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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35647

FusionGeneSummary for SPEN_EFHD2

check button Fusion gene summary
Fusion gene informationFusion gene name: SPEN_EFHD2
Fusion gene ID: 35647
HgeneTgene
Gene symbol

SPEN

EFHD2

Gene ID

64783

79180

Gene nameRNA binding motif protein 15EF-hand domain family member D2
SynonymsOTT|OTT1|SPENSWS1
Cytomap

1p13.3

1p36.21

Type of geneprotein-codingprotein-coding
Descriptionputative RNA-binding protein 15one twenty two proteinone twenty-twoone-twenty two protein 1EF-hand domain-containing protein D2EF hand domain containing 2swiprosin 1testicular tissue protein Li 62
Modification date2018052320180522
UniProtAcc

Q96T58

Q96C19

Ensembl transtripts involved in fusion geneENST00000375759, ENST00000471538, 
ENST00000375980, 
Fusion gene scores* DoF score15 X 10 X 12=18004 X 3 X 4=48
# samples 224
** MAII scorelog2(22/1800*10)=-3.03242147769238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPEN [Title/Abstract] AND EFHD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPEN

GO:0045892

negative regulation of transcription, DNA-templated

16129689


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-DK-A3X2-01ASPENchr1

16174645

+EFHD2chr1

15752367

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000375759ENST00000375980SPENchr1

16174645

+EFHD2chr1

15752367

+
intron-3CDSENST00000471538ENST00000375980SPENchr1

16174645

+EFHD2chr1

15752367

+

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FusionProtFeatures for SPEN_EFHD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPEN

Q96T58

EFHD2

Q96C19

May serve as a nuclear matrix platform that organizesand integrates transcriptional responses. In osteoblasts, supportstranscription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element(OCFRE) (By similarity). Has also been shown to be an essentialcorepressor protein, which probably regulates different keypathways such as the Notch pathway. Negative regulator of theNotch pathway via its interaction with RBPSUH, which prevents theassociation between NOTCH1 and RBPSUH, and therefore suppressesthe transactivation activity of Notch signaling. Blocks thedifferentiation of precursor B-cells into marginal zone B-cells.Probably represses transcription via the recruitment of largecomplexes containing histone deacetylase proteins. May bind bothto DNA and RNA. {ECO:0000250, ECO:0000269|PubMed:11331609,ECO:0000269|PubMed:12374742}. May regulate B-cell receptor (BCR)-induced immature andprimary B-cell apoptosis. Plays a role as negative regulator ofthe canonical NF-kappa-B-activating branch. Controls spontaneousapoptosis through the regulation of BCL2L1 abundance.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEFHD2chr1:16174645chr1:15752367ENST00000375980+04105_116102241Calcium binding1
TgeneEFHD2chr1:16174645chr1:15752367ENST00000375980+04141_152102241Calcium binding2
TgeneEFHD2chr1:16174645chr1:15752367ENST00000375980+04128_163102241DomainEF-hand 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+1151170_1191273665Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+1151408_1428273665Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+1151496_1529273665Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+1151592_1612273665Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+1151928_1944273665Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+115688_715273665Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+115977_1004273665Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+115125_277273665Compositional biasNote=Arg-rich
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+115240_325273665Compositional biasNote=Ser-rich
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+1152428_2520273665Compositional biasNote=Pro-rich
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+1153220_3482273665Compositional biasNote=Pro-rich
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+115616_810273665Compositional biasNote=Arg-rich
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+115624_697273665Compositional biasNote=Tyr-rich
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+1151_573273665DNA bindingOntology_term=ECO:0000250
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+1152201_2707273665DomainNote=RID
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+115335_415273665DomainRRM 2
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+1153498_3664273665DomainSPOC
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+115438_513273665DomainRRM 3
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+115517_589273665DomainRRM 4
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+1156_81273665DomainRRM 1
TgeneEFHD2chr1:16174645chr1:15752367ENST00000375980+0492_127102241DomainEF-hand 1


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FusionGeneSequence for SPEN_EFHD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SPEN_ENST00000375759_chr1_16174645_+_EFHD2_ENST00000375980_chr1_15752367_+_166aa
MVRETRHLWVGNLPENVREEKIIEHFKRYDAGRDGFIDLMELKLMMEKLGAPQTHLGLKNMIKEVDEDFDSKLSFREFLLIFRKAAAGEL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SPEN_ENST00000375759_chr1_16174645_+_EFHD2_ENST00000375980_chr1_15752367_+_498nt
ATGGTCCGGGAAACCAGGCATCTCTGGGTGGGCAACTTACCCGAGAACGTGCGGGAAGAGAAGATCATCGAGCATTTCAAACGGTATGAT
GCCGGGCGGGACGGCTTCATCGACCTGATGGAGCTAAAACTCATGATGGAGAAACTTGGGGCCCCTCAGACCCACCTGGGCCTGAAAAAC
ATGATCAAGGAGGTGGATGAGGACTTTGACAGCAAGCTGAGCTTCCGGGAGTTCCTCCTGATCTTCCGCAAGGCGGCGGCCGGGGAGCTT
CAGGAGGACAGCGGGCTGTGCGTGCTGGCCCGCCTCTCTGAGATCGACGTCTCCAGTGAGGGTGTCAAGGGGGCCAAGAGCTTCTTTGAG
GCCAAGGTCCAGGCCATCAACGTGTCCAGCCGCTTCGAGGAGGAGATCAAGGCAGAGCAGGAGGAAAGGAAGAAGCAGGCGGAGGAGATG


