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Fusion gene ID: 35709 |
FusionGeneSummary for SPINT2_MAP4K1 |
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Fusion gene information | Fusion gene name: SPINT2_MAP4K1 | Fusion gene ID: 35709 | Hgene | Tgene | Gene symbol | SPINT2 | MAP4K1 | Gene ID | 10653 | 11184 |
Gene name | serine peptidase inhibitor, Kunitz type 2 | mitogen-activated protein kinase kinase kinase kinase 1 | |
Synonyms | DIAR3|HAI-2|HAI2|Kop|PB | HPK1 | |
Cytomap | 19q13.2 | 19q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | kunitz-type protease inhibitor 2hepatocyte growth factor activator inhibitor type 2serine protease inhibitor, Kunitz type, 2testicular tissue protein Li 183 | mitogen-activated protein kinase kinase kinase kinase 1MAPK/ERK kinase kinase kinase 1MEK kinase kinase 1MEKKK 1hematopoietic progenitor kinase 1 | |
Modification date | 20180522 | 20180527 | |
UniProtAcc | O43291 | Q92918 | |
Ensembl transtripts involved in fusion gene | ENST00000301244, ENST00000587090, ENST00000454580, | ENST00000591517, ENST00000586296, ENST00000589130, ENST00000396857, ENST00000423454, ENST00000589002, | |
Fusion gene scores | * DoF score | 9 X 4 X 8=288 | 4 X 3 X 4=48 |
# samples | 9 | 4 | |
** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SPINT2 [Title/Abstract] AND MAP4K1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SPINT2 | GO:0022408 | negative regulation of cell-cell adhesion | 19592578 |
Hgene | SPINT2 | GO:2000146 | negative regulation of cell motility | 19592578 |
Tgene | MAP4K1 | GO:0006468 | protein phosphorylation | 8824585 |
Tgene | MAP4K1 | GO:0007257 | activation of JUN kinase activity | 8824585 |
Tgene | MAP4K1 | GO:0018105 | peptidyl-serine phosphorylation | 11053428|24362026 |
Tgene | MAP4K1 | GO:0046777 | protein autophosphorylation | 8824585|24362026 |
Tgene | MAP4K1 | GO:1904628 | cellular response to phorbol 13-acetate 12-myristate | 8824585 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-55-A492-01A | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000301244 | ENST00000591517 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000301244 | ENST00000586296 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000301244 | ENST00000589130 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000301244 | ENST00000396857 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000301244 | ENST00000423454 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000301244 | ENST00000589002 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
In-frame | ENST00000587090 | ENST00000591517 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000587090 | ENST00000586296 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000587090 | ENST00000589130 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000587090 | ENST00000396857 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000587090 | ENST00000423454 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000587090 | ENST00000589002 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
In-frame | ENST00000454580 | ENST00000591517 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000454580 | ENST00000586296 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000454580 | ENST00000589130 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000454580 | ENST00000396857 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000454580 | ENST00000423454 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
5CDS-intron | ENST00000454580 | ENST00000589002 | SPINT2 | chr19 | 38781215 | + | MAP4K1 | chr19 | 39087777 | - |
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FusionProtFeatures for SPINT2_MAP4K1 |
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Hgene | Tgene |
SPINT2 | MAP4K1 |
Inhibitor of HGF activator. Also inhibits plasmin,plasma and tissue kallikrein, and factor XIa. | Serine/threonine-protein kinase, which may play a rolein the response to environmental stress. Appears to act upstreamof the JUN N-terminal pathway. May play a role in hematopoieticlineage decisions and growth regulation. Able toautophosphorylate. {ECO:0000269|PubMed:24362026,ECO:0000269|PubMed:8824585}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | SPINT2 | chr19:38781215 | chr19:39087777 | ENST00000301244 | + | 6 | 7 | 28_197 | 197 | 253 | Topological domain | Extracellular |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >SPINT2 | chr19:38781215 | chr19:39087777 | ENST00000301244 | + | 6 | 7 | 219_252 | 197 | 253 | Topological domain | Cytoplasmic |
Hgene | >SPINT2 | chr19:38781215 | chr19:39087777 | ENST00000454580 | + | 5 | 6 | 219_252 | 140 | 196 | Topological domain | Cytoplasmic |
Hgene | >SPINT2 | chr19:38781215 | chr19:39087777 | ENST00000454580 | + | 5 | 6 | 28_197 | 140 | 196 | Topological domain | Extracellular |
Hgene | >SPINT2 | chr19:38781215 | chr19:39087777 | ENST00000301244 | + | 6 | 7 | 198_218 | 197 | 253 | Transmembrane | Helical |
Hgene | >SPINT2 | chr19:38781215 | chr19:39087777 | ENST00000454580 | + | 5 | 6 | 198_218 | 140 | 196 | Transmembrane | Helical |
Tgene | MAP4K1 | chr19:38781215 | chr19:39087777 | ENST00000396857 | - | 23 | 31 | 17_274 | 612 | 822 | Domain | Protein kinase |
Tgene | MAP4K1 | chr19:38781215 | chr19:39087777 | ENST00000396857 | - | 23 | 31 | 495_800 | 612 | 822 | Domain | CNH |
Tgene | MAP4K1 | chr19:38781215 | chr19:39087777 | ENST00000591517 | - | 23 | 32 | 17_274 | 612 | 834 | Domain | Protein kinase |
Tgene | MAP4K1 | chr19:38781215 | chr19:39087777 | ENST00000591517 | - | 23 | 32 | 495_800 | 612 | 834 | Domain | CNH |
Tgene | MAP4K1 | chr19:38781215 | chr19:39087777 | ENST00000396857 | - | 23 | 31 | 23_31 | 612 | 822 | Nucleotide binding | ATP |
Tgene | MAP4K1 | chr19:38781215 | chr19:39087777 | ENST00000591517 | - | 23 | 32 | 23_31 | 612 | 834 | Nucleotide binding | ATP |
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FusionGeneSequence for SPINT2_MAP4K1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SPINT2_ENST00000301244_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_419aa MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCAT VTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACM LRCFRQQENPPLPLGSKAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKS VLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWA >In-frame_SPINT2_ENST00000587090_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_369aa MPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTG PCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKAEGASSGGPFLCGALETSVVLLQWYQPMNKFLL VRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPE GSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASAS >In-frame_SPINT2_ENST00000454580_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_362aa MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFP RWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFP LPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGL RTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITG |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SPINT2_ENST00000301244_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_1257nt ATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGA GAACGCAGCATCCACGACTTCTGCCTGGTGTCGAAGGTGGTGGGCAGATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGAC GGATCCTGCCAGCTGTTTGTGTATGGGGGCTGTGACGGAAACAGCAATAATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACT GTCACAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAA GACCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTAC TTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATG CTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGCGGAGGGTGCGAGCTCTGGGGGCCCGTTCCTGTGCGGT GCATTGGAGACGTCCGTTGTCCTGCTTCAGTGGTACCAGCCCATGAACAAATTCCTGCTTGTCCGGCAGGTGCTGTTCCCACTGCCGACG CCTCTGTCCGTGTTCGCGCTGCTGACCGGGCCAGGCTCTGAGCTGCCCGCTGTGTGCATCGGCGTGAGCCCCGGGCGGCCGGGGAAGTCG GTGCTCTTCCACACGGTGCGCTTTGGCGCGCTCTCTTGCTGGCTGGGCGAGATGAGCACCGAGCACAGGGGACCCGTGCAGGTGACCCAG GTAGAGGAAGATATGGTGATGGTGTTGATGGATGGCTCTGTGAAGCTGGTGACCCCGGAGGGGTCCCCAGTCCGGGGACTTCGCACACCT GAGATCCCCATGACCGAAGCGGTGGAGGCCGTGGCTATGGTTGGAGGTCAGCTTCAGGCCTTCTGGAAGCATGGAGTGCAGGTGTGGGCT CTAGGCTCGGATCAGCTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCTGGAGTGCAGTGGCACG >In-frame_SPINT2_ENST00000587090_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_1107nt ATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTGCCAGCTGTTTGTGTATGGGGGCTGTGACGGAAACAGCAATAATTACCTGACC AAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTC CCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGG CCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAG AACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGCGGAGGGT GCGAGCTCTGGGGGCCCGTTCCTGTGCGGTGCATTGGAGACGTCCGTTGTCCTGCTTCAGTGGTACCAGCCCATGAACAAATTCCTGCTT GTCCGGCAGGTGCTGTTCCCACTGCCGACGCCTCTGTCCGTGTTCGCGCTGCTGACCGGGCCAGGCTCTGAGCTGCCCGCTGTGTGCATC GGCGTGAGCCCCGGGCGGCCGGGGAAGTCGGTGCTCTTCCACACGGTGCGCTTTGGCGCGCTCTCTTGCTGGCTGGGCGAGATGAGCACC GAGCACAGGGGACCCGTGCAGGTGACCCAGGTAGAGGAAGATATGGTGATGGTGTTGATGGATGGCTCTGTGAAGCTGGTGACCCCGGAG GGGTCCCCAGTCCGGGGACTTCGCACACCTGAGATCCCCATGACCGAAGCGGTGGAGGCCGTGGCTATGGTTGGAGGTCAGCTTCAGGCC TTCTGGAAGCATGGAGTGCAGGTGTGGGCTCTAGGCTCGGATCAGCTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTT GGCTCCCCCAGGCTGGAGTGCAGTGGCACGATCTCGCCTCACTGCAACCTCCTCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCC >In-frame_SPINT2_ENST00000454580_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_1086nt ATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGA GAACGCAGCATCCACGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAG GATTCTGAAGACCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCA CGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAG GCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGCGGAGGGTGCGAGCTCTGGGGGCCCGTTC CTGTGCGGTGCATTGGAGACGTCCGTTGTCCTGCTTCAGTGGTACCAGCCCATGAACAAATTCCTGCTTGTCCGGCAGGTGCTGTTCCCA CTGCCGACGCCTCTGTCCGTGTTCGCGCTGCTGACCGGGCCAGGCTCTGAGCTGCCCGCTGTGTGCATCGGCGTGAGCCCCGGGCGGCCG GGGAAGTCGGTGCTCTTCCACACGGTGCGCTTTGGCGCGCTCTCTTGCTGGCTGGGCGAGATGAGCACCGAGCACAGGGGACCCGTGCAG GTGACCCAGGTAGAGGAAGATATGGTGATGGTGTTGATGGATGGCTCTGTGAAGCTGGTGACCCCGGAGGGGTCCCCAGTCCGGGGACTT CGCACACCTGAGATCCCCATGACCGAAGCGGTGGAGGCCGTGGCTATGGTTGGAGGTCAGCTTCAGGCCTTCTGGAAGCATGGAGTGCAG GTGTGGGCTCTAGGCTCGGATCAGCTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCTGGAGTGC AGTGGCACGATCTCGCCTCACTGCAACCTCCTCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SPINT2_ENST00000301244_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_1861nt GCGGCCGCGCAGGTGCCTGCCCTTTGCGCCTGCGCCCAGCTCGCCCTGCCTAGCCAGGTGCGCCCCGCCCCCTGCCTGCCCGGCCACCTT CGGGAGCCGCTTCCAATAGGCGTTCGCCATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCC GTTGAGTGTCGCAGGCGGCGAGGGCGCGAGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCC GGAAAGGCGACTTCCGGGGGCTTTGGCACCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGT TGAGGGGCTTCCCGCACCTGATCGCGAGACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGC GGGCTGAGGCGGAGCCGGGCGTTTCTCGCCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCAC GACTTCTGCCTGGTGTCGAAGGTGGTGGGCAGATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTGCCAGCTG TTTGTGTATGGGGGCTGTGACGGAAACAGCAATAATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGAGAATGCC ACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGAT ATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGG AACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGC CAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGCGGAGGGTGCGAGCTCTGGGGGCCCGTTCCTGTGCGGTGCATTGGAGACGTCC GTTGTCCTGCTTCAGTGGTACCAGCCCATGAACAAATTCCTGCTTGTCCGGCAGGTGCTGTTCCCACTGCCGACGCCTCTGTCCGTGTTC GCGCTGCTGACCGGGCCAGGCTCTGAGCTGCCCGCTGTGTGCATCGGCGTGAGCCCCGGGCGGCCGGGGAAGTCGGTGCTCTTCCACACG GTGCGCTTTGGCGCGCTCTCTTGCTGGCTGGGCGAGATGAGCACCGAGCACAGGGGACCCGTGCAGGTGACCCAGGTAGAGGAAGATATG GTGATGGTGTTGATGGATGGCTCTGTGAAGCTGGTGACCCCGGAGGGGTCCCCAGTCCGGGGACTTCGCACACCTGAGATCCCCATGACC GAAGCGGTGGAGGCCGTGGCTATGGTTGGAGGTCAGCTTCAGGCCTTCTGGAAGCATGGAGTGCAGGTGTGGGCTCTAGGCTCGGATCAG CTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCTGGAGTGCAGTGGCACGATCTCGCCTCACTGC AACCTCCTCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCCTGTAGTGGTGGAGACACGCCCAG TGGATGATCCTACTGCTCCCAGCAACCTCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCCCCTCCCCCA >In-frame_SPINT2_ENST00000587090_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_1468nt ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGACTTCTGCCTGGTGTCGAAGGTGGTGGGCAGA TGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTGCCAGCTGTTTGTGTATGGGGGCTGTGACGGAAACAGCAAT AATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGAGAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCG GATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAAC GCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGC CGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCA AAGGCGGAGGGTGCGAGCTCTGGGGGCCCGTTCCTGTGCGGTGCATTGGAGACGTCCGTTGTCCTGCTTCAGTGGTACCAGCCCATGAAC AAATTCCTGCTTGTCCGGCAGGTGCTGTTCCCACTGCCGACGCCTCTGTCCGTGTTCGCGCTGCTGACCGGGCCAGGCTCTGAGCTGCCC GCTGTGTGCATCGGCGTGAGCCCCGGGCGGCCGGGGAAGTCGGTGCTCTTCCACACGGTGCGCTTTGGCGCGCTCTCTTGCTGGCTGGGC GAGATGAGCACCGAGCACAGGGGACCCGTGCAGGTGACCCAGGTAGAGGAAGATATGGTGATGGTGTTGATGGATGGCTCTGTGAAGCTG GTGACCCCGGAGGGGTCCCCAGTCCGGGGACTTCGCACACCTGAGATCCCCATGACCGAAGCGGTGGAGGCCGTGGCTATGGTTGGAGGT CAGCTTCAGGCCTTCTGGAAGCATGGAGTGCAGGTGTGGGCTCTAGGCTCGGATCAGCTGCTACAGGAGCTGAGAGACCCTACCCTCACT TTCCGTCTGCTTGGCTCCCCCAGGCTGGAGTGCAGTGGCACGATCTCGCCTCACTGCAACCTCCTCCTCCCAGGTTCAAGCAATTCTCCT GCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCCTGTAGTGGTGGAGACACGCCCAGTGGATGATCCTACTGCTCCCAGCAACCTCTACA TCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCCCCTCCCCCATAGACACACTAGTGGTCATGGCATGTCCTCATC >In-frame_SPINT2_ENST00000454580_chr19_38781215_+_MAP4K1_ENST00000591517_chr19_39087777_-_1572nt ATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGCGGCTCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCG AGTGAGGAGCAGACCCAGGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCCGGAAAGGCGACTTCCGGGGGCTTTGGCA CCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCATTGCGCGTGCGCGTTGAGGGGCTTCCCGCACCTGATCGCGAG ACCCCAACGGCTGGTGGCGTCGCCTGCGCGTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCG CCCTGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCACGAGAATGCCACGGGTGACCTGGCCACCA GCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGATATGTTCAACTATGAAGAAT ACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCA TCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAATCCTCCCC TGCCCCTTGGCTCAAAGGCGGAGGGTGCGAGCTCTGGGGGCCCGTTCCTGTGCGGTGCATTGGAGACGTCCGTTGTCCTGCTTCAGTGGT ACCAGCCCATGAACAAATTCCTGCTTGTCCGGCAGGTGCTGTTCCCACTGCCGACGCCTCTGTCCGTGTTCGCGCTGCTGACCGGGCCAG GCTCTGAGCTGCCCGCTGTGTGCATCGGCGTGAGCCCCGGGCGGCCGGGGAAGTCGGTGCTCTTCCACACGGTGCGCTTTGGCGCGCTCT CTTGCTGGCTGGGCGAGATGAGCACCGAGCACAGGGGACCCGTGCAGGTGACCCAGGTAGAGGAAGATATGGTGATGGTGTTGATGGATG GCTCTGTGAAGCTGGTGACCCCGGAGGGGTCCCCAGTCCGGGGACTTCGCACACCTGAGATCCCCATGACCGAAGCGGTGGAGGCCGTGG CTATGGTTGGAGGTCAGCTTCAGGCCTTCTGGAAGCATGGAGTGCAGGTGTGGGCTCTAGGCTCGGATCAGCTGCTACAGGAGCTGAGAG ACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCTGGAGTGCAGTGGCACGATCTCGCCTCACTGCAACCTCCTCCTCCCAGGTT CAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCCTGTAGTGGTGGAGACACGCCCAGTGGATGATCCTACTGCTCC CAGCAACCTCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCCCCTCCCCCATAGACACACTAGTGGTCAT |
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FusionGenePPI for SPINT2_MAP4K1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SPINT2 | ITIH2, APP, TUBG1, MOV10, CUL7, ILK, TUBGCP2, LSR, ATP12A, LIN54, TBC1D9B, TBC1D15, ATP2A3, ITPRIPL1, FNDC3A, ZNF696, OCRL, ABCA3, RPS7, TMEM214, NCAPD3, SREBF2, THAP11, IQCB1, TSC2, WDR44, LEMD3, POM121, UBR3, TBL2, ATP8B2, DIP2A, NFRKB, SACM1L, ZDHHC13, RETSAT, DHRS7, SPTLC2, ARFGEF1, CCZ1, ACVR1B, CYP51A1, PRR14, LRIF1, MAP7D3, CDC20, TYW1, C20orf24, SMC2, DNAJC16, MOSPD2, BAG3, KIF14, EPHX1, TAF6L, ALG5, NOP9, OSBPL8, NUS1, SLC35F5, TEX264, CKAP5, TMUB1, POLE2, HMGCR, UPK3BL, FNDC3B, VRK2, MZT2B, SLC39A10, SEC22A, ELF2, SLC39A6, C1orf112, USP33, NDC1, SLC30A7, LMF1, GOLGA5, GTPBP3, DAGLB, VANGL2, FAM189B, DPH1, FRMD5, CHD8, PI4K2B, SLC27A3, CMTM6, EGFL7, PKMYT1, LRP10, CNTNAP1, ZDHHC18, CTU1, TIGD5, KLHL26, LRP12, ASPHD2, SCARF2, HGFAC, RNF13, MARC1, GPN3, ARL6IP6 | MAP4K1 | GRB2, CRK, CRKL, BLNK, DBNL, GRAP2, NCK1, EGFR, MAP3K7, MAP3K11, HCLS1, LAT, PPP4C, COPS5, LRRK1, SPRY1, HSP90AA1, TMEM101, SKP1, RBX1, CUL7, FBXW8, FBXW7, MAP4K1, HIST1H2AB, HSD17B10, PDHA1, SDHA, SOD1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPINT2_MAP4K1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPINT2_MAP4K1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SPINT2 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | SPINT2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | SPINT2 | C0027794 | Neural Tube Defects | 1 | CTD_human |
Hgene | SPINT2 | C0032045 | Placenta Disorders | 1 | CTD_human |
Hgene | SPINT2 | C0267663 | Congenital secretory diarrhea, sodium type (disorder) | 1 | CTD_human;ORPHANET;UNIPROT |