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Fusion gene ID: 35606 |
FusionGeneSummary for SPCS3_P2RX7 |
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Fusion gene information | Fusion gene name: SPCS3_P2RX7 | Fusion gene ID: 35606 | Hgene | Tgene | Gene symbol | SPCS3 | P2RX7 | Gene ID | 60559 | 5027 |
Gene name | signal peptidase complex subunit 3 | purinergic receptor P2X 7 | |
Synonyms | PRO3567|SPC22/23|SPC3|YLR066W | P2X7 | |
Cytomap | 4q34.2 | 12q24.31 | |
Type of gene | protein-coding | protein-coding | |
Description | signal peptidase complex subunit 3SPase 22 kDa subunitSPase 22/23 kDa subunitmicrosomal signal peptidase 22/23 kDa subunitmicrosomal signal peptidase 23 kDa subunitsignal peptidase complex subunit 3 homolog | P2X purinoceptor 7ATP receptorP2X7 receptorP2Z receptorpurinergic receptor P2X, ligand gated ion channel, 7purinergic receptor P2X7 variant A | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | P61009 | Q99572 | |
Ensembl transtripts involved in fusion gene | ENST00000503362, ENST00000507001, | ENST00000546057, ENST00000377162, ENST00000328963, ENST00000535250, ENST00000443520, ENST00000541446, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 1=4 |
# samples | 3 | 3 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/4*10)=2.90689059560852 | |
Context | PubMed: SPCS3 [Title/Abstract] AND P2RX7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SPCS3 | GO:0006508 | proteolysis | 27499293 |
Tgene | P2RX7 | GO:0010524 | positive regulation of calcium ion transport into cytosol | 9038151 |
Tgene | P2RX7 | GO:0017121 | phospholipid scrambling | 25651887 |
Tgene | P2RX7 | GO:0032060 | bleb assembly | 12107182 |
Tgene | P2RX7 | GO:0033198 | response to ATP | 9038151 |
Tgene | P2RX7 | GO:0046931 | pore complex assembly | 9038151 |
Tgene | P2RX7 | GO:0050718 | positive regulation of interleukin-1 beta secretion | 17036048|18089587 |
Tgene | P2RX7 | GO:0051899 | membrane depolarization | 9038151 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI332621 | SPCS3 | chr4 | 177252983 | - | P2RX7 | chr12 | 121624320 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000503362 | ENST00000546057 | SPCS3 | chr4 | 177252983 | - | P2RX7 | chr12 | 121624320 | - |
3UTR-intron | ENST00000503362 | ENST00000377162 | SPCS3 | chr4 | 177252983 | - | P2RX7 | chr12 | 121624320 | - |
3UTR-intron | ENST00000503362 | ENST00000328963 | SPCS3 | chr4 | 177252983 | - | P2RX7 | chr12 | 121624320 | - |
3UTR-intron | ENST00000503362 | ENST00000535250 | SPCS3 | chr4 | 177252983 | - | P2RX7 | chr12 | 121624320 | - |
3UTR-intron | ENST00000503362 | ENST00000443520 | SPCS3 | chr4 | 177252983 | - | P2RX7 | chr12 | 121624320 | - |
3UTR-intron | ENST00000503362 | ENST00000541446 | SPCS3 | chr4 | 177252983 | - | P2RX7 | chr12 | 121624320 | - |
intron-intron | ENST00000507001 | ENST00000546057 | SPCS3 | chr4 | 177252983 | - | P2RX7 | chr12 | 121624320 | - |
intron-intron | ENST00000507001 | ENST00000377162 | SPCS3 | chr4 | 177252983 | - | P2RX7 | chr12 | 121624320 | - |
intron-intron | ENST00000507001 | ENST00000328963 | SPCS3 | chr4 | 177252983 | - | P2RX7 | chr12 | 121624320 | - |
intron-intron | ENST00000507001 | ENST00000535250 | SPCS3 | chr4 | 177252983 | - | P2RX7 | chr12 | 121624320 | - |
intron-intron | ENST00000507001 | ENST00000443520 | SPCS3 | chr4 | 177252983 | - | P2RX7 | chr12 | 121624320 | - |
intron-intron | ENST00000507001 | ENST00000541446 | SPCS3 | chr4 | 177252983 | - | P2RX7 | chr12 | 121624320 | - |
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FusionProtFeatures for SPCS3_P2RX7 |
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Hgene | Tgene |
SPCS3 | P2RX7 |
Component of the microsomal signal peptidase complexwhich removes signal peptides and other N-terminal peptides fromnascent proteins as they are translocated into the lumen of theendoplasmic reticulum. {ECO:0000269|PubMed:27499293}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SPCS3_P2RX7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SPCS3_P2RX7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPCS3_P2RX7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPCS3_P2RX7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | P2RX7 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
Tgene | P2RX7 | C0011570 | Mental Depression | 5 | PSYGENET |
Tgene | P2RX7 | C0011581 | Depressive disorder | 5 | PSYGENET |
Tgene | P2RX7 | C0525045 | Mood Disorders | 5 | PSYGENET |
Tgene | P2RX7 | C0014556 | Epilepsy, Temporal Lobe | 2 | CTD_human |
Tgene | P2RX7 | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human;ORPHANET |
Tgene | P2RX7 | C0026769 | Multiple Sclerosis | 1 | CTD_human |