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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35606

FusionGeneSummary for SPCS3_P2RX7

check button Fusion gene summary
Fusion gene informationFusion gene name: SPCS3_P2RX7
Fusion gene ID: 35606
HgeneTgene
Gene symbol

SPCS3

P2RX7

Gene ID

60559

5027

Gene namesignal peptidase complex subunit 3purinergic receptor P2X 7
SynonymsPRO3567|SPC22/23|SPC3|YLR066WP2X7
Cytomap

4q34.2

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionsignal peptidase complex subunit 3SPase 22 kDa subunitSPase 22/23 kDa subunitmicrosomal signal peptidase 22/23 kDa subunitmicrosomal signal peptidase 23 kDa subunitsignal peptidase complex subunit 3 homologP2X purinoceptor 7ATP receptorP2X7 receptorP2Z receptorpurinergic receptor P2X, ligand gated ion channel, 7purinergic receptor P2X7 variant A
Modification date2018052320180527
UniProtAcc

P61009

Q99572

Ensembl transtripts involved in fusion geneENST00000503362, ENST00000507001, 
ENST00000546057, ENST00000377162, 
ENST00000328963, ENST00000535250, 
ENST00000443520, ENST00000541446, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 2 X 1=4
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/4*10)=2.90689059560852
Context

PubMed: SPCS3 [Title/Abstract] AND P2RX7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPCS3

GO:0006508

proteolysis

27499293

TgeneP2RX7

GO:0010524

positive regulation of calcium ion transport into cytosol

9038151

TgeneP2RX7

GO:0017121

phospholipid scrambling

25651887

TgeneP2RX7

GO:0032060

bleb assembly

12107182

TgeneP2RX7

GO:0033198

response to ATP

9038151

TgeneP2RX7

GO:0046931

pore complex assembly

9038151

TgeneP2RX7

GO:0050718

positive regulation of interleukin-1 beta secretion

17036048|18089587

TgeneP2RX7

GO:0051899

membrane depolarization

9038151


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI332621SPCS3chr4

177252983

-P2RX7chr12

121624320

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000503362ENST00000546057SPCS3chr4

177252983

-P2RX7chr12

121624320

-
3UTR-intronENST00000503362ENST00000377162SPCS3chr4

177252983

-P2RX7chr12

121624320

-
3UTR-intronENST00000503362ENST00000328963SPCS3chr4

177252983

-P2RX7chr12

121624320

-
3UTR-intronENST00000503362ENST00000535250SPCS3chr4

177252983

-P2RX7chr12

121624320

-
3UTR-intronENST00000503362ENST00000443520SPCS3chr4

177252983

-P2RX7chr12

121624320

-
3UTR-intronENST00000503362ENST00000541446SPCS3chr4

177252983

-P2RX7chr12

121624320

-
intron-intronENST00000507001ENST00000546057SPCS3chr4

177252983

-P2RX7chr12

121624320

-
intron-intronENST00000507001ENST00000377162SPCS3chr4

177252983

-P2RX7chr12

121624320

-
intron-intronENST00000507001ENST00000328963SPCS3chr4

177252983

-P2RX7chr12

121624320

-
intron-intronENST00000507001ENST00000535250SPCS3chr4

177252983

-P2RX7chr12

121624320

-
intron-intronENST00000507001ENST00000443520SPCS3chr4

177252983

-P2RX7chr12

121624320

-
intron-intronENST00000507001ENST00000541446SPCS3chr4

177252983

-P2RX7chr12

121624320

-

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FusionProtFeatures for SPCS3_P2RX7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPCS3

P61009

P2RX7

Q99572

Component of the microsomal signal peptidase complexwhich removes signal peptides and other N-terminal peptides fromnascent proteins as they are translocated into the lumen of theendoplasmic reticulum. {ECO:0000269|PubMed:27499293}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPCS3_P2RX7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPCS3_P2RX7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPCS3_P2RX7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPCS3_P2RX7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneP2RX7C0005586Bipolar Disorder5PSYGENET
TgeneP2RX7C0011570Mental Depression5PSYGENET
TgeneP2RX7C0011581Depressive disorder5PSYGENET
TgeneP2RX7C0525045Mood Disorders5PSYGENET
TgeneP2RX7C0014556Epilepsy, Temporal Lobe2CTD_human
TgeneP2RX7C0023434Chronic Lymphocytic Leukemia1CTD_human;ORPHANET
TgeneP2RX7C0026769Multiple Sclerosis1CTD_human