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Fusion gene ID: 3561 |
FusionGeneSummary for ATXN10_TBC1D22A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATXN10_TBC1D22A | Fusion gene ID: 3561 | Hgene | Tgene | Gene symbol | ATXN10 | TBC1D22A | Gene ID | 25814 | 25771 |
| Gene name | ataxin 10 | TBC1 domain family member 22A | |
| Synonyms | E46L|HUMEEP|SCA10 | C22orf4|HSC79E021 | |
| Cytomap | 22q13.31 | 22q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ataxin-10brain protein E46 homologspinocerebellar ataxia type 10 protein | TBC1 domain family member 22Aputative GTPase activator | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9UBB4 | Q8WUA7 | |
| Ensembl transtripts involved in fusion gene | ENST00000381061, ENST00000252934, ENST00000498009, ENST00000402380, | ENST00000337137, ENST00000380995, ENST00000407381, ENST00000355704, ENST00000472791, ENST00000406733, | |
| Fusion gene scores | * DoF score | 10 X 4 X 9=360 | 8 X 6 X 7=336 |
| # samples | 10 | 8 | |
| ** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ATXN10 [Title/Abstract] AND TBC1D22A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATXN10 | GO:0031175 | neuron projection development | 16498633 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-2Y-A9HA-01A | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000381061 | ENST00000337137 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| 5CDS-intron | ENST00000381061 | ENST00000380995 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| 5CDS-intron | ENST00000381061 | ENST00000407381 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| 5CDS-intron | ENST00000381061 | ENST00000355704 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| 5CDS-intron | ENST00000381061 | ENST00000472791 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| 5CDS-intron | ENST00000381061 | ENST00000406733 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| In-frame | ENST00000252934 | ENST00000337137 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| 5CDS-intron | ENST00000252934 | ENST00000380995 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| 5CDS-intron | ENST00000252934 | ENST00000407381 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| 5CDS-intron | ENST00000252934 | ENST00000355704 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| 5CDS-intron | ENST00000252934 | ENST00000472791 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| 5CDS-intron | ENST00000252934 | ENST00000406733 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| intron-3CDS | ENST00000498009 | ENST00000337137 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| intron-intron | ENST00000498009 | ENST00000380995 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| intron-intron | ENST00000498009 | ENST00000407381 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| intron-intron | ENST00000498009 | ENST00000355704 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| intron-intron | ENST00000498009 | ENST00000472791 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| intron-intron | ENST00000498009 | ENST00000406733 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| intron-3CDS | ENST00000402380 | ENST00000337137 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| intron-intron | ENST00000402380 | ENST00000380995 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| intron-intron | ENST00000402380 | ENST00000407381 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| intron-intron | ENST00000402380 | ENST00000355704 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| intron-intron | ENST00000402380 | ENST00000472791 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
| intron-intron | ENST00000402380 | ENST00000406733 | ATXN10 | chr22 | 46136418 | + | TBC1D22A | chr22 | 47507404 | + |
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FusionProtFeatures for ATXN10_TBC1D22A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATXN10 | TBC1D22A |
| Necessary for the survival of cerebellar neurons.Induces neuritogenesis by activating the Ras-MAP kinase pathway.May play a role in the maintenance of a critical intracellularglycosylation level and homeostasis. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TBC1D22A | chr22:46136418 | chr22:47507404 | ENST00000380995 | + | 0 | 9 | 222_446 | -99 | 325 | Domain | Rab-GAP TBC |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | TBC1D22A | chr22:46136418 | chr22:47507404 | ENST00000337137 | + | 10 | 13 | 222_446 | 443 | 518 | Domain | Rab-GAP TBC |
| Tgene | TBC1D22A | chr22:46136418 | chr22:47507404 | ENST00000355704 | + | 8 | 11 | 222_446 | 365 | 440 | Domain | Rab-GAP TBC |
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FusionGeneSequence for ATXN10_TBC1D22A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ATXN10_ENST00000381061_chr22_46136418_+_TBC1D22A_ENST00000337137_chr22_47507404_+_402aa MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVW VHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERV TLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVI DLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQE >In-frame_ATXN10_ENST00000252934_chr22_46136418_+_TBC1D22A_ENST00000337137_chr22_47507404_+_466aa MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSSHAVELACRDPSQVENLASSLQLITECFRCLRN ACIECSVNQNSIRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMI LFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLR HAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAE GDISNVANGFKSHLIRLIGNLCYKNKDNQDKSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLLLAEAY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ATXN10_ENST00000381061_chr22_46136418_+_TBC1D22A_ENST00000337137_chr22_47507404_+_1206nt ATGGCGGCGCCCAGGCCGCCGCCTGCCAGGCTGTCGGGCGTCATGGTGCCGGCGCCCATCCAAGACCTGGAGGCCCTGCGCGCGCTCACG GCGCTCTTCAAAGAGCAGCGGAACCGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCGAGTGGAA CAGGAATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTATTGTTTGG GTGCATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTTTACATCC CTTAATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGAATCAGAA TGGCCGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAAAGAGTT ACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCTGAGTTG ATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCTACAATT AGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGAGTGATT GATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGACATCTCC AATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGTCTGAACCG GACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAATACTAGAAGAAAAAGATTTTCAAGAG CTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCTGGCCGAGGCCTACCGCCTCAAGTTT >In-frame_ATXN10_ENST00000252934_chr22_46136418_+_TBC1D22A_ENST00000337137_chr22_47507404_+_1398nt ATGGCGGCGCCCAGGCCGCCGCCTGCCAGGCTGTCGGGCGTCATGGTGCCGGCGCCCATCCAAGACCTGGAGGCCCTGCGCGCGCTCACG GCGCTCTTCAAAGAGCAGCGGAACCGAGAAACAGCACCCAGGACTATCTTCCAAAGAGTTCTGGATATCCTAAAGAAATCTTCTCATGCT GTTGAGCTTGCCTGCAGAGATCCATCCCAAGTGGAAAACCTGGCTTCCAGTCTGCAGTTAATAACAGAATGCTTCAGGTGTCTTCGCAAT GCTTGCATAGAGTGTTCTGTGAACCAGAATTCAATCAGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAA CTGCGAGTGGAACAGGAATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAG TCTATTGTTTGGGTGCATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATT TTGTTTACATCCCTTAATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACAT CCTGAATCAGAATGGCCGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAAT CAAGAAAGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGG CATGCTGAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCA CTGGCTACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTG GAAAGAGTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAA GGTGACATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGAC AAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAATACTAGAAGAAAAA GATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCTGGCCGAGGCCTAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ATXN10_ENST00000381061_chr22_46136418_+_TBC1D22A_ENST00000337137_chr22_47507404_+_3539nt AGGCGGGACTTCCGCCGGCGCCCCCTCCCCCGCGGCGCCGTCTCCTCCTCCCGCCTGAGGCGAGTCTGGGCTCAGCCTAGAGCTCTCCGG CGGCGGCGCAGCTTCAGGGCAGCGCGGGCTGCAGCGGCGGCGGCGGTTAGGGCTGTGTAGGGCGAGGCCTCCCCCTTCCTCCTCGCCATC CTACTCCTCCCTCCTCGTCATCCTCCCCCTTCGTCCTCCTCGCCTTCCTCCTCCTCGTCAGGCTCGACCCAGCTGTGAGCGGCAAGATGG CGGCGCCCAGGCCGCCGCCTGCCAGGCTGTCGGGCGTCATGGTGCCGGCGCCCATCCAAGACCTGGAGGCCCTGCGCGCGCTCACGGCGC TCTTCAAAGAGCAGCGGAACCGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCGAGTGGAACAGG AATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTATTGTTTGGGTGC ATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTTTACATCCCTTA ATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGAATCAGAATGGC CGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAAAGAGTTACAC TGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCTGAGTTGATTG CAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCTACAATTAGGC TTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGAGTGATTGATC TTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGACATCTCCAATG TGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGTCTGAACCGGACG GCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAATACTAGAAGAAAAAGATTTTCAAGAGCTGC TGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCTGGCCGAGGCCTACCGCCTCAAGTTTGCTT TTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCAGCTGGCCTCACTGTCCCGGGTGGCGCGCCCCACCTGCCTGG CTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGTGAGGTGGCCCCACCCTCCAGGGGAGCTGGTGAAGATGGGCC ACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTGAGATACCAAAGAGAGCCAGGGGAGGGCCCCGGGTTCGGCGG CCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGCCAAATGACTGCCTCGTGCTGCCCCTAGTCCGGGGCAGCCTA GGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAACGAGGTAGTGGCCATCTCATACCTACTCTGAAATGCAAAAC TTCTATTCTGTTGAGTGAAAGAATAAAATGTAGACAAAATCTAGACCGAGACGTTGCGCTGACCCGGGGTCTCTGTGCCGCGAGGTCCCC TCACAGCTGTATTTCACTGCTGCTGGCCCTTTCCCTCCGTGTGTTTTCCTGCTTGCTTGGTTTAAACGTGGCTGGGAAGCTGAAGGCTGG AGTCCAAGCCGTGAGCCCGCCGAGTGCCTGGGAGGCCGTGGGACCAAAGGCTGGGAGCAGAGGGAGGCCTCGCCATCGCCTTACTTTCCA CCTTGAACCTCTTTTACAAGAGAGAAACCCCCACCTCCCTGAGGTCCAGGGCCAAGTGGCCCCGCCACGCAGGTAGGCGCCGGCCTCAGC CAGAGCCCCTGGAGGCCCACCCAGGCTGTCGGGCCATGTTGGGCTGGCAGACGGGCAGGGGGTCGCGTCCCTGTCATCAAAGCCCTGAAC CACAGTGCTCTTCTCACCGCAGCCTGGAAGCGGAATGAGCTTTTGGAGACTTCCTGGGACTTGCTGTCCTTGTCCAGGTCTGCCAGGTGT AGGGGAGGTGTGACTGGTTCCATCATGGACCGGTTCCTCCATGGACCGGTTCCTCCGTGGACCGGTTCCGCCATGGACCGGTTCCGCCAT GGACCACTCCTGCCCTGGACCACTCCTGCCCTGGACCGGTTCTGCCGTGGACTGGTTCCCGCCGTGGACCAGTTCCCGCTGTATACTGGT TCTGCCCTGGACTGGTTCCCGCTGTGGACTGGTTCCTTGGGGCTCTAAGTGCGGAAGGGCCCAGAGCTGGTCCCTGCCCAGCGCCCTGCT AGGGCTGTGTCCTTGGCTCCAGGGGCCTTGGGACTGGCTTCCCAGCGTTCCCTCGGTGTGTCACAGGCTGCATGACCCCTGGAATGCGGG CAGGGCCACAGCCACAGTCTGTCTGATCCCTGAGCCCAGGACAGGCTCACGTCCTCAGCGACCCACTGGTGACTGACTTCCCAGACTCTC CTCTGTCCCTCAGGAGCAGCCGTGTCCTCTCCCAGGCCCTAGGACACTGCCAGAGACTGTGGGACATACAGGCATAAGTGATGTGTGTGT TTCTGCTTCTGTTTTAAAAATCCAGGGTCATTACACACAGCATGGAAATTAGCACAAAATGCTGTGCAAACGTCAGATGCTCCCAAACCA GCAAAGGGATGGGCTTGCTTCACATCAGATGCGGGCACGCCTTACCCCTGCCTTCCGTGTCCCCACCCCAGGGTCAAGGGTTCCTCAGAC CAGCCATGCCTCCTCCTCCTGCCGCCTCCTTTTCTAGATGGGGAGGGGATTCCGTCACAAGAAGAGCCGCCCCTCGGCCGTGTGCAGGAA GCCCCATGTCGCTTTGCCGAGATCAGCCCTGGGAGGATCCCCTTCTCCAGCTCAGATCATGCCGTGTGGCCAGAAGGCTGCGGACACAAC TGACCTGCTTCTCGAGGTGGTTGATGTTTTAAACAGGAAGCTCCACGGAGTTCAGCCCTGTGTGCATTTCCTCATGTATGTAAACGCCAA GACTGAATGTGAGAGGTGTTGGCCGCGGGCCTTAAGTCTGAGCAGATCCATCTGGAATGTTCGGGGTGTGCTGTCTGGATGTGGTGCGCT >In-frame_ATXN10_ENST00000252934_chr22_46136418_+_TBC1D22A_ENST00000337137_chr22_47507404_+_3730nt GGCGGGACTTCCGCCGGCGCCCCCTCCCCCGCGGCGCCGTCTCCTCCTCCCGCCTGAGGCGAGTCTGGGCTCAGCCTAGAGCTCTCCGGC GGCGGCGCAGCTTCAGGGCAGCGCGGGCTGCAGCGGCGGCGGCGGTTAGGGCTGTGTAGGGCGAGGCCTCCCCCTTCCTCCTCGCCATCC TACTCCTCCCTCCTCGTCATCCTCCCCCTTCGTCCTCCTCGCCTTCCTCCTCCTCGTCAGGCTCGACCCAGCTGTGAGCGGCAAGATGGC GGCGCCCAGGCCGCCGCCTGCCAGGCTGTCGGGCGTCATGGTGCCGGCGCCCATCCAAGACCTGGAGGCCCTGCGCGCGCTCACGGCGCT CTTCAAAGAGCAGCGGAACCGAGAAACAGCACCCAGGACTATCTTCCAAAGAGTTCTGGATATCCTAAAGAAATCTTCTCATGCTGTTGA GCTTGCCTGCAGAGATCCATCCCAAGTGGAAAACCTGGCTTCCAGTCTGCAGTTAATAACAGAATGCTTCAGGTGTCTTCGCAATGCTTG CATAGAGTGTTCTGTGAACCAGAATTCAATCAGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCG AGTGGAACAGGAATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTAT TGTTTGGGTGCATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTT TACATCCCTTAATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGA ATCAGAATGGCCGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGA AAGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGC TGAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGC TACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAG AGTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGA CATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGTC TGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAATACTAGAAGAAAAAGATTT TCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCTGGCCGAGGCCTACCGCCT CAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCAGCTGGCCTCACTGTCCCGGGTGGCGCGCCC CACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGTGAGGTGGCCCCACCCTCCAGGGGAGCTGGT GAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTGAGATACCAAAGAGAGCCAGGGGAGGGCCCC GGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGCCAAATGACTGCCTCGTGCTGCCCCTAGTCC GGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAACGAGGTAGTGGCCATCTCATACCTACTCTG AAATGCAAAACTTCTATTCTGTTGAGTGAAAGAATAAAATGTAGACAAAATCTAGACCGAGACGTTGCGCTGACCCGGGGTCTCTGTGCC GCGAGGTCCCCTCACAGCTGTATTTCACTGCTGCTGGCCCTTTCCCTCCGTGTGTTTTCCTGCTTGCTTGGTTTAAACGTGGCTGGGAAG CTGAAGGCTGGAGTCCAAGCCGTGAGCCCGCCGAGTGCCTGGGAGGCCGTGGGACCAAAGGCTGGGAGCAGAGGGAGGCCTCGCCATCGC CTTACTTTCCACCTTGAACCTCTTTTACAAGAGAGAAACCCCCACCTCCCTGAGGTCCAGGGCCAAGTGGCCCCGCCACGCAGGTAGGCG CCGGCCTCAGCCAGAGCCCCTGGAGGCCCACCCAGGCTGTCGGGCCATGTTGGGCTGGCAGACGGGCAGGGGGTCGCGTCCCTGTCATCA AAGCCCTGAACCACAGTGCTCTTCTCACCGCAGCCTGGAAGCGGAATGAGCTTTTGGAGACTTCCTGGGACTTGCTGTCCTTGTCCAGGT CTGCCAGGTGTAGGGGAGGTGTGACTGGTTCCATCATGGACCGGTTCCTCCATGGACCGGTTCCTCCGTGGACCGGTTCCGCCATGGACC GGTTCCGCCATGGACCACTCCTGCCCTGGACCACTCCTGCCCTGGACCGGTTCTGCCGTGGACTGGTTCCCGCCGTGGACCAGTTCCCGC TGTATACTGGTTCTGCCCTGGACTGGTTCCCGCTGTGGACTGGTTCCTTGGGGCTCTAAGTGCGGAAGGGCCCAGAGCTGGTCCCTGCCC AGCGCCCTGCTAGGGCTGTGTCCTTGGCTCCAGGGGCCTTGGGACTGGCTTCCCAGCGTTCCCTCGGTGTGTCACAGGCTGCATGACCCC TGGAATGCGGGCAGGGCCACAGCCACAGTCTGTCTGATCCCTGAGCCCAGGACAGGCTCACGTCCTCAGCGACCCACTGGTGACTGACTT CCCAGACTCTCCTCTGTCCCTCAGGAGCAGCCGTGTCCTCTCCCAGGCCCTAGGACACTGCCAGAGACTGTGGGACATACAGGCATAAGT GATGTGTGTGTTTCTGCTTCTGTTTTAAAAATCCAGGGTCATTACACACAGCATGGAAATTAGCACAAAATGCTGTGCAAACGTCAGATG CTCCCAAACCAGCAAAGGGATGGGCTTGCTTCACATCAGATGCGGGCACGCCTTACCCCTGCCTTCCGTGTCCCCACCCCAGGGTCAAGG GTTCCTCAGACCAGCCATGCCTCCTCCTCCTGCCGCCTCCTTTTCTAGATGGGGAGGGGATTCCGTCACAAGAAGAGCCGCCCCTCGGCC GTGTGCAGGAAGCCCCATGTCGCTTTGCCGAGATCAGCCCTGGGAGGATCCCCTTCTCCAGCTCAGATCATGCCGTGTGGCCAGAAGGCT GCGGACACAACTGACCTGCTTCTCGAGGTGGTTGATGTTTTAAACAGGAAGCTCCACGGAGTTCAGCCCTGTGTGCATTTCCTCATGTAT GTAAACGCCAAGACTGAATGTGAGAGGTGTTGGCCGCGGGCCTTAAGTCTGAGCAGATCCATCTGGAATGTTCGGGGTGTGCTGTCTGGA |
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FusionGenePPI for ATXN10_TBC1D22A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ATXN10 | BSG, STYXL1, MAGED1, GSTK1, CUL3, PPP1R12A, GNB1, GNB2, FN1, MRPS16, GLS, GOLGA1, ABCA1, CA9, VCP, EGFR, SERPINH1, HSPA1A, HSPA8, CCDC8, ABCE1, HTR6, HSPB1, CEP162, CEP152, CEP128, SCLT1, CENPJ, LAMB3, MYC, UBE2A, TUBA1C, MTMR14, DUSP22, PTPRN, STOM, DLD | TBC1D22A | YWHAB, HSPA1L, ACBD3, FDXR, ACSL4, FLYWCH2, BIRC6, ARFGEF1, QSOX2, MICU1, KIRREL, MICU2, DNAJB4, SUPT6H, EFNB3, EPHA4, EXOG, METTL13, PVRL2, DNAJB5, AMBRA1, CERK, TBC1D22B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATXN10_TBC1D22A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATXN10_TBC1D22A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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