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Fusion gene ID: 35571 |
FusionGeneSummary for SPATA18_EXOC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPATA18_EXOC1 | Fusion gene ID: 35571 | Hgene | Tgene | Gene symbol | SPATA18 | EXOC1 | Gene ID | 132671 | 55763 |
| Gene name | spermatogenesis associated 18 | exocyst complex component 1 | |
| Synonyms | Mieap|SPETEX1 | BM-102|SEC3|SEC3L1|SEC3P | |
| Cytomap | 4q12 | 4q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitochondria-eating proteinspermatogenesis associated 18 homologtestis tissue sperm-binding protein Li 71n | exocyst complex component 1SEC3-like 1exocyst complex component Sec3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8TC71 | Q9NV70 | |
| Ensembl transtripts involved in fusion gene | ENST00000295213, ENST00000419395, ENST00000506829, | ENST00000381295, ENST00000346134, ENST00000349598, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SPATA18 [Title/Abstract] AND EXOC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SPATA18 | GO:0006974 | cellular response to DNA damage stimulus | 21264221 |
| Tgene | EXOC1 | GO:0048015 | phosphatidylinositol-mediated signaling | 25591774 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-22-4591-01A | SPATA18 | chr4 | 52917957 | + | EXOC1 | chr4 | 56768510 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000295213 | ENST00000381295 | SPATA18 | chr4 | 52917957 | + | EXOC1 | chr4 | 56768510 | + |
| In-frame | ENST00000295213 | ENST00000346134 | SPATA18 | chr4 | 52917957 | + | EXOC1 | chr4 | 56768510 | + |
| In-frame | ENST00000295213 | ENST00000349598 | SPATA18 | chr4 | 52917957 | + | EXOC1 | chr4 | 56768510 | + |
| In-frame | ENST00000419395 | ENST00000381295 | SPATA18 | chr4 | 52917957 | + | EXOC1 | chr4 | 56768510 | + |
| In-frame | ENST00000419395 | ENST00000346134 | SPATA18 | chr4 | 52917957 | + | EXOC1 | chr4 | 56768510 | + |
| In-frame | ENST00000419395 | ENST00000349598 | SPATA18 | chr4 | 52917957 | + | EXOC1 | chr4 | 56768510 | + |
| 3UTR-3CDS | ENST00000506829 | ENST00000381295 | SPATA18 | chr4 | 52917957 | + | EXOC1 | chr4 | 56768510 | + |
| 3UTR-3CDS | ENST00000506829 | ENST00000346134 | SPATA18 | chr4 | 52917957 | + | EXOC1 | chr4 | 56768510 | + |
| 3UTR-3CDS | ENST00000506829 | ENST00000349598 | SPATA18 | chr4 | 52917957 | + | EXOC1 | chr4 | 56768510 | + |
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FusionProtFeatures for SPATA18_EXOC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPATA18 | EXOC1 |
| Key regulator of mitochondrial quality that mediates therepairing or degradation of unhealthy mitochondria in response tomitochondrial damage. Mediator of mitochondrial protein catabolicprocess (also named MALM) by mediating the degradation of damagedproteins inside mitochondria by promoting the accumulation in themitochondrial matrix of hydrolases that are characteristic of thelysosomal lumen. Also involved in mitochondrion degradation ofdamaged mitochondria by promoting the formation of vacuole-likestructures (named MIV), which engulf and degrade unhealthymitochondria by accumulating lysosomes. The physical interactionof SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outermembrane regulates the opening of a pore in the mitochondrialdouble membrane in order to mediate the translocation of lysosomalproteins from the cytoplasm to the mitochondrial matrix.{ECO:0000269|PubMed:21264221, ECO:0000269|PubMed:21264228,ECO:0000269|PubMed:22292033}. | Component of the exocyst complex involved in the dockingof exocytic vesicles with fusion sites on the plasma membrane. (Microbial infection) Has an antiviral effect againstflaviviruses by affecting viral RNA transcription and translationthrough the sequestration of elongation factor 1-alpha (EEF1A1).This results in decreased viral RNA synthesis and decreased viralprotein translation. {ECO:0000269|PubMed:19889084}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SPATA18 | chr4:52917957 | chr4:56768510 | ENST00000295213 | + | 1 | 13 | 118_187 | 29 | 539 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SPATA18 | chr4:52917957 | chr4:56768510 | ENST00000295213 | + | 1 | 13 | 219_256 | 29 | 539 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SPATA18 | chr4:52917957 | chr4:56768510 | ENST00000419395 | + | 1 | 12 | 118_187 | 29 | 507 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SPATA18 | chr4:52917957 | chr4:56768510 | ENST00000419395 | + | 1 | 12 | 219_256 | 29 | 507 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SPATA18 | chr4:52917957 | chr4:56768510 | ENST00000295213 | + | 1 | 13 | 257_313 | 29 | 539 | Compositional bias | Note=Ser-rich |
| Hgene | >SPATA18 | chr4:52917957 | chr4:56768510 | ENST00000419395 | + | 1 | 12 | 257_313 | 29 | 507 | Compositional bias | Note=Ser-rich |
| Tgene | EXOC1 | chr4:52917957 | chr4:56768510 | ENST00000346134 | + | 16 | 19 | 152_174 | 779 | 895 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | EXOC1 | chr4:52917957 | chr4:56768510 | ENST00000346134 | + | 16 | 19 | 205_259 | 779 | 895 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | EXOC1 | chr4:52917957 | chr4:56768510 | ENST00000349598 | + | 15 | 18 | 152_174 | 764 | 880 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | EXOC1 | chr4:52917957 | chr4:56768510 | ENST00000349598 | + | 15 | 18 | 205_259 | 764 | 880 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | EXOC1 | chr4:52917957 | chr4:56768510 | ENST00000381295 | + | 16 | 19 | 152_174 | 779 | 895 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | EXOC1 | chr4:52917957 | chr4:56768510 | ENST00000381295 | + | 16 | 19 | 205_259 | 779 | 895 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for SPATA18_EXOC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SPATA18_ENST00000295213_chr4_52917957_+_EXOC1_ENST00000381295_chr4_56768510_+_145aa MAENLKRLVSNETLRTLQEKLDFWLKEYNHFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE >In-frame_SPATA18_ENST00000295213_chr4_52917957_+_EXOC1_ENST00000346134_chr4_56768510_+_145aa MAENLKRLVSNETLRTLQEKLDFWLKEYNHFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE >In-frame_SPATA18_ENST00000295213_chr4_52917957_+_EXOC1_ENST00000349598_chr4_56768510_+_145aa MAENLKRLVSNETLRTLQEKLDFWLKEYNHFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE >In-frame_SPATA18_ENST00000419395_chr4_52917957_+_EXOC1_ENST00000381295_chr4_56768510_+_145aa MAENLKRLVSNETLRTLQEKLDFWLKEYNHFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE >In-frame_SPATA18_ENST00000419395_chr4_52917957_+_EXOC1_ENST00000346134_chr4_56768510_+_145aa MAENLKRLVSNETLRTLQEKLDFWLKEYNHFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE >In-frame_SPATA18_ENST00000419395_chr4_52917957_+_EXOC1_ENST00000349598_chr4_56768510_+_145aa MAENLKRLVSNETLRTLQEKLDFWLKEYNHFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SPATA18_ENST00000295213_chr4_52917957_+_EXOC1_ENST00000381295_chr4_56768510_+_435nt ATGGCGGAAAACCTGAAAAGACTGGTCTCAAACGAAACTTTACGAACGTTGCAGGAAAAGCTAGACTTCTGGCTGAAGGAGTACAACCAT TTCTTTGAAGGTGTTGAAGCTCGCGTGGCACAGGGCATAAGGGAGGAGGAAGTAAGTTACCAACTTGCATTTAACAAACAAGAACTTCGT AAAGTCATTAAGGAGTACCCTGGAAAGGAAGTAAAAAAAGGTCTAGATAACCTCTACAAGAAAGTTGATAAACATTTATGTGAAGAAGAG AACTTACTTCAGGTGGTGTGGCACTCCATGCAAGATGAATTTATACGCCAGTATAAGCACTTTGAAGGTTTGATAGCTCGCTGTTATCCT >In-frame_SPATA18_ENST00000295213_chr4_52917957_+_EXOC1_ENST00000346134_chr4_56768510_+_435nt ATGGCGGAAAACCTGAAAAGACTGGTCTCAAACGAAACTTTACGAACGTTGCAGGAAAAGCTAGACTTCTGGCTGAAGGAGTACAACCAT TTCTTTGAAGGTGTTGAAGCTCGCGTGGCACAGGGCATAAGGGAGGAGGAAGTAAGTTACCAACTTGCATTTAACAAACAAGAACTTCGT AAAGTCATTAAGGAGTACCCTGGAAAGGAAGTAAAAAAAGGTCTAGATAACCTCTACAAGAAAGTTGATAAACATTTATGTGAAGAAGAG AACTTACTTCAGGTGGTGTGGCACTCCATGCAAGATGAATTTATACGCCAGTATAAGCACTTTGAAGGTTTGATAGCTCGCTGTTATCCT >In-frame_SPATA18_ENST00000295213_chr4_52917957_+_EXOC1_ENST00000349598_chr4_56768510_+_435nt ATGGCGGAAAACCTGAAAAGACTGGTCTCAAACGAAACTTTACGAACGTTGCAGGAAAAGCTAGACTTCTGGCTGAAGGAGTACAACCAT TTCTTTGAAGGTGTTGAAGCTCGCGTGGCACAGGGCATAAGGGAGGAGGAAGTAAGTTACCAACTTGCATTTAACAAACAAGAACTTCGT AAAGTCATTAAGGAGTACCCTGGAAAGGAAGTAAAAAAAGGTCTAGATAACCTCTACAAGAAAGTTGATAAACATTTATGTGAAGAAGAG AACTTACTTCAGGTGGTGTGGCACTCCATGCAAGATGAATTTATACGCCAGTATAAGCACTTTGAAGGTTTGATAGCTCGCTGTTATCCT >In-frame_SPATA18_ENST00000419395_chr4_52917957_+_EXOC1_ENST00000381295_chr4_56768510_+_435nt ATGGCGGAAAACCTGAAAAGACTGGTCTCAAACGAAACTTTACGAACGTTGCAGGAAAAGCTAGACTTCTGGCTGAAGGAGTACAACCAT TTCTTTGAAGGTGTTGAAGCTCGCGTGGCACAGGGCATAAGGGAGGAGGAAGTAAGTTACCAACTTGCATTTAACAAACAAGAACTTCGT AAAGTCATTAAGGAGTACCCTGGAAAGGAAGTAAAAAAAGGTCTAGATAACCTCTACAAGAAAGTTGATAAACATTTATGTGAAGAAGAG AACTTACTTCAGGTGGTGTGGCACTCCATGCAAGATGAATTTATACGCCAGTATAAGCACTTTGAAGGTTTGATAGCTCGCTGTTATCCT >In-frame_SPATA18_ENST00000419395_chr4_52917957_+_EXOC1_ENST00000346134_chr4_56768510_+_435nt ATGGCGGAAAACCTGAAAAGACTGGTCTCAAACGAAACTTTACGAACGTTGCAGGAAAAGCTAGACTTCTGGCTGAAGGAGTACAACCAT TTCTTTGAAGGTGTTGAAGCTCGCGTGGCACAGGGCATAAGGGAGGAGGAAGTAAGTTACCAACTTGCATTTAACAAACAAGAACTTCGT AAAGTCATTAAGGAGTACCCTGGAAAGGAAGTAAAAAAAGGTCTAGATAACCTCTACAAGAAAGTTGATAAACATTTATGTGAAGAAGAG AACTTACTTCAGGTGGTGTGGCACTCCATGCAAGATGAATTTATACGCCAGTATAAGCACTTTGAAGGTTTGATAGCTCGCTGTTATCCT >In-frame_SPATA18_ENST00000419395_chr4_52917957_+_EXOC1_ENST00000349598_chr4_56768510_+_435nt ATGGCGGAAAACCTGAAAAGACTGGTCTCAAACGAAACTTTACGAACGTTGCAGGAAAAGCTAGACTTCTGGCTGAAGGAGTACAACCAT TTCTTTGAAGGTGTTGAAGCTCGCGTGGCACAGGGCATAAGGGAGGAGGAAGTAAGTTACCAACTTGCATTTAACAAACAAGAACTTCGT AAAGTCATTAAGGAGTACCCTGGAAAGGAAGTAAAAAAAGGTCTAGATAACCTCTACAAGAAAGTTGATAAACATTTATGTGAAGAAGAG AACTTACTTCAGGTGGTGTGGCACTCCATGCAAGATGAATTTATACGCCAGTATAAGCACTTTGAAGGTTTGATAGCTCGCTGTTATCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SPATA18_ENST00000295213_chr4_52917957_+_EXOC1_ENST00000381295_chr4_56768510_+_1327nt ACCCAGGGCGGGGCGGCGCGGGCGTTGCCACGACGCGGGCCGCGCGCGTCCCTGGCAGCCAACCCGTCCACGTCAAGGTTTGTTTAATAA TCGCCAGGGTATCTATGGCCGGGCTCAGGCGGCTGCTGGGGAGCCAGGAGACCGCGCGGGACGGCGGATGAGGCGCGGCGGCTGCGGCCC AGGGCACCTCCCCTCTGGCTTCCCGAACCCGGCCAGGTCCGACCCGAGGGGGAGGATGGAAACACCTGCCGCGCTCTGAGCCCCCCAGAA GAGAACACCCTTCCCGCCATATCACCCCACGGTCCTGCGGAGGCCACCGCCTGGTCCCCCCAAGTCTCCATCGCGCAGCGTGGGGCCGAG AGGAATAGTGAGCGATGGCGGAAAACCTGAAAAGACTGGTCTCAAACGAAACTTTACGAACGTTGCAGGAAAAGCTAGACTTCTGGCTGA AGGAGTACAACCATTTCTTTGAAGGTGTTGAAGCTCGCGTGGCACAGGGCATAAGGGAGGAGGAAGTAAGTTACCAACTTGCATTTAACA AACAAGAACTTCGTAAAGTCATTAAGGAGTACCCTGGAAAGGAAGTAAAAAAAGGTCTAGATAACCTCTACAAGAAAGTTGATAAACATT TATGTGAAGAAGAGAACTTACTTCAGGTGGTGTGGCACTCCATGCAAGATGAATTTATACGCCAGTATAAGCACTTTGAAGGTTTGATAG CTCGCTGTTATCCTGGATCTGGTGTTACAATGGAATTCACTATTCAGGACATTCTGGATTATTGTTCCAGCATTGCACAGTCCCACTAAA CCTTGTGAAAGAAGAAAAGATAACTGAATGAAGCATTTGAGTATAACAGACACTATACCAAAATACCAAGCAACTGTTTTGAGAACCCAG ACTTAAAATTTTATGTATTATTAAATGTTAGATAAATGGGTAGTACCATACTACAAATATTTAAATGCAAAATTACCAACCTATATAGCA GTTTTATTTGCCCTATAGGTTGCATACTAACTTAAGCATTCATGTCACCATAAAATGCCTTTAGCATTTCTCAATGACTGGATGGGAAAT TTTCCTTTATTGCCTAGCTGCTTGTGTTTGAGTGGTTGTCCTATGAGCAATGCATTTGGAGTTCTTCAGCTTTCACTACTTCTCTGTTGC TTGCTAATCATGTAACTACTAAAATACTGTACAAAATTGTTTTTTCACACTAACAAATGTGTATATGGAGAAGAGGGCTCATGTGATGAT >In-frame_SPATA18_ENST00000295213_chr4_52917957_+_EXOC1_ENST00000346134_chr4_56768510_+_1348nt ACCCAGGGCGGGGCGGCGCGGGCGTTGCCACGACGCGGGCCGCGCGCGTCCCTGGCAGCCAACCCGTCCACGTCAAGGTTTGTTTAATAA TCGCCAGGGTATCTATGGCCGGGCTCAGGCGGCTGCTGGGGAGCCAGGAGACCGCGCGGGACGGCGGATGAGGCGCGGCGGCTGCGGCCC AGGGCACCTCCCCTCTGGCTTCCCGAACCCGGCCAGGTCCGACCCGAGGGGGAGGATGGAAACACCTGCCGCGCTCTGAGCCCCCCAGAA GAGAACACCCTTCCCGCCATATCACCCCACGGTCCTGCGGAGGCCACCGCCTGGTCCCCCCAAGTCTCCATCGCGCAGCGTGGGGCCGAG AGGAATAGTGAGCGATGGCGGAAAACCTGAAAAGACTGGTCTCAAACGAAACTTTACGAACGTTGCAGGAAAAGCTAGACTTCTGGCTGA AGGAGTACAACCATTTCTTTGAAGGTGTTGAAGCTCGCGTGGCACAGGGCATAAGGGAGGAGGAAGTAAGTTACCAACTTGCATTTAACA AACAAGAACTTCGTAAAGTCATTAAGGAGTACCCTGGAAAGGAAGTAAAAAAAGGTCTAGATAACCTCTACAAGAAAGTTGATAAACATT TATGTGAAGAAGAGAACTTACTTCAGGTGGTGTGGCACTCCATGCAAGATGAATTTATACGCCAGTATAAGCACTTTGAAGGTTTGATAG CTCGCTGTTATCCTGGATCTGGTGTTACAATGGAATTCACTATTCAGGACATTCTGGATTATTGTTCCAGCATTGCACAGTCCCACTAAA CCTTGTGAAAGAAGAAAAGATAACTGAATGAAGCATTTGAGTATAACAGACACTATACCAAAATACCAAGCAACTGTTTTGAGAACCCAG ACTTAAAATTTTATGTATTATTAAATGTTAGATAAATGGGTAGTACCATACTACAAATATTTAAATGCAAAATTACCAACCTATATAGCA GTTTTATTTGCCCTATAGGTTGCATACTAACTTAAGCATTCATGTCACCATAAAATGCCTTTAGCATTTCTCAATGACTGGATGGGAAAT TTTCCTTTATTGCCTAGCTGCTTGTGTTTGAGTGGTTGTCCTATGAGCAATGCATTTGGAGTTCTTCAGCTTTCACTACTTCTCTGTTGC TTGCTAATCATGTAACTACTAAAATACTGTACAAAATTGTTTTTTCACACTAACAAATGTGTATATGGAGAAGAGGGCTCATGTGATGAT >In-frame_SPATA18_ENST00000295213_chr4_52917957_+_EXOC1_ENST00000349598_chr4_56768510_+_1348nt ACCCAGGGCGGGGCGGCGCGGGCGTTGCCACGACGCGGGCCGCGCGCGTCCCTGGCAGCCAACCCGTCCACGTCAAGGTTTGTTTAATAA TCGCCAGGGTATCTATGGCCGGGCTCAGGCGGCTGCTGGGGAGCCAGGAGACCGCGCGGGACGGCGGATGAGGCGCGGCGGCTGCGGCCC AGGGCACCTCCCCTCTGGCTTCCCGAACCCGGCCAGGTCCGACCCGAGGGGGAGGATGGAAACACCTGCCGCGCTCTGAGCCCCCCAGAA GAGAACACCCTTCCCGCCATATCACCCCACGGTCCTGCGGAGGCCACCGCCTGGTCCCCCCAAGTCTCCATCGCGCAGCGTGGGGCCGAG AGGAATAGTGAGCGATGGCGGAAAACCTGAAAAGACTGGTCTCAAACGAAACTTTACGAACGTTGCAGGAAAAGCTAGACTTCTGGCTGA AGGAGTACAACCATTTCTTTGAAGGTGTTGAAGCTCGCGTGGCACAGGGCATAAGGGAGGAGGAAGTAAGTTACCAACTTGCATTTAACA AACAAGAACTTCGTAAAGTCATTAAGGAGTACCCTGGAAAGGAAGTAAAAAAAGGTCTAGATAACCTCTACAAGAAAGTTGATAAACATT TATGTGAAGAAGAGAACTTACTTCAGGTGGTGTGGCACTCCATGCAAGATGAATTTATACGCCAGTATAAGCACTTTGAAGGTTTGATAG CTCGCTGTTATCCTGGATCTGGTGTTACAATGGAATTCACTATTCAGGACATTCTGGATTATTGTTCCAGCATTGCACAGTCCCACTAAA CCTTGTGAAAGAAGAAAAGATAACTGAATGAAGCATTTGAGTATAACAGACACTATACCAAAATACCAAGCAACTGTTTTGAGAACCCAG ACTTAAAATTTTATGTATTATTAAATGTTAGATAAATGGGTAGTACCATACTACAAATATTTAAATGCAAAATTACCAACCTATATAGCA GTTTTATTTGCCCTATAGGTTGCATACTAACTTAAGCATTCATGTCACCATAAAATGCCTTTAGCATTTCTCAATGACTGGATGGGAAAT TTTCCTTTATTGCCTAGCTGCTTGTGTTTGAGTGGTTGTCCTATGAGCAATGCATTTGGAGTTCTTCAGCTTTCACTACTTCTCTGTTGC TTGCTAATCATGTAACTACTAAAATACTGTACAAAATTGTTTTTTCACACTAACAAATGTGTATATGGAGAAGAGGGCTCATGTGATGAT >In-frame_SPATA18_ENST00000419395_chr4_52917957_+_EXOC1_ENST00000381295_chr4_56768510_+_1242nt AATAATCGCCAGGGTATCTATGGCCGGGCTCAGGCGGCTGCTGGGGAGCCAGGAGACCGCGCGGGACGGCGGATGAGGCGCGGCGGCTGC GGCCCAGGGCACCTCCCCTCTGGCTTCCCGAACCCGGCCAGGTCCGACCCGAGGGGGAGGATGGAAACACCTGCCGCGCTCTGAGCCCCC CAGAAGAGAACACCCTTCCCGCCATATCACCCCACGGTCCTGCGGAGGCCACCGCCTGGTCCCCCCAAGTCTCCATCGCGCAGCGTGGGG CCGAGAGGAATAGTGAGCGATGGCGGAAAACCTGAAAAGACTGGTCTCAAACGAAACTTTACGAACGTTGCAGGAAAAGCTAGACTTCTG