* Fusion transcript sequences (Full-length transcript).
>In-frame_SPEN_ENST00000375759_chr1_16174645_+_EFHD2_ENST00000375980_chr1_15752367_+_2321nt
TGAGCTGCGAGGCCCGAGAGTCAGAACCTGGGGGAGAGGGATGGTCTCTGCACGGGGGGGAGCCGGAGGAGCCGCCGCCGCTGCCGACGC
CACCGCCGCAGCCGCCGCCGCCGCCGCCCCGGCACCCGCCTCCCGGCGCTGACGGTCTCGTACGAAGCCGGCGAGGGGGAGCCAGCAGCG
GCGGTCGCCGGCACGCCGCCCAGCATGGTCCGGGAAACCAGGCATCTCTGGGTGGGCAACTTACCCGAGAACGTGCGGGAAGAGAAGATC
ATCGAGCATTTCAAACGGTATGATGCCGGGCGGGACGGCTTCATCGACCTGATGGAGCTAAAACTCATGATGGAGAAACTTGGGGCCCCT
CAGACCCACCTGGGCCTGAAAAACATGATCAAGGAGGTGGATGAGGACTTTGACAGCAAGCTGAGCTTCCGGGAGTTCCTCCTGATCTTC
CGCAAGGCGGCGGCCGGGGAGCTTCAGGAGGACAGCGGGCTGTGCGTGCTGGCCCGCCTCTCTGAGATCGACGTCTCCAGTGAGGGTGTC
AAGGGGGCCAAGAGCTTCTTTGAGGCCAAGGTCCAGGCCATCAACGTGTCCAGCCGCTTCGAGGAGGAGATCAAGGCAGAGCAGGAGGAA
AGGAAGAAGCAGGCGGAGGAGATGAAGCAGCGGAAAGCGGCCTTCAAGGAGCTGCAGTCCACCTTTAAGTAGCGGGGGCTGCAGCCGACC
GCCCTGCTCCGGCCCCAGTGTGGTGGGCGAGGGTGGCGCATGGGAGGCCGAGCCTGAATCCTTGCCTGTGTCTGACGGGACCACTACTAA
AAACCTAAAAATATCTGTGAATGGAGCAAGTTCAGGGGTCTTATGGAGGTGGCCCGGCCCCTCCCCGCTCCCTTCCACTCTGCACGAGGC
CGCCACACCGGCGCTGGCTCCCTGCCCGGCCCGGCCCTCCCTGGCAATCCCTGGGCTCTCTTGCACCCCTAACTGCCCCCTGCCTGCTCC
GGCACTGCCCCAGGCCCAGCTCCTGGCCCTAGGTCCCTCCCAGCCCCATGTGCCTGCCGCCTGCCCTCCACACATCCCTGTCCCCCCAAC
CCGGGAACCCCTGCCCTCCTCCAGCAGGCCGCACCGCCCCTGGGGCCCCCTGCCAGCCCCTTCCCAGGCTGGGAGACGGCAGAAGAGATA
GAATCAGGGCTGCCCCCACAGAGTGGGACCCAAGGGGCTAATTGGAGGCACGAGGGGACCCCTCCCCAGGGCCTTTTCCTCCTCTGCGTC
TTCCATCTACTGAAATGGGAGAGGGGGTGGGGAGCTTCTGTTCTGGTGAAGGGACCCGGGCAGGCCCCCAGCACCCCATGCTGACTTGGA
GAACCCCAGATCTCTGGGGCCCAGCCAGGCAGGGTGTGGGGGCAGCTGTGCCAATCTACCTCACAGGCCCACCCCCTGCCGGGCATGCCG
TGGGATCATGGGCAGGGAAGGCTCTGGGGGTCGGAGACACCGCTGCTTAGCACCCCCAGCCAGAACACCCTGAGGGTCTCGGGGCTCTGG
AGAGAGTGGGGCGGGAGGAAGAATTGGCACCTTCCTAGGGAAGGAGACGAGCGCTTCGCCTTGATTCTCCGAGAAGCCTCCGAGAAGTGC
TTTAAGTGTGTTTGCATGCGCCAGGCGGTGGGCAGCGGGGGCCTGTCCAGCCCTCTCCCGCCATCCTTCCCCAAGTGACGTCCACTGCCT
TGTCACCAGCGACCTGCCTGTCATGCCCACCCCCTGAGGAAGCATGGGGACCCTAACACCCTGGTGCCCTGCACCAGACAGGCCGTGGTC
AGGCCCAGGCCACCGGCCGGGTTCTGCCACAGCTTCCCACGTGCTTGCTGACATGCGTGTGCCTGTGTGTGGTGTCTGTTGCTGTGTCGT
GAAACTGTGACCATCACTCAGTCCAAACAAGTGAGTGGCCCTCGAGGCCACAGTTATGCAACTTTCAGTGTGTGTCATAACGACGTCACT
GCTTTTTAAACTCGATAACTCTTTATTTTAGTAAAATGCCCAGGAGTCCTGGAAGCTACGCGGACTTGCAGAGGTTTTATTTTTTGGCCT
TAGAATCTGCAGAAATTAGGAGGCACCGAGCCCAGCGCAGCAGCCTCGGACCCGGATTGCGTTTGCCTTAGCGGATATGTTTATACAGAT
GAATATAAAATGTTTTTTTCTTTGGGCTTTTTGCTTCTTTTTTCCCCCCCTTCTCACCTTCCCTTCTCCCCGACCCCACCCCCCAAAAAA


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FusionGenePPI for SPEN_EFHD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPENNCOR2, PPARD, HDAC1, SRA1, RBPJ, NCOR1, CTBP1, RBBP8, RUNX1T1, RUNX1, SIRT7, UBE2E2, UBE2L6, ATXN1, NOTCH2, BPGM, TTN, PRDX3, PCBP3, NUP54, PIR, SCYL2, SOX2, HRSP12, SERTAD1, CUL7, OBSL1, EED, BMI1, CCNC, WRAP73, MED23, SRPK2, CLK1, DYNLT1, BCLAF1, FERMT3, USP37, DPPA4, EGFR, TRIML2, CAMKV, PIP4K2A, NR3C1EFHD2ELAVL1, LRRK2, APP, PAN2, FBXO6, CHMP4A, COASY, DCK, ENO2, GLRX3, GMPS, IDH1, PTPN11, RCN1, TSTA3, ACTR2, ARPC2, ARPC3, ARPC4-TTLL3, ARPC4, RAE1, TMOD1, VARS, MYH9, LIMA1, MYO18A, USP11, CDH1, GTF2E2, FSD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+1152130_2464273665MSX2
HgeneSPENchr1:16174645chr1:15752367ENST00000375759+1152709_2870273665RBPSUH


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPEN_EFHD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPEN_EFHD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource