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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35734

FusionGeneSummary for SPOCK3_ADCY2

check button Fusion gene summary
Fusion gene informationFusion gene name: SPOCK3_ADCY2
Fusion gene ID: 35734
HgeneTgene
Gene symbol

SPOCK3

ADCY2

Gene ID

50859

108

Gene nameSPARC (osteonectin), cwcv and kazal like domains proteoglycan 3adenylate cyclase 2
SynonymsHSAJ1454|TES-3|TICN3AC2|HBAC2
Cytomap

4q32.3

5p15.31

Type of geneprotein-codingprotein-coding
Descriptiontestican-3SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3adenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclase
Modification date2018052320180522
UniProtAcc

Q9BQ16

Q08462

Ensembl transtripts involved in fusion geneENST00000357154, ENST00000357545, 
ENST00000504953, ENST00000511531, 
ENST00000506886, ENST00000507137, 
ENST00000510741, ENST00000502330, 
ENST00000541354, ENST00000512681, 
ENST00000511269, ENST00000535728, 
ENST00000421836, ENST00000534949, 
ENST00000541637, ENST00000512648, 
ENST00000338316, ENST00000537121, 
ENST00000513693, 
Fusion gene scores* DoF score2 X 2 X 1=413 X 12 X 5=780
# samples 213
** MAII scorelog2(2/4*10)=2.32192809488736log2(13/780*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPOCK3 [Title/Abstract] AND ADCY2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM968972SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000357154ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000357154ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000357154ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000357545ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000357545ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000357545ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000504953ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000504953ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000504953ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000511531ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000511531ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000511531ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000506886ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000506886ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000506886ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000507137ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000507137ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000507137ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000510741ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000510741ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000510741ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000502330ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000502330ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000502330ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000541354ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000541354ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000541354ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000512681ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000512681ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000512681ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000511269ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000511269ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000511269ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000535728ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000535728ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000535728ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000421836ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000421836ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000421836ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000534949ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000534949ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000534949ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000541637ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000541637ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000541637ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000512648ENST00000338316SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000512648ENST00000537121SPOCK3chr4

167654988

+ADCY2chr1

152005098

-
intron-intronENST00000512648ENST00000513693SPOCK3chr4

167654988

+ADCY2chr1

152005098

-

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FusionProtFeatures for SPOCK3_ADCY2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPOCK3

Q9BQ16

ADCY2

Q08462

Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling (PubMed:15385642). Down-streamsignaling cascades mediate changes in gene expression patterns andlead to increased IL6 production. Functions in signaling cascadesdownstream of the muscarinic acetylcholine receptors (Bysimilarity). {ECO:0000250|UniProtKB:P26769,ECO:0000269|PubMed:15385642}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPOCK3_ADCY2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPOCK3_ADCY2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPOCK3_ADCY2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneADCY2Q08462DB09121AurothioglucoseAdenylate cyclase type 2small moleculeapproved|withdrawn

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RelatedDiseases for SPOCK3_ADCY2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneADCY2C0004096Asthma1CTD_human
TgeneADCY2C0005586Bipolar Disorder1PSYGENET