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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35612

FusionGeneSummary for SPDL1_CDKL2

check button Fusion gene summary
Fusion gene informationFusion gene name: SPDL1_CDKL2
Fusion gene ID: 35612
HgeneTgene
Gene symbol

SPDL1

CDKL2

Gene ID

54908

8999

Gene namespindle apparatus coiled-coil protein 1cyclin dependent kinase like 2
SynonymsCCDC99KKIAMRE|P56
Cytomap

5q35.1

4q21.1

Type of geneprotein-codingprotein-coding
Descriptionprotein Spindlyarsenite-related gene 1 proteincoiled-coil domain-containing protein 99rhabdomyosarcoma antigen MU-RMS-40.4Arrhabdomyosarcoma antigen protein MU-RMS-40.4Acyclin-dependent kinase-like 2CDC2-related kinasep56 KKIAMRE protein kinaseprotein kinase p56 KKIAMREserine/threonine protein kinase KKIAMREtesticular tissue protein Li 35
Modification date2018052320180523
UniProtAcc

Q96EA4

Q92772

Ensembl transtripts involved in fusion geneENST00000265295, ENST00000510751, 
ENST00000429927, ENST00000307465, 
Fusion gene scores* DoF score4 X 4 X 2=322 X 2 X 2=8
# samples 63
** MAII scorelog2(6/32*10)=0.906890595608518
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/8*10)=1.90689059560852
Context

PubMed: SPDL1 [Title/Abstract] AND CDKL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB139392SPDL1chr5

169010896

+CDKL2chr4

76507110

-
ChiTaRS3.1CB137971SPDL1chr5

169010896

+CDKL2chr4

76507110

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000265295ENST00000429927SPDL1chr5

169010896

+CDKL2chr4

76507110

-
5UTR-3CDSENST00000265295ENST00000307465SPDL1chr5

169010896

+CDKL2chr4

76507110

-
3UTR-3CDSENST00000510751ENST00000429927SPDL1chr5

169010896

+CDKL2chr4

76507110

-
3UTR-3CDSENST00000510751ENST00000307465SPDL1chr5

169010896

+CDKL2chr4

76507110

-

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FusionProtFeatures for SPDL1_CDKL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPDL1

Q96EA4

CDKL2

Q92772

Required for the localization of dynein and dynactin tothe mitotic kintochore. Dynein is believed to control the initiallateral interaction between the kinetochore and spindlemicrotubules and to facilitate the subsequent formation of end-onkinetochore-microtubule attachments mediated by the NDC80 complex.Also required for correct spindle orientation. Does not appear tobe required for the removal of spindle assembly checkpoint (SAC)proteins from the kinetochore upon bipolar spindle attachment(PubMed:17576797, PubMed:19468067). Acts as an adapter proteinlinking the dynein motor complex to various cargos and convertsdynein from a non-processive to a highly processive motor in thepresence of dynactin. Facilitates the interaction between dyneinand dynactin and activates dynein processivity (the ability tomove along a microtubule for a long distance without falling offthe track) (PubMed:25035494). {ECO:0000255|HAMAP-Rule:MF_03041,ECO:0000269|PubMed:17576797, ECO:0000269|PubMed:19468067,ECO:0000269|PubMed:25035494}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPDL1_CDKL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPDL1_CDKL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPDL1GPS2, KIAA1377, ITSN1, HMGCS1, DHX40, SF3B3, YLPM1, SIRT1, NEK9, CA8, TRAF4, USP15, SPDL1, DYX1C1, PPP1R18, RTP5, GSTA1, NFKBIA, SEC13, HAUS7, FNTB, HARS, PSMD14, RPS5, UBXN1, EWSR1, FBXW7, GSTT2B, TXLNB, PMEL, THUMPD2, IL12A, KIAA1467, ASB16CDKL2APP, FRY, HSP90AA1, HSP90AA5P, HSP90AA4P, CDC37, CDK14


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPDL1_CDKL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPDL1_CDKL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCDKL2C0007621Neoplastic Cell Transformation1CTD_human
TgeneCDKL2C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneCDKL2C0027627Neoplasm Metastasis1CTD_human