GCTGAAGGAGTACAACCATTTCTTTGAAGGTGTTGAAGCTCGCGTGGCACAGGGCATAAGGGAGGAGGAAGTAAGTTACCAACTTGCATT TAACAAACAAGAACTTCGTAAAGTCATTAAGGAGTACCCTGGAAAGGAAGTAAAAAAAGGTCTAGATAACCTCTACAAGAAAGTTGATAA ACATTTATGTGAAGAAGAGAACTTACTTCAGGTGGTGTGGCACTCCATGCAAGATGAATTTATACGCCAGTATAAGCACTTTGAAGGTTT GATAGCTCGCTGTTATCCTGGATCTGGTGTTACAATGGAATTCACTATTCAGGACATTCTGGATTATTGTTCCAGCATTGCACAGTCCCA CTAAACCTTGTGAAAGAAGAAAAGATAACTGAATGAAGCATTTGAGTATAACAGACACTATACCAAAATACCAAGCAACTGTTTTGAGAA CCCAGACTTAAAATTTTATGTATTATTAAATGTTAGATAAATGGGTAGTACCATACTACAAATATTTAAATGCAAAATTACCAACCTATA TAGCAGTTTTATTTGCCCTATAGGTTGCATACTAACTTAAGCATTCATGTCACCATAAAATGCCTTTAGCATTTCTCAATGACTGGATGG GAAATTTTCCTTTATTGCCTAGCTGCTTGTGTTTGAGTGGTTGTCCTATGAGCAATGCATTTGGAGTTCTTCAGCTTTCACTACTTCTCT GTTGCTTGCTAATCATGTAACTACTAAAATACTGTACAAAATTGTTTTTTCACACTAACAAATGTGTATATGGAGAAGAGGGCTCATGTG >In-frame_SPATA18_ENST00000419395_chr4_52917957_+_EXOC1_ENST00000346134_chr4_56768510_+_1263nt AATAATCGCCAGGGTATCTATGGCCGGGCTCAGGCGGCTGCTGGGGAGCCAGGAGACCGCGCGGGACGGCGGATGAGGCGCGGCGGCTGC GGCCCAGGGCACCTCCCCTCTGGCTTCCCGAACCCGGCCAGGTCCGACCCGAGGGGGAGGATGGAAACACCTGCCGCGCTCTGAGCCCCC CAGAAGAGAACACCCTTCCCGCCATATCACCCCACGGTCCTGCGGAGGCCACCGCCTGGTCCCCCCAAGTCTCCATCGCGCAGCGTGGGG CCGAGAGGAATAGTGAGCGATGGCGGAAAACCTGAAAAGACTGGTCTCAAACGAAACTTTACGAACGTTGCAGGAAAAGCTAGACTTCTG GCTGAAGGAGTACAACCATTTCTTTGAAGGTGTTGAAGCTCGCGTGGCACAGGGCATAAGGGAGGAGGAAGTAAGTTACCAACTTGCATT TAACAAACAAGAACTTCGTAAAGTCATTAAGGAGTACCCTGGAAAGGAAGTAAAAAAAGGTCTAGATAACCTCTACAAGAAAGTTGATAA ACATTTATGTGAAGAAGAGAACTTACTTCAGGTGGTGTGGCACTCCATGCAAGATGAATTTATACGCCAGTATAAGCACTTTGAAGGTTT GATAGCTCGCTGTTATCCTGGATCTGGTGTTACAATGGAATTCACTATTCAGGACATTCTGGATTATTGTTCCAGCATTGCACAGTCCCA CTAAACCTTGTGAAAGAAGAAAAGATAACTGAATGAAGCATTTGAGTATAACAGACACTATACCAAAATACCAAGCAACTGTTTTGAGAA CCCAGACTTAAAATTTTATGTATTATTAAATGTTAGATAAATGGGTAGTACCATACTACAAATATTTAAATGCAAAATTACCAACCTATA TAGCAGTTTTATTTGCCCTATAGGTTGCATACTAACTTAAGCATTCATGTCACCATAAAATGCCTTTAGCATTTCTCAATGACTGGATGG GAAATTTTCCTTTATTGCCTAGCTGCTTGTGTTTGAGTGGTTGTCCTATGAGCAATGCATTTGGAGTTCTTCAGCTTTCACTACTTCTCT GTTGCTTGCTAATCATGTAACTACTAAAATACTGTACAAAATTGTTTTTTCACACTAACAAATGTGTATATGGAGAAGAGGGCTCATGTG ATGATCATTTGTGAACTTAGATTTTTGAGGATTATGTGACTAGTAATAAATGTGAAATAAATTTTCAAAAAAGTTGACATTTGATAATAT >In-frame_SPATA18_ENST00000419395_chr4_52917957_+_EXOC1_ENST00000349598_chr4_56768510_+_1263nt AATAATCGCCAGGGTATCTATGGCCGGGCTCAGGCGGCTGCTGGGGAGCCAGGAGACCGCGCGGGACGGCGGATGAGGCGCGGCGGCTGC