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Fusion gene ID: 35664 |
FusionGeneSummary for SPG7_EFCAB12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPG7_EFCAB12 | Fusion gene ID: 35664 | Hgene | Tgene | Gene symbol | SPG7 | EFCAB12 | Gene ID | 6687 | 90288 |
| Gene name | SPG7, paraplegin matrix AAA peptidase subunit | EF-hand calcium binding domain 12 | |
| Synonyms | CAR|CMAR|PGN|SPG5C | C3orf25 | |
| Cytomap | 16q24.3 | 3q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | paraplegincell matrix adhesion regulatorspastic paraplegia 7 (pure and complicated autosomal recessive)spastic paraplegia 7 protein | EF-hand calcium-binding domain-containing protein 12EF-hand domain-containing protein C3orf25 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UQ90 | Q6NXP0 | |
| Ensembl transtripts involved in fusion gene | ENST00000268704, ENST00000341316, ENST00000565891, | ENST00000505956, ENST00000326085, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 2 X 1 X 2=4 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: SPG7 [Title/Abstract] AND EFCAB12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-EY-A54A-01A | SPG7 | chr16 | 89599044 | + | EFCAB12 | chr3 | 129140646 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000268704 | ENST00000505956 | SPG7 | chr16 | 89599044 | + | EFCAB12 | chr3 | 129140646 | - |
| In-frame | ENST00000268704 | ENST00000326085 | SPG7 | chr16 | 89599044 | + | EFCAB12 | chr3 | 129140646 | - |
| In-frame | ENST00000341316 | ENST00000505956 | SPG7 | chr16 | 89599044 | + | EFCAB12 | chr3 | 129140646 | - |
| In-frame | ENST00000341316 | ENST00000326085 | SPG7 | chr16 | 89599044 | + | EFCAB12 | chr3 | 129140646 | - |
| intron-3CDS | ENST00000565891 | ENST00000505956 | SPG7 | chr16 | 89599044 | + | EFCAB12 | chr3 | 129140646 | - |
| intron-3CDS | ENST00000565891 | ENST00000326085 | SPG7 | chr16 | 89599044 | + | EFCAB12 | chr3 | 129140646 | - |
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FusionProtFeatures for SPG7_EFCAB12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPG7 | EFCAB12 |
| ATP-dependent zinc metalloprotease. Plays a role in theformation and regulation of the mitochondrial permeabilitytransition pore (mPTP) and its proteolytic activity is dispensablefor this function (PubMed:26387735). {ECO:0000269|PubMed:26387735,ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SPG7 | chr16:89599044 | chr3:129140646 | ENST00000268704 | + | 9 | 17 | 349_357 | 441 | 796 | Nucleotide binding | ATP |
| Hgene | SPG7 | chr16:89599044 | chr3:129140646 | ENST00000341316 | + | 9 | 10 | 349_357 | 441 | 490 | Nucleotide binding | ATP |
| Hgene | SPG7 | chr16:89599044 | chr3:129140646 | ENST00000268704 | + | 9 | 17 | 106_144 | 441 | 796 | Topological domain | Mitochondrial matrix |
| Hgene | SPG7 | chr16:89599044 | chr3:129140646 | ENST00000268704 | + | 9 | 17 | 166_248 | 441 | 796 | Topological domain | Mitochondrial intermembrane |
| Hgene | SPG7 | chr16:89599044 | chr3:129140646 | ENST00000341316 | + | 9 | 10 | 106_144 | 441 | 490 | Topological domain | Mitochondrial matrix |
| Hgene | SPG7 | chr16:89599044 | chr3:129140646 | ENST00000341316 | + | 9 | 10 | 166_248 | 441 | 490 | Topological domain | Mitochondrial intermembrane |
| Hgene | SPG7 | chr16:89599044 | chr3:129140646 | ENST00000268704 | + | 9 | 17 | 145_165 | 441 | 796 | Transmembrane | Helical |
| Hgene | SPG7 | chr16:89599044 | chr3:129140646 | ENST00000268704 | + | 9 | 17 | 249_269 | 441 | 796 | Transmembrane | Helical |
| Hgene | SPG7 | chr16:89599044 | chr3:129140646 | ENST00000341316 | + | 9 | 10 | 145_165 | 441 | 490 | Transmembrane | Helical |
| Hgene | SPG7 | chr16:89599044 | chr3:129140646 | ENST00000341316 | + | 9 | 10 | 249_269 | 441 | 490 | Transmembrane | Helical |
| Tgene | >EFCAB12 | chr16:89599044 | chr3:129140646 | ENST00000326085 | - | 0 | 9 | 206_217 | 16 | 573 | Calcium binding | Ontology_term=ECO:0000255 |
| Tgene | >EFCAB12 | chr16:89599044 | chr3:129140646 | ENST00000505956 | - | 0 | 9 | 206_217 | 16 | 573 | Calcium binding | Ontology_term=ECO:0000255 |
| Tgene | >EFCAB12 | chr16:89599044 | chr3:129140646 | ENST00000326085 | - | 0 | 9 | 196_231 | 16 | 573 | Domain | EF-hand |
| Tgene | >EFCAB12 | chr16:89599044 | chr3:129140646 | ENST00000505956 | - | 0 | 9 | 196_231 | 16 | 573 | Domain | EF-hand |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SPG7 | chr16:89599044 | chr3:129140646 | ENST00000268704 | + | 9 | 17 | 270_795 | 441 | 796 | Topological domain | Mitochondrial matrix |
