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Fusion gene ID: 35705 |
FusionGeneSummary for SPINT1_SERP1 |
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Fusion gene information | Fusion gene name: SPINT1_SERP1 | Fusion gene ID: 35705 | Hgene | Tgene | Gene symbol | SPINT1 | SERP1 | Gene ID | 6692 | 27230 |
Gene name | serine peptidase inhibitor, Kunitz type 1 | stress associated endoplasmic reticulum protein 1 | |
Synonyms | HAI|HAI1|MANSC2 | RAMP4 | |
Cytomap | 15q15.1 | 3q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | kunitz-type protease inhibitor 1HAI-1hepatocyte growth factor activator inhibitor type 1serine protease inhibitor, Kunitz type 1 | stress-associated endoplasmic reticulum protein 1ribosome associated membrane protein 4ribosome-attached membrane protein 4 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O43278 | Q9Y6X1 | |
Ensembl transtripts involved in fusion gene | ENST00000562057, ENST00000344051, ENST00000431806, | ENST00000239944, ENST00000479209, ENST00000487153, ENST00000491660, ENST00000490945, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 3 X 1 X 3=9 |
# samples | 5 | 3 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SPINT1 [Title/Abstract] AND SERP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-BR-A4PE-01A | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000562057 | ENST00000239944 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
5CDS-intron | ENST00000562057 | ENST00000479209 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
5CDS-intron | ENST00000562057 | ENST00000487153 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
5CDS-intron | ENST00000562057 | ENST00000491660 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
5CDS-5UTR | ENST00000562057 | ENST00000490945 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
5CDS-intron | ENST00000344051 | ENST00000239944 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
5CDS-intron | ENST00000344051 | ENST00000479209 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
5CDS-intron | ENST00000344051 | ENST00000487153 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
5CDS-intron | ENST00000344051 | ENST00000491660 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
5CDS-5UTR | ENST00000344051 | ENST00000490945 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
5CDS-intron | ENST00000431806 | ENST00000239944 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
5CDS-intron | ENST00000431806 | ENST00000479209 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
5CDS-intron | ENST00000431806 | ENST00000487153 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
5CDS-intron | ENST00000431806 | ENST00000491660 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
5CDS-5UTR | ENST00000431806 | ENST00000490945 | SPINT1 | chr15 | 41137227 | + | SERP1 | chr3 | 150284893 | - |
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FusionProtFeatures for SPINT1_SERP1 |
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Hgene | Tgene |
SPINT1 | SERP1 |
Inhibitor of HGF activator. Also acts as an inhibitor ofmatriptase (ST14). | Interacts with target proteins during theirtranslocation into the lumen of the endoplasmic reticulum.Protects unfolded target proteins against degradation during ERstress. May facilitate glycosylation of target proteins aftertermination of ER stress. May modulate the use of N-glycosylationsites on target proteins (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SPINT1_SERP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SPINT1_SERP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SPINT1 | ST14, UBQLN4, FAM46A, ZNF250, NLGN3 | SERP1 | SCNN1B, SCNN1G, SCNN1A, APP, VKORC1, SGTA, TMEM79, LMNA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPINT1_SERP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPINT1_SERP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |