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Fusion gene ID: 35544 |
FusionGeneSummary for SPARCL1_PKP4 |
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Fusion gene information | Fusion gene name: SPARCL1_PKP4 | Fusion gene ID: 35544 | Hgene | Tgene | Gene symbol | SPARCL1 | PKP4 | Gene ID | 8404 | 8502 |
Gene name | SPARC like 1 | plakophilin 4 | |
Synonyms | MAST 9|MAST9|PIG33|SC1 | p0071 | |
Cytomap | 4q22.1 | 2q24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | SPARC-like protein 1SPARC-like 1 (hevin)high endothelial venule proteinproliferation-inducing protein 33 | plakophilin-4catenin 4 | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q14515 | Q99569 | |
Ensembl transtripts involved in fusion gene | ENST00000282470, ENST00000418378, ENST00000503414, | ENST00000389757, ENST00000389759, ENST00000495123, | |
Fusion gene scores | * DoF score | 6 X 7 X 1=42 | 10 X 12 X 5=600 |
# samples | 7 | 13 | |
** MAII score | log2(7/42*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/600*10)=-2.20645087746743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SPARCL1 [Title/Abstract] AND PKP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PKP4 | GO:0043547 | positive regulation of GTPase activity | 17115030 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF951590 | SPARCL1 | chr4 | 88416186 | + | PKP4 | chr2 | 159519580 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000282470 | ENST00000389757 | SPARCL1 | chr4 | 88416186 | + | PKP4 | chr2 | 159519580 | - |
intron-3CDS | ENST00000282470 | ENST00000389759 | SPARCL1 | chr4 | 88416186 | + | PKP4 | chr2 | 159519580 | - |
intron-3UTR | ENST00000282470 | ENST00000495123 | SPARCL1 | chr4 | 88416186 | + | PKP4 | chr2 | 159519580 | - |
intron-3CDS | ENST00000418378 | ENST00000389757 | SPARCL1 | chr4 | 88416186 | + | PKP4 | chr2 | 159519580 | - |
intron-3CDS | ENST00000418378 | ENST00000389759 | SPARCL1 | chr4 | 88416186 | + | PKP4 | chr2 | 159519580 | - |
intron-3UTR | ENST00000418378 | ENST00000495123 | SPARCL1 | chr4 | 88416186 | + | PKP4 | chr2 | 159519580 | - |
intron-3CDS | ENST00000503414 | ENST00000389757 | SPARCL1 | chr4 | 88416186 | + | PKP4 | chr2 | 159519580 | - |
intron-3CDS | ENST00000503414 | ENST00000389759 | SPARCL1 | chr4 | 88416186 | + | PKP4 | chr2 | 159519580 | - |
intron-3UTR | ENST00000503414 | ENST00000495123 | SPARCL1 | chr4 | 88416186 | + | PKP4 | chr2 | 159519580 | - |
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FusionProtFeatures for SPARCL1_PKP4 |
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Hgene | Tgene |
SPARCL1 | PKP4 |
Plays a role as a regulator of Rho activity duringcytokinesis. May play a role in junctional plaques.{ECO:0000269|PubMed:17115030}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SPARCL1_PKP4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SPARCL1_PKP4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPARCL1_PKP4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPARCL1_PKP4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SPARCL1 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | SPARCL1 | C0014544 | Epilepsy | 1 | CTD_human |