![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 35552 |
FusionGeneSummary for SPARC_COL2A1 |
![]() |
Fusion gene information | Fusion gene name: SPARC_COL2A1 | Fusion gene ID: 35552 | Hgene | Tgene | Gene symbol | SPARC | COL2A1 | Gene ID | 6678 | 1280 |
Gene name | secreted protein acidic and cysteine rich | collagen type II alpha 1 chain | |
Synonyms | BM-40|OI17|ON | ANFH|AOM|COL11A3|SEDC|STL1 | |
Cytomap | 5q33.1 | 12q13.11 | |
Type of gene | protein-coding | protein-coding | |
Description | SPARCbasement-membrane protein 40secreted protein, acidic, cysteine-rich (osteonectin) | collagen alpha-1(II) chainalpha-1 type II collagenarthroophthalmopathy, progressive (Stickler syndrome)cartilage collagenchondrocalcincollagen II, alpha-1 polypeptidecollagen, type II, alpha 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P09486 | P02458 | |
Ensembl transtripts involved in fusion gene | ENST00000231061, ENST00000537849, | ENST00000380518, ENST00000493991, ENST00000337299, | |
Fusion gene scores | * DoF score | 12 X 16 X 5=960 | 5 X 6 X 4=120 |
# samples | 18 | 6 | |
** MAII score | log2(18/960*10)=-2.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SPARC [Title/Abstract] AND COL2A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SPARC | GO:0001937 | negative regulation of endothelial cell proliferation | 12867428 |
Hgene | SPARC | GO:0010595 | positive regulation of endothelial cell migration | 12867428 |
Hgene | SPARC | GO:0016525 | negative regulation of angiogenesis | 12867428 |
Hgene | SPARC | GO:0022604 | regulation of cell morphogenesis | 15389586 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DV462786 | SPARC | chr5 | 151042263 | - | COL2A1 | chr12 | 48367008 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000231061 | ENST00000380518 | SPARC | chr5 | 151042263 | - | COL2A1 | chr12 | 48367008 | - |
intron-5UTR | ENST00000231061 | ENST00000493991 | SPARC | chr5 | 151042263 | - | COL2A1 | chr12 | 48367008 | - |
intron-intron | ENST00000231061 | ENST00000337299 | SPARC | chr5 | 151042263 | - | COL2A1 | chr12 | 48367008 | - |
intron-3UTR | ENST00000537849 | ENST00000380518 | SPARC | chr5 | 151042263 | - | COL2A1 | chr12 | 48367008 | - |
intron-5UTR | ENST00000537849 | ENST00000493991 | SPARC | chr5 | 151042263 | - | COL2A1 | chr12 | 48367008 | - |
intron-intron | ENST00000537849 | ENST00000337299 | SPARC | chr5 | 151042263 | - | COL2A1 | chr12 | 48367008 | - |
Top |
FusionProtFeatures for SPARC_COL2A1 |
![]() |
Hgene | Tgene |
SPARC | COL2A1 |
Appears to regulate cell growth through interactionswith the extracellular matrix and cytokines. Binds calcium andcopper, several types of collagen, albumin, thrombospondin, PDGFand cell membranes. There are two calcium binding sites; an acidicdomain that binds 5 to 8 Ca(2+) with a low affinity and an EF-handloop that binds a Ca(2+) ion with a high affinity. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SPARC_COL2A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SPARC_COL2A1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SPARC_COL2A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | SPARC | P09486 | DB11093 | Calcium Citrate | SPARC | small molecule | approved |
Hgene | SPARC | P09486 | DB11348 | Calcium Phosphate | SPARC | small molecule | approved |
Tgene | COL2A1 | P02458 | DB00048 | Collagenase clostridium histolyticum | Collagen alpha-1(II) chain {ECO:0000305} | biotech | approved|investigational |
Top |
RelatedDiseases for SPARC_COL2A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SPARC | C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_human |
Hgene | SPARC | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Hgene | SPARC | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | SPARC | C0019158 | Hepatitis | 1 | CTD_human |
Hgene | SPARC | C0020429 | Hyperalgesia | 1 | CTD_human |
Hgene | SPARC | C0022658 | Kidney Diseases | 1 | CTD_human |
Hgene | SPARC | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | SPARC | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | SPARC | C0024031 | Low Back Pain | 1 | CTD_human |
Hgene | SPARC | C0026764 | Multiple Myeloma | 1 | CTD_human |
Hgene | SPARC | C0027540 | Necrosis | 1 | CTD_human |
Hgene | SPARC | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Hgene | SPARC | C0029434 | Osteogenesis Imperfecta | 1 | CTD_human |
Hgene | SPARC | C0041948 | Uremia | 1 | CTD_human |
Hgene | SPARC | C0043094 | Weight Gain | 1 | CTD_human |
Hgene | SPARC | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | SPARC | C0158266 | Intervertebral Disc Degeneration | 1 | CTD_human |
Hgene | SPARC | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
Hgene | SPARC | C0919267 | ovarian neoplasm | 1 | CTD_human |
Hgene | SPARC | C4225301 | OSTEOGENESIS IMPERFECTA, TYPE XVII | 1 | UNIPROT |
Tgene | COL2A1 | C0220685 | Achondrogenesis type 2 | 9 | CTD_human;ORPHANET;UNIPROT |
Tgene | COL2A1 | C0993582 | Arthritis, Experimental | 7 | CTD_human |
Tgene | COL2A1 | C2745959 | Spondyloepiphyseal dysplasia, congenita | 7 | CTD_human;ORPHANET;UNIPROT |
Tgene | COL2A1 | C1858079 | Osteoarthritis with Mild Chondrodysplasia | 5 | CTD_human;ORPHANET;UNIPROT |
Tgene | COL2A1 | C1836080 | Stickler Syndrome, Type I, Nonsyndromic Ocular | 4 | CTD_human;ORPHANET;UNIPROT |
Tgene | COL2A1 | C1836683 | Czech dysplasia, metatarsal type | 4 | ORPHANET;UNIPROT |
Tgene | COL2A1 | C0410480 | Avascular Necrosis of Femur Head | 3 | ORPHANET;UNIPROT |
Tgene | COL2A1 | C1835437 | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | 3 | CTD_human;ORPHANET;UNIPROT |
Tgene | COL2A1 | C0003864 | Arthritis | 2 | CTD_human |
Tgene | COL2A1 | C0029408 | Degenerative polyarthritis | 2 | CTD_human;HPO |
Tgene | COL2A1 | C0265279 | Kniest dysplasia | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | COL2A1 | C0376634 | Craniofacial Abnormalities | 2 | CTD_human |
Tgene | COL2A1 | C0700635 | Strudwick syndrome | 2 | CTD_human;HPO;ORPHANET;UNIPROT |
Tgene | COL2A1 | C1851536 | Epiphyseal Dysplasia, Multiple, with Myopia and Conductive Deafness | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | COL2A1 | C2020284 | Stickler syndrome, type 1 | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | COL2A1 | C0008479 | Chondrosarcoma | 1 | CTD_human |
Tgene | COL2A1 | C0008925 | Cleft Palate | 1 | CTD_human;HPO |
Tgene | COL2A1 | C0013604 | Edema | 1 | CTD_human;HPO |
Tgene | COL2A1 | C0018784 | Sensorineural Hearing Loss (disorder) | 1 | CTD_human;HPO |
Tgene | COL2A1 | C0020507 | Hyperplasia | 1 | CTD_human |
Tgene | COL2A1 | C0021368 | Inflammation | 1 | CTD_human |
Tgene | COL2A1 | C0025202 | melanoma | 1 | CTD_human |
Tgene | COL2A1 | C0027092 | Myopia | 1 | CTD_human;HPO |
Tgene | COL2A1 | C0029422 | Osteochondrodysplasias | 1 | CTD_human;HPO |
Tgene | COL2A1 | C0035305 | Retinal Detachment | 1 | CTD_human;HPO |
Tgene | COL2A1 | C0039103 | Synovitis | 1 | CTD_human |
Tgene | COL2A1 | C0041834 | Erythema | 1 | CTD_human |
Tgene | COL2A1 | C0086543 | Cataract | 1 | CTD_human;HPO |
Tgene | COL2A1 | C1262477 | Weight decreased | 1 | CTD_human |
Tgene | COL2A1 | C1840452 | Hyaloideoretinal degeneration of Wagner | 1 | CTD_human |
Tgene | COL2A1 | C1855310 | Megaepiphyseal dwarfism | 1 | CTD_human |
Tgene | COL2A1 | C4225273 | SPONDYLOEPIPHYSEAL DYSPLASIA, STANESCU TYPE | 1 | ORPHANET;UNIPROT |