| Hgene | >SPG7 | chr16:89599044 | chr3:129140646 | ENST00000341316 | + | 9 | 10 | 270_795 | 441 | 490 | Topological domain | Mitochondrial matrix |
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FusionGeneSequence for SPG7_EFCAB12 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SPG7_ENST00000268704_chr16_89599044_+_EFCAB12_ENST00000505956_chr3_129140646_-_998aa MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVR LWQLLGGTFYFNTSRLKQKNKEKDKSKGKAPEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEV QRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWY VFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAK AVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGLCPSKTPI NENAPVFDPEPVIAHCFKQFQQKDFRLPQTRRRIIMVPRKEDQTPLNPASQPQAPPKPIPSFKVLEARDIQEQPEDRKTWLSQRSKLRQE LESFGDVKRWLENKPSITPSEAKVLHMIHEEQSAQPNASQATTRTTRKKAPRLSRLSRQMVPQLQLPEPPALSVMYSYLHSRKIKILEIF HKVGQGENQRITREEFIAAVKAVGVPLKNQEVEDIVIYLSSLGKHNTITMDILANTYKQWSMAQQRSSLATAREHYILAKHRDSLKGPLK KQEVDSAPQLPKVDLLTVPAVDTQMETRPMTLEEMEEVGKRYRERQRQHKLTIPSIQYTEQCHLVRCGNRHFDEHCLPSTIHGDMRELID SARRHNFLVYLQCWKLCKSYGLPLTEDILMKALLYPGDKIIFQMDKVCPIRQPGGYYSDWKVFSPNLALLRSQGPGKSKRTDKKTPKKSK KMRFKEFEEFTRKLKVKRSSGLQQTHPNSFWPGHLLDKLQLYLPTVATDRSLALFSCVQHQPHVYPATYHPDHWWPLRNKNYMTHAHYDA >In-frame_SPG7_ENST00000268704_chr16_89599044_+_EFCAB12_ENST00000326085_chr3_129140646_-_998aa MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVR LWQLLGGTFYFNTSRLKQKNKEKDKSKGKAPEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEV QRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWY VFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAK AVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGLCPSKTPI NENAPVFDPEPVIAHCFKQFQQKDFRLPQTRRRIIMVPRKEDQTPLNPASQPQAPPKPIPSFKVLEARDIQEQPEDRKTWLSQRSKLRQE LESFGDVKRWLENKPSITPSEAKVLHMIHEEQSAQPNASQATTRTTRKKAPRLSRLSRQMVPQLQLPEPPALSVMYSYLHSRKIKILEIF HKVGQGENQRITREEFIAAVKAVGVPLKNQEVEDIVIYLSSLGKHNTITMDILANTYKQWSMAQQRSSLATAREHYILAKHRDSLKGPLK KQEVDSAPQLPKVDLLTVPAVDTQMETRPMTLEEMEEVGKRYRERQRQHKLTIPSIQYTEQCHLVRCGNRHFDEHCLPSTIHGDMRELID SARRHNFLVYLQCWKLCKSYGLPLTEDILMKALLYPGDKIIFQMDKVCPIRQPGGYYSDWKVFSPNLALLRSQGPGKSKRTDKKTPKKSK KMRFKEFEEFTRKLKVKRSSGLQQTHPNSFWPGHLLDKLQLYLPTVATDRSLALFSCVQHQPHVYPATYHPDHWWPLRNKNYMTHAHYDA >In-frame_SPG7_ENST00000341316_chr16_89599044_+_EFCAB12_ENST00000505956_chr3_129140646_-_998aa MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVR LWQLLGGTFYFNTSRLKQKNKEKDKSKGKAPEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEV QRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWY VFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAK AVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGLCPSKTPI NENAPVFDPEPVIAHCFKQFQQKDFRLPQTRRRIIMVPRKEDQTPLNPASQPQAPPKPIPSFKVLEARDIQEQPEDRKTWLSQRSKLRQE LESFGDVKRWLENKPSITPSEAKVLHMIHEEQSAQPNASQATTRTTRKKAPRLSRLSRQMVPQLQLPEPPALSVMYSYLHSRKIKILEIF HKVGQGENQRITREEFIAAVKAVGVPLKNQEVEDIVIYLSSLGKHNTITMDILANTYKQWSMAQQRSSLATAREHYILAKHRDSLKGPLK KQEVDSAPQLPKVDLLTVPAVDTQMETRPMTLEEMEEVGKRYRERQRQHKLTIPSIQYTEQCHLVRCGNRHFDEHCLPSTIHGDMRELID SARRHNFLVYLQCWKLCKSYGLPLTEDILMKALLYPGDKIIFQMDKVCPIRQPGGYYSDWKVFSPNLALLRSQGPGKSKRTDKKTPKKSK KMRFKEFEEFTRKLKVKRSSGLQQTHPNSFWPGHLLDKLQLYLPTVATDRSLALFSCVQHQPHVYPATYHPDHWWPLRNKNYMTHAHYDA >In-frame_SPG7_ENST00000341316_chr16_89599044_+_EFCAB12_ENST00000326085_chr3_129140646_-_998aa MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVR LWQLLGGTFYFNTSRLKQKNKEKDKSKGKAPEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEV QRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWY VFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAK AVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGLCPSKTPI NENAPVFDPEPVIAHCFKQFQQKDFRLPQTRRRIIMVPRKEDQTPLNPASQPQAPPKPIPSFKVLEARDIQEQPEDRKTWLSQRSKLRQE LESFGDVKRWLENKPSITPSEAKVLHMIHEEQSAQPNASQATTRTTRKKAPRLSRLSRQMVPQLQLPEPPALSVMYSYLHSRKIKILEIF HKVGQGENQRITREEFIAAVKAVGVPLKNQEVEDIVIYLSSLGKHNTITMDILANTYKQWSMAQQRSSLATAREHYILAKHRDSLKGPLK KQEVDSAPQLPKVDLLTVPAVDTQMETRPMTLEEMEEVGKRYRERQRQHKLTIPSIQYTEQCHLVRCGNRHFDEHCLPSTIHGDMRELID SARRHNFLVYLQCWKLCKSYGLPLTEDILMKALLYPGDKIIFQMDKVCPIRQPGGYYSDWKVFSPNLALLRSQGPGKSKRTDKKTPKKSK KMRFKEFEEFTRKLKVKRSSGLQQTHPNSFWPGHLLDKLQLYLPTVATDRSLALFSCVQHQPHVYPATYHPDHWWPLRNKNYMTHAHYDA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SPG7_ENST00000268704_chr16_89599044_+_EFCAB12_ENST00000505956_chr3_129140646_-_2994nt ATGGCCGTGCTGCTGCTGCTGCTCCGTGCCCTCCGCCGGGGTCCAGGCCCGGGTCCTCGGCCGCTGTGGGGCCCAGGCCCGGCCTGGAGT CCAGGGTTCCCCGCCAGGCCCGGGAGGGGGCGGCCGTACATGGCCAGCAGGCCTCCGGGGGACCTCGCCGAGGCTGGAGGCCGAGCTCTG