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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35544

FusionGeneSummary for SPARCL1_PKP4

check button Fusion gene summary
Fusion gene informationFusion gene name: SPARCL1_PKP4
Fusion gene ID: 35544
HgeneTgene
Gene symbol

SPARCL1

PKP4

Gene ID

8404

8502

Gene nameSPARC like 1plakophilin 4
SynonymsMAST 9|MAST9|PIG33|SC1p0071
Cytomap

4q22.1

2q24.1

Type of geneprotein-codingprotein-coding
DescriptionSPARC-like protein 1SPARC-like 1 (hevin)high endothelial venule proteinproliferation-inducing protein 33plakophilin-4catenin 4
Modification date2018052320180527
UniProtAcc

Q14515

Q99569

Ensembl transtripts involved in fusion geneENST00000282470, ENST00000418378, 
ENST00000503414, 
ENST00000389757, 
ENST00000389759, ENST00000495123, 
Fusion gene scores* DoF score6 X 7 X 1=4210 X 12 X 5=600
# samples 713
** MAII scorelog2(7/42*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(13/600*10)=-2.20645087746743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPARCL1 [Title/Abstract] AND PKP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePKP4

GO:0043547

positive regulation of GTPase activity

17115030


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF951590SPARCL1chr4

88416186

+PKP4chr2

159519580

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000282470ENST00000389757SPARCL1chr4

88416186

+PKP4chr2

159519580

-
intron-3CDSENST00000282470ENST00000389759SPARCL1chr4

88416186

+PKP4chr2

159519580

-
intron-3UTRENST00000282470ENST00000495123SPARCL1chr4

88416186

+PKP4chr2

159519580

-
intron-3CDSENST00000418378ENST00000389757SPARCL1chr4

88416186

+PKP4chr2

159519580

-
intron-3CDSENST00000418378ENST00000389759SPARCL1chr4

88416186

+PKP4chr2

159519580

-
intron-3UTRENST00000418378ENST00000495123SPARCL1chr4

88416186

+PKP4chr2

159519580

-
intron-3CDSENST00000503414ENST00000389757SPARCL1chr4

88416186

+PKP4chr2

159519580

-
intron-3CDSENST00000503414ENST00000389759SPARCL1chr4

88416186

+PKP4chr2

159519580

-
intron-3UTRENST00000503414ENST00000495123SPARCL1chr4

88416186

+PKP4chr2

159519580

-

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FusionProtFeatures for SPARCL1_PKP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPARCL1

Q14515

PKP4

Q99569

Plays a role as a regulator of Rho activity duringcytokinesis. May play a role in junctional plaques.{ECO:0000269|PubMed:17115030}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPARCL1_PKP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPARCL1_PKP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPARCL1_PKP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPARCL1_PKP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPARCL1C0014175Endometriosis1CTD_human
HgeneSPARCL1C0014544Epilepsy1CTD_human