![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 35546 |
FusionGeneSummary for SPARCL1_SPARCL1 |
![]() |
Fusion gene information | Fusion gene name: SPARCL1_SPARCL1 | Fusion gene ID: 35546 | Hgene | Tgene | Gene symbol | SPARCL1 | SPARCL1 | Gene ID | 8404 | 8404 |
Gene name | SPARC like 1 | SPARC like 1 | |
Synonyms | MAST 9|MAST9|PIG33|SC1 | MAST 9|MAST9|PIG33|SC1 | |
Cytomap | 4q22.1 | 4q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | SPARC-like protein 1SPARC-like 1 (hevin)high endothelial venule proteinproliferation-inducing protein 33 | SPARC-like protein 1SPARC-like 1 (hevin)high endothelial venule proteinproliferation-inducing protein 33 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q14515 | Q14515 | |
Ensembl transtripts involved in fusion gene | ENST00000282470, ENST00000418378, ENST00000503414, | ENST00000282470, ENST00000418378, ENST00000503414, | |
Fusion gene scores | * DoF score | 6 X 7 X 1=42 | 10 X 8 X 5=400 |
# samples | 7 | 11 | |
** MAII score | log2(7/42*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/400*10)=-1.86249647625006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SPARCL1 [Title/Abstract] AND SPARCL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE856511 | SPARCL1 | chr4 | 88415325 | + | SPARCL1 | chr4 | 88414978 | + | ||
ChiTaRS3.1 | BF222593 | SPARCL1 | chr4 | 88415479 | + | SPARCL1 | chr4 | 88414789 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000282470 | ENST00000282470 | SPARCL1 | chr4 | 88415325 | + | SPARCL1 | chr4 | 88414978 | + |
intron-3CDS | ENST00000282470 | ENST00000418378 | SPARCL1 | chr4 | 88415325 | + | SPARCL1 | chr4 | 88414978 | + |
intron-3CDS | ENST00000282470 | ENST00000503414 | SPARCL1 | chr4 | 88415325 | + | SPARCL1 | chr4 | 88414978 | + |
intron-3CDS | ENST00000418378 | ENST00000282470 | SPARCL1 | chr4 | 88415325 | + | SPARCL1 | chr4 | 88414978 | + |
intron-3CDS | ENST00000418378 | ENST00000418378 | SPARCL1 | chr4 | 88415325 | + | SPARCL1 | chr4 | 88414978 | + |
intron-3CDS | ENST00000418378 | ENST00000503414 | SPARCL1 | chr4 | 88415325 | + | SPARCL1 | chr4 | 88414978 | + |
intron-3CDS | ENST00000503414 | ENST00000282470 | SPARCL1 | chr4 | 88415325 | + | SPARCL1 | chr4 | 88414978 | + |
intron-3CDS | ENST00000503414 | ENST00000418378 | SPARCL1 | chr4 | 88415325 | + | SPARCL1 | chr4 | 88414978 | + |
intron-3CDS | ENST00000503414 | ENST00000503414 | SPARCL1 | chr4 | 88415325 | + | SPARCL1 | chr4 | 88414978 | + |
intron-3CDS | ENST00000282470 | ENST00000282470 | SPARCL1 | chr4 | 88415479 | + | SPARCL1 | chr4 | 88414789 | + |
intron-3CDS | ENST00000282470 | ENST00000418378 | SPARCL1 | chr4 | 88415479 | + | SPARCL1 | chr4 | 88414789 | + |
intron-3CDS | ENST00000282470 | ENST00000503414 | SPARCL1 | chr4 | 88415479 | + | SPARCL1 | chr4 | 88414789 | + |
intron-3CDS | ENST00000418378 | ENST00000282470 | SPARCL1 | chr4 | 88415479 | + | SPARCL1 | chr4 | 88414789 | + |
intron-3CDS | ENST00000418378 | ENST00000418378 | SPARCL1 | chr4 | 88415479 | + | SPARCL1 | chr4 | 88414789 | + |
intron-3CDS | ENST00000418378 | ENST00000503414 | SPARCL1 | chr4 | 88415479 | + | SPARCL1 | chr4 | 88414789 | + |
intron-3CDS | ENST00000503414 | ENST00000282470 | SPARCL1 | chr4 | 88415479 | + | SPARCL1 | chr4 | 88414789 | + |
intron-3CDS | ENST00000503414 | ENST00000418378 | SPARCL1 | chr4 | 88415479 | + | SPARCL1 | chr4 | 88414789 | + |
intron-3CDS | ENST00000503414 | ENST00000503414 | SPARCL1 | chr4 | 88415479 | + | SPARCL1 | chr4 | 88414789 | + |
Top |
FusionProtFeatures for SPARCL1_SPARCL1 |
![]() |
Hgene | Tgene |
SPARCL1 | SPARCL1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SPARCL1_SPARCL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SPARCL1_SPARCL1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SPARCL1_SPARCL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SPARCL1_SPARCL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SPARCL1 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | SPARCL1 | C0014544 | Epilepsy | 1 | CTD_human |
Tgene | SPARCL1 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | SPARCL1 | C0014544 | Epilepsy | 1 | CTD_human |