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Fusion gene ID: 35747 |
FusionGeneSummary for SPOP_AARSD1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: SPOP_AARSD1 | Fusion gene ID: 35747 | Hgene | Tgene | Gene symbol | SPOP | AARSD1 | Gene ID | 8405 | 80755 |
Gene name | speckle type BTB/POZ protein | alanyl-tRNA synthetase domain containing 1 | |
Synonyms | BTBD32|TEF2 | - | |
Cytomap | 17q21.33 | 17q21.31 | |
Type of gene | protein-coding | protein-coding | |
Description | speckle-type POZ proteinHIB homolog 1roadkill homolog 1 | alanyl-tRNA editing protein Aarsd1alanyl-tRNA synthetase domain-containing protein 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O43791 | Q9BTE6 | |
Ensembl transtripts involved in fusion gene | ENST00000393328, ENST00000393331, ENST00000347630, ENST00000504102, ENST00000503676, ENST00000513080, | ENST00000427569, ENST00000416949, | |
Fusion gene scores | * DoF score | 20 X 8 X 13=2080 | 3 X 3 X 3=27 |
# samples | 22 | 3 | |
** MAII score | log2(22/2080*10)=-3.24100809950379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SPOP [Title/Abstract] AND AARSD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | ACC | TCGA-OR-A5KT-01A | SPOP | chr17 | 47688642 | - | AARSD1 | chr17 | 41116254 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000393328 | ENST00000427569 | SPOP | chr17 | 47688642 | - | AARSD1 | chr17 | 41116254 | - |
5CDS-5UTR | ENST00000393328 | ENST00000416949 | SPOP | chr17 | 47688642 | - | AARSD1 | chr17 | 41116254 | - |
Frame-shift | ENST00000393331 | ENST00000427569 | SPOP | chr17 | 47688642 | - | AARSD1 | chr17 | 41116254 | - |
5CDS-5UTR | ENST00000393331 | ENST00000416949 | SPOP | chr17 | 47688642 | - | AARSD1 | chr17 | 41116254 | - |
Frame-shift | ENST00000347630 | ENST00000427569 | SPOP | chr17 | 47688642 | - | AARSD1 | chr17 | 41116254 | - |
5CDS-5UTR | ENST00000347630 | ENST00000416949 | SPOP | chr17 | 47688642 | - | AARSD1 | chr17 | 41116254 | - |
Frame-shift | ENST00000504102 | ENST00000427569 | SPOP | chr17 | 47688642 | - | AARSD1 | chr17 | 41116254 | - |
5CDS-5UTR | ENST00000504102 | ENST00000416949 | SPOP | chr17 | 47688642 | - | AARSD1 | chr17 | 41116254 | - |
In-frame | ENST00000503676 | ENST00000427569 | SPOP | chr17 | 47688642 | - | AARSD1 | chr17 | 41116254 | - |
5CDS-5UTR | ENST00000503676 | ENST00000416949 | SPOP | chr17 | 47688642 | - | AARSD1 | chr17 | 41116254 | - |
