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Fusion gene ID: 35712 |
FusionGeneSummary for SPINT2_TYROBP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPINT2_TYROBP | Fusion gene ID: 35712 | Hgene | Tgene | Gene symbol | SPINT2 | TYROBP | Gene ID | 10653 | 7305 |
| Gene name | serine peptidase inhibitor, Kunitz type 2 | TYRO protein tyrosine kinase binding protein | |
| Synonyms | DIAR3|HAI-2|HAI2|Kop|PB | DAP12|KARAP|PLOSL | |
| Cytomap | 19q13.2 | 19q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kunitz-type protease inhibitor 2hepatocyte growth factor activator inhibitor type 2serine protease inhibitor, Kunitz type, 2testicular tissue protein Li 183 | TYRO protein tyrosine kinase-binding proteinDNAX-activation protein 12KAR-associated proteinkiller-activating receptor-associated protein | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | O43291 | O43914 | |
| Ensembl transtripts involved in fusion gene | ENST00000301244, ENST00000587090, ENST00000454580, | ENST00000424586, ENST00000585901, ENST00000544690, ENST00000262629, ENST00000589517, | |
| Fusion gene scores | * DoF score | 9 X 4 X 8=288 | 3 X 2 X 2=12 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SPINT2 [Title/Abstract] AND TYROBP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SPINT2 | GO:0022408 | negative regulation of cell-cell adhesion | 19592578 |
| Hgene | SPINT2 | GO:2000146 | negative regulation of cell motility | 19592578 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-57-1994-01A | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000301244 | ENST00000424586 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| In-frame | ENST00000301244 | ENST00000585901 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| In-frame | ENST00000301244 | ENST00000544690 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| In-frame | ENST00000301244 | ENST00000262629 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| In-frame | ENST00000301244 | ENST00000589517 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| intron-3CDS | ENST00000587090 | ENST00000424586 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| intron-3CDS | ENST00000587090 | ENST00000585901 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| intron-3CDS | ENST00000587090 | ENST00000544690 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| intron-3CDS | ENST00000587090 | ENST00000262629 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| intron-3CDS | ENST00000587090 | ENST00000589517 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| In-frame | ENST00000454580 | ENST00000424586 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| In-frame | ENST00000454580 | ENST00000585901 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| In-frame | ENST00000454580 | ENST00000544690 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| In-frame | ENST00000454580 | ENST00000262629 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
| In-frame | ENST00000454580 | ENST00000589517 | SPINT2 | chr19 | 38755638 | + | TYROBP | chr19 | 36398482 | - |
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FusionProtFeatures for SPINT2_TYROBP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPINT2 | TYROBP |
| Inhibitor of HGF activator. Also inhibits plasmin,plasma and tissue kallikrein, and factor XIa. | Non-covalently associates with activating receptors ofthe CD300 family. Cross-linking of CD300-TYROBP complexes resultsin cellular activation. Involved for instance in neutrophilactivation mediated by integrin. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TYROBP | chr19:38755638 | chr19:36398482 | ENST00000262629 | - | 1 | 5 | 80_108 | 31 | 114 | Domain | Note=ITAM |
| Tgene | >TYROBP | chr19:38755638 | chr19:36398482 | ENST00000544690 | - | 0 | 4 | 80_108 | 20 | 103 | Domain | Note=ITAM |
| Tgene | >TYROBP | chr19:38755638 | chr19:36398482 | ENST00000589517 | - | 1 | 5 | 80_108 | 31 | 113 | Domain | Note=ITAM |
| Tgene | >TYROBP | chr19:38755638 | chr19:36398482 | ENST00000262629 | - | 1 | 5 | 62_113 | 31 | 114 | Topological domain | Cytoplasmic |
| Tgene | >TYROBP | chr19:38755638 | chr19:36398482 | ENST00000544690 | - | 0 | 4 | 22_40 | 20 | 103 | Topological domain | Extracellular |
| Tgene | >TYROBP | chr19:38755638 | chr19:36398482 | ENST00000544690 | - | 0 | 4 | 62_113 | 20 | 103 | Topological domain | Cytoplasmic |
| Tgene | >TYROBP | chr19:38755638 | chr19:36398482 | ENST00000589517 | - | 1 | 5 | 62_113 | 31 | 113 | Topological domain | Cytoplasmic |
| Tgene | >TYROBP | chr19:38755638 | chr19:36398482 | ENST00000262629 | - | 1 | 5 | 41_61 | 31 | 114 | Transmembrane | Helical |
| Tgene | >TYROBP | chr19:38755638 | chr19:36398482 | ENST00000544690 | - | 0 | 4 | 41_61 | 20 | 103 | Transmembrane | Helical |
| Tgene | >TYROBP | chr19:38755638 | chr19:36398482 | ENST00000589517 | - | 1 | 5 | 41_61 | 31 | 113 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SPINT2 | chr19:38755638 | chr19:36398482 | ENST00000301244 | + | 1 | 7 | 219_252 | 35 | 253 | Topological domain | Cytoplasmic |
| Hgene | >SPINT2 | chr19:38755638 | chr19:36398482 | ENST00000301244 | + | 1 | 7 | 28_197 | 35 | 253 | Topological domain | Extracellular |
| Hgene | >SPINT2 | chr19:38755638 | chr19:36398482 | ENST00000454580 | + | 1 | 6 | 219_252 | 35 | 196 | Topological domain | Cytoplasmic |
| Hgene | >SPINT2 | chr19:38755638 | chr19:36398482 | ENST00000454580 | + | 1 | 6 | 28_197 | 35 | 196 | Topological domain | Extracellular |
| Hgene | >SPINT2 | chr19:38755638 | chr19:36398482 | ENST00000301244 | + | 1 | 7 | 198_218 | 35 | 253 | Transmembrane | Helical |
| Hgene | >SPINT2 | chr19:38755638 | chr19:36398482 | ENST00000454580 | + | 1 | 6 | 198_218 | 35 | 196 | Transmembrane | Helical |
| Tgene | TYROBP | chr19:38755638 | chr19:36398482 | ENST00000262629 | - | 1 | 5 | 22_40 | 31 | 114 | Topological domain | Extracellular |
| Tgene | TYROBP | chr19:38755638 | chr19:36398482 | ENST00000589517 | - | 1 | 5 | 22_40 | 31 | 113 | Topological domain | Extracellular |
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FusionGeneSequence for SPINT2_TYROBP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000424586_chr19_36398482_-_117aa MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITET >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000585901_chr19_36398482_-_149aa MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEGMVMEVLIWN >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000544690_chr19_36398482_-_118aa MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITE >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000262629_chr19_36398482_-_118aa MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITE >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000589517_chr19_36398482_-_117aa MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITET >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000424586_chr19_36398482_-_117aa MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITET >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000585901_chr19_36398482_-_149aa MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEGMVMEVLIWN >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000544690_chr19_36398482_-_118aa MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITE >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000262629_chr19_36398482_-_118aa MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITE >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000589517_chr19_36398482_-_117aa MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITET |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000424586_chr19_36398482_-_351nt ATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGA GAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTC ATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCGACCCGGAAACAGCGTATCACTGAGACC >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000585901_chr19_36398482_-_447nt ATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGA GAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTC ATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGGGATGGTAATGGAGGTGCTGATTTGGAAT GACAAAACACCCTCAACTCACCACTCTGCCTGTCTCTGCACCCCACAACACCCCTCACCTCCAGCAGCGACCCGGAAACAGCGTATCACT >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000544690_chr19_36398482_-_354nt ATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGA GAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTC ATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCAGCGACCCGGAAACAGCGTATCACTGAG >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000262629_chr19_36398482_-_354nt ATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGA GAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTC ATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCAGCGACCCGGAAACAGCGTATCACTGAG >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000589517_chr19_36398482_-_351nt ATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGA GAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTC ATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCGACCCGGAAACAGCGTATCACTGAGACC >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000424586_chr19_36398482_-_351nt ATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGA GAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTC ATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCGACCCGGAAACAGCGTATCACTGAGACC >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000585901_chr19_36398482_-_447nt ATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGA GAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTC ATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGGGATGGTAATGGAGGTGCTGATTTGGAAT GACAAAACACCCTCAACTCACCACTCTGCCTGTCTCTGCACCCCACAACACCCCTCACCTCCAGCAGCGACCCGGAAACAGCGTATCACT >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000544690_chr19_36398482_-_354nt ATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGA GAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTC ATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCAGCGACCCGGAAACAGCGTATCACTGAG >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000262629_chr19_36398482_-_354nt ATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGA GAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTC ATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCAGCGACCCGGAAACAGCGTATCACTGAG >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000589517_chr19_36398482_-_351nt ATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGA GAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTC ATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCGACCCGGAAACAGCGTATCACTGAGACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000424586_chr19_36398482_-_954nt GCGGCCGCGCAGGTGCCTGCCCTTTGCGCCTGCGCCCAGCTCGCCCTGCCTAGCCAGGTGCGCCCCGCCCCCTGCCTGCCCGGCCACCTT CGGGAGCCGCTTCCAATAGGCGTTCGCCATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCC GTTGAGTGTCGCAGGCGGCGAGGGCGCGAGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCC GGAAAGGCGACTTCCGGGGGCTTTGGCACCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGT TGAGGGGCTTCCCGCACCTGATCGCGAGACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGC GGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCAC GATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTG TACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTATCAG GAGCTCCAGGGTCAGAGGTCGGATGTCTACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTCAGCAAC ATGATACCTGGATCCAGCCATTCCTGAAGCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCATCCCTGA >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000585901_chr19_36398482_-_1048nt GCGGCCGCGCAGGTGCCTGCCCTTTGCGCCTGCGCCCAGCTCGCCCTGCCTAGCCAGGTGCGCCCCGCCCCCTGCCTGCCCGGCCACCTT CGGGAGCCGCTTCCAATAGGCGTTCGCCATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCC GTTGAGTGTCGCAGGCGGCGAGGGCGCGAGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCC GGAAAGGCGACTTCCGGGGGCTTTGGCACCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGT TGAGGGGCTTCCCGCACCTGATCGCGAGACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGC GGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCAC GATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTG TACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGGGATGGTAATGGAGGTGCTGATTTGGAATGACAAAACACCCTCA ACTCACCACTCTGCCTGTCTCTGCACCCCACAACACCCCTCACCTCCAGCAGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCT TATCAGGAGCTCCAGGGTCAGAGGTCGGATGTCTACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTC AGCAACATGATACCTGGATCCAGCCATTCCTGAAGCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCAT >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000544690_chr19_36398482_-_955nt GCGGCCGCGCAGGTGCCTGCCCTTTGCGCCTGCGCCCAGCTCGCCCTGCCTAGCCAGGTGCGCCCCGCCCCCTGCCTGCCCGGCCACCTT CGGGAGCCGCTTCCAATAGGCGTTCGCCATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCC GTTGAGTGTCGCAGGCGGCGAGGGCGCGAGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCC GGAAAGGCGACTTCCGGGGGCTTTGGCACCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGT TGAGGGGCTTCCCGCACCTGATCGCGAGACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGC GGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCAC GATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTG TACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCAGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTAT CAGGAGCTCCAGGGTCAGAGGTCGGATGTCTACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTCAGC AACATGATACCTGGATCCAGCCATTCCTGAAGCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCATCCC >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000262629_chr19_36398482_-_948nt GCGGCCGCGCAGGTGCCTGCCCTTTGCGCCTGCGCCCAGCTCGCCCTGCCTAGCCAGGTGCGCCCCGCCCCCTGCCTGCCCGGCCACCTT CGGGAGCCGCTTCCAATAGGCGTTCGCCATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCC GTTGAGTGTCGCAGGCGGCGAGGGCGCGAGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCC GGAAAGGCGACTTCCGGGGGCTTTGGCACCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGT TGAGGGGCTTCCCGCACCTGATCGCGAGACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGC GGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCAC GATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTG TACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCAGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTAT CAGGAGCTCCAGGGTCAGAGGTCGGATGTCTACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTCAGC AACATGATACCTGGATCCAGCCATTCCTGAAGCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCATCCC >In-frame_SPINT2_ENST00000301244_chr19_38755638_+_TYROBP_ENST00000589517_chr19_36398482_-_795nt GCGGCCGCGCAGGTGCCTGCCCTTTGCGCCTGCGCCCAGCTCGCCCTGCCTAGCCAGGTGCGCCCCGCCCCCTGCCTGCCCGGCCACCTT CGGGAGCCGCTTCCAATAGGCGTTCGCCATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCC GTTGAGTGTCGCAGGCGGCGAGGGCGCGAGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCC GGAAAGGCGACTTCCGGGGGCTTTGGCACCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGT TGAGGGGCTTCCCGCACCTGATCGCGAGACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGC GGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCAC GATTGCAGTTGCTCTACGGTGAGCCCGGGCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTG TACTTCCTGGGCCGGCTGGTCCCTCGGGGGCGAGGGGCTGCGGAGGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTATCAG >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000424586_chr19_36398482_-_836nt ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCCGGAAAGGCGACTTCCGGGGGCTTTGGCA CCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGTTGAGGGGCTTCCCGCACCTGATCGCGAG ACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCG CCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGG GCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGG GGCGAGGGGCTGCGGAGGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTATCAGGAGCTCCAGGGTCAGAGGTCGGATGTCT ACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTCAGCAACATGATACCTGGATCCAGCCATTCCTGAA GCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCATCCCTGAGAGACCAGACCGCTCCCCAATACTCTCC >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000585901_chr19_36398482_-_930nt ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCCGGAAAGGCGACTTCCGGGGGCTTTGGCA CCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGTTGAGGGGCTTCCCGCACCTGATCGCGAG ACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCG CCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGG GCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGG GGCGAGGGGCTGCGGAGGGGATGGTAATGGAGGTGCTGATTTGGAATGACAAAACACCCTCAACTCACCACTCTGCCTGTCTCTGCACCC CACAACACCCCTCACCTCCAGCAGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTATCAGGAGCTCCAGGGTCAGAGGTCGG ATGTCTACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTCAGCAACATGATACCTGGATCCAGCCATT CCTGAAGCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCATCCCTGAGAGACCAGACCGCTCCCCAATA >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000544690_chr19_36398482_-_837nt ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCCGGAAAGGCGACTTCCGGGGGCTTTGGCA CCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGTTGAGGGGCTTCCCGCACCTGATCGCGAG ACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCG CCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGG GCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGG GGCGAGGGGCTGCGGAGGCAGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTATCAGGAGCTCCAGGGTCAGAGGTCGGATG TCTACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTCAGCAACATGATACCTGGATCCAGCCATTCCT GAAGCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCATCCCTGAGAGACCAGACCGCTCCCCAATACTC >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000262629_chr19_36398482_-_830nt ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCCGGAAAGGCGACTTCCGGGGGCTTTGGCA CCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGTTGAGGGGCTTCCCGCACCTGATCGCGAG ACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCG CCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGG GCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGG GGCGAGGGGCTGCGGAGGCAGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTATCAGGAGCTCCAGGGTCAGAGGTCGGATG TCTACAGCGACCTCAACACACAGAGGCCGTATTACAAATGAGCCCGAATCATGACAGTCAGCAACATGATACCTGGATCCAGCCATTCCT GAAGCCCACCCTGCACCTCATTCCAACTCCTACCGCGATACAGACCCACAGAGTGCCATCCCTGAGAGACCAGACCGCTCCCCAATACTC >In-frame_SPINT2_ENST00000454580_chr19_38755638_+_TYROBP_ENST00000589517_chr19_36398482_-_677nt ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCCGGAAAGGCGACTTCCGGGGGCTTTGGCA CCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGTTGAGGGGCTTCCCGCACCTGATCGCGAG ACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCG CCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCACGATTGCAGTTGCTCTACGGTGAGCCCGG GCGTGCTGGCAGGGATCGTGATGGGAGACCTGGTGCTGACAGTGCTCATTGCCCTGGCCGTGTACTTCCTGGGCCGGCTGGTCCCTCGGG GGCGAGGGGCTGCGGAGGCGACCCGGAAACAGCGTATCACTGAGACCGAGTCGCCTTATCAGGAGCTCCAGGGTCAGAGGTCGGATGTCT |
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FusionGenePPI for SPINT2_TYROBP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SPINT2 | ITIH2, APP, TUBG1, MOV10, CUL7, ILK, TUBGCP2, LSR, ATP12A, LIN54, TBC1D9B, TBC1D15, ATP2A3, ITPRIPL1, FNDC3A, ZNF696, OCRL, ABCA3, RPS7, TMEM214, NCAPD3, SREBF2, THAP11, IQCB1, TSC2, WDR44, LEMD3, POM121, UBR3, TBL2, ATP8B2, DIP2A, NFRKB, SACM1L, ZDHHC13, RETSAT, DHRS7, SPTLC2, ARFGEF1, CCZ1, ACVR1B, CYP51A1, PRR14, LRIF1, MAP7D3, CDC20, TYW1, C20orf24, SMC2, DNAJC16, MOSPD2, BAG3, KIF14, EPHX1, TAF6L, ALG5, NOP9, OSBPL8, NUS1, SLC35F5, TEX264, CKAP5, TMUB1, POLE2, HMGCR, UPK3BL, FNDC3B, VRK2, MZT2B, SLC39A10, SEC22A, ELF2, SLC39A6, C1orf112, USP33, NDC1, SLC30A7, LMF1, GOLGA5, GTPBP3, DAGLB, VANGL2, FAM189B, DPH1, FRMD5, CHD8, PI4K2B, SLC27A3, CMTM6, EGFL7, PKMYT1, LRP10, CNTNAP1, ZDHHC18, CTU1, TIGD5, KLHL26, LRP12, ASPHD2, SCARF2, HGFAC, RNF13, MARC1, GPN3, ARL6IP6 | TYROBP | SIRPB1, TREM1, KIR2DS2, ZAP70, NCR2, KLRAP1, SYK |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPINT2_TYROBP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPINT2_TYROBP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SPINT2 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | SPINT2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | SPINT2 | C0027794 | Neural Tube Defects | 1 | CTD_human |
| Hgene | SPINT2 | C0032045 | Placenta Disorders | 1 | CTD_human |
| Hgene | SPINT2 | C0267663 | Congenital secretory diarrhea, sodium type (disorder) | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | TYROBP | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | TYROBP | C0023895 | Liver diseases | 1 | CTD_human |
| Tgene | TYROBP | C0036341 | Schizophrenia | 1 | PSYGENET |
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