CAGAGCTTACAATTGAGACTGCTAACCCCTACCTTTGAAGGGATCAACGGATTGTTGTTGAAACAACATTTAGTTCAGAATCCAGTCAGA CTCTGGCAACTTTTAGGTGGTACTTTCTATTTTAACACCTCAAGGTTGAAGCAGAAGAATAAGGAGAAGGATAAGTCGAAGGGGAAGGCG CCTGAAGAGGACGAAGAGGAGAGGAGACGCCGTGAGCGGGACGACCAGATGTACCGAGAGCGGCTGCGCACCTTGCTGGTCATCGCGGTT GTCATGAGCCTCCTGAATGCTCTCAGCACCAGCGGAGGCAGCATTTCCTGGAACGACTTTGTCCACGAGATGCTGGCCAAGGGCGAGGTG CAGCGCGTCCAGGTGGTGCCTGAGAGCGACGTGGTGGAAGTCTACCTGCACCCTGGAGCCGTGGTGTTTGGGCGGCCTCGGCTAGCCTTG ATGTACCGAATGCAGGTTGCAAATATTGACAAGTTTGAAGAGAAGCTTCGAGCAGCTGAAGATGAGCTGAATATCGAGGCCAAGGACAGG ATCCCAGTTTCCTACAAGCGAACAGGATTCTTTGGAAATGCCCTGTACTCTGTGGGGATGACGGCAGTGGGCCTGGCCATCCTGTGGTAT GTTTTCCGTCTGGCCGGGATGACTGGAAGGGAAGGTGGATTCAGTGCTTTTAATCAGCTTAAAATGGCTCGTTTCACCATTGTGGATGGG AAGATGGGGAAAGGAGTCAGCTTCAAAGACGTGGCAGGAATGCACGAAGCCAAACTGGAAGTCCGCGAGTTTGTGGATTATCTGAAGAGC CCAGAACGCTTCCTCCAGCTTGGCGCCAAGGTCCCAAAGGGCGCACTGCTGCTCGGCCCCCCCGGCTGTGGGAAGACGCTGCTGGCCAAG GCGGTGGCCACGGAGGCTCAGGTGCCCTTCCTGGCGATGGCCGGCCCAGAGTTCGTGGAGGTCATTGGAGGCCTCGGCGCTGCCCGTGTG CGGAGCCTCTTTAAGGAAGCCCGAGCCCGGGCCCCCTGCATCGTCTACATCGATGAGATCGACGCGGTGGGCAAGAAGCGCTCCACCACC ATGTCCGGCTTCTCCAACACGGAGGAGGAGCAGACGCTCAACCAGCTTCTGGTAGAAATGGATGGACTCTGCCCGTCTAAGACTCCCATC AATGAAAATGCTCCCGTCTTTGATCCTGAACCGGTCATTGCCCACTGCTTCAAGCAGTTCCAGCAGAAGGACTTCCGCCTGCCTCAGACC CGCCGGCGAATCATCATGGTGCCTCGCAAGGAGGATCAGACACCCCTTAATCCTGCATCCCAACCTCAGGCTCCCCCAAAGCCCATCCCC AGCTTCAAAGTTCTGGAAGCTAGAGATATCCAAGAGCAGCCAGAGGACAGGAAGACCTGGCTGAGCCAGAGGTCGAAGCTGCGGCAGGAG CTAGAGTCCTTTGGTGATGTAAAGAGGTGGCTGGAGAACAAGCCCAGCATCACGCCTTCAGAGGCCAAGGTCTTACACATGATCCACGAG GAGCAGAGTGCCCAGCCAAATGCCTCCCAGGCAACTACCAGGACCACCAGGAAGAAAGCCCCCAGGCTCTCCCGGCTGTCCCGCCAGATG GTGCCCCAGCTCCAGCTGCCCGAGCCCCCTGCCCTGTCGGTCATGTACTCCTACCTGCATAGCCGCAAGATCAAGATCCTGGAGATATTT CACAAGGTGGGCCAGGGTGAGAACCAGAGAATCACCAGGGAGGAGTTCATCGCGGCTGTAAAGGCAGTCGGAGTCCCTCTGAAGAACCAA GAGGTGGAGGATATAGTGATCTACCTCAGCTCTCTTGGGAAGCACAACACCATCACCATGGATATCCTGGCCAATACCTACAAGCAGTGG TCTATGGCTCAGCAAAGGAGCAGCCTGGCCACTGCAAGGGAGCATTATATCTTGGCCAAGCACAGAGATTCCCTGAAGGGTCCGCTCAAG AAGCAGGAGGTGGATTCAGCCCCACAGCTTCCCAAAGTGGACCTACTGACGGTGCCTGCAGTCGACACGCAGATGGAGACGCGGCCCATG ACCCTGGAGGAGATGGAGGAAGTGGGCAAGCGGTACCGCGAGCGGCAGCGACAGCACAAGCTCACGATCCCCTCCATCCAGTACACGGAG CAATGTCACCTGGTGCGCTGTGGGAATCGGCACTTTGATGAGCACTGCCTCCCGTCCACCATCCACGGGGATATGAGGGAGCTCATTGAC TCGGCCCGCAGGCACAACTTTCTGGTCTACCTGCAATGCTGGAAGCTCTGTAAGTCCTATGGCCTCCCGCTGACAGAGGACATCCTCATG AAAGCCTTGCTGTACCCAGGAGACAAGATCATTTTCCAGATGGACAAAGTGTGCCCCATCCGGCAGCCGGGAGGCTACTACTCTGACTGG AAGGTCTTTTCTCCGAATCTGGCTCTGCTCCGGTCCCAGGGCCCTGGCAAGTCTAAGAGGACTGACAAGAAAACGCCAAAGAAAAGCAAG AAAATGCGCTTTAAGGAGTTTGAGGAATTTACCAGGAAGCTGAAGGTGAAGAGGTCCAGTGGTCTGCAGCAAACACACCCCAATTCCTTC TGGCCGGGTCATCTTCTGGATAAGCTGCAGCTCTACCTGCCCACTGTGGCCACAGACCGGAGCCTGGCGCTCTTCAGTTGTGTTCAACAC CAGCCCCATGTCTACCCAGCCACCTACCACCCTGACCACTGGTGGCCCCTTAGGAACAAGAACTACATGACCCACGCCCATTATGATGCC >In-frame_SPG7_ENST00000268704_chr16_89599044_+_EFCAB12_ENST00000326085_chr3_129140646_-_2994nt ATGGCCGTGCTGCTGCTGCTGCTCCGTGCCCTCCGCCGGGGTCCAGGCCCGGGTCCTCGGCCGCTGTGGGGCCCAGGCCCGGCCTGGAGT CCAGGGTTCCCCGCCAGGCCCGGGAGGGGGCGGCCGTACATGGCCAGCAGGCCTCCGGGGGACCTCGCCGAGGCTGGAGGCCGAGCTCTG CAGAGCTTACAATTGAGACTGCTAACCCCTACCTTTGAAGGGATCAACGGATTGTTGTTGAAACAACATTTAGTTCAGAATCCAGTCAGA CTCTGGCAACTTTTAGGTGGTACTTTCTATTTTAACACCTCAAGGTTGAAGCAGAAGAATAAGGAGAAGGATAAGTCGAAGGGGAAGGCG CCTGAAGAGGACGAAGAGGAGAGGAGACGCCGTGAGCGGGACGACCAGATGTACCGAGAGCGGCTGCGCACCTTGCTGGTCATCGCGGTT GTCATGAGCCTCCTGAATGCTCTCAGCACCAGCGGAGGCAGCATTTCCTGGAACGACTTTGTCCACGAGATGCTGGCCAAGGGCGAGGTG CAGCGCGTCCAGGTGGTGCCTGAGAGCGACGTGGTGGAAGTCTACCTGCACCCTGGAGCCGTGGTGTTTGGGCGGCCTCGGCTAGCCTTG ATGTACCGAATGCAGGTTGCAAATATTGACAAGTTTGAAGAGAAGCTTCGAGCAGCTGAAGATGAGCTGAATATCGAGGCCAAGGACAGG ATCCCAGTTTCCTACAAGCGAACAGGATTCTTTGGAAATGCCCTGTACTCTGTGGGGATGACGGCAGTGGGCCTGGCCATCCTGTGGTAT GTTTTCCGTCTGGCCGGGATGACTGGAAGGGAAGGTGGATTCAGTGCTTTTAATCAGCTTAAAATGGCTCGTTTCACCATTGTGGATGGG AAGATGGGGAAAGGAGTCAGCTTCAAAGACGTGGCAGGAATGCACGAAGCCAAACTGGAAGTCCGCGAGTTTGTGGATTATCTGAAGAGC CCAGAACGCTTCCTCCAGCTTGGCGCCAAGGTCCCAAAGGGCGCACTGCTGCTCGGCCCCCCCGGCTGTGGGAAGACGCTGCTGGCCAAG GCGGTGGCCACGGAGGCTCAGGTGCCCTTCCTGGCGATGGCCGGCCCAGAGTTCGTGGAGGTCATTGGAGGCCTCGGCGCTGCCCGTGTG CGGAGCCTCTTTAAGGAAGCCCGAGCCCGGGCCCCCTGCATCGTCTACATCGATGAGATCGACGCGGTGGGCAAGAAGCGCTCCACCACC ATGTCCGGCTTCTCCAACACGGAGGAGGAGCAGACGCTCAACCAGCTTCTGGTAGAAATGGATGGACTCTGCCCGTCTAAGACTCCCATC AATGAAAATGCTCCCGTCTTTGATCCTGAACCGGTCATTGCCCACTGCTTCAAGCAGTTCCAGCAGAAGGACTTCCGCCTGCCTCAGACC CGCCGGCGAATCATCATGGTGCCTCGCAAGGAGGATCAGACACCCCTTAATCCTGCATCCCAACCTCAGGCTCCCCCAAAGCCCATCCCC AGCTTCAAAGTTCTGGAAGCTAGAGATATCCAAGAGCAGCCAGAGGACAGGAAGACCTGGCTGAGCCAGAGGTCGAAGCTGCGGCAGGAG CTAGAGTCCTTTGGTGATGTAAAGAGGTGGCTGGAGAACAAGCCCAGCATCACGCCTTCAGAGGCCAAGGTCTTACACATGATCCACGAG GAGCAGAGTGCCCAGCCAAATGCCTCCCAGGCAACTACCAGGACCACCAGGAAGAAAGCCCCCAGGCTCTCCCGGCTGTCCCGCCAGATG GTGCCCCAGCTCCAGCTGCCCGAGCCCCCTGCCCTGTCGGTCATGTACTCCTACCTGCATAGCCGCAAGATCAAGATCCTGGAGATATTT CACAAGGTGGGCCAGGGTGAGAACCAGAGAATCACCAGGGAGGAGTTCATCGCGGCTGTAAAGGCAGTCGGAGTCCCTCTGAAGAACCAA GAGGTGGAGGATATAGTGATCTACCTCAGCTCTCTTGGGAAGCACAACACCATCACCATGGATATCCTGGCCAATACCTACAAGCAGTGG TCTATGGCTCAGCAAAGGAGCAGCCTGGCCACTGCAAGGGAGCATTATATCTTGGCCAAGCACAGAGATTCCCTGAAGGGTCCGCTCAAG AAGCAGGAGGTGGATTCAGCCCCACAGCTTCCCAAAGTGGACCTACTGACGGTGCCTGCAGTCGACACGCAGATGGAGACGCGGCCCATG ACCCTGGAGGAGATGGAGGAAGTGGGCAAGCGGTACCGCGAGCGGCAGCGACAGCACAAGCTCACGATCCCCTCCATCCAGTACACGGAG CAATGTCACCTGGTGCGCTGTGGGAATCGGCACTTTGATGAGCACTGCCTCCCGTCCACCATCCACGGGGATATGAGGGAGCTCATTGAC TCGGCCCGCAGGCACAACTTTCTGGTCTACCTGCAATGCTGGAAGCTCTGTAAGTCCTATGGCCTCCCGCTGACAGAGGACATCCTCATG AAAGCCTTGCTGTACCCAGGAGACAAGATCATTTTCCAGATGGACAAAGTGTGCCCCATCCGGCAGCCGGGAGGCTACTACTCTGACTGG AAGGTCTTTTCTCCGAATCTGGCTCTGCTCCGGTCCCAGGGCCCTGGCAAGTCTAAGAGGACTGACAAGAAAACGCCAAAGAAAAGCAAG AAAATGCGCTTTAAGGAGTTTGAGGAATTTACCAGGAAGCTGAAGGTGAAGAGGTCCAGTGGTCTGCAGCAAACACACCCCAATTCCTTC TGGCCGGGTCATCTTCTGGATAAGCTGCAGCTCTACCTGCCCACTGTGGCCACAGACCGGAGCCTGGCGCTCTTCAGTTGTGTTCAACAC CAGCCCCATGTCTACCCAGCCACCTACCACCCTGACCACTGGTGGCCCCTTAGGAACAAGAACTACATGACCCACGCCCATTATGATGCC >In-frame_SPG7_ENST00000341316_chr16_89599044_+_EFCAB12_ENST00000505956_chr3_129140646_-_2994nt ATGGCCGTGCTGCTGCTGCTGCTCCGTGCCCTCCGCCGGGGTCCAGGCCCGGGTCCTCGGCCGCTGTGGGGCCCAGGCCCGGCCTGGAGT CCAGGGTTCCCCGCCAGGCCCGGGAGGGGGCGGCCGTACATGGCCAGCAGGCCTCCGGGGGACCTCGCCGAGGCTGGAGGCCGAGCTCTG CAGAGCTTACAATTGAGACTGCTAACCCCTACCTTTGAAGGGATCAACGGATTGTTGTTGAAACAACATTTAGTTCAGAATCCAGTCAGA CTCTGGCAACTTTTAGGTGGTACTTTCTATTTTAACACCTCAAGGTTGAAGCAGAAGAATAAGGAGAAGGATAAGTCGAAGGGGAAGGCG CCTGAAGAGGACGAAGAGGAGAGGAGACGCCGTGAGCGGGACGACCAGATGTACCGAGAGCGGCTGCGCACCTTGCTGGTCATCGCGGTT GTCATGAGCCTCCTGAATGCTCTCAGCACCAGCGGAGGCAGCATTTCCTGGAACGACTTTGTCCACGAGATGCTGGCCAAGGGCGAGGTG CAGCGCGTCCAGGTGGTGCCTGAGAGCGACGTGGTGGAAGTCTACCTGCACCCTGGAGCCGTGGTGTTTGGGCGGCCTCGGCTAGCCTTG ATGTACCGAATGCAGGTTGCAAATATTGACAAGTTTGAAGAGAAGCTTCGAGCAGCTGAAGATGAGCTGAATATCGAGGCCAAGGACAGG ATCCCAGTTTCCTACAAGCGAACAGGATTCTTTGGAAATGCCCTGTACTCTGTGGGGATGACGGCAGTGGGCCTGGCCATCCTGTGGTAT GTTTTCCGTCTGGCCGGGATGACTGGAAGGGAAGGTGGATTCAGTGCTTTTAATCAGCTTAAAATGGCTCGTTTCACCATTGTGGATGGG AAGATGGGGAAAGGAGTCAGCTTCAAAGACGTGGCAGGAATGCACGAAGCCAAACTGGAAGTCCGCGAGTTTGTGGATTATCTGAAGAGC CCAGAACGCTTCCTCCAGCTTGGCGCCAAGGTCCCAAAGGGCGCACTGCTGCTCGGCCCCCCCGGCTGTGGGAAGACGCTGCTGGCCAAG GCGGTGGCCACGGAGGCTCAGGTGCCCTTCCTGGCGATGGCCGGCCCAGAGTTCGTGGAGGTCATTGGAGGCCTCGGCGCTGCCCGTGTG CGGAGCCTCTTTAAGGAAGCCCGAGCCCGGGCCCCCTGCATCGTCTACATCGATGAGATCGACGCGGTGGGCAAGAAGCGCTCCACCACC ATGTCCGGCTTCTCCAACACGGAGGAGGAGCAGACGCTCAACCAGCTTCTGGTAGAAATGGATGGACTCTGCCCGTCTAAGACTCCCATC AATGAAAATGCTCCCGTCTTTGATCCTGAACCGGTCATTGCCCACTGCTTCAAGCAGTTCCAGCAGAAGGACTTCCGCCTGCCTCAGACC CGCCGGCGAATCATCATGGTGCCTCGCAAGGAGGATCAGACACCCCTTAATCCTGCATCCCAACCTCAGGCTCCCCCAAAGCCCATCCCC AGCTTCAAAGTTCTGGAAGCTAGAGATATCCAAGAGCAGCCAGAGGACAGGAAGACCTGGCTGAGCCAGAGGTCGAAGCTGCGGCAGGAG CTAGAGTCCTTTGGTGATGTAAAGAGGTGGCTGGAGAACAAGCCCAGCATCACGCCTTCAGAGGCCAAGGTCTTACACATGATCCACGAG GAGCAGAGTGCCCAGCCAAATGCCTCCCAGGCAACTACCAGGACCACCAGGAAGAAAGCCCCCAGGCTCTCCCGGCTGTCCCGCCAGATG GTGCCCCAGCTCCAGCTGCCCGAGCCCCCTGCCCTGTCGGTCATGTACTCCTACCTGCATAGCCGCAAGATCAAGATCCTGGAGATATTT CACAAGGTGGGCCAGGGTGAGAACCAGAGAATCACCAGGGAGGAGTTCATCGCGGCTGTAAAGGCAGTCGGAGTCCCTCTGAAGAACCAA GAGGTGGAGGATATAGTGATCTACCTCAGCTCTCTTGGGAAGCACAACACCATCACCATGGATATCCTGGCCAATACCTACAAGCAGTGG TCTATGGCTCAGCAAAGGAGCAGCCTGGCCACTGCAAGGGAGCATTATATCTTGGCCAAGCACAGAGATTCCCTGAAGGGTCCGCTCAAG AAGCAGGAGGTGGATTCAGCCCCACAGCTTCCCAAAGTGGACCTACTGACGGTGCCTGCAGTCGACACGCAGATGGAGACGCGGCCCATG ACCCTGGAGGAGATGGAGGAAGTGGGCAAGCGGTACCGCGAGCGGCAGCGACAGCACAAGCTCACGATCCCCTCCATCCAGTACACGGAG CAATGTCACCTGGTGCGCTGTGGGAATCGGCACTTTGATGAGCACTGCCTCCCGTCCACCATCCACGGGGATATGAGGGAGCTCATTGAC TCGGCCCGCAGGCACAACTTTCTGGTCTACCTGCAATGCTGGAAGCTCTGTAAGTCCTATGGCCTCCCGCTGACAGAGGACATCCTCATG AAAGCCTTGCTGTACCCAGGAGACAAGATCATTTTCCAGATGGACAAAGTGTGCCCCATCCGGCAGCCGGGAGGCTACTACTCTGACTGG AAGGTCTTTTCTCCGAATCTGGCTCTGCTCCGGTCCCAGGGCCCTGGCAAGTCTAAGAGGACTGACAAGAAAACGCCAAAGAAAAGCAAG AAAATGCGCTTTAAGGAGTTTGAGGAATTTACCAGGAAGCTGAAGGTGAAGAGGTCCAGTGGTCTGCAGCAAACACACCCCAATTCCTTC TGGCCGGGTCATCTTCTGGATAAGCTGCAGCTCTACCTGCCCACTGTGGCCACAGACCGGAGCCTGGCGCTCTTCAGTTGTGTTCAACAC CAGCCCCATGTCTACCCAGCCACCTACCACCCTGACCACTGGTGGCCCCTTAGGAACAAGAACTACATGACCCACGCCCATTATGATGCC >In-frame_SPG7_ENST00000341316_chr16_89599044_+_EFCAB12_ENST00000326085_chr3_129140646_-_2994nt ATGGCCGTGCTGCTGCTGCTGCTCCGTGCCCTCCGCCGGGGTCCAGGCCCGGGTCCTCGGCCGCTGTGGGGCCCAGGCCCGGCCTGGAGT CCAGGGTTCCCCGCCAGGCCCGGGAGGGGGCGGCCGTACATGGCCAGCAGGCCTCCGGGGGACCTCGCCGAGGCTGGAGGCCGAGCTCTG CAGAGCTTACAATTGAGACTGCTAACCCCTACCTTTGAAGGGATCAACGGATTGTTGTTGAAACAACATTTAGTTCAGAATCCAGTCAGA CTCTGGCAACTTTTAGGTGGTACTTTCTATTTTAACACCTCAAGGTTGAAGCAGAAGAATAAGGAGAAGGATAAGTCGAAGGGGAAGGCG CCTGAAGAGGACGAAGAGGAGAGGAGACGCCGTGAGCGGGACGACCAGATGTACCGAGAGCGGCTGCGCACCTTGCTGGTCATCGCGGTT GTCATGAGCCTCCTGAATGCTCTCAGCACCAGCGGAGGCAGCATTTCCTGGAACGACTTTGTCCACGAGATGCTGGCCAAGGGCGAGGTG CAGCGCGTCCAGGTGGTGCCTGAGAGCGACGTGGTGGAAGTCTACCTGCACCCTGGAGCCGTGGTGTTTGGGCGGCCTCGGCTAGCCTTG ATGTACCGAATGCAGGTTGCAAATATTGACAAGTTTGAAGAGAAGCTTCGAGCAGCTGAAGATGAGCTGAATATCGAGGCCAAGGACAGG ATCCCAGTTTCCTACAAGCGAACAGGATTCTTTGGAAATGCCCTGTACTCTGTGGGGATGACGGCAGTGGGCCTGGCCATCCTGTGGTAT GTTTTCCGTCTGGCCGGGATGACTGGAAGGGAAGGTGGATTCAGTGCTTTTAATCAGCTTAAAATGGCTCGTTTCACCATTGTGGATGGG AAGATGGGGAAAGGAGTCAGCTTCAAAGACGTGGCAGGAATGCACGAAGCCAAACTGGAAGTCCGCGAGTTTGTGGATTATCTGAAGAGC CCAGAACGCTTCCTCCAGCTTGGCGCCAAGGTCCCAAAGGGCGCACTGCTGCTCGGCCCCCCCGGCTGTGGGAAGACGCTGCTGGCCAAG GCGGTGGCCACGGAGGCTCAGGTGCCCTTCCTGGCGATGGCCGGCCCAGAGTTCGTGGAGGTCATTGGAGGCCTCGGCGCTGCCCGTGTG CGGAGCCTCTTTAAGGAAGCCCGAGCCCGGGCCCCCTGCATCGTCTACATCGATGAGATCGACGCGGTGGGCAAGAAGCGCTCCACCACC ATGTCCGGCTTCTCCAACACGGAGGAGGAGCAGACGCTCAACCAGCTTCTGGTAGAAATGGATGGACTCTGCCCGTCTAAGACTCCCATC AATGAAAATGCTCCCGTCTTTGATCCTGAACCGGTCATTGCCCACTGCTTCAAGCAGTTCCAGCAGAAGGACTTCCGCCTGCCTCAGACC CGCCGGCGAATCATCATGGTGCCTCGCAAGGAGGATCAGACACCCCTTAATCCTGCATCCCAACCTCAGGCTCCCCCAAAGCCCATCCCC AGCTTCAAAGTTCTGGAAGCTAGAGATATCCAAGAGCAGCCAGAGGACAGGAAGACCTGGCTGAGCCAGAGGTCGAAGCTGCGGCAGGAG CTAGAGTCCTTTGGTGATGTAAAGAGGTGGCTGGAGAACAAGCCCAGCATCACGCCTTCAGAGGCCAAGGTCTTACACATGATCCACGAG GAGCAGAGTGCCCAGCCAAATGCCTCCCAGGCAACTACCAGGACCACCAGGAAGAAAGCCCCCAGGCTCTCCCGGCTGTCCCGCCAGATG GTGCCCCAGCTCCAGCTGCCCGAGCCCCCTGCCCTGTCGGTCATGTACTCCTACCTGCATAGCCGCAAGATCAAGATCCTGGAGATATTT CACAAGGTGGGCCAGGGTGAGAACCAGAGAATCACCAGGGAGGAGTTCATCGCGGCTGTAAAGGCAGTCGGAGTCCCTCTGAAGAACCAA GAGGTGGAGGATATAGTGATCTACCTCAGCTCTCTTGGGAAGCACAACACCATCACCATGGATATCCTGGCCAATACCTACAAGCAGTGG TCTATGGCTCAGCAAAGGAGCAGCCTGGCCACTGCAAGGGAGCATTATATCTTGGCCAAGCACAGAGATTCCCTGAAGGGTCCGCTCAAG AAGCAGGAGGTGGATTCAGCCCCACAGCTTCCCAAAGTGGACCTACTGACGGTGCCTGCAGTCGACACGCAGATGGAGACGCGGCCCATG ACCCTGGAGGAGATGGAGGAAGTGGGCAAGCGGTACCGCGAGCGGCAGCGACAGCACAAGCTCACGATCCCCTCCATCCAGTACACGGAG CAATGTCACCTGGTGCGCTGTGGGAATCGGCACTTTGATGAGCACTGCCTCCCGTCCACCATCCACGGGGATATGAGGGAGCTCATTGAC TCGGCCCGCAGGCACAACTTTCTGGTCTACCTGCAATGCTGGAAGCTCTGTAAGTCCTATGGCCTCCCGCTGACAGAGGACATCCTCATG AAAGCCTTGCTGTACCCAGGAGACAAGATCATTTTCCAGATGGACAAAGTGTGCCCCATCCGGCAGCCGGGAGGCTACTACTCTGACTGG AAGGTCTTTTCTCCGAATCTGGCTCTGCTCCGGTCCCAGGGCCCTGGCAAGTCTAAGAGGACTGACAAGAAAACGCCAAAGAAAAGCAAG AAAATGCGCTTTAAGGAGTTTGAGGAATTTACCAGGAAGCTGAAGGTGAAGAGGTCCAGTGGTCTGCAGCAAACACACCCCAATTCCTTC TGGCCGGGTCATCTTCTGGATAAGCTGCAGCTCTACCTGCCCACTGTGGCCACAGACCGGAGCCTGGCGCTCTTCAGTTGTGTTCAACAC CAGCCCCATGTCTACCCAGCCACCTACCACCCTGACCACTGGTGGCCCCTTAGGAACAAGAACTACATGACCCACGCCCATTATGATGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SPG7_ENST00000268704_chr16_89599044_+_EFCAB12_ENST00000505956_chr3_129140646_-_3281nt GGCTTTCAGGCCAACATGGCCGTGCTGCTGCTGCTGCTCCGTGCCCTCCGCCGGGGTCCAGGCCCGGGTCCTCGGCCGCTGTGGGGCCCA GGCCCGGCCTGGAGTCCAGGGTTCCCCGCCAGGCCCGGGAGGGGGCGGCCGTACATGGCCAGCAGGCCTCCGGGGGACCTCGCCGAGGCT GGAGGCCGAGCTCTGCAGAGCTTACAATTGAGACTGCTAACCCCTACCTTTGAAGGGATCAACGGATTGTTGTTGAAACAACATTTAGTT CAGAATCCAGTCAGACTCTGGCAACTTTTAGGTGGTACTTTCTATTTTAACACCTCAAGGTTGAAGCAGAAGAATAAGGAGAAGGATAAG TCGAAGGGGAAGGCGCCTGAAGAGGACGAAGAGGAGAGGAGACGCCGTGAGCGGGACGACCAGATGTACCGAGAGCGGCTGCGCACCTTG CTGGTCATCGCGGTTGTCATGAGCCTCCTGAATGCTCTCAGCACCAGCGGAGGCAGCATTTCCTGGAACGACTTTGTCCACGAGATGCTG GCCAAGGGCGAGGTGCAGCGCGTCCAGGTGGTGCCTGAGAGCGACGTGGTGGAAGTCTACCTGCACCCTGGAGCCGTGGTGTTTGGGCGG CCTCGGCTAGCCTTGATGTACCGAATGCAGGTTGCAAATATTGACAAGTTTGAAGAGAAGCTTCGAGCAGCTGAAGATGAGCTGAATATC GAGGCCAAGGACAGGATCCCAGTTTCCTACAAGCGAACAGGATTCTTTGGAAATGCCCTGTACTCTGTGGGGATGACGGCAGTGGGCCTG GCCATCCTGTGGTATGTTTTCCGTCTGGCCGGGATGACTGGAAGGGAAGGTGGATTCAGTGCTTTTAATCAGCTTAAAATGGCTCGTTTC ACCATTGTGGATGGGAAGATGGGGAAAGGAGTCAGCTTCAAAGACGTGGCAGGAATGCACGAAGCCAAACTGGAAGTCCGCGAGTTTGTG GATTATCTGAAGAGCCCAGAACGCTTCCTCCAGCTTGGCGCCAAGGTCCCAAAGGGCGCACTGCTGCTCGGCCCCCCCGGCTGTGGGAAG ACGCTGCTGGCCAAGGCGGTGGCCACGGAGGCTCAGGTGCCCTTCCTGGCGATGGCCGGCCCAGAGTTCGTGGAGGTCATTGGAGGCCTC