intron-3CDS | ENST00000513080 | ENST00000427569 | SPOP | chr17 | 47688642 | - | AARSD1 | chr17 | 41116254 | - |
intron-5UTR | ENST00000513080 | ENST00000416949 | SPOP | chr17 | 47688642 | - | AARSD1 | chr17 | 41116254 | - |
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FusionProtFeatures for SPOP_AARSD1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SPOP | AARSD1 |
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3ubiquitin-protein ligase complex that mediates the ubiquitinationof target proteins, leading most often to their proteasomaldegradation. In complex with CUL3, involved in ubiquitination andproteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3.In complex with CUL3, involved in ubiquitination of H2AFY andBMI1; this does not lead to their proteasomal degradation.Inhibits transcriptional activation of PDX1/IPF1 targets, such asinsulin, by promoting PDX1/IPF1 degradation. The cullin-RING-basedBCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containinghomodimeric SPOP has higher ubiquitin ligase activity than thecomplex that contains the heterodimer formed by SPOP and SPOPL.{ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469,ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708,ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832}. | Functions in trans to edit the amino acid moiety fromincorrectly charged tRNA(Ala). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000347630 | - | 7 | 11 | 31_161 | 219 | 375 | Domain | MATH |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000393328 | - | 7 | 11 | 31_161 | 219 | 375 | Domain | MATH |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000393331 | - | 8 | 12 | 31_161 | 219 | 375 | Domain | MATH |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000503676 | - | 7 | 11 | 31_161 | 219 | 375 | Domain | MATH |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000504102 | - | 6 | 10 | 31_161 | 219 | 375 | Domain | MATH |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000347630 | - | 7 | 11 | 123_133 | 219 | 375 | Region | Note=Important for binding substrate proteins |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000347630 | - | 7 | 11 | 186_217 | 219 | 375 | Region | Note=Important for homodimerization |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000347630 | - | 7 | 11 | 71_191 | 219 | 375 | Region | Note=Required for nuclear localization |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000393328 | - | 7 | 11 | 123_133 | 