GGCCCAGGGCACCTCCCCTCTGGCTTCCCGAACCCGGCCAGGTCCGACCCGAGGGGGAGGATGGAAACACCTGCCGCGCTCTGAGCCCCC CAGAAGAGAACACCCTTCCCGCCATATCACCCCACGGTCCTGCGGAGGCCACCGCCTGGTCCCCCCAAGTCTCCATCGCGCAGCGTGGGG CCGAGAGGAATAGTGAGCGATGGCGGAAAACCTGAAAAGACTGGTCTCAAACGAAACTTTACGAACGTTGCAGGAAAAGCTAGACTTCTG GCTGAAGGAGTACAACCATTTCTTTGAAGGTGTTGAAGCTCGCGTGGCACAGGGCATAAGGGAGGAGGAAGTAAGTTACCAACTTGCATT TAACAAACAAGAACTTCGTAAAGTCATTAAGGAGTACCCTGGAAAGGAAGTAAAAAAAGGTCTAGATAACCTCTACAAGAAAGTTGATAA ACATTTATGTGAAGAAGAGAACTTACTTCAGGTGGTGTGGCACTCCATGCAAGATGAATTTATACGCCAGTATAAGCACTTTGAAGGTTT GATAGCTCGCTGTTATCCTGGATCTGGTGTTACAATGGAATTCACTATTCAGGACATTCTGGATTATTGTTCCAGCATTGCACAGTCCCA CTAAACCTTGTGAAAGAAGAAAAGATAACTGAATGAAGCATTTGAGTATAACAGACACTATACCAAAATACCAAGCAACTGTTTTGAGAA CCCAGACTTAAAATTTTATGTATTATTAAATGTTAGATAAATGGGTAGTACCATACTACAAATATTTAAATGCAAAATTACCAACCTATA TAGCAGTTTTATTTGCCCTATAGGTTGCATACTAACTTAAGCATTCATGTCACCATAAAATGCCTTTAGCATTTCTCAATGACTGGATGG GAAATTTTCCTTTATTGCCTAGCTGCTTGTGTTTGAGTGGTTGTCCTATGAGCAATGCATTTGGAGTTCTTCAGCTTTCACTACTTCTCT GTTGCTTGCTAATCATGTAACTACTAAAATACTGTACAAAATTGTTTTTTCACACTAACAAATGTGTATATGGAGAAGAGGGCTCATGTG ATGATCATTTGTGAACTTAGATTTTTGAGGATTATGTGACTAGTAATAAATGTGAAATAAATTTTCAAAAAAGTTGACATTTGATAATAT |
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FusionGenePPI for SPATA18_EXOC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SPATA18 | PAXIP1, CEP128, ODF2 | EXOC1 | CDC5L, DISC1, TRAF3IP1, TRIO, DST, LUC7L2, EXOC4, SYBU, SPTAN1, SFR1, CCSER2, CCDC93, CCDC88A, KDM1A, NUF2, MACF1, SRGAP2, GOLGA4, SH3BP5, CEP295, KIAA1551, KIF5A, TRIM9, KANSL1, COLEC12, IQCB1, KIAA0226, RB1CC1, ATG14, SNAP29, BSG, CD274, THAP7, KIR2DS2, CA14, DTNBP1, TMEFF1, SCN2B, EXOC2, EXOC3, NTRK1, MED4, SNW1, EXOC6, NCKAP5L, TUFT1, GRIPAP1, CLOCK, FKBP15, PTRF, BLOC1S4, IKBIP, RABEP2, RABGAP1L, NDC80, PHF21A, IL1R2, EXOC6B, EXOC8, VPS53, RABGEF1, CCDC6, CCDC132, TRIM32, EXOC5, KXD1, GIT2, POTEE, ARHGEF7, SNAPIN, VPS51, BLOC1S2, EXOC7, USP4, THAP11, TSKS, JUN, TSSC1, TNFRSF8, CCHCR1, SIKE1, GIT1, KIF5B, RABEP1, NUP54, TNIP1, GOLGA5, COG6, KIF5C, STRN3, STRN, APLNR, PCNT, CCDC122, EDNRB, ZWINT, VTI1B, TMED1, RALB, MTNR1A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPATA18_EXOC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPATA18_EXOC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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