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Fusion gene ID: 35551 |
FusionGeneSummary for SPARC_BOLA2 |
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Fusion gene information | Fusion gene name: SPARC_BOLA2 | Fusion gene ID: 35551 | Hgene | Tgene | Gene symbol | SPARC | BOLA2 | Gene ID | 6678 | 654483 |
Gene name | secreted protein acidic and cysteine rich | bolA family member 2B | |
Synonyms | BM-40|OI17|ON | BOLA2 | |
Cytomap | 5q33.1 | 16p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | SPARCbasement-membrane protein 40secreted protein, acidic, cysteine-rich (osteonectin) | bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P09486 | Q9H3K6 | |
Ensembl transtripts involved in fusion gene | ENST00000231061, ENST00000537849, | ENST00000330978, | |
Fusion gene scores | * DoF score | 12 X 16 X 5=960 | 19 X 26 X 1=494 |
# samples | 18 | 28 | |
** MAII score | log2(18/960*10)=-2.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(28/494*10)=-0.819084214639711 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SPARC [Title/Abstract] AND BOLA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SPARC | GO:0001937 | negative regulation of endothelial cell proliferation | 12867428 |
Hgene | SPARC | GO:0010595 | positive regulation of endothelial cell migration | 12867428 |
Hgene | SPARC | GO:0016525 | negative regulation of angiogenesis | 12867428 |
Hgene | SPARC | GO:0022604 | regulation of cell morphogenesis | 15389586 |
Tgene | BOLA2 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
Tgene | BOLA2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE928982 | SPARC | chr5 | 151043775 | - | BOLA2 | chr16 | 30078618 | + | ||
ChiTaRS3.1 | BE928949 | SPARC | chr5 | 151043775 | - | BOLA2 | chr16 | 30078618 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000231061 | ENST00000330978 | SPARC | chr5 | 151043775 | - | BOLA2 | chr16 | 30078618 | + |
intron-intron | ENST00000537849 | ENST00000330978 | SPARC | chr5 | 151043775 | - | BOLA2 | chr16 | 30078618 | + |
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FusionProtFeatures for SPARC_BOLA2 |
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Hgene | Tgene |
SPARC | BOLA2 |
Appears to regulate cell growth through interactionswith the extracellular matrix and cytokines. Binds calcium andcopper, several types of collagen, albumin, thrombospondin, PDGFand cell membranes. There are two calcium binding sites; an acidicdomain that binds 5 to 8 Ca(2+) with a low affinity and an EF-handloop that binds a Ca(2+) ion with a high affinity. | Acts as a cytosolic iron-sulfur (Fe-S) cluster assemblyfactor that facilitates [2Fe-2S] cluster insertion into a subsetof cytosolic proteins (PubMed:26613676, PubMed:27519415). Actstogether with the monothiol glutaredoxin GLRX3 (PubMed:26613676,PubMed:27519415). {ECO:0000269|PubMed:26613676,ECO:0000269|PubMed:27519415}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SPARC_BOLA2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SPARC_BOLA2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPARC_BOLA2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | SPARC | P09486 | DB11093 | Calcium Citrate | SPARC | small molecule | approved |
Hgene | SPARC | P09486 | DB11348 | Calcium Phosphate | SPARC | small molecule | approved |
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RelatedDiseases for SPARC_BOLA2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SPARC | C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_human |
Hgene | SPARC | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Hgene | SPARC | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | SPARC | C0019158 | Hepatitis | 1 | CTD_human |
Hgene | SPARC | C0020429 | Hyperalgesia | 1 | CTD_human |
Hgene | SPARC | C0022658 | Kidney Diseases | 1 | CTD_human |
Hgene | SPARC | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | SPARC | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | SPARC | C0024031 | Low Back Pain | 1 | CTD_human |
Hgene | SPARC | C0026764 | Multiple Myeloma | 1 | CTD_human |
Hgene | SPARC | C0027540 | Necrosis | 1 | CTD_human |
Hgene | SPARC | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Hgene | SPARC | C0029434 | Osteogenesis Imperfecta | 1 | CTD_human |
Hgene | SPARC | C0041948 | Uremia | 1 | CTD_human |
Hgene | SPARC | C0043094 | Weight Gain | 1 | CTD_human |
Hgene | SPARC | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | SPARC | C0158266 | Intervertebral Disc Degeneration | 1 | CTD_human |
Hgene | SPARC | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
Hgene | SPARC | C0919267 | ovarian neoplasm | 1 | CTD_human |
Hgene | SPARC | C4225301 | OSTEOGENESIS IMPERFECTA, TYPE XVII | 1 | UNIPROT |