219 | 375 | Region | Note=Important for binding substrate proteins |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000393328 | - | 7 | 11 | 186_217 | 219 | 375 | Region | Note=Important for homodimerization |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000393328 | - | 7 | 11 | 71_191 | 219 | 375 | Region | Note=Required for nuclear localization |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000393331 | - | 8 | 12 | 123_133 | 219 | 375 | Region | Note=Important for binding substrate proteins |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000393331 | - | 8 | 12 | 186_217 | 219 | 375 | Region | Note=Important for homodimerization |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000393331 | - | 8 | 12 | 71_191 | 219 | 375 | Region | Note=Required for nuclear localization |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000503676 | - | 7 | 11 | 123_133 | 219 | 375 | Region | Note=Important for binding substrate proteins |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000503676 | - | 7 | 11 | 186_217 | 219 | 375 | Region | Note=Important for homodimerization |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000503676 | - | 7 | 11 | 71_191 | 219 | 375 | Region | Note=Required for nuclear localization |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000504102 | - | 6 | 10 | 123_133 | 219 | 375 | Region | Note=Important for binding substrate proteins |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000504102 | - | 6 | 10 | 186_217 | 219 | 375 | Region | Note=Important for homodimerization |
Hgene | SPOP | chr17:47688642 | chr17:41116254 | ENST00000504102 | - | 6 | 10 | 71_191 | 219 | 375 | Region | Note=Required for nuclear localization |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >SPOP | chr17:47688642 | chr17:41116254 | ENST00000347630 | - | 7 | 11 | 173_297 | 219 | 375 | Domain | BTB |
Hgene | >SPOP | chr17:47688642 | chr17:41116254 | ENST00000393328 | - | 7 | 11 | 173_297 | 219 | 375 | Domain | BTB |
Hgene | >SPOP | chr17:47688642 | chr17:41116254 | ENST00000393331 | - | 8 | 12 | 173_297 | 219 | 375 | Domain | BTB |
Hgene | >SPOP | chr17:47688642 | chr17:41116254 | ENST00000503676 | - | 7 | 11 | 173_297 | 219 | 375 | Domain | BTB |
Hgene | >SPOP | chr17:47688642 | chr17:41116254 | ENST00000504102 | - | 6 | 10 | 173_297 | 219 | 375 | Domain | BTB |
Hgene | >SPOP | chr17:47688642 | chr17:41116254 | ENST00000347630 | - | 7 | 11 | 297_355 | 219 | 375 | Region | Note=Important for homodimerization |
