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Fusion gene ID: 35709 |
FusionGeneSummary for SPINT2_MAP4K1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPINT2_MAP4K1 | Fusion gene ID: 35709 | Hgene | Tgene | Gene symbol | SPINT2 | MAP4K1 | Gene ID | 10653 | 11184 |
| Gene name | serine peptidase inhibitor, Kunitz type 2 | mitogen-activated protein kinase kinase kinase kinase 1 | |
| Synonyms | DIAR3|HAI-2|HAI2|Kop|PB | HPK1 | |
| Cytomap | 19q13.2 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kunitz-type protease inhibitor 2hepatocyte growth factor activator inhibitor type 2serine protease inhibitor, Kunitz type, 2testicular tissue protein Li 183 | mitogen-activated protein kinase kinase kinase kinase 1MAPK/ERK kinase kinase kinase 1MEK kinase kinase 1MEKKK 1hematopoietic progenitor kinase 1 | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | O43291 | Q92918 | |
| Ensembl transtripts involved in fusion gene | ENST00000301244, ENST00000587090, ENST00000454580, | ENST00000591517, ENST00000586296, ENST00000589130, ENST00000396857, ENST00000423454, ENST00000589002, | |
| Fusion gene scores | * DoF score | 9 X 4 X 8=288 | 4 X 3 X 4=48 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SPINT2 [Title/Abstract] AND MAP4K1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SPINT2 | GO:0022408 | negative regulation of cell-cell adhesion | 19592578 |
| Hgene | SPINT2 | GO:2000146 | negative regulation of cell motility | 19592578 |
| Tgene | MAP4K1 | GO:0006468 | protein phosphorylation | 8824585 |
| Tgene | MAP4K1 | GO:0007257 | activation of JUN kinase activity | 8824585 |
| Tgene | MAP4K1 | GO:0018105 | peptidyl-serine phosphorylation | 11053428|24362026 |
| Tgene | MAP4K1 | GO:0046777 | protein autophosphorylation | 8824585|24362026 |
| Tgene | MAP4K1 | GO:1904628 | cellular response to phorbol 13-acetate 12-myristate | 8824585 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-55-A492-01A | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000301244 | ENST00000591517 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000301244 | ENST00000586296 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000301244 | ENST00000589130 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000301244 | ENST00000396857 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000301244 | ENST00000423454 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000301244 | ENST00000589002 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| In-frame | ENST00000587090 | ENST00000591517 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000587090 | ENST00000586296 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000587090 | ENST00000589130 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000587090 | ENST00000396857 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000587090 | ENST00000423454 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000587090 | ENST00000589002 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| In-frame | ENST00000454580 | ENST00000591517 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000454580 | ENST00000586296 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000454580 | ENST00000589130 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000454580 | ENST00000396857 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000454580 | ENST00000423454 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
| 5CDS-intron | ENST00000454580 | ENST00000589002 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
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FusionProtFeatures for SPINT2_MAP4K1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPINT2 | MAP4K1 |
| Inhibitor of HGF activator. Also inhibits plasmin,plasma and tissue kallikrein, and factor XIa. | Serine/threonine-protein kinase, which may play a rolein the response to environmental stress. Appears to act upstreamof the JUN N-terminal pathway. May play a role in hematopoieticlineage decisions and growth regulation. Able toautophosphorylate. {ECO:0000269|PubMed:24362026,ECO:0000269|PubMed:8824585}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SPINT2 | chr19:38781215 | chr19:39087777 | ENST00000301244 | + | 6 | 7 | 28_197 | 197 | 253 | Topological domain | Extracellular |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SPINT2 | chr19:38781215 | chr19:39087777 | ENST00000301244 | + | 6 | 7 | 219_252 | 197 | 253 | Topological domain | Cytoplasmic |
| Hgene | >SPINT2 | chr19:38781215 | chr19:39087777 | ENST00000454580 | + | 5 | 6 | 219_252 | 140 | 196 | Topological domain | Cytoplasmic |
| Hgene | >SPINT2 | chr19:38781215 | chr19:39087777 | ENST00000454580 | + | 5 | 6 | 28_197 | 140 | 196 | Topological domain | Extracellular |
| Hgene | >SPINT2 | chr19:38781215 | chr19:39087777 | ENST00000301244 | + | 6 | 7 | 198_218 | 197 | 253 | Transmembrane | Helical |
| Hgene | >SPINT2 | chr19:38781215 | chr19:39087777 | ENST00000454580 | + | 5 | 6 | 198_218 | 140 | 196 | Transmembrane | Helical |
| Tgene | MAP4K1 | chr19:38781215 | chr19:39087777 | ENST00000396857 | - | 23 | 31 | 17_274 | 612 | 822 | Domain | Protein kinase |
| Tgene | MAP4K1 | chr19:38781215 | chr19:39087777 | ENST00000396857 | - | 23 | 31 | 495_800 | 612 | 822 | Domain | CNH |
| Tgene | MAP4K1 | chr19:38781215 | chr19:39087777 | ENST00000591517 | - | 23 | 32 | 17_274 | 612 | 834 | Domain | Protein kinase |
| Tgene | MAP4K1 | chr19:38781215 | chr19:39087777 | ENST00000591517 | - | 23 | 32 | 495_800 | 612 | 834 | Domain | CNH |
| Tgene | MAP4K1 | chr19:38781215 | chr19:39087777 | ENST00000396857 | - | 23 | 31 | 23_31 | 612 | 822 | Nucleotide binding | ATP |
| Tgene | MAP4K1 | chr19:38781215 | chr19:39087777 | ENST00000591517 | - | 23 | 32 | 23_31 | 612 | 834 | Nucleotide binding | ATP |
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FusionGeneSequence for SPINT2_MAP4K1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SPINT2_ENST00000301244_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_419aa MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCAT VTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACM LRCFRQQENPPLPLGSKAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKS VLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWA >In-frame_SPINT2_ENST00000587090_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_369aa MPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTG PCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKAEGASSGGPFLCGALETSVVLLQWYQPMNKFLL VRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPE GSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASAS >In-frame_SPINT2_ENST00000454580_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_362aa MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFP RWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFP LPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGL RTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SPINT2_ENST00000301244_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_1257nt ATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGA GAACGCAGCATCCACGACTTCTGCCTGGTGTCGAAGGTGGTGGGCAGATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGAC GGATCCTGCCAGCTGTTTGTGTATGGGGGCTGTGACGGAAACAGCAATAATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACT GTCACAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAA GACCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTAC TTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATG CTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGCGGAGGGTGCGAGCTCTGGGGGCCCGTTCCTGTGCGGT GCATTGGAGACGTCCGTTGTCCTGCTTCAGTGGTACCAGCCCATGAACAAATTCCTGCTTGTCCGGCAGGTGCTGTTCCCACTGCCGACG CCTCTGTCCGTGTTCGCGCTGCTGACCGGGCCAGGCTCTGAGCTGCCCGCTGTGTGCATCGGCGTGAGCCCCGGGCGGCCGGGGAAGTCG GTGCTCTTCCACACGGTGCGCTTTGGCGCGCTCTCTTGCTGGCTGGGCGAGATGAGCACCGAGCACAGGGGACCCGTGCAGGTGACCCAG GTAGAGGAAGATATGGTGATGGTGTTGATGGATGGCTCTGTGAAGCTGGTGACCCCGGAGGGGTCCCCAGTCCGGGGACTTCGCACACCT GAGATCCCCATGACCGAAGCGGTGGAGGCCGTGGCTATGGTTGGAGGTCAGCTTCAGGCCTTCTGGAAGCATGGAGTGCAGGTGTGGGCT CTAGGCTCGGATCAGCTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCTGGAGTGCAGTGGCACG >In-frame_SPINT2_ENST00000587090_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_1107nt ATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTGCCAGCTGTTTGTGTATGGGGGCTGTGACGGAAACAGCAATAATTACCTGACC AAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTC CCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGG CCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAG AACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGCGGAGGGT GCGAGCTCTGGGGGCCCGTTCCTGTGCGGTGCATTGGAGACGTCCGTTGTCCTGCTTCAGTGGTACCAGCCCATGAACAAATTCCTGCTT GTCCGGCAGGTGCTGTTCCCACTGCCGACGCCTCTGTCCGTGTTCGCGCTGCTGACCGGGCCAGGCTCTGAGCTGCCCGCTGTGTGCATC GGCGTGAGCCCCGGGCGGCCGGGGAAGTCGGTGCTCTTCCACACGGTGCGCTTTGGCGCGCTCTCTTGCTGGCTGGGCGAGATGAGCACC GAGCACAGGGGACCCGTGCAGGTGACCCAGGTAGAGGAAGATATGGTGATGGTGTTGATGGATGGCTCTGTGAAGCTGGTGACCCCGGAG GGGTCCCCAGTCCGGGGACTTCGCACACCTGAGATCCCCATGACCGAAGCGGTGGAGGCCGTGGCTATGGTTGGAGGTCAGCTTCAGGCC TTCTGGAAGCATGGAGTGCAGGTGTGGGCTCTAGGCTCGGATCAGCTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTT GGCTCCCCCAGGCTGGAGTGCAGTGGCACGATCTCGCCTCACTGCAACCTCCTCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCC >In-frame_SPINT2_ENST00000454580_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_1086nt ATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGA GAACGCAGCATCCACGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAG GATTCTGAAGACCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCA CGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAG GCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGCGGAGGGTGCGAGCTCTGGGGGCCCGTTC CTGTGCGGTGCATTGGAGACGTCCGTTGTCCTGCTTCAGTGGTACCAGCCCATGAACAAATTCCTGCTTGTCCGGCAGGTGCTGTTCCCA CTGCCGACGCCTCTGTCCGTGTTCGCGCTGCTGACCGGGCCAGGCTCTGAGCTGCCCGCTGTGTGCATCGGCGTGAGCCCCGGGCGGCCG GGGAAGTCGGTGCTCTTCCACACGGTGCGCTTTGGCGCGCTCTCTTGCTGGCTGGGCGAGATGAGCACCGAGCACAGGGGACCCGTGCAG GTGACCCAGGTAGAGGAAGATATGGTGATGGTGTTGATGGATGGCTCTGTGAAGCTGGTGACCCCGGAGGGGTCCCCAGTCCGGGGACTT CGCACACCTGAGATCCCCATGACCGAAGCGGTGGAGGCCGTGGCTATGGTTGGAGGTCAGCTTCAGGCCTTCTGGAAGCATGGAGTGCAG GTGTGGGCTCTAGGCTCGGATCAGCTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCTGGAGTGC AGTGGCACGATCTCGCCTCACTGCAACCTCCTCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SPINT2_ENST00000301244_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_1861nt GCGGCCGCGCAGGTGCCTGCCCTTTGCGCCTGCGCCCAGCTCGCCCTGCCTAGCCAGGTGCGCCCCGCCCCCTGCCTGCCCGGCCACCTT CGGGAGCCGCTTCCAATAGGCGTTCGCCATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCC GTTGAGTGTCGCAGGCGGCGAGGGCGCGAGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCC GGAAAGGCGACTTCCGGGGGCTTTGGCACCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGT TGAGGGGCTTCCCGCACCTGATCGCGAGACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGC GGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCAC GACTTCTGCCTGGTGTCGAAGGTGGTGGGCAGATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTGCCAGCTG TTTGTGTATGGGGGCTGTGACGGAAACAGCAATAATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGAGAATGCC ACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGAT ATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGG AACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGC CAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGCGGAGGGTGCGAGCTCTGGGGGCCCGTTCCTGTGCGGTGCATTGGAGACGTCC GTTGTCCTGCTTCAGTGGTACCAGCCCATGAACAAATTCCTGCTTGTCCGGCAGGTGCTGTTCCCACTGCCGACGCCTCTGTCCGTGTTC GCGCTGCTGACCGGGCCAGGCTCTGAGCTGCCCGCTGTGTGCATCGGCGTGAGCCCCGGGCGGCCGGGGAAGTCGGTGCTCTTCCACACG GTGCGCTTTGGCGCGCTCTCTTGCTGGCTGGGCGAGATGAGCACCGAGCACAGGGGACCCGTGCAGGTGACCCAGGTAGAGGAAGATATG GTGATGGTGTTGATGGATGGCTCTGTGAAGCTGGTGACCCCGGAGGGGTCCCCAGTCCGGGGACTTCGCACACCTGAGATCCCCATGACC GAAGCGGTGGAGGCCGTGGCTATGGTTGGAGGTCAGCTTCAGGCCTTCTGGAAGCATGGAGTGCAGGTGTGGGCTCTAGGCTCGGATCAG CTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCTGGAGTGCAGTGGCACGATCTCGCCTCACTGC AACCTCCTCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCCTGTAGTGGTGGAGACACGCCCAG TGGATGATCCTACTGCTCCCAGCAACCTCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCCCCTCCCCCA >In-frame_SPINT2_ENST00000587090_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_1468nt ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGACTTCTGCCTGGTGTCGAAGGTGGTGGGCAGA TGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTGCCAGCTGTTTGTGTATGGGGGCTGTGACGGAAACAGCAAT AATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCG GATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAAC GCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGC CGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCA AAGGCGGAGGGTGCGAGCTCTGGGGGCCCGTTCCTGTGCGGTGCATTGGAGACGTCCGTTGTCCTGCTTCAGTGGTACCAGCCCATGAAC AAATTCCTGCTTGTCCGGCAGGTGCTGTTCCCACTGCCGACGCCTCTGTCCGTGTTCGCGCTGCTGACCGGGCCAGGCTCTGAGCTGCCC GCTGTGTGCATCGGCGTGAGCCCCGGGCGGCCGGGGAAGTCGGTGCTCTTCCACACGGTGCGCTTTGGCGCGCTCTCTTGCTGGCTGGGC GAGATGAGCACCGAGCACAGGGGACCCGTGCAGGTGACCCAGGTAGAGGAAGATATGGTGATGGTGTTGATGGATGGCTCTGTGAAGCTG GTGACCCCGGAGGGGTCCCCAGTCCGGGGACTTCGCACACCTGAGATCCCCATGACCGAAGCGGTGGAGGCCGTGGCTATGGTTGGAGGT CAGCTTCAGGCCTTCTGGAAGCATGGAGTGCAGGTGTGGGCTCTAGGCTCGGATCAGCTGCTACAGGAGCTGAGAGACCCTACCCTCACT TTCCGTCTGCTTGGCTCCCCCAGGCTGGAGTGCAGTGGCACGATCTCGCCTCACTGCAACCTCCTCCTCCCAGGTTCAAGCAATTCTCCT GCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCCTGTAGTGGTGGAGACACGCCCAGTGGATGATCCTACTGCTCCCAGCAACCTCTACA TCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCCCCTCCCCCATAGACACACTAGTGGTCATGGCATGTCCTCATC >In-frame_SPINT2_ENST00000454580_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_1572nt ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCCGGAAAGGCGACTTCCGGGGGCTTTGGCA CCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGTTGAGGGGCTTCCCGCACCTGATCGCGAG ACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCG CCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCACGAGAATGCCACGGGTGACCTGGCCACCA GCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGATATGTTCAACTATGAAGAAT ACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCA TCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCC TGCCCCTTGGCTCAAAGGCGGAGGGTGCGAGCTCTGGGGGCCCGTTCCTGTGCGGTGCATTGGAGACGTCCGTTGTCCTGCTTCAGTGGT ACCAGCCCATGAACAAATTCCTGCTTGTCCGGCAGGTGCTGTTCCCACTGCCGACGCCTCTGTCCGTGTTCGCGCTGCTGACCGGGCCAG GCTCTGAGCTGCCCGCTGTGTGCATCGGCGTGAGCCCCGGGCGGCCGGGGAAGTCGGTGCTCTTCCACACGGTGCGCTTTGGCGCGCTCT CTTGCTGGCTGGGCGAGATGAGCACCGAGCACAGGGGACCCGTGCAGGTGACCCAGGTAGAGGAAGATATGGTGATGGTGTTGATGGATG GCTCTGTGAAGCTGGTGACCCCGGAGGGGTCCCCAGTCCGGGGACTTCGCACACCTGAGATCCCCATGACCGAAGCGGTGGAGGCCGTGG CTATGGTTGGAGGTCAGCTTCAGGCCTTCTGGAAGCATGGAGTGCAGGTGTGGGCTCTAGGCTCGGATCAGCTGCTACAGGAGCTGAGAG ACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCTGGAGTGCAGTGGCACGATCTCGCCTCACTGCAACCTCCTCCTCCCAGGTT CAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCCTGTAGTGGTGGAGACACGCCCAGTGGATGATCCTACTGCTCC CAGCAACCTCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCCCCTCCCCCATAGACACACTAGTGGTCAT |
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FusionGenePPI for SPINT2_MAP4K1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SPINT2 | ITIH2, APP, TUBG1, MOV10, CUL7, ILK, TUBGCP2, LSR, ATP12A, LIN54, TBC1D9B, TBC1D15, ATP2A3, ITPRIPL1, FNDC3A, ZNF696, OCRL, ABCA3, RPS7, TMEM214, NCAPD3, SREBF2, THAP11, IQCB1, TSC2, WDR44, LEMD3, POM121, UBR3, TBL2, ATP8B2, DIP2A, NFRKB, SACM1L, ZDHHC13, RETSAT, DHRS7, SPTLC2, ARFGEF1, CCZ1, ACVR1B, CYP51A1, PRR14, LRIF1, MAP7D3, CDC20, TYW1, C20orf24, SMC2, DNAJC16, MOSPD2, BAG3, KIF14, EPHX1, TAF6L, ALG5, NOP9, OSBPL8, NUS1, SLC35F5, TEX264, CKAP5, TMUB1, POLE2, HMGCR, UPK3BL, FNDC3B, VRK2, MZT2B, SLC39A10, SEC22A, ELF2, SLC39A6, C1orf112, USP33, NDC1, SLC30A7, LMF1, GOLGA5, GTPBP3, DAGLB, VANGL2, FAM189B, DPH1, FRMD5, CHD8, PI4K2B, SLC27A3, CMTM6, EGFL7, PKMYT1, LRP10, CNTNAP1, ZDHHC18, CTU1, TIGD5, KLHL26, LRP12, ASPHD2, SCARF2, HGFAC, RNF13, MARC1, GPN3, ARL6IP6 | MAP4K1 | GRB2, CRK, CRKL, BLNK, DBNL, GRAP2, NCK1, EGFR, MAP3K7, MAP3K11, HCLS1, LAT, PPP4C, COPS5, LRRK1, SPRY1, HSP90AA1, TMEM101, SKP1, RBX1, CUL7, FBXW8, FBXW7, MAP4K1, HIST1H2AB, HSD17B10, PDHA1, SDHA, SOD1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPINT2_MAP4K1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPINT2_MAP4K1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SPINT2 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | SPINT2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | SPINT2 | C0027794 | Neural Tube Defects | 1 | CTD_human |
| Hgene | SPINT2 | C0032045 | Placenta Disorders | 1 | CTD_human |
| Hgene | SPINT2 | C0267663 | Congenital secretory diarrhea, sodium type (disorder) | 1 | CTD_human;ORPHANET;UNIPROT |
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