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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35724

FusionGeneSummary for SPNS1_ZNF668

check button Fusion gene summary
Fusion gene informationFusion gene name: SPNS1_ZNF668
Fusion gene ID: 35724
HgeneTgene
Gene symbol

SPNS1

ZNF668

Gene ID

83985

79759

Gene namesphingolipid transporter 1 (putative)zinc finger protein 668
SynonymsHSpin1|LAT|PP2030|SPIN1|SPINL|nrs-
Cytomap

16p11.2

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionprotein spinster homolog 1SPNS sphingolipid transporter 1 (putative)spinster homolog 1spinster-like protein 1zinc finger protein 668
Modification date2018052220180519
UniProtAcc

Q9H2V7

Q96K58

Ensembl transtripts involved in fusion geneENST00000565975, ENST00000311008, 
ENST00000323081, ENST00000334536, 
ENST00000352260, ENST00000561868, 
ENST00000535577, ENST00000426488, 
ENST00000538906, ENST00000394983, 
ENST00000300849, ENST00000539836, 
ENST00000417110, ENST00000564456, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: SPNS1 [Title/Abstract] AND ZNF668 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-HT-7689-01ASPNS1chr16

28989365

+ZNF668chr16

31075802

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000565975ENST00000535577SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000565975ENST00000426488SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000565975ENST00000538906SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000565975ENST00000394983SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000565975ENST00000300849SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000565975ENST00000539836SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-intronENST00000565975ENST00000417110SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-intronENST00000565975ENST00000564456SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000311008ENST00000535577SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000311008ENST00000426488SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000311008ENST00000538906SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000311008ENST00000394983SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000311008ENST00000300849SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000311008ENST00000539836SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-intronENST00000311008ENST00000417110SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-intronENST00000311008ENST00000564456SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000323081ENST00000535577SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000323081ENST00000426488SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000323081ENST00000538906SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000323081ENST00000394983SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000323081ENST00000300849SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000323081ENST00000539836SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-intronENST00000323081ENST00000417110SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-intronENST00000323081ENST00000564456SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000334536ENST00000535577SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000334536ENST00000426488SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000334536ENST00000538906SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000334536ENST00000394983SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000334536ENST00000300849SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000334536ENST00000539836SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-intronENST00000334536ENST00000417110SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-intronENST00000334536ENST00000564456SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000352260ENST00000535577SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000352260ENST00000426488SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000352260ENST00000538906SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000352260ENST00000394983SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000352260ENST00000300849SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-5UTRENST00000352260ENST00000539836SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-intronENST00000352260ENST00000417110SPNS1chr16

28989365

+ZNF668chr16

31075802

-
5CDS-intronENST00000352260ENST00000564456SPNS1chr16

28989365

+ZNF668chr16

31075802

-
intron-5UTRENST00000561868ENST00000535577SPNS1chr16

28989365

+ZNF668chr16

31075802

-
intron-5UTRENST00000561868ENST00000426488SPNS1chr16

28989365

+ZNF668chr16

31075802

-
intron-5UTRENST00000561868ENST00000538906SPNS1chr16

28989365

+ZNF668chr16

31075802

-
intron-5UTRENST00000561868ENST00000394983SPNS1chr16

28989365

+ZNF668chr16

31075802

-
intron-5UTRENST00000561868ENST00000300849SPNS1chr16

28989365

+ZNF668chr16

31075802

-
intron-5UTRENST00000561868ENST00000539836SPNS1chr16

28989365

+ZNF668chr16

31075802

-
intron-intronENST00000561868ENST00000417110SPNS1chr16

28989365

+ZNF668chr16

31075802

-
intron-intronENST00000561868ENST00000564456SPNS1chr16

28989365

+ZNF668chr16

31075802

-

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FusionProtFeatures for SPNS1_ZNF668


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPNS1

Q9H2V7

ZNF668

Q96K58

May be involved in transcriptional regulation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPNS1_ZNF668


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPNS1_ZNF668


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPNS1BCL2, BCL2L1, NLRX1, UNC93B1, CLN5, TESZNF668NPM1, TP53, MDM2, ELAVL1, HIST1H1A, NOL12, RPL14, RPL8, RPS8, PRR11, CLCN2, KIF22, LLGL2, RBM4, MATR3, KIF2C, SGTB, KIF21A, CEP170P1, WDR46, GPATCH4, HIST1H1T, RPL30, RPL7, DGCR8, RRP8, ZNF512, HIST1H1E, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SPNS1_ZNF668


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPNS1_ZNF668


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZNF668C0014474Ependymoma1CTD_human