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Fusion gene ID: 35607 |
FusionGeneSummary for SPCS3_SKAP2 |
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Fusion gene information | Fusion gene name: SPCS3_SKAP2 | Fusion gene ID: 35607 | Hgene | Tgene | Gene symbol | SPCS3 | SKAP2 | Gene ID | 60559 | 8935 |
Gene name | signal peptidase complex subunit 3 | src kinase associated phosphoprotein 2 | |
Synonyms | PRO3567|SPC22/23|SPC3|YLR066W | PRAP|RA70|SAPS|SCAP2|SKAP-HOM|SKAP55R | |
Cytomap | 4q34.2 | 7p15.2 | |
Type of gene | protein-coding | protein-coding | |
Description | signal peptidase complex subunit 3SPase 22 kDa subunitSPase 22/23 kDa subunitmicrosomal signal peptidase 22/23 kDa subunitmicrosomal signal peptidase 23 kDa subunitsignal peptidase complex subunit 3 homolog | src kinase-associated phosphoprotein 2Fyn-associated phosphoprotein SKAP55 homologuePyk2/RAFTK-associated proteinSKAP-55HOMSKAP55 homologretinoic acid-induced protein 70src family-associated phosphoprotein 2src kinase-associated phosphoprotein of 5 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P61009 | O75563 | |
Ensembl transtripts involved in fusion gene | ENST00000503362, ENST00000507001, | ENST00000345317, ENST00000539623, ENST00000489977, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 6 X 5=180 |
# samples | 3 | 8 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/180*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SPCS3 [Title/Abstract] AND SKAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SPCS3 | GO:0006508 | proteolysis | 27499293 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-DX-A8BR-01A | SPCS3 | chr4 | 177245408 | + | SKAP2 | chr7 | 26729981 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000503362 | ENST00000345317 | SPCS3 | chr4 | 177245408 | + | SKAP2 | chr7 | 26729981 | - |
Frame-shift | ENST00000503362 | ENST00000539623 | SPCS3 | chr4 | 177245408 | + | SKAP2 | chr7 | 26729981 | - |
5CDS-5UTR | ENST00000503362 | ENST00000489977 | SPCS3 | chr4 | 177245408 | + | SKAP2 | chr7 | 26729981 | - |
intron-3CDS | ENST00000507001 | ENST00000345317 | SPCS3 | chr4 | 177245408 | + | SKAP2 | chr7 | 26729981 | - |
intron-3CDS | ENST00000507001 | ENST00000539623 | SPCS3 | chr4 | 177245408 | + | SKAP2 | chr7 | 26729981 | - |
intron-5UTR | ENST00000507001 | ENST00000489977 | SPCS3 | chr4 | 177245408 | + | SKAP2 | chr7 | 26729981 | - |
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FusionProtFeatures for SPCS3_SKAP2 |
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Hgene | Tgene |
SPCS3 | SKAP2 |
Component of the microsomal signal peptidase complexwhich removes signal peptides and other N-terminal peptides fromnascent proteins as they are translocated into the lumen of theendoplasmic reticulum. {ECO:0000269|PubMed:27499293}. | May be involved in B-cell and macrophage adhesionprocesses. In B-cells, may act by coupling the B-cell receptor(BCR) to integrin activation. May play a role in src signalingpathway. {ECO:0000269|PubMed:12893833,ECO:0000269|PubMed:9837776}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SPCS3_SKAP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SPCS3_SKAP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SPCS3 | FBXO6, TCTN2, TCTN3, EVC2, TCTN1, TMEM17, TMEM216, TMEM67, MCM2, SEC11C, PTPRO, TRIM25 | SKAP2 | PRAM1, FYN, LYN, HCK, KHDRBS1, FASLG, PTK2B, SRC, GRB2, APP, SKAP1, RGS3, ABHD5, FRMD1, SNRPN |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPCS3_SKAP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPCS3_SKAP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SKAP2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |