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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35543

FusionGeneSummary for SPARCL1_GBAS

check button Fusion gene summary
Fusion gene informationFusion gene name: SPARCL1_GBAS
Fusion gene ID: 35543
HgeneTgene
Gene symbol

SPARCL1

GBAS

Gene ID

8404

Gene nameSPARC like 1
SynonymsMAST 9|MAST9|PIG33|SC1
Cytomap

4q22.1

Type of geneprotein-coding
DescriptionSPARC-like protein 1SPARC-like 1 (hevin)high endothelial venule proteinproliferation-inducing protein 33
Modification date20180523
UniProtAcc

Q14515

Ensembl transtripts involved in fusion geneENST00000282470, ENST00000418378, 
ENST00000503414, 
ENST00000446778, 
ENST00000322090, ENST00000487370, 
Fusion gene scores* DoF score6 X 7 X 1=422 X 2 X 2=8
# samples 72
** MAII scorelog2(7/42*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: SPARCL1 [Title/Abstract] AND GBAS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA235147SPARCL1chr4

88415716

-GBASchr7

56047621

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000282470ENST00000446778SPARCL1chr4

88415716

-GBASchr7

56047621

+
intron-intronENST00000282470ENST00000322090SPARCL1chr4

88415716

-GBASchr7

56047621

+
intron-intronENST00000282470ENST00000487370SPARCL1chr4

88415716

-GBASchr7

56047621

+
intron-intronENST00000418378ENST00000446778SPARCL1chr4

88415716

-GBASchr7

56047621

+
intron-intronENST00000418378ENST00000322090SPARCL1chr4

88415716

-GBASchr7

56047621

+
intron-intronENST00000418378ENST00000487370SPARCL1chr4

88415716

-GBASchr7

56047621

+
intron-intronENST00000503414ENST00000446778SPARCL1chr4

88415716

-GBASchr7

56047621

+
intron-intronENST00000503414ENST00000322090SPARCL1chr4

88415716

-GBASchr7

56047621

+
intron-intronENST00000503414ENST00000487370SPARCL1chr4

88415716

-GBASchr7

56047621

+

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FusionProtFeatures for SPARCL1_GBAS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPARCL1

Q14515

GBAS

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SPARCL1_GBAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SPARCL1_GBAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPARCL1_GBAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPARCL1_GBAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPARCL1C0014175Endometriosis1CTD_human
HgeneSPARCL1C0014544Epilepsy1CTD_human