Hgene | >SPOP | chr17:47688642 | chr17:41116254 | ENST00000393328 | - | 7 | 11 | 297_355 | 219 | 375 | Region | Note=Important for homodimerization |
Hgene | >SPOP | chr17:47688642 | chr17:41116254 | ENST00000393331 | - | 8 | 12 | 297_355 | 219 | 375 | Region | Note=Important for homodimerization |
Hgene | >SPOP | chr17:47688642 | chr17:41116254 | ENST00000503676 | - | 7 | 11 | 297_355 | 219 | 375 | Region | Note=Important for homodimerization |
Hgene | >SPOP | chr17:47688642 | chr17:41116254 | ENST00000504102 | - | 6 | 10 | 297_355 | 219 | 375 | Region | Note=Important for homodimerization |
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FusionGeneSequence for SPOP_AARSD1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SPOP_ENST00000393328_chr17_47688642_-_AARSD1_ENST00000427569_chr17_41116254_-_619aa MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLL VSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAVHHHRGLLLSRGAADXREQRQERSAERFPSGAGRHSAFPXGRGTAXXPWYN QXHLCAESDSPWGTGXSFHPDTPGSRKPGSGPGRLGAEVXPHAAAFRAASHHGSCXPSIXAEDNIMGVREISECDXAGHPLYDCRASSCH XAERQXKNQRSAACECPRTEPGXSXGGAGEWPGFAXXSCWAHSGCXHRGRXFQHVLWDPCEQSQXPSGHXDSGHXEGEKEQNQPDISVWE PGAEVDGEKSWNXKSTDCSAXVWSRGSCGSSEKAPELHQDPAEEXPESAQRPGCAHCPXPQEQSRLGRCGHITQEGGXFRVHEYHCQXDW >In-frame_SPOP_ENST00000503676_chr17_47688642_-_AARSD1_ENST00000427569_chr17_41116254_-_619aa MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLL VSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAVHHHRGLLLSRGAADXREQRQERSAERFPSGAGRHSAFPXGRGTAXXPWYN QXHLCAESDSPWGTGXSFHPDTPGSRKPGSGPGRLGAEVXPHAAAFRAASHHGSCXPSIXAEDNIMGVREISECDXAGHPLYDCRASSCH XAERQXKNQRSAACECPRTEPGXSXGGAGEWPGFAXXSCWAHSGCXHRGRXFQHVLWDPCEQSQXPSGHXDSGHXEGEKEQNQPDISVWE PGAEVDGEKSWNXKSTDCSAXVWSRGSCGSSEKAPELHQDPAEEXPESAQRPGCAHCPXPQEQSRLGRCGHITQEGGXFRVHEYHCQXDW |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SPOP_ENST00000393328_chr17_47688642_-_AARSD1_ENST00000427569_chr17_41116254_-_1858nt ATGTCAAGGGTTCCAAGTCCTCCACCTCCGGCAGAAATGTCGAGTGGCCCCGTAGCTGAGAGTTGGTGCTACACACAGATCAAGGTAGTG AAATTCTCCTACATGTGGACCATCAATAACTTTAGCTTTTGCCGGGAGGAAATGGGTGAAGTCATTAAAAGTTCTACATTTTCATCAGGA GCAAATGATAAACTGAAATGGTGTTTGCGAGTAAACCCCAAAGGGTTAGATGAAGAAAGCAAAGATTACCTGTCACTTTACCTGTTACTG GTCAGCTGTCCAAAGAGTGAAGTTCGGGCAAAATTCAAATTCTCCATCCTGAATGCCAAGGGAGAAGAAACCAAAGCTATGGAGAGTCAA CGGGCATATAGGTTTGTGCAAGGCAAAGACTGGGGATTCAAGAAATTCATCCGTAGAGATTTTCTTTTGGATGAGGCCAACGGGCTTCTC CCTGATGACAAGCTTACCCTCTTCTGCGAGGTGAGTGTTGTGCAAGATTCTGTCAACATTTCTGGCCAGAATACCATGAACATGGTAAAG GTTCCTGAGTGCCGGCTGGCAGATGAGTTAGGAGGACTGTGGGAGAATTCCCGGTTCACAGACTGCTGCTTGTGTGTTGCCGGCCAGGAA TTCCAGGCTCACAAGGCTATCTTAGCAGTTCACCACCACCGTGGTCTCCTGCTGTCCCGCGGAGCTGCAGACTGAAGGGAGCAACGGCAA GAAAGAAGTGCTGAGCGGTTTCCAAGTGGTGCTGGAAGACACAGTGCTTTTCCCTGAGGGCGGGGGACAGCCTGATGACCGTGGTACAAT CAATGACATCTCTGTGCTGAGAGTGACTCGCCGTGGGGAACAGGCTGATCATTTCACCCAGACACCCCTGGATCCAGGAAGCCAGGTTCT GGTCCGGGTAGATTGGGAGCGGAGGTTTGACCACATGCAGCAGCATTCAGGGCAGCATCTCATCACGGCAGTTGCTGACCATCTATTTAA GCTGAAGACAACATCATGGGAGTTAGGGAGATTTCGGAGTGCGATTGAGCTGGACACCCCCTCTATGACTGCAGAGCAAGTAGCTGCCAT TGAGCAGAGCGTCAATGAAAAAATCAGAGATCGGCTGCCTGTGAATGTCCGAGAACTGAGCCTGGATGATCCTGAGGTGGAGCAGGTGAG TGGCCGGGGTTTGCCTGATGATCATGCTGGGCCCATTCGGGTTGTTAACATCGAGGGCGTTGATTCCAACATGTGCTGTGGGACCCATGT GAGCAATCTCAGTGACCTTCAGGTCATTAAGATTCTGGGCACTGAGAAGGGGAAAAAGAACAGAACCAACCTGATATTTCTGTCTGGGAA CCGGGTGCTGAAGTGGATGGAGAGAAGTCATGGAACTGAAAAAGCACTGACTGCTCTGCTTAAGTGTGGAGCAGAGGATCATGTGGAAGC AGTGAAAAAGCTCCAGAACTCCACCAAGATCCTGCAGAAGAATAACCTGAATCTGCTCAGAGACCTGGCTGTGCACATTGCCCATAGCCT CAGGAACAGTCCAGACTGGGGAGGTGTGGTCATATTACACAGGAAGGAGGGTGATTCAGAGTTCATGAATATCATTGCCAATGAGATTGG GTCAGAGGAGACCCTCCTGTTCTTAACTGTGGGCGATGAGAAAGGTGGTGGACTCTTCTTACTGGCAGGGCCACCTGCGTCTGTGGAGAC CCTGGGGCCCAGGGTGGCTGAGGTCCTGGAAGGCAAAGGAGCAGGGAAGAAAGGCCGTTTTCAGGGCAAGGCCACCAAGATGAGCCGGCG >In-frame_SPOP_ENST00000503676_chr17_47688642_-_AARSD1_ENST00000427569_chr17_41116254_-_1858nt ATGTCAAGGGTTCCAAGTCCTCCACCTCCGGCAGAAATGTCGAGTGGCCCCGTAGCTGAGAGTTGGTGCTACACACAGATCAAGGTAGTG AAATTCTCCTACATGTGGACCATCAATAACTTTAGCTTTTGCCGGGAGGAAATGGGTGAAGTCATTAAAAGTTCTACATTTTCATCAGGA GCAAATGATAAACTGAAATGGTGTTTGCGAGTAAACCCCAAAGGGTTAGATGAAGAAAGCAAAGATTACCTGTCACTTTACCTGTTACTG GTCAGCTGTCCAAAGAGTGAAGTTCGGGCAAAATTCAAATTCTCCATCCTGAATGCCAAGGGAGAAGAAACCAAAGCTATGGAGAGTCAA CGGGCATATAGGTTTGTGCAAGGCAAAGACTGGGGATTCAAGAAATTCATCCGTAGAGATTTTCTTTTGGATGAGGCCAACGGGCTTCTC CCTGATGACAAGCTTACCCTCTTCTGCGAGGTGAGTGTTGTGCAAGATTCTGTCAACATTTCTGGCCAGAATACCATGAACATGGTAAAG GTTCCTGAGTGCCGGCTGGCAGATGAGTTAGGAGGACTGTGGGAGAATTCCCGGTTCACAGACTGCTGCTTGTGTGTTGCCGGCCAGGAA TTCCAGGCTCACAAGGCTATCTTAGCAGTTCACCACCACCGTGGTCTCCTGCTGTCCCGCGGAGCTGCAGACTGAAGGGAGCAACGGCAA GAAAGAAGTGCTGAGCGGTTTCCAAGTGGTGCTGGAAGACACAGTGCTTTTCCCTGAGGGCGGGGGACAGCCTGATGACCGTGGTACAAT CAATGACATCTCTGTGCTGAGAGTGACTCGCCGTGGGGAACAGGCTGATCATTTCACCCAGACACCCCTGGATCCAGGAAGCCAGGTTCT GGTCCGGGTAGATTGGGAGCGGAGGTTTGACCACATGCAGCAGCATTCAGGGCAGCATCTCATCACGGCAGTTGCTGACCATCTATTTAA