GGCGCTGCCCGTGTGCGGAGCCTCTTTAAGGAAGCCCGAGCCCGGGCCCCCTGCATCGTCTACATCGATGAGATCGACGCGGTGGGCAAG AAGCGCTCCACCACCATGTCCGGCTTCTCCAACACGGAGGAGGAGCAGACGCTCAACCAGCTTCTGGTAGAAATGGATGGACTCTGCCCG TCTAAGACTCCCATCAATGAAAATGCTCCCGTCTTTGATCCTGAACCGGTCATTGCCCACTGCTTCAAGCAGTTCCAGCAGAAGGACTTC CGCCTGCCTCAGACCCGCCGGCGAATCATCATGGTGCCTCGCAAGGAGGATCAGACACCCCTTAATCCTGCATCCCAACCTCAGGCTCCC CCAAAGCCCATCCCCAGCTTCAAAGTTCTGGAAGCTAGAGATATCCAAGAGCAGCCAGAGGACAGGAAGACCTGGCTGAGCCAGAGGTCG AAGCTGCGGCAGGAGCTAGAGTCCTTTGGTGATGTAAAGAGGTGGCTGGAGAACAAGCCCAGCATCACGCCTTCAGAGGCCAAGGTCTTA CACATGATCCACGAGGAGCAGAGTGCCCAGCCAAATGCCTCCCAGGCAACTACCAGGACCACCAGGAAGAAAGCCCCCAGGCTCTCCCGG CTGTCCCGCCAGATGGTGCCCCAGCTCCAGCTGCCCGAGCCCCCTGCCCTGTCGGTCATGTACTCCTACCTGCATAGCCGCAAGATCAAG ATCCTGGAGATATTTCACAAGGTGGGCCAGGGTGAGAACCAGAGAATCACCAGGGAGGAGTTCATCGCGGCTGTAAAGGCAGTCGGAGTC CCTCTGAAGAACCAAGAGGTGGAGGATATAGTGATCTACCTCAGCTCTCTTGGGAAGCACAACACCATCACCATGGATATCCTGGCCAAT ACCTACAAGCAGTGGTCTATGGCTCAGCAAAGGAGCAGCCTGGCCACTGCAAGGGAGCATTATATCTTGGCCAAGCACAGAGATTCCCTG AAGGGTCCGCTCAAGAAGCAGGAGGTGGATTCAGCCCCACAGCTTCCCAAAGTGGACCTACTGACGGTGCCTGCAGTCGACACGCAGATG GAGACGCGGCCCATGACCCTGGAGGAGATGGAGGAAGTGGGCAAGCGGTACCGCGAGCGGCAGCGACAGCACAAGCTCACGATCCCCTCC ATCCAGTACACGGAGCAATGTCACCTGGTGCGCTGTGGGAATCGGCACTTTGATGAGCACTGCCTCCCGTCCACCATCCACGGGGATATG AGGGAGCTCATTGACTCGGCCCGCAGGCACAACTTTCTGGTCTACCTGCAATGCTGGAAGCTCTGTAAGTCCTATGGCCTCCCGCTGACA GAGGACATCCTCATGAAAGCCTTGCTGTACCCAGGAGACAAGATCATTTTCCAGATGGACAAAGTGTGCCCCATCCGGCAGCCGGGAGGC TACTACTCTGACTGGAAGGTCTTTTCTCCGAATCTGGCTCTGCTCCGGTCCCAGGGCCCTGGCAAGTCTAAGAGGACTGACAAGAAAACG CCAAAGAAAAGCAAGAAAATGCGCTTTAAGGAGTTTGAGGAATTTACCAGGAAGCTGAAGGTGAAGAGGTCCAGTGGTCTGCAGCAAACA CACCCCAATTCCTTCTGGCCGGGTCATCTTCTGGATAAGCTGCAGCTCTACCTGCCCACTGTGGCCACAGACCGGAGCCTGGCGCTCTTC AGTTGTGTTCAACACCAGCCCCATGTCTACCCAGCCACCTACCACCCTGACCACTGGTGGCCCCTTAGGAACAAGAACTACATGACCCAC GCCCATTATGATGCCGCCAAGGTGTACTACATCAACTAGAGCTAGCCAGGTGTTGCCGGACCCAGCCTTCCTGGGCCAGGGGCCAGTGCA GCCAGCGGCCCAGAGCCCAGACACAAGAGGAGTGTCAAAGAGTCAAACTAAAGAAATCCTTTCAAAGAGGGATGGACCGGGGGCCAGTTC CCTCTGGACTCAAAGTGTCCAGTGTCTCAGAGGGTAGATGTGTCCAAGGAATGACGTGCAGTTTTTGACTATTTCCCTCCCCTGACCTCT >In-frame_SPG7_ENST00000268704_chr16_89599044_+_EFCAB12_ENST00000326085_chr3_129140646_-_3280nt GGCTTTCAGGCCAACATGGCCGTGCTGCTGCTGCTGCTCCGTGCCCTCCGCCGGGGTCCAGGCCCGGGTCCTCGGCCGCTGTGGGGCCCA GGCCCGGCCTGGAGTCCAGGGTTCCCCGCCAGGCCCGGGAGGGGGCGGCCGTACATGGCCAGCAGGCCTCCGGGGGACCTCGCCGAGGCT GGAGGCCGAGCTCTGCAGAGCTTACAATTGAGACTGCTAACCCCTACCTTTGAAGGGATCAACGGATTGTTGTTGAAACAACATTTAGTT CAGAATCCAGTCAGACTCTGGCAACTTTTAGGTGGTACTTTCTATTTTAACACCTCAAGGTTGAAGCAGAAGAATAAGGAGAAGGATAAG TCGAAGGGGAAGGCGCCTGAAGAGGACGAAGAGGAGAGGAGACGCCGTGAGCGGGACGACCAGATGTACCGAGAGCGGCTGCGCACCTTG CTGGTCATCGCGGTTGTCATGAGCCTCCTGAATGCTCTCAGCACCAGCGGAGGCAGCATTTCCTGGAACGACTTTGTCCACGAGATGCTG GCCAAGGGCGAGGTGCAGCGCGTCCAGGTGGTGCCTGAGAGCGACGTGGTGGAAGTCTACCTGCACCCTGGAGCCGTGGTGTTTGGGCGG CCTCGGCTAGCCTTGATGTACCGAATGCAGGTTGCAAATATTGACAAGTTTGAAGAGAAGCTTCGAGCAGCTGAAGATGAGCTGAATATC GAGGCCAAGGACAGGATCCCAGTTTCCTACAAGCGAACAGGATTCTTTGGAAATGCCCTGTACTCTGTGGGGATGACGGCAGTGGGCCTG GCCATCCTGTGGTATGTTTTCCGTCTGGCCGGGATGACTGGAAGGGAAGGTGGATTCAGTGCTTTTAATCAGCTTAAAATGGCTCGTTTC ACCATTGTGGATGGGAAGATGGGGAAAGGAGTCAGCTTCAAAGACGTGGCAGGAATGCACGAAGCCAAACTGGAAGTCCGCGAGTTTGTG GATTATCTGAAGAGCCCAGAACGCTTCCTCCAGCTTGGCGCCAAGGTCCCAAAGGGCGCACTGCTGCTCGGCCCCCCCGGCTGTGGGAAG ACGCTGCTGGCCAAGGCGGTGGCCACGGAGGCTCAGGTGCCCTTCCTGGCGATGGCCGGCCCAGAGTTCGTGGAGGTCATTGGAGGCCTC GGCGCTGCCCGTGTGCGGAGCCTCTTTAAGGAAGCCCGAGCCCGGGCCCCCTGCATCGTCTACATCGATGAGATCGACGCGGTGGGCAAG AAGCGCTCCACCACCATGTCCGGCTTCTCCAACACGGAGGAGGAGCAGACGCTCAACCAGCTTCTGGTAGAAATGGATGGACTCTGCCCG TCTAAGACTCCCATCAATGAAAATGCTCCCGTCTTTGATCCTGAACCGGTCATTGCCCACTGCTTCAAGCAGTTCCAGCAGAAGGACTTC CGCCTGCCTCAGACCCGCCGGCGAATCATCATGGTGCCTCGCAAGGAGGATCAGACACCCCTTAATCCTGCATCCCAACCTCAGGCTCCC CCAAAGCCCATCCCCAGCTTCAAAGTTCTGGAAGCTAGAGATATCCAAGAGCAGCCAGAGGACAGGAAGACCTGGCTGAGCCAGAGGTCG AAGCTGCGGCAGGAGCTAGAGTCCTTTGGTGATGTAAAGAGGTGGCTGGAGAACAAGCCCAGCATCACGCCTTCAGAGGCCAAGGTCTTA CACATGATCCACGAGGAGCAGAGTGCCCAGCCAAATGCCTCCCAGGCAACTACCAGGACCACCAGGAAGAAAGCCCCCAGGCTCTCCCGG CTGTCCCGCCAGATGGTGCCCCAGCTCCAGCTGCCCGAGCCCCCTGCCCTGTCGGTCATGTACTCCTACCTGCATAGCCGCAAGATCAAG ATCCTGGAGATATTTCACAAGGTGGGCCAGGGTGAGAACCAGAGAATCACCAGGGAGGAGTTCATCGCGGCTGTAAAGGCAGTCGGAGTC CCTCTGAAGAACCAAGAGGTGGAGGATATAGTGATCTACCTCAGCTCTCTTGGGAAGCACAACACCATCACCATGGATATCCTGGCCAAT ACCTACAAGCAGTGGTCTATGGCTCAGCAAAGGAGCAGCCTGGCCACTGCAAGGGAGCATTATATCTTGGCCAAGCACAGAGATTCCCTG AAGGGTCCGCTCAAGAAGCAGGAGGTGGATTCAGCCCCACAGCTTCCCAAAGTGGACCTACTGACGGTGCCTGCAGTCGACACGCAGATG