FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 35636

FusionGeneSummary for SPECC1_SPECC1

check button Fusion gene summary
Fusion gene informationFusion gene name: SPECC1_SPECC1
Fusion gene ID: 35636
HgeneTgene
Gene symbol

SPECC1

SPECC1

Gene ID

92521

92521

Gene namesperm antigen with calponin homology and coiled-coil domains 1sperm antigen with calponin homology and coiled-coil domains 1
SynonymsCYTSB|HCMOGT-1|HCMOGT1|NSPCYTSB|HCMOGT-1|HCMOGT1|NSP
Cytomap

17p11.2

17p11.2

Type of geneprotein-codingprotein-coding
Descriptioncytospin-BNSP5cytokinesis and spindle organization Bnuclear structure protein 5sperm antigen HCMOGT-1sperm antigen with calponin-like and coiled coil domains 1structure protein NSP5a3astructure protein NSP5a3bstructure protein NSP5b3astructure prcytospin-BNSP5cytokinesis and spindle organization Bnuclear structure protein 5sperm antigen HCMOGT-1sperm antigen with calponin-like and coiled coil domains 1structure protein NSP5a3astructure protein NSP5a3bstructure protein NSP5b3astructure pr
Modification date2018052320180523
UniProtAcc

Q5M775

Q5M775

Ensembl transtripts involved in fusion geneENST00000472876, ENST00000395527, 
ENST00000395529, ENST00000261503, 
ENST00000395530, ENST00000536879, 
ENST00000395522, ENST00000395525, 
ENST00000584527, 
ENST00000472876, 
ENST00000395527, ENST00000395529, 
ENST00000261503, ENST00000395530, 
ENST00000536879, ENST00000395522, 
ENST00000395525, ENST00000584527, 
Fusion gene scores* DoF score6 X 6 X 3=1086 X 4 X 5=120
# samples 66
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPECC1 [Title/Abstract] AND SPECC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF908879SPECC1chr17

20107643

-SPECC1chr17

20109226

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000472876ENST00000472876SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000472876ENST00000395527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000472876ENST00000395529SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000472876ENST00000261503SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000472876ENST00000395530SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000472876ENST00000536879SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000472876ENST00000395522SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000472876ENST00000395525SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000472876ENST00000584527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395527ENST00000472876SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395527ENST00000395527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395527ENST00000395529SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395527ENST00000261503SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395527ENST00000395530SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395527ENST00000536879SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395527ENST00000395522SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395527ENST00000395525SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395527ENST00000584527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395529ENST00000472876SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395529ENST00000395527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395529ENST00000395529SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395529ENST00000261503SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395529ENST00000395530SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395529ENST00000536879SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395529ENST00000395522SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395529ENST00000395525SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395529ENST00000584527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000261503ENST00000472876SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000261503ENST00000395527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000261503ENST00000395529SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000261503ENST00000261503SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000261503ENST00000395530SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000261503ENST00000536879SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000261503ENST00000395522SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000261503ENST00000395525SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000261503ENST00000584527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395530ENST00000472876SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395530ENST00000395527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395530ENST00000395529SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395530ENST00000261503SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395530ENST00000395530SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395530ENST00000536879SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395530ENST00000395522SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395530ENST00000395525SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395530ENST00000584527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000536879ENST00000472876SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000536879ENST00000395527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000536879ENST00000395529SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000536879ENST00000261503SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000536879ENST00000395530SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000536879ENST00000536879SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000536879ENST00000395522SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000536879ENST00000395525SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000536879ENST00000584527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395522ENST00000472876SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395522ENST00000395527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395522ENST00000395529SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395522ENST00000261503SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395522ENST00000395530SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395522ENST00000536879SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395522ENST00000395522SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395522ENST00000395525SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395522ENST00000584527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395525ENST00000472876SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395525ENST00000395527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395525ENST00000395529SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395525ENST00000261503SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395525ENST00000395530SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395525ENST00000536879SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395525ENST00000395522SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395525ENST00000395525SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000395525ENST00000584527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000584527ENST00000472876SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000584527ENST00000395527SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000584527ENST00000395529SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000584527ENST00000261503SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000584527ENST00000395530SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000584527ENST00000536879SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000584527ENST00000395522SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000584527ENST00000395525SPECC1chr17

20107643

-SPECC1chr17

20109226

-
intron-intronENST00000584527ENST00000584527SPECC1chr17

20107643

-SPECC1chr17

20109226

-

Top

FusionProtFeatures for SPECC1_SPECC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPECC1

Q5M775

SPECC1

Q5M775


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SPECC1_SPECC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SPECC1_SPECC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SPECC1_SPECC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SPECC1_SPECC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource