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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35545

FusionGeneSummary for SPARCL1_SGSM1

check button Fusion gene summary
Fusion gene informationFusion gene name: SPARCL1_SGSM1
Fusion gene ID: 35545
HgeneTgene
Gene symbol

SPARCL1

SGSM1

Gene ID

8404

129049

Gene nameSPARC like 1small G protein signaling modulator 1
SynonymsMAST 9|MAST9|PIG33|SC1RUTBC2
Cytomap

4q22.1

22q11.23

Type of geneprotein-codingprotein-coding
DescriptionSPARC-like protein 1SPARC-like 1 (hevin)high endothelial venule proteinproliferation-inducing protein 33small G protein signaling modulator 1RUN and TBC1 domain containing 2RUN and TBC1 domain-containing protein 2small G protein signaling modulator 1 protein
Modification date2018052320180523
UniProtAcc

Q14515

Q2NKQ1

Ensembl transtripts involved in fusion geneENST00000282470, ENST00000418378, 
ENST00000503414, 
ENST00000400358, 
ENST00000400359, ENST00000470591, 
Fusion gene scores* DoF score6 X 7 X 1=423 X 3 X 3=27
# samples 73
** MAII scorelog2(7/42*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SPARCL1 [Title/Abstract] AND SGSM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB570293SPARCL1chr4

88415694

-SGSM1chr22

25322581

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000282470ENST00000400358SPARCL1chr4

88415694

-SGSM1chr22

25322581

+
intron-intronENST00000282470ENST00000400359SPARCL1chr4

88415694

-SGSM1chr22

25322581

+
intron-intronENST00000282470ENST00000470591SPARCL1chr4

88415694

-SGSM1chr22

25322581

+
intron-3UTRENST00000418378ENST00000400358SPARCL1chr4

88415694

-SGSM1chr22

25322581

+
intron-intronENST00000418378ENST00000400359SPARCL1chr4

88415694

-SGSM1chr22

25322581

+
intron-intronENST00000418378ENST00000470591SPARCL1chr4

88415694

-SGSM1chr22

25322581

+
intron-3UTRENST00000503414ENST00000400358SPARCL1chr4

88415694

-SGSM1chr22

25322581

+
intron-intronENST00000503414ENST00000400359SPARCL1chr4

88415694

-SGSM1chr22

25322581

+
intron-intronENST00000503414ENST00000470591SPARCL1chr4

88415694

-SGSM1chr22

25322581

+

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FusionProtFeatures for SPARCL1_SGSM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPARCL1

Q14515

SGSM1

Q2NKQ1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPARCL1_SGSM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPARCL1_SGSM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPARCL1_SGSM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPARCL1_SGSM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPARCL1C0014175Endometriosis1CTD_human
HgeneSPARCL1C0014544Epilepsy1CTD_human