GAGACGCGGCCCATGACCCTGGAGGAGATGGAGGAAGTGGGCAAGCGGTACCGCGAGCGGCAGCGACAGCACAAGCTCACGATCCCCTCC ATCCAGTACACGGAGCAATGTCACCTGGTGCGCTGTGGGAATCGGCACTTTGATGAGCACTGCCTCCCGTCCACCATCCACGGGGATATG AGGGAGCTCATTGACTCGGCCCGCAGGCACAACTTTCTGGTCTACCTGCAATGCTGGAAGCTCTGTAAGTCCTATGGCCTCCCGCTGACA GAGGACATCCTCATGAAAGCCTTGCTGTACCCAGGAGACAAGATCATTTTCCAGATGGACAAAGTGTGCCCCATCCGGCAGCCGGGAGGC TACTACTCTGACTGGAAGGTCTTTTCTCCGAATCTGGCTCTGCTCCGGTCCCAGGGCCCTGGCAAGTCTAAGAGGACTGACAAGAAAACG CCAAAGAAAAGCAAGAAAATGCGCTTTAAGGAGTTTGAGGAATTTACCAGGAAGCTGAAGGTGAAGAGGTCCAGTGGTCTGCAGCAAACA CACCCCAATTCCTTCTGGCCGGGTCATCTTCTGGATAAGCTGCAGCTCTACCTGCCCACTGTGGCCACAGACCGGAGCCTGGCGCTCTTC AGTTGTGTTCAACACCAGCCCCATGTCTACCCAGCCACCTACCACCCTGACCACTGGTGGCCCCTTAGGAACAAGAACTACATGACCCAC GCCCATTATGATGCCGCCAAGGTGTACTACATCAACTAGAGCTAGCCAGGTGTTGCCGGACCCAGCCTTCCTGGGCCAGGGGCCAGTGCA GCCAGCGGCCCAGAGCCCAGACACAAGAGGAGTGTCAAAGAGTCAAACTAAAGAAATCCTTTCAAAGAGGGATGGACCGGGGGCCAGTTC CCTCTGGACTCAAAGTGTCCAGTGTCTCAGAGGGTAGATGTGTCCAAGGAATGACGTGCAGTTTTTGACTATTTCCCTCCCCTGACCTCT >In-frame_SPG7_ENST00000341316_chr16_89599044_+_EFCAB12_ENST00000505956_chr3_129140646_-_3273nt GGCCAACATGGCCGTGCTGCTGCTGCTGCTCCGTGCCCTCCGCCGGGGTCCAGGCCCGGGTCCTCGGCCGCTGTGGGGCCCAGGCCCGGC CTGGAGTCCAGGGTTCCCCGCCAGGCCCGGGAGGGGGCGGCCGTACATGGCCAGCAGGCCTCCGGGGGACCTCGCCGAGGCTGGAGGCCG AGCTCTGCAGAGCTTACAATTGAGACTGCTAACCCCTACCTTTGAAGGGATCAACGGATTGTTGTTGAAACAACATTTAGTTCAGAATCC AGTCAGACTCTGGCAACTTTTAGGTGGTACTTTCTATTTTAACACCTCAAGGTTGAAGCAGAAGAATAAGGAGAAGGATAAGTCGAAGGG GAAGGCGCCTGAAGAGGACGAAGAGGAGAGGAGACGCCGTGAGCGGGACGACCAGATGTACCGAGAGCGGCTGCGCACCTTGCTGGTCAT CGCGGTTGTCATGAGCCTCCTGAATGCTCTCAGCACCAGCGGAGGCAGCATTTCCTGGAACGACTTTGTCCACGAGATGCTGGCCAAGGG CGAGGTGCAGCGCGTCCAGGTGGTGCCTGAGAGCGACGTGGTGGAAGTCTACCTGCACCCTGGAGCCGTGGTGTTTGGGCGGCCTCGGCT AGCCTTGATGTACCGAATGCAGGTTGCAAATATTGACAAGTTTGAAGAGAAGCTTCGAGCAGCTGAAGATGAGCTGAATATCGAGGCCAA GGACAGGATCCCAGTTTCCTACAAGCGAACAGGATTCTTTGGAAATGCCCTGTACTCTGTGGGGATGACGGCAGTGGGCCTGGCCATCCT GTGGTATGTTTTCCGTCTGGCCGGGATGACTGGAAGGGAAGGTGGATTCAGTGCTTTTAATCAGCTTAAAATGGCTCGTTTCACCATTGT GGATGGGAAGATGGGGAAAGGAGTCAGCTTCAAAGACGTGGCAGGAATGCACGAAGCCAAACTGGAAGTCCGCGAGTTTGTGGATTATCT GAAGAGCCCAGAACGCTTCCTCCAGCTTGGCGCCAAGGTCCCAAAGGGCGCACTGCTGCTCGGCCCCCCCGGCTGTGGGAAGACGCTGCT GGCCAAGGCGGTGGCCACGGAGGCTCAGGTGCCCTTCCTGGCGATGGCCGGCCCAGAGTTCGTGGAGGTCATTGGAGGCCTCGGCGCTGC CCGTGTGCGGAGCCTCTTTAAGGAAGCCCGAGCCCGGGCCCCCTGCATCGTCTACATCGATGAGATCGACGCGGTGGGCAAGAAGCGCTC CACCACCATGTCCGGCTTCTCCAACACGGAGGAGGAGCAGACGCTCAACCAGCTTCTGGTAGAAATGGATGGACTCTGCCCGTCTAAGAC TCCCATCAATGAAAATGCTCCCGTCTTTGATCCTGAACCGGTCATTGCCCACTGCTTCAAGCAGTTCCAGCAGAAGGACTTCCGCCTGCC TCAGACCCGCCGGCGAATCATCATGGTGCCTCGCAAGGAGGATCAGACACCCCTTAATCCTGCATCCCAACCTCAGGCTCCCCCAAAGCC CATCCCCAGCTTCAAAGTTCTGGAAGCTAGAGATATCCAAGAGCAGCCAGAGGACAGGAAGACCTGGCTGAGCCAGAGGTCGAAGCTGCG GCAGGAGCTAGAGTCCTTTGGTGATGTAAAGAGGTGGCTGGAGAACAAGCCCAGCATCACGCCTTCAGAGGCCAAGGTCTTACACATGAT CCACGAGGAGCAGAGTGCCCAGCCAAATGCCTCCCAGGCAACTACCAGGACCACCAGGAAGAAAGCCCCCAGGCTCTCCCGGCTGTCCCG CCAGATGGTGCCCCAGCTCCAGCTGCCCGAGCCCCCTGCCCTGTCGGTCATGTACTCCTACCTGCATAGCCGCAAGATCAAGATCCTGGA GATATTTCACAAGGTGGGCCAGGGTGAGAACCAGAGAATCACCAGGGAGGAGTTCATCGCGGCTGTAAAGGCAGTCGGAGTCCCTCTGAA GAACCAAGAGGTGGAGGATATAGTGATCTACCTCAGCTCTCTTGGGAAGCACAACACCATCACCATGGATATCCTGGCCAATACCTACAA GCAGTGGTCTATGGCTCAGCAAAGGAGCAGCCTGGCCACTGCAAGGGAGCATTATATCTTGGCCAAGCACAGAGATTCCCTGAAGGGTCC GCTCAAGAAGCAGGAGGTGGATTCAGCCCCACAGCTTCCCAAAGTGGACCTACTGACGGTGCCTGCAGTCGACACGCAGATGGAGACGCG GCCCATGACCCTGGAGGAGATGGAGGAAGTGGGCAAGCGGTACCGCGAGCGGCAGCGACAGCACAAGCTCACGATCCCCTCCATCCAGTA CACGGAGCAATGTCACCTGGTGCGCTGTGGGAATCGGCACTTTGATGAGCACTGCCTCCCGTCCACCATCCACGGGGATATGAGGGAGCT CATTGACTCGGCCCGCAGGCACAACTTTCTGGTCTACCTGCAATGCTGGAAGCTCTGTAAGTCCTATGGCCTCCCGCTGACAGAGGACAT CCTCATGAAAGCCTTGCTGTACCCAGGAGACAAGATCATTTTCCAGATGGACAAAGTGTGCCCCATCCGGCAGCCGGGAGGCTACTACTC TGACTGGAAGGTCTTTTCTCCGAATCTGGCTCTGCTCCGGTCCCAGGGCCCTGGCAAGTCTAAGAGGACTGACAAGAAAACGCCAAAGAA AAGCAAGAAAATGCGCTTTAAGGAGTTTGAGGAATTTACCAGGAAGCTGAAGGTGAAGAGGTCCAGTGGTCTGCAGCAAACACACCCCAA TTCCTTCTGGCCGGGTCATCTTCTGGATAAGCTGCAGCTCTACCTGCCCACTGTGGCCACAGACCGGAGCCTGGCGCTCTTCAGTTGTGT TCAACACCAGCCCCATGTCTACCCAGCCACCTACCACCCTGACCACTGGTGGCCCCTTAGGAACAAGAACTACATGACCCACGCCCATTA TGATGCCGCCAAGGTGTACTACATCAACTAGAGCTAGCCAGGTGTTGCCGGACCCAGCCTTCCTGGGCCAGGGGCCAGTGCAGCCAGCGG CCCAGAGCCCAGACACAAGAGGAGTGTCAAAGAGTCAAACTAAAGAAATCCTTTCAAAGAGGGATGGACCGGGGGCCAGTTCCCTCTGGA CTCAAAGTGTCCAGTGTCTCAGAGGGTAGATGTGTCCAAGGAATGACGTGCAGTTTTTGACTATTTCCCTCCCCTGACCTCTGCCCTTTC >In-frame_SPG7_ENST00000341316_chr16_89599044_+_EFCAB12_ENST00000326085_chr3_129140646_-_3272nt