GCTGAAGACAACATCATGGGAGTTAGGGAGATTTCGGAGTGCGATTGAGCTGGACACCCCCTCTATGACTGCAGAGCAAGTAGCTGCCAT TGAGCAGAGCGTCAATGAAAAAATCAGAGATCGGCTGCCTGTGAATGTCCGAGAACTGAGCCTGGATGATCCTGAGGTGGAGCAGGTGAG TGGCCGGGGTTTGCCTGATGATCATGCTGGGCCCATTCGGGTTGTTAACATCGAGGGCGTTGATTCCAACATGTGCTGTGGGACCCATGT GAGCAATCTCAGTGACCTTCAGGTCATTAAGATTCTGGGCACTGAGAAGGGGAAAAAGAACAGAACCAACCTGATATTTCTGTCTGGGAA CCGGGTGCTGAAGTGGATGGAGAGAAGTCATGGAACTGAAAAAGCACTGACTGCTCTGCTTAAGTGTGGAGCAGAGGATCATGTGGAAGC AGTGAAAAAGCTCCAGAACTCCACCAAGATCCTGCAGAAGAATAACCTGAATCTGCTCAGAGACCTGGCTGTGCACATTGCCCATAGCCT CAGGAACAGTCCAGACTGGGGAGGTGTGGTCATATTACACAGGAAGGAGGGTGATTCAGAGTTCATGAATATCATTGCCAATGAGATTGG GTCAGAGGAGACCCTCCTGTTCTTAACTGTGGGCGATGAGAAAGGTGGTGGACTCTTCTTACTGGCAGGGCCACCTGCGTCTGTGGAGAC CCTGGGGCCCAGGGTGGCTGAGGTCCTGGAAGGCAAAGGAGCAGGGAAGAAAGGCCGTTTTCAGGGCAAGGCCACCAAGATGAGCCGGCG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SPOP_ENST00000393328_chr17_47688642_-_AARSD1_ENST00000427569_chr17_41116254_-_2271nt GTGCTGACGCCATGACGCCCCGGCTGGTGTGTGTCGGTGTGTATGTGTGTGTGTGAGTGTGCGCGCTCCGAGTGTGTGTGTATTTGTGTA TCGGCGGTCCCGCAGGTCCCGGATGTTGCGGACAGTATGAGGCAAGCGCAGGGGGACGGGGACCAGCAGCTGTCGCCGCCGCTCTCAGAT CGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCCACCTTTGCCTCCTGGGTTCAAGCGATTCTTCTG CCTCAGCCTCCCGAGTAGCTGGGATTACAGGGTGAAGAGGGAACAGAAATCTTTGCCCCCTGACTTTGGAAATCTCGTTTAACCTTCAAA CTGGCGATGTCAAGGGTTCCAAGTCCTCCACCTCCGGCAGAAATGTCGAGTGGCCCCGTAGCTGAGAGTTGGTGCTACACACAGATCAAG GTAGTGAAATTCTCCTACATGTGGACCATCAATAACTTTAGCTTTTGCCGGGAGGAAATGGGTGAAGTCATTAAAAGTTCTACATTTTCA TCAGGAGCAAATGATAAACTGAAATGGTGTTTGCGAGTAAACCCCAAAGGGTTAGATGAAGAAAGCAAAGATTACCTGTCACTTTACCTG TTACTGGTCAGCTGTCCAAAGAGTGAAGTTCGGGCAAAATTCAAATTCTCCATCCTGAATGCCAAGGGAGAAGAAACCAAAGCTATGGAG AGTCAACGGGCATATAGGTTTGTGCAAGGCAAAGACTGGGGATTCAAGAAATTCATCCGTAGAGATTTTCTTTTGGATGAGGCCAACGGG CTTCTCCCTGATGACAAGCTTACCCTCTTCTGCGAGGTGAGTGTTGTGCAAGATTCTGTCAACATTTCTGGCCAGAATACCATGAACATG GTAAAGGTTCCTGAGTGCCGGCTGGCAGATGAGTTAGGAGGACTGTGGGAGAATTCCCGGTTCACAGACTGCTGCTTGTGTGTTGCCGGC CAGGAATTCCAGGCTCACAAGGCTATCTTAGCAGTTCACCACCACCGTGGTCTCCTGCTGTCCCGCGGAGCTGCAGACTGAAGGGAGCAA CGGCAAGAAAGAAGTGCTGAGCGGTTTCCAAGTGGTGCTGGAAGACACAGTGCTTTTCCCTGAGGGCGGGGGACAGCCTGATGACCGTGG TACAATCAATGACATCTCTGTGCTGAGAGTGACTCGCCGTGGGGAACAGGCTGATCATTTCACCCAGACACCCCTGGATCCAGGAAGCCA GGTTCTGGTCCGGGTAGATTGGGAGCGGAGGTTTGACCACATGCAGCAGCATTCAGGGCAGCATCTCATCACGGCAGTTGCTGACCATCT ATTTAAGCTGAAGACAACATCATGGGAGTTAGGGAGATTTCGGAGTGCGATTGAGCTGGACACCCCCTCTATGACTGCAGAGCAAGTAGC TGCCATTGAGCAGAGCGTCAATGAAAAAATCAGAGATCGGCTGCCTGTGAATGTCCGAGAACTGAGCCTGGATGATCCTGAGGTGGAGCA GGTGAGTGGCCGGGGTTTGCCTGATGATCATGCTGGGCCCATTCGGGTTGTTAACATCGAGGGCGTTGATTCCAACATGTGCTGTGGGAC CCATGTGAGCAATCTCAGTGACCTTCAGGTCATTAAGATTCTGGGCACTGAGAAGGGGAAAAAGAACAGAACCAACCTGATATTTCTGTC TGGGAACCGGGTGCTGAAGTGGATGGAGAGAAGTCATGGAACTGAAAAAGCACTGACTGCTCTGCTTAAGTGTGGAGCAGAGGATCATGT GGAAGCAGTGAAAAAGCTCCAGAACTCCACCAAGATCCTGCAGAAGAATAACCTGAATCTGCTCAGAGACCTGGCTGTGCACATTGCCCA TAGCCTCAGGAACAGTCCAGACTGGGGAGGTGTGGTCATATTACACAGGAAGGAGGGTGATTCAGAGTTCATGAATATCATTGCCAATGA GATTGGGTCAGAGGAGACCCTCCTGTTCTTAACTGTGGGCGATGAGAAAGGTGGTGGACTCTTCTTACTGGCAGGGCCACCTGCGTCTGT GGAGACCCTGGGGCCCAGGGTGGCTGAGGTCCTGGAAGGCAAAGGAGCAGGGAAGAAAGGCCGTTTTCAGGGCAAGGCCACCAAGATGAG CCGGCGGATGGAGGCGCAGGCGCTTCTCCAGGACTACATCAGCACGCAGAGTGCTAAGGAGTGAGGGCTTAGGGCACTCACCTCCTGTTT >In-frame_SPOP_ENST00000503676_chr17_47688642_-_AARSD1_ENST00000427569_chr17_41116254_-_2537nt ATATAGCTTAAAGCATTTAACTGGAAAGGACCTTGGAAATCCTTTTAAAGGAGGATGGGGGTGGAAATGCACAGGTTGCTTCTCTCTCTC TCTCTCTTTTTTTTTTTTTTTGAGACGGTCACCCAGGCTGTAGTGCAGTGGCGTGATCTCGGCTCACTGTGGCCTCCACCTCCCAAGTAG CTGGGATTACAGGCTTGCGCCATCATGCAGGGCTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCATCATGTTGGCCAGGCTGGTCTGG AACTCCTGACCTCAAGTGATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTAAAGGCATGAGCCACCACGCCTGGCCTAGGTTGTTCC TCTACTGTGAATCTTGAGGTTATGGTTTCCACTAGACTATAGTGCTCAACTATAGTGGCCTATTTTAAGTGGCCTTATAATTCCTAACCA AAGTGACTTGTGAAACAGAGGACCCTGGATAAATTTAAATGTTATAAAGATGATAAAATGTACAGAGATTTCCTGTTAGACAAGACAAAT TAGAGTTTTCCTACTGACTTAACTTGGGTGAAGAGGGAACAGAAATCTTTGCCCCCTGACTTTGGAAATCTCGTTTAACCTTCAAACTGG CGATGTCAAGGGTTCCAAGTCCTCCACCTCCGGCAGAAATGTCGAGTGGCCCCGTAGCTGAGAGTTGGTGCTACACACAGATCAAGGTAG TGAAATTCTCCTACATGTGGACCATCAATAACTTTAGCTTTTGCCGGGAGGAAATGGGTGAAGTCATTAAAAGTTCTACATTTTCATCAG GAGCAAATGATAAACTGAAATGGTGTTTGCGAGTAAACCCCAAAGGGTTAGATGAAGAAAGCAAAGATTACCTGTCACTTTACCTGTTAC TGGTCAGCTGTCCAAAGAGTGAAGTTCGGGCAAAATTCAAATTCTCCATCCTGAATGCCAAGGGAGAAGAAACCAAAGCTATGGAGAGTC AACGGGCATATAGGTTTGTGCAAGGCAAAGACTGGGGATTCAAGAAATTCATCCGTAGAGATTTTCTTTTGGATGAGGCCAACGGGCTTC TCCCTGATGACAAGCTTACCCTCTTCTGCGAGGTGAGTGTTGTGCAAGATTCTGTCAACATTTCTGGCCAGAATACCATGAACATGGTAA AGGTTCCTGAGTGCCGGCTGGCAGATGAGTTAGGAGGACTGTGGGAGAATTCCCGGTTCACAGACTGCTGCTTGTGTGTTGCCGGCCAGG AATTCCAGGCTCACAAGGCTATCTTAGCAGTTCACCACCACCGTGGTCTCCTGCTGTCCCGCGGAGCTGCAGACTGAAGGGAGCAACGGC AAGAAAGAAGTGCTGAGCGGTTTCCAAGTGGTGCTGGAAGACACAGTGCTTTTCCCTGAGGGCGGGGGACAGCCTGATGACCGTGGTACA ATCAATGACATCTCTGTGCTGAGAGTGACTCGCCGTGGGGAACAGGCTGATCATTTCACCCAGACACCCCTGGATCCAGGAAGCCAGGTT CTGGTCCGGGTAGATTGGGAGCGGAGGTTTGACCACATGCAGCAGCATTCAGGGCAGCATCTCATCACGGCAGTTGCTGACCATCTATTT AAGCTGAAGACAACATCATGGGAGTTAGGGAGATTTCGGAGTGCGATTGAGCTGGACACCCCCTCTATGACTGCAGAGCAAGTAGCTGCC ATTGAGCAGAGCGTCAATGAAAAAATCAGAGATCGGCTGCCTGTGAATGTCCGAGAACTGAGCCTGGATGATCCTGAGGTGGAGCAGGTG AGTGGCCGGGGTTTGCCTGATGATCATGCTGGGCCCATTCGGGTTGTTAACATCGAGGGCGTTGATTCCAACATGTGCTGTGGGACCCAT GTGAGCAATCTCAGTGACCTTCAGGTCATTAAGATTCTGGGCACTGAGAAGGGGAAAAAGAACAGAACCAACCTGATATTTCTGTCTGGG AACCGGGTGCTGAAGTGGATGGAGAGAAGTCATGGAACTGAAAAAGCACTGACTGCTCTGCTTAAGTGTGGAGCAGAGGATCATGTGGAA GCAGTGAAAAAGCTCCAGAACTCCACCAAGATCCTGCAGAAGAATAACCTGAATCTGCTCAGAGACCTGGCTGTGCACATTGCCCATAGC CTCAGGAACAGTCCAGACTGGGGAGGTGTGGTCATATTACACAGGAAGGAGGGTGATTCAGAGTTCATGAATATCATTGCCAATGAGATT GGGTCAGAGGAGACCCTCCTGTTCTTAACTGTGGGCGATGAGAAAGGTGGTGGACTCTTCTTACTGGCAGGGCCACCTGCGTCTGTGGAG ACCCTGGGGCCCAGGGTGGCTGAGGTCCTGGAAGGCAAAGGAGCAGGGAAGAAAGGCCGTTTTCAGGGCAAGGCCACCAAGATGAGCCGG CGGATGGAGGCGCAGGCGCTTCTCCAGGACTACATCAGCACGCAGAGTGCTAAGGAGTGAGGGCTTAGGGCACTCACCTCCTGTTTCCAC |
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FusionGenePPI for SPOP_AARSD1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SPOP | ZBTB16, DPPA2, RXRB, DDIT3, RTN3, MYD88, SIRT2, DOK2, KPNA6, GDI1, PIP5K1B, TRAF1, TRAF6, AR, BMI1, NCOA3, CUL3, ESR1, DAXX, SPOP, PIP4K2B, UBE2E3, FADD, PIAS1, GIT2, SRRM1, ATM, GLI2, DEK, BRMS1, NUP50, RTN4, GCC1, ERG, ERF, PGR, GLI3, UBE2D1, UBE2D2, NANOG, PTEN, DUSP7, EGLN2, RFWD2, SOST, ARIH1, MSRB3, BRD4, BRD3, BRD2 | AARSD1 | ARPC1A, ARPC2, ARPC5, CALR, CALU, EFTUD2, GTF2E1, HARS, LAP3, PFDN1, PFDN5, PPP1R12A, PPP2CB, PRKACA, TRMT10A, RPA1, RPA3, RPRD1B, RPUSD2, SH3GL1, SH3GLB1, SH3GLB2, THG1L, TP53RK, TTC1, UBQLN2, XPO5, FUBP1, NIF3L1, TPD52L2, IRS4, DYNLT1, HECTD1, TUBA1A, HSPB1, SERPINH1, RHOJ, JADE2, TAT, PARVG, TARS, PPP1R14B, SBDS, SEPT2, SEPT8, SRM, TBCB, RGS20, TRIM45, YKT6, MAP3K7, DDHD2, NPHP3, C12orf74, ALKBH2, TAB1, USP10, ALMS1, LUZP1, SASS6, FIGNL1, ERCC6L, SSFA2, FBXO7, RBM14-RBM4, HPS5, POC5, WNK1, HOOK1, RPL23, UBXN1, APAF1, STIL, MLF1, BORA, FAM83H, KIF1A, RAD21, ARRB2, RICTOR, RIC8B, TRAPPC4, BRCA2, PEAK1, NCAPG, TRIP13 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPOP_AARSD1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPOP_AARSD1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SPOP | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Hgene | SPOP | C0033578 | Prostatic Neoplasms | 1 | CTD_human |