP_NBPF1

check button Fusion gene summary
Fusion gene informationFusion gene name: SPOP_NBPF1
Fusion gene ID: 35756
HgeneTgene
Gene symbol

SPOP

NBPF1

Gene ID

8405

55672

Gene namespeckle type BTB/POZ proteinNBPF member 1
SynonymsBTBD32|TEF2AB13|AB14|AB23|AD2|NBG|NBPF
Cytomap

17q21.33

1p36.13

Type of geneprotein-codingprotein-coding
Descriptionspeckle-type POZ proteinHIB homolog 1roadkill homolog 1neuroblastoma breakpoint family member 1
Modification date2018052320180519
UniProtAcc

O43791

Ensembl transtripts involved in fusion geneENST00000393328, ENST00000393331, 
ENST00000347630, ENST00000504102, 
ENST00000503676, ENST00000513080, 
ENST00000430580, ENST00000420031, 
ENST00000432949, ENST00000287968, 
ENST00000599908, 
Fusion gene scores* DoF score20 X 8 X 13=20801 X 1 X 1=1
# samples 221
** MAII scorelog2(22/2080*10)=-3.24100809950379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: SPOP [Title/Abstract] AND NBPF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-QH-A6CV-01ASPOPchr17

47688642

-NBPF1chr1

16890681

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000393328ENST00000430580SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000393328ENST00000420031SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000393328ENST00000432949SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000393328ENST00000287968SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000393328ENST00000599908SPOPchr17

47688642

-NBPF1chr1

16890681

-
Frame-shiftENST00000393331ENST00000430580SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000393331ENST00000420031SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000393331ENST00000432949SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000393331ENST00000287968SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000393331ENST00000599908SPOPchr17

47688642

-NBPF1chr1

16890681

-
Frame-shiftENST00000347630ENST00000430580SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000347630ENST00000420031SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000347630ENST00000432949SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000347630ENST00000287968SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000347630ENST00000599908SPOPchr17

47688642

-NBPF1chr1

16890681

-
Frame-shiftENST00000504102ENST00000430580SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000504102ENST00000420031SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000504102ENST00000432949SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000504102ENST00000287968SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000504102ENST00000599908SPOPchr17

47688642

-NBPF1chr1

16890681

-
In-frameENST00000503676ENST00000430580SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000503676ENST00000420031SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000503676ENST00000432949SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000503676ENST00000287968SPOPchr17

47688642

-NBPF1chr1

16890681

-
5CDS-intronENST00000503676ENST00000599908SPOPchr17

47688642

-NBPF1chr1

16890681

-
intron-3CDSENST00000513080ENST00000430580SPOPchr17

47688642

-NBPF1chr1

16890681

-
intron-intronENST00000513080ENST00000420031SPOPchr17

47688642

-NBPF1chr1

16890681

-
intron-intronENST00000513080ENST00000432949SPOPchr17

47688642

-NBPF1chr1

16890681

-
intron-intronENST00000513080ENST00000287968SPOPchr17

47688642

-NBPF1chr1

16890681

-
intron-intronENST00000513080ENST00000599908SPOPchr17

47688642

-NBPF1chr1

16890681

-

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FusionProtFeatures for SPOP_NBPF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPOP

O43791

NBPF1

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3ubiquitin-protein ligase complex that mediates the ubiquitinationof target proteins, leading most often to their proteasomaldegradation. In complex with CUL3, involved in ubiquitination andproteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3.In complex with CUL3, involved in ubiquitination of H2AFY andBMI1; this does not lead to their proteasomal degradation.Inhibits transcriptional activation of PDX1/IPF1 targets, such asinsulin, by promoting PDX1/IPF1 degradation. The cullin-RING-basedBCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containinghomodimeric SPOP has higher ubiquitin ligase activity than thecomplex that contains the heterodimer formed by SPOP and SPOPL.{ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469,ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708,ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPOPchr17:47688642chr1:16890681ENST00000347630-71131_161219375DomainMATH
HgeneSPOPchr17:47688642chr1:16890681ENST00000393328-71131_161219375DomainMATH
HgeneSPOPchr17:47688642chr1:16890681ENST00000393331-81231_161219375DomainMATH
HgeneSPOPchr17:47688642chr1:16890681ENST00000503676-71131_161219375DomainMATH
HgeneSPOPchr17:47688642chr1:16890681ENST00000504102-61031_161219375DomainMATH
HgeneSPOPchr17:47688642chr1:16890681ENST00000347630-711123_133219375RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47688642chr1:16890681ENST00000347630-711186_217219375RegionNote=Important for homodimerization
HgeneSPOPchr17:47688642chr1:16890681ENST00000347630-71171_191219375RegionNote=Required for nuclear localization
HgeneSPOPchr17:47688642chr1:16890681ENST00000393328-711123_133219375RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47688642chr1:16890681ENST00000393328-711186_217219375RegionNote=Important for homodimerization
HgeneSPOPchr17:47688642chr1:16890681ENST00000393328-71171_191219375RegionNote=Required for nuclear localization
HgeneSPOPchr17:47688642chr1:16890681ENST00000393331-812123_133219375RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47688642chr1:16890681ENST00000393331-812186_217219375RegionNote=Important for homodimerization
HgeneSPOPchr17:47688642chr1:16890681ENST00000393331-81271_191219375RegionNote=Required for nuclear localization
HgeneSPOPchr17:47688642chr1:16890681ENST00000503676-711123_133219375RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47688642chr1:16890681ENST00000503676-711186_217219375RegionNote=Important for homodimerization
HgeneSPOPchr17:47688642chr1:16890681ENST00000503676-71171_191219375RegionNote=Required for nuclear localization
HgeneSPOPchr17:47688642chr1:16890681ENST00000504102-610123_133219375RegionNote=Important for binding substrate proteins
HgeneSPOPchr17:47688642chr1:16890681ENST00000504102-610186_217219375RegionNote=Important for homodimerization
HgeneSPOPchr17:47688642chr1:16890681ENST00000504102-61071_191219375RegionNote=Required for nuclear localization

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPOPchr17:47688642chr1:16890681ENST00000347630-711173_297219375DomainBTB
HgeneSPOPchr17:47688642chr1:16890681ENST00000393328-711173_297219375DomainBTB
HgeneSPOPchr17:47688642chr1:16890681ENST00000393331-812173_297219375DomainBTB
HgeneSPOPchr17:47688642chr1:16890681ENST00000503676-711173_297219375DomainBTB
HgeneSPOPchr17:47688642chr1:16890681ENST00000504102-610173_297219375DomainBTB
HgeneSPOPchr17:47688642chr1:16890681ENST00000347630-711297_355219375RegionNote=Important for homodimerization
HgeneSPOPchr17:47688642chr1:16890681ENST00000393328-711297_355219375RegionNote=Important for homodimerization
HgeneSPOPchr17:47688642chr1:16890681ENST00000393331-812297_355219375RegionNote=Important for homodimerization
HgeneSPOPchr17:47688642chr1:16890681ENST00000503676-711297_355219375RegionNote=Important for homodimerization
HgeneSPOPchr17:47688642chr1:16890681ENST00000504102-610297_355219375RegionNote=Important for homodimerization


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FusionGeneSequence for SPOP_NBPF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SPOP_ENST00000393328_chr17_47688642_-_NBPF1_ENST00000430580_chr1_16890681_-_300aa
MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLL
VSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK
VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAGSAACXWKWKSLKSCRTHWIDVIRLRQCTLNYLTHSSTTEVCFTHLRNSTS

>In-frame_SPOP_ENST00000503676_chr17_47688642_-_NBPF1_ENST00000430580_chr1_16890681_-_300aa
MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLL
VSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK
VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAGSAACXWKWKSLKSCRTHWIDVIRLRQCTLNYLTHSSTTEVCFTHLRNSTS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SPOP_ENST00000393328_chr17_47688642_-_NBPF1_ENST00000430580_chr1_16890681_-_902nt
ATGTCAAGGGTTCCAAGTCCTCCACCTCCGGCAGAAATGTCGAGTGGCCCCGTAGCTGAGAGTTGGTGCTACACACAGATCAAGGTAGTG
AAATTCTCCTACATGTGGACCATCAATAACTTTAGCTTTTGCCGGGAGGAAATGGGTGAAGTCATTAAAAGTTCTACATTTTCATCAGGA
GCAAATGATAAACTGAAATGGTGTTTGCGAGTAAACCCCAAAGGGTTAGATGAAGAAAGCAAAGATTACCTGTCACTTTACCTGTTACTG
GTCAGCTGTCCAAAGAGTGAAGTTCGGGCAAAATTCAAATTCTCCATCCTGAATGCCAAGGGAGAAGAAACCAAAGCTATGGAGAGTCAA
CGGGCATATAGGTTTGTGCAAGGCAAAGACTGGGGATTCAAGAAATTCATCCGTAGAGATTTTCTTTTGGATGAGGCCAACGGGCTTCTC
CCTGATGACAAGCTTACCCTCTTCTGCGAGGTGAGTGTTGTGCAAGATTCTGTCAACATTTCTGGCCAGAATACCATGAACATGGTAAAG
GTTCCTGAGTGCCGGCTGGCAGATGAGTTAGGAGGACTGTGGGAGAATTCCCGGTTCACAGACTGCTGCTTGTGTGTTGCCGGCCAGGAA
TTCCAGGCTCACAAGGCTATCTTAGCAGGCTCAGCGGCATGCTGATGGAAGTGGAAGAGCCTGAAGTCTTGCAGGACTCACTGGATAGAT
GTTATTCGACTCCGTCAATGTACTTTGAACTACCTGACTCATTCCAGCACTACAGAAGTGTGTTTTACTCATTTGAGGAACAGCACATCA
GCTTCGCCCTTGACGTGGACAATAGGTTTCTTACTTTGATGGGAACAAGTCTCCACCTGGTCTTCCAGATGGGAGTCATATTCCCACAGT

>In-frame_SPOP_ENST00000503676_chr17_47688642_-_NBPF1_ENST00000430580_chr1_16890681_-_902nt
ATGTCAAGGGTTCCAAGTCCTCCACCTCCGGCAGAAATGTCGAGTGGCCCCGTAGCTGAGAGTTGGTGCTACACACAGATCAAGGTAGTG
AAATTCTCCTACATGTGGACCATCAATAACTTTAGCTTTTGCCGGGAGGAAATGGGTGAAGTCATTAAAAGTTCTACATTTTCATCAGGA
GCAAATGATAAACTGAAATGGTGTTTGCGAGTAAACCCCAAAGGGTTAGATGAAGAAAGCAAAGATTACCTGTCACTTTACCTGTTACTG
GTCAGCTGTCCAAAGAGTGAAGTTCGGGCAAAATTCAAATTCTCCATCCTGAATGCCAAGGGAGAAGAAACCAAAGCTATGGAGAGTCAA
CGGGCATATAGGTTTGTGCAAGGCAAAGACTGGGGATTCAAGAAATTCATCCGTAGAGATTTTCTTTTGGATGAGGCCAACGGGCTTCTC
CCTGATGACAAGCTTACCCTCTTCTGCGAGGTGAGTGTTGTGCAAGATTCTGTCAACATTTCTGGCCAGAATACCATGAACATGGTAAAG
GTTCCTGAGTGCCGGCTGGCAGATGAGTTAGGAGGACTGTGGGAGAATTCCCGGTTCACAGACTGCTGCTTGTGTGTTGCCGGCCAGGAA
TTCCAGGCTCACAAGGCTATCTTAGCAGGCTCAGCGGCATGCTGATGGAAGTGGAAGAGCCTGAAGTCTTGCAGGACTCACTGGATAGAT
GTTATTCGACTCCGTCAATGTACTTTGAACTACCTGACTCATTCCAGCACTACAGAAGTGTGTTTTACTCATTTGAGGAACAGCACATCA
GCTTCGCCCTTGACGTGGACAATAGGTTTCTTACTTTGATGGGAACAAGTCTCCACCTGGTCTTCCAGATGGGAGTCATATTCCCACAGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_SPOP_ENST00000393328_chr17_47688642_-_NBPF1_ENST00000430580_chr1_16890681_-_2892nt
GTGCTGACGCCATGACGCCCCGGCTGGTGTGTGTCGGTGTGTATGTGTGTGTGTGAGTGTGCGCGCTCCGAGTGTGTGTGTATTTGTGTA
TCGGCGGTCCCGCAGGTCCCGGATGTTGCGGACAGTATGAGGCAAGCGCAGGGGGACGGGGACCAGCAGCTGTCGCCGCCGCTCTCAGAT
CGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCCACCTTTGCCTCCTGGGTTCAAGCGATTCTTCTG
CCTCAGCCTCCCGAGTAGCTGGGATTACAGGGTGAAGAGGGAACAGAAATCTTTGCCCCCTGACTTTGGAAATCTCGTTTAACCTTCAAA
CTGGCGATGTCAAGGGTTCCAAGTCCTCCACCTCCGGCAGAAATGTCGAGTGGCCCCGTAGCTGAGAGTTGGTGCTACACACAGATCAAG
GTAGTGAAATTCTCCTACATGTGGACCATCAATAACTTTAGCTTTTGCCGGGAGGAAATGGGTGAAGTCATTAAAAGTTCTACATTTTCA
TCAGGAGCAAATGATAAACTGAAATGGTGTTTGCGAGTAAACCCCAAAGGGTTAGATGAAGAAAGCAAAGATTACCTGTCACTTTACCTG
TTACTGGTCAGCTGTCCAAAGAGTGAAGTTCGGGCAAAATTCAAATTCTCCATCCTGAATGCCAAGGGAGAAGAAACCAAAGCTATGGAG
AGTCAACGGGCATATAGGTTTGTGCAAGGCAAAGACTGGGGATTCAAGAAATTCATCCGTAGAGATTTTCTTTTGGATGAGGCCAACGGG
CTTCTCCCTGATGACAAGCTTACCCTCTTCTGCGAGGTGAGTGTTGTGCAAGATTCTGTCAACATTTCTGGCCAGAATACCATGAACATG
GTAAAGGTTCCTGAGTGCCGGCTGGCAGATGAGTTAGGAGGACTGTGGGAGAATTCCCGGTTCACAGACTGCTGCTTGTGTGTTGCCGGC
CAGGAATTCCAGGCTCACAAGGCTATCTTAGCAGGCTCAGCGGCATGCTGATGGAAGTGGAAGAGCCTGAAGTCTTGCAGGACTCACTGG
ATAGATGTTATTCGACTCCGTCAATGTACTTTGAACTACCTGACTCATTCCAGCACTACAGAAGTGTGTTTTACTCATTTGAGGAACAGC
ACATCAGCTTCGCCCTTGACGTGGACAATAGGTTTCTTACTTTGATGGGAACAAGTCTCCACCTGGTCTTCCAGATGGGAGTCATATTCC
CACAGTAAGCAGCCCTTACTAAGCCGAGAGATGTCATTCCTGCAGGCAGGACCTATAGGCACGTGAAGATTTGAATGAAACTATAGTTCC
ATTTGGAAGCCCAGACATAGGATGGGTCAGTGGGCATGGCTCTATTCCTATTCTCAGACCATGCCAGTGGCACCCTGTGCTCAGTCTGAA
GACAATGGACCCAAGTTAGGTGTGACACGTTCACATAACTGTGCAGCACATGCCGGGAGTGATCAGTCAGACATTTTAATTTGAACCACT
TATCTCTGGGTAGCTACAAAGTTCCTCAGGGATTTCATTTTGCAGTCATGTCTCTGAGCTTCTATACCTGCTCAAGGTCAGTGTCATCTT
TGTGTTTAGCTCATCCAAAGGTGTTACCCTGGTTTCAATGAACCTAACCTCATTCTTTGTATCTTCAGTGTTGAATTGTTTTAGCTGATC
CATCTTTAACACAGGAGGGATCCTTGGCTGAGGATTGTATTTCAGAACCACCAACTGCTCTTGACAATTGTTAACCCGCTAGGCTCCTTT
GGTTAGAGAAGCCACAGTCCTTCAGCCTCCAATTGGTGTCAGTACTTAGGAAGACCACAGCTAGATGGACAAACAGCATTGGGAGGCCTT
AGCCCTGCTCCTCTCGATTCCATCCTGTAGAGAACAGGAGTCAGGAGCCGCTGGCAGGAGACAGCATGTCACCCAGGACTCTGCCGGTGC
AGAATATGAACAACGCCATGTTCTTGCAGAAAACGCTTAGCCTGAGTTTCATAGGAGGTAATTACCAGACAACTGCAGAATGTAGAACAC
TGAGCAGGACAACTGACCTGTCTCCTTCACATAGTCCATATCACCACAAATCACACAACAAAAAGGAGAAGAGATATTTTGGGTTCAAAA
AAAGTAAAAAGATAATATAGCTGCATTTCTTTAGTTATTTTGAACCCCAAATATTTCCTCATCTTTTTGTTGTTGTCATTGATGGTGGTG
ACATGGACTTGTTTATAGAGGACAGGTCAGCTCTCTGGCTCAATGATCTACATTCTGAAGTTGTCTGAAAATGTCTTCATGATTAAATTC
AGCCTAAACGTTTTGCCGGGAACACTGCAGAGACAATGCTGTGAGTTTCCAACCTTAGCCCATCTGCGGGCAGAGAAGGTCTAGTTTGTC
CATCAGCATTATCATGATATCAGGACTGGTTACTTGGTTAAGGAGGGGTCTAGGAGATCTGTCCCTTTTAGAGACACCTTACTTATAATG
AAGTATTTGGGAGGGTGGTTTTCAAAATTAGAAATGTCCTGTATTCCAATGATCATCCTGTAAACATTTTATCATTTATTAATCATCCCT
GCCTGTGTCTATTATTATATTCATATCTCTACGCTGGAAACTTTCTGCCTCAATGTTTACTGTGCCTTTGTTTTTGCTAGTGTGTGTTGT
TGAAAAAAAAAACATTCTCTGCCTGAGTTTTAATTTTTGTCCAAAGTTATTTTAATCTATACAATTAAAAGCTTTTGCCTATCACTCTGG
ACTGTTGGATTGTTTTTTACATTCAGTGTTATAATCTTTTGTTATGCTGATTGGTTTTGGTGGGTACTGATGTGAATTAATAAAAACATT

>In-frame_SPOP_ENST00000503676_chr17_47688642_-_NBPF1_ENST00000430580_chr1_16890681_-_3158nt
ATATAGCTTAAAGCATTTAACTGGAAAGGACCTTGGAAATCCTTTTAAAGGAGGATGGGGGTGGAAATGCACAGGTTGCTTCTCTCTCTC
TCTCTCTTTTTTTTTTTTTTTGAGACGGTCACCCAGGCTGTAGTGCAGTGGCGTGATCTCGGCTCACTGTGGCCTCCACCTCCCAAGTAG
CTGGGATTACAGGCTTGCGCCATCATGCAGGGCTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCATCATGTTGGCCAGGCTGGTCTGG
AACTCCTGACCTCAAGTGATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTAAAGGCATGAGCCACCACGCCTGGCCTAGGTTGTTCC
TCTACTGTGAATCTTGAGGTTATGGTTTCCACTAGACTATAGTGCTCAACTATAGTGGCCTATTTTAAGTGGCCTTATAATTCCTAACCA
AAGTGACTTGTGAAACAGAGGACCCTGGATAAATTTAAATGTTATAAAGATGATAAAATGTACAGAGATTTCCTGTTAGACAAGACAAAT
TAGAGTTTTCCTACTGACTTAACTTGGGTGAAGAGGGAACAGAAATCTTTGCCCCCTGACTTTGGAAATCTCGTTTAACCTTCAAACTGG
CGATGTCAAGGGTTCCAAGTCCTCCACCTCCGGCAGAAATGTCGAGTGGCCCCGTAGCTGAGAGTTGGTGCTACACACAGATCAAGGTAG
TGAAATTCTCCTACATGTGGACCATCAATAACTTTAGCTTTTGCCGGGAGGAAATGGGTGAAGTCATTAAAAGTTCTACATTTTCATCAG
GAGCAAATGATAAACTGAAATGGTGTTTGCGAGTAAACCCCAAAGGGTTAGATGAAGAAAGCAAAGATTACCTGTCACTTTACCTGTTAC
TGGTCAGCTGTCCAAAGAGTGAAGTTCGGGCAAAATTCAAATTCTCCATCCTGAATGCCAAGGGAGAAGAAACCAAAGCTATGGAGAGTC
AACGGGCATATAGGTTTGTGCAAGGCAAAGACTGGGGATTCAAGAAATTCATCCGTAGAGATTTTCTTTTGGATGAGGCCAACGGGCTTC
TCCCTGATGACAAGCTTACCCTCTTCTGCGAGGTGAGTGTTGTGCAAGATTCTGTCAACATTTCTGGCCAGAATACCATGAACATGGTAA
AGGTTCCTGAGTGCCGGCTGGCAGATGAGTTAGGAGGACTGTGGGAGAATTCCCGGTTCACAGACTGCTGCTTGTGTGTTGCCGGCCAGG
AATTCCAGGCTCACAAGGCTATCTTAGCAGGCTCAGCGGCATGCTGATGGAAGTGGAAGAGCCTGAAGTCTTGCAGGACTCACTGGATAG
ATGTTATTCGACTCCGTCAATGTACTTTGAACTACCTGACTCATTCCAGCACTACAGAAGTGTGTTTTACTCATTTGAGGAACAGCACAT
CAGCTTCGCCCTTGACGTGGACAATAGGTTTCTTACTTTGATGGGAACAAGTCTCCACCTGGTCTTCCAGATGGGAGTCATATTCCCACA
GTAAGCAGCCCTTACTAAGCCGAGAGATGTCATTCCTGCAGGCAGGACCTATAGGCACGTGAAGATTTGAATGAAACTATAGTTCCATTT
GGAAGCCCAGACATAGGATGGGTCAGTGGGCATGGCTCTATTCCTATTCTCAGACCATGCCAGTGGCACCCTGTGCTCAGTCTGAAGACA
ATGGACCCAAGTTAGGTGTGACACGTTCACATAACTGTGCAGCACATGCCGGGAGTGATCAGTCAGACATTTTAATTTGAACCACTTATC
TCTGGGTAGCTACAAAGTTCCTCAGGGATTTCATTTTGCAGTCATGTCTCTGAGCTTCTATACCTGCTCAAGGTCAGTGTCATCTTTGTG
TTTAGCTCATCCAAAGGTGTTACCCTGGTTTCAATGAACCTAACCTCATTCTTTGTATCTTCAGTGTTGAATTGTTTTAGCTGATCCATC
TTTAACACAGGAGGGATCCTTGGCTGAGGATTGTATTTCAGAACCACCAACTGCTCTTGACAATTGTTAACCCGCTAGGCTCCTTTGGTT
AGAGAAGCCACAGTCCTTCAGCCTCCAATTGGTGTCAGTACTTAGGAAGACCACAGCTAGATGGACAAACAGCATTGGGAGGCCTTAGCC
CTGCTCCTCTCGATTCCATCCTGTAGAGAACAGGAGTCAGGAGCCGCTGGCAGGAGACAGCATGTCACCCAGGACTCTGCCGGTGCAGAA
TATGAACAACGCCATGTTCTTGCAGAAAACGCTTAGCCTGAGTTTCATAGGAGGTAATTACCAGACAACTGCAGAATGTAGAACACTGAG
CAGGACAACTGACCTGTCTCCTTCACATAGTCCATATCACCACAAATCACACAACAAAAAGGAGAAGAGATATTTTGGGTTCAAAAAAAG
TAAAAAGATAATATAGCTGCATTTCTTTAGTTATTTTGAACCCCAAATATTTCCTCATCTTTTTGTTGTTGTCATTGATGGTGGTGACAT
GGACTTGTTTATAGAGGACAGGTCAGCTCTCTGGCTCAATGATCTACATTCTGAAGTTGTCTGAAAATGTCTTCATGATTAAATTCAGCC
TAAACGTTTTGCCGGGAACACTGCAGAGACAATGCTGTGAGTTTCCAACCTTAGCCCATCTGCGGGCAGAGAAGGTCTAGTTTGTCCATC
AGCATTATCATGATATCAGGACTGGTTACTTGGTTAAGGAGGGGTCTAGGAGATCTGTCCCTTTTAGAGACACCTTACTTATAATGAAGT
ATTTGGGAGGGTGGTTTTCAAAATTAGAAATGTCCTGTATTCCAATGATCATCCTGTAAACATTTTATCATTTATTAATCATCCCTGCCT
GTGTCTATTATTATATTCATATCTCTACGCTGGAAACTTTCTGCCTCAATGTTTACTGTGCCTTTGTTTTTGCTAGTGTGTGTTGTTGAA
AAAAAAAACATTCTCTGCCTGAGTTTTAATTTTTGTCCAAAGTTATTTTAATCTATACAATTAAAAGCTTTTGCCTATCACTCTGGACTG
TTGGATTGTTTTTTACATTCAGTGTTATAATCTTTTGTTATGCTGATTGGTTTTGGTGGGTACTGATGTGAATTAATAAAAACATTTCCA


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FusionGenePPI for SPOP_NBPF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPOPZBTB16, DPPA2, RXRB, DDIT3, RTN3, MYD88, SIRT2, DOK2, KPNA6, GDI1, PIP5K1B, TRAF1, TRAF6, AR, BMI1, NCOA3, CUL3, ESR1, DAXX, SPOP, PIP4K2B, UBE2E3, FADD, PIAS1, GIT2, SRRM1, ATM, GLI2, DEK, BRMS1, NUP50, RTN4, GCC1, ERG, ERF, PGR, GLI3, UBE2D1, UBE2D2, NANOG, PTEN, DUSP7, EGLN2, RFWD2, SOST, ARIH1, MSRB3, BRD4, BRD3, BRD2NBPF1UBC, NBPF3, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPOP_NBPF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPOP_NBPF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPOPC0014170Endometrial Neoplasms1CTD_human
HgeneSPOPC0033578Prostatic Neoplasms1CTD_human