GGCCAACATGGCCGTGCTGCTGCTGCTGCTCCGTGCCCTCCGCCGGGGTCCAGGCCCGGGTCCTCGGCCGCTGTGGGGCCCAGGCCCGGC CTGGAGTCCAGGGTTCCCCGCCAGGCCCGGGAGGGGGCGGCCGTACATGGCCAGCAGGCCTCCGGGGGACCTCGCCGAGGCTGGAGGCCG AGCTCTGCAGAGCTTACAATTGAGACTGCTAACCCCTACCTTTGAAGGGATCAACGGATTGTTGTTGAAACAACATTTAGTTCAGAATCC AGTCAGACTCTGGCAACTTTTAGGTGGTACTTTCTATTTTAACACCTCAAGGTTGAAGCAGAAGAATAAGGAGAAGGATAAGTCGAAGGG GAAGGCGCCTGAAGAGGACGAAGAGGAGAGGAGACGCCGTGAGCGGGACGACCAGATGTACCGAGAGCGGCTGCGCACCTTGCTGGTCAT CGCGGTTGTCATGAGCCTCCTGAATGCTCTCAGCACCAGCGGAGGCAGCATTTCCTGGAACGACTTTGTCCACGAGATGCTGGCCAAGGG CGAGGTGCAGCGCGTCCAGGTGGTGCCTGAGAGCGACGTGGTGGAAGTCTACCTGCACCCTGGAGCCGTGGTGTTTGGGCGGCCTCGGCT AGCCTTGATGTACCGAATGCAGGTTGCAAATATTGACAAGTTTGAAGAGAAGCTTCGAGCAGCTGAAGATGAGCTGAATATCGAGGCCAA GGACAGGATCCCAGTTTCCTACAAGCGAACAGGATTCTTTGGAAATGCCCTGTACTCTGTGGGGATGACGGCAGTGGGCCTGGCCATCCT GTGGTATGTTTTCCGTCTGGCCGGGATGACTGGAAGGGAAGGTGGATTCAGTGCTTTTAATCAGCTTAAAATGGCTCGTTTCACCATTGT GGATGGGAAGATGGGGAAAGGAGTCAGCTTCAAAGACGTGGCAGGAATGCACGAAGCCAAACTGGAAGTCCGCGAGTTTGTGGATTATCT GAAGAGCCCAGAACGCTTCCTCCAGCTTGGCGCCAAGGTCCCAAAGGGCGCACTGCTGCTCGGCCCCCCCGGCTGTGGGAAGACGCTGCT GGCCAAGGCGGTGGCCACGGAGGCTCAGGTGCCCTTCCTGGCGATGGCCGGCCCAGAGTTCGTGGAGGTCATTGGAGGCCTCGGCGCTGC CCGTGTGCGGAGCCTCTTTAAGGAAGCCCGAGCCCGGGCCCCCTGCATCGTCTACATCGATGAGATCGACGCGGTGGGCAAGAAGCGCTC CACCACCATGTCCGGCTTCTCCAACACGGAGGAGGAGCAGACGCTCAACCAGCTTCTGGTAGAAATGGATGGACTCTGCCCGTCTAAGAC TCCCATCAATGAAAATGCTCCCGTCTTTGATCCTGAACCGGTCATTGCCCACTGCTTCAAGCAGTTCCAGCAGAAGGACTTCCGCCTGCC TCAGACCCGCCGGCGAATCATCATGGTGCCTCGCAAGGAGGATCAGACACCCCTTAATCCTGCATCCCAACCTCAGGCTCCCCCAAAGCC CATCCCCAGCTTCAAAGTTCTGGAAGCTAGAGATATCCAAGAGCAGCCAGAGGACAGGAAGACCTGGCTGAGCCAGAGGTCGAAGCTGCG GCAGGAGCTAGAGTCCTTTGGTGATGTAAAGAGGTGGCTGGAGAACAAGCCCAGCATCACGCCTTCAGAGGCCAAGGTCTTACACATGAT CCACGAGGAGCAGAGTGCCCAGCCAAATGCCTCCCAGGCAACTACCAGGACCACCAGGAAGAAAGCCCCCAGGCTCTCCCGGCTGTCCCG CCAGATGGTGCCCCAGCTCCAGCTGCCCGAGCCCCCTGCCCTGTCGGTCATGTACTCCTACCTGCATAGCCGCAAGATCAAGATCCTGGA GATATTTCACAAGGTGGGCCAGGGTGAGAACCAGAGAATCACCAGGGAGGAGTTCATCGCGGCTGTAAAGGCAGTCGGAGTCCCTCTGAA GAACCAAGAGGTGGAGGATATAGTGATCTACCTCAGCTCTCTTGGGAAGCACAACACCATCACCATGGATATCCTGGCCAATACCTACAA GCAGTGGTCTATGGCTCAGCAAAGGAGCAGCCTGGCCACTGCAAGGGAGCATTATATCTTGGCCAAGCACAGAGATTCCCTGAAGGGTCC GCTCAAGAAGCAGGAGGTGGATTCAGCCCCACAGCTTCCCAAAGTGGACCTACTGACGGTGCCTGCAGTCGACACGCAGATGGAGACGCG GCCCATGACCCTGGAGGAGATGGAGGAAGTGGGCAAGCGGTACCGCGAGCGGCAGCGACAGCACAAGCTCACGATCCCCTCCATCCAGTA CACGGAGCAATGTCACCTGGTGCGCTGTGGGAATCGGCACTTTGATGAGCACTGCCTCCCGTCCACCATCCACGGGGATATGAGGGAGCT CATTGACTCGGCCCGCAGGCACAACTTTCTGGTCTACCTGCAATGCTGGAAGCTCTGTAAGTCCTATGGCCTCCCGCTGACAGAGGACAT CCTCATGAAAGCCTTGCTGTACCCAGGAGACAAGATCATTTTCCAGATGGACAAAGTGTGCCCCATCCGGCAGCCGGGAGGCTACTACTC TGACTGGAAGGTCTTTTCTCCGAATCTGGCTCTGCTCCGGTCCCAGGGCCCTGGCAAGTCTAAGAGGACTGACAAGAAAACGCCAAAGAA AAGCAAGAAAATGCGCTTTAAGGAGTTTGAGGAATTTACCAGGAAGCTGAAGGTGAAGAGGTCCAGTGGTCTGCAGCAAACACACCCCAA TTCCTTCTGGCCGGGTCATCTTCTGGATAAGCTGCAGCTCTACCTGCCCACTGTGGCCACAGACCGGAGCCTGGCGCTCTTCAGTTGTGT TCAACACCAGCCCCATGTCTACCCAGCCACCTACCACCCTGACCACTGGTGGCCCCTTAGGAACAAGAACTACATGACCCACGCCCATTA TGATGCCGCCAAGGTGTACTACATCAACTAGAGCTAGCCAGGTGTTGCCGGACCCAGCCTTCCTGGGCCAGGGGCCAGTGCAGCCAGCGG CCCAGAGCCCAGACACAAGAGGAGTGTCAAAGAGTCAAACTAAAGAAATCCTTTCAAAGAGGGATGGACCGGGGGCCAGTTCCCTCTGGA CTCAAAGTGTCCAGTGTCTCAGAGGGTAGATGTGTCCAAGGAATGACGTGCAGTTTTTGACTATTTCCCTCCCCTGACCTCTGCCCTTTC |
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FusionGenePPI for SPG7_EFCAB12 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SPG7 | PLSCR1, KRTAP4-12, MDFI, RALY, LRIF1, TRIM28, MAPK6, HNRNPR, SFXN2, SRSF3, SLC25A3, SPATS1, STAMBP, HNRNPK, PSTPIP1, PNMA1, PSME3, RBPMS, MTUS2, CCNDBP1, LZTS2, KRT40, KHDRBS2, KRTAP10-7, KRTAP10-9, KRTAP10-3, NOTCH2NL, GPR55, SDF4, ART3, NDUFB9, ISLR, FAF2, HTR3C, KRTAP5-9, PDK1, EMC2, CERK, C2orf47, MAS1, LPAR4, LPCAT4, FAM109A, CPA5, FAM174A, HDAC10, CD79A, SLC2A12, ITM2A, AP3S1, APLNR | EFCAB12 | FHL3, KRAS, SRPK2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SPG7 | chr16:89599044 | chr3:129140646 | ENST00000268704 | + | 9 | 17 | 701_795 | 441 | 796 | PPIF |
| Hgene | SPG7 | chr16:89599044 | chr3:129140646 | ENST00000341316 | + | 9 | 10 | 701_795 | 441 | 490 | PPIF |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPG7_EFCAB12 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPG7_EFCAB12 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SPG7 | C1846564 | SPASTIC PARAPLEGIA 7, AUTOSOMAL RECESSIVE | 2 | CTD_human;ORPHANET;UNIPROT |
| Hgene | SPG7 | C0030486 | Paraplegia | 1 | CTD_human |
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