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Fusion gene ID: 35703 |
FusionGeneSummary for SPINT1_CALM3 |
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Fusion gene information | Fusion gene name: SPINT1_CALM3 | Fusion gene ID: 35703 | Hgene | Tgene | Gene symbol | SPINT1 | CALM3 | Gene ID | 6692 | 808 |
Gene name | serine peptidase inhibitor, Kunitz type 1 | calmodulin 3 | |
Synonyms | HAI|HAI1|MANSC2 | CaM|CaMIII|HEL-S-72|PHKD|PHKD3 | |
Cytomap | 15q15.1 | 19q13.32 | |
Type of gene | protein-coding | protein-coding | |
Description | kunitz-type protease inhibitor 1HAI-1hepatocyte growth factor activator inhibitor type 1serine protease inhibitor, Kunitz type 1 | calmodulin-3epididymis secretory protein Li 72phosphorylase kinase subunit deltaprepro-calmodulin 3 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O43278 | ||
Ensembl transtripts involved in fusion gene | ENST00000562057, ENST00000344051, ENST00000431806, | ENST00000391918, ENST00000291295, ENST00000597743, ENST00000477244, ENST00000598871, ENST00000594523, ENST00000599839, ENST00000596362, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 8 X 9 X 3=216 |
# samples | 5 | 10 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/216*10)=-1.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SPINT1 [Title/Abstract] AND CALM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CALM3 | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 20226167 |
Tgene | CALM3 | GO:0030801 | positive regulation of cyclic nucleotide metabolic process | 8631777 |
Tgene | CALM3 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 8631777 |
Tgene | CALM3 | GO:0035307 | positive regulation of protein dephosphorylation | 8631777 |
Tgene | CALM3 | GO:0051343 | positive regulation of cyclic-nucleotide phosphodiesterase activity | 8631777 |
Tgene | CALM3 | GO:0051592 | response to calcium ion | 7607248 |
Tgene | CALM3 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 20226167 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG979974 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000562057 | ENST00000391918 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-3UTR | ENST00000562057 | ENST00000291295 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-intron | ENST00000562057 | ENST00000597743 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-intron | ENST00000562057 | ENST00000477244 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-intron | ENST00000562057 | ENST00000598871 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-intron | ENST00000562057 | ENST00000594523 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-3UTR | ENST00000562057 | ENST00000599839 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-3UTR | ENST00000562057 | ENST00000596362 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-intron | ENST00000344051 | ENST00000391918 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-3UTR | ENST00000344051 | ENST00000291295 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-intron | ENST00000344051 | ENST00000597743 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-intron | ENST00000344051 | ENST00000477244 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-intron | ENST00000344051 | ENST00000598871 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-intron | ENST00000344051 | ENST00000594523 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-3UTR | ENST00000344051 | ENST00000599839 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-3UTR | ENST00000344051 | ENST00000596362 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-intron | ENST00000431806 | ENST00000391918 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-3UTR | ENST00000431806 | ENST00000291295 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-intron | ENST00000431806 | ENST00000597743 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-intron | ENST00000431806 | ENST00000477244 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-intron | ENST00000431806 | ENST00000598871 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-intron | ENST00000431806 | ENST00000594523 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-3UTR | ENST00000431806 | ENST00000599839 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
3UTR-3UTR | ENST00000431806 | ENST00000596362 | SPINT1 | chr15 | 41149688 | - | CALM3 | chr19 | 47112592 | - |
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FusionProtFeatures for SPINT1_CALM3 |
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Hgene | Tgene |
SPINT1 | CALM3 |
Inhibitor of HGF activator. Also acts as an inhibitor ofmatriptase (ST14). | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SPINT1_CALM3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SPINT1_CALM3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPINT1_CALM3